Based on the practice of oil and gas exploration in the Huizhou Sag of the Pearl River Mouth Basin,the geochemical indexes of source rocks were measured,the reservoir development morphology was restored,the rocks and ...Based on the practice of oil and gas exploration in the Huizhou Sag of the Pearl River Mouth Basin,the geochemical indexes of source rocks were measured,the reservoir development morphology was restored,the rocks and minerals were characterized microscopically,the measured trap sealing indexes were compared,the biomarker compounds of crude oil were extracted,the genesis of condensate gas was identified,and the reservoir-forming conditions were examined.On this basis,the Paleogene Enping Formation in the Huizhou 26 subsag was systematically analyzed for the potential of oil and gas resources,the development characteristics of large-scale high-quality conglomerate reservoirs,the trapping effectiveness of faults,the hydrocarbon migration and accumulation model,and the formation conditions and exploration targets of large-and medium-sized glutenite-rich oil and gas fields.The research results were obtained in four aspects.First,the Paleogene Wenchang Formation in the Huizhou 26 subsag develops extensive and thick high-quality source rocks of semi-deep to deep lacustrine subfacies,which have typical hydrocarbon expulsion characteristics of"great oil generation in the early stage and huge gas expulsion in the late stage",providing a sufficient material basis for hydrocarbon accumulation in the Enping Formation.Second,under the joint control of the steep slope zone and transition zone of the fault within the sag,the large-scale near-source glutenite reservoirs are highly heterogeneous,with the development scale dominated hierarchically by three factors(favorable facies zone,particle component,and microfracture).The(subaqueous)distributary channels near the fault system,with equal grains,a low mud content(<5%),and a high content of feldspar composition,are conducive to the development of sweet spot reservoirs.Third,the strike-slip pressurization trap covered by stable lake flooding mudstone is a necessary condition for oil and gas preservation,and the NE and nearly EW faults obliquely to the principal stress have the best control on traps.Fourth,the spatiotemporal configuration of high-quality source rocks,fault transport/sealing,and glutenite reservoirs controls the degree of hydrocarbon enrichment.From top to bottom,three hydrocarbon accumulation units,i.e.low-fill zone,transition zone,and high-fill zone,are recognized.The main area of the channel in the nearly pressurized source-connecting fault zone is favorable for large-scale hydrocarbon enrichment.The research results suggest a new direction for the exploration of large-scale glutenite-rich reservoirs in the Enping Formation of the Pearl River Mouth Basin,and present a major breakthrough in oil and gas exploration.展开更多
Objective: To study the application effect of mouth-opening training sticks combined with oral massage on patients with mouth-opening difficulty after treatment for head and neck cancer. Methods: Using convenient samp...Objective: To study the application effect of mouth-opening training sticks combined with oral massage on patients with mouth-opening difficulty after treatment for head and neck cancer. Methods: Using convenient sampling, 60 patients with mouth-opening difficulty after treatment for head and neck cancer admitted to the Oncology Department from February 2022 to October 2023 were selected for a 2-week exercise and nursing program. The patients were divided into a control group (February 1, 2022 to November 30, 2022) and an observation group (December 1, 2022 to October 31, 2023), with 30 patients in each group. The control group underwent routine mouth-opening functional exercises combined with cork for oral support training, while the observation group underwent routine mouth-opening functional exercises combined with oral massage and mouth-opening training sticks for oral support training. The mouth-opening degree, mouth-opening difficulty level, comfort level, compliance, and quality of life were observed in both groups. Results: Before the intervention, there were no statistically significant differences in mouth-opening degree and mouth-opening difficulty level between the two groups (P > 0.05). After the intervention, the mouth-opening degree, mouth-opening difficulty level, oral comfort level, compliance, and QLICP-HN scores in the observation group were all better than those in the control group, with statistically significant differences (P < 0.05). Conclusion: The combination of mouth-opening training sticks and oral massage with mouth-opening functional exercises can effectively improve the degree of mouth-opening difficulty, enhance oral comfort, increase compliance with mouth-opening exercises, and improve quality of life.展开更多
The coupling relationship between shelf-edge deltas and deep-water fan sand bodies is a hot and cutting-edge field of international sedimentology and deep-water oil and gas exploration.Based on the newly acquired high...The coupling relationship between shelf-edge deltas and deep-water fan sand bodies is a hot and cutting-edge field of international sedimentology and deep-water oil and gas exploration.Based on the newly acquired high-resolution 3D seismic,logging and core data of Pearl River Mouth Basin(PRMB),this paper dissected the shelf-edge delta to deep-water fan(SEDDF)depositional system in the Oligocene Zhuhai Formation of Paleogene in south subsag of Baiyun Sag,and revealed the complex coupling relationship from the continental shelf edge to deep-water fan sedimentation and its genetic mechanisms.The results show that during the deposition of the fourth to first members of the Zhuhai Formation,the scale of the SEDDF depositional system in the study area showed a pattern of first increasing and then decreasing,with deep-water fan developed in the third to first members and the largest plane distribution scale developed in the late stage of the second member.Based on the development of SEDDF depositional system along the source direction,three types of coupling relationships are divided,namely,deltas that are linked downdip to fans,deltas that lack downdip fans and fans that lack updip coeval deltas,with different depositional characteristics and genetic mechanisms.(1)Deltas that are linked downdip to fans:with the development of shelf-edge deltas in the shelf area and deep-water fans in the downdip slope area,and the strong source supply and relative sea level decline are the two key factors which control the development of this type of source-to-sink(S2S).The development of channels on the continental shelf edge is conducive to the formation of this type of S2S system even with weak source supply and high sea level.(2)Deltas that lack downdip fans:with the development of shelf edge deltas in shelf area,while deep water fans are not developed in the downdip slope area.The lack of“sources”and“channels”,and fluid transformation are the three main reasons for the formation of this type of S2S system.(3)Fans that lack updip coeval deltas:with the development of deep-water fans in continental slope area and the absence of updip coeval shelf edge deltas,which is jointly controlled by the coupling of fluid transformation at the shelf edge and the“channels”in the continental slope area.展开更多
Based on high-resolution 3D seismic data acquired in the Pearl(Zhujiang)River Mouth Basin of the northern South China Sea,this study investigated the geometry,spatial extension,and throw distribution of the post-rift ...Based on high-resolution 3D seismic data acquired in the Pearl(Zhujiang)River Mouth Basin of the northern South China Sea,this study investigated the geometry,spatial extension,and throw distribution of the post-rift normal fault through detailed seismic interpretation and fault modeling.A total of 289 post-rift normal faults were identified in the study area and can be classified into four types:(1)isolated normal faults above the carbonate platform;(2)isolated normal faults cutting through the carbonate platform;(3)conjugate normal faults,and(4)connecting normal faults.Throw distribution analysis on the fault planes show that the vertical throw profiles of most normal fault exhibit flat-topped profiles.Isolated normal faults above the carbonate platform exhibit roughly concentric ellipses with maximum throw zones in the central section whereas the normal faults cutting through the carbonate platform miss the lowermost section due to the chaotic seismic reflections in the interior of the carbonate platform.The vertical throws of conjugate normal faults anomalously decrease toward their intersection region on the fault plane whereas the connecting normal faults present two maximum throw zones in the central section of the fault plane.According to the symmetric elliptical distribution model of fault throw,an estimation was made indicating that normal faults cutting through the carbonate platform extended downward between-1308 s and-1780 s(two-way travel time)in depth and may not penetrate the entire Liuhua carbonate platform.Moreover,it is observed that the distribution of karst caves on the top of the carbonate platform disaccord with those of hydrocarbon reservoirs and the post-rift normal faults cutting through the carbonate platform in the study area.We propose that these karst caves formed most probably by corrosive fluids derived from magmatic activities during the Dongsha event,rather than pore waters or hydrocarbons.展开更多
A transfer zone in rift basins preserves important information on regional tectonic evolution and plays significant roles in hydrocarbon accumulation.Based on the systematic analysis of 3D seismic data and hydrocarbon...A transfer zone in rift basins preserves important information on regional tectonic evolution and plays significant roles in hydrocarbon accumulation.Based on the systematic analysis of 3D seismic data and hydrocarbon accumulation conditions,the geometry,kinematics,and reservoir control of a large synthetic overlapping transfer zone in the south of the Wenchang A subsag in the Zhujiang(Pearl)River Mouth basin were investigated.Results indicate that the development and evolution of the transfer zone was controlled by the interaction between pre-existing faults and regional stress transformation.The intense rifting of the main faults of the transfer zone controlled the development of source rocks and faultcontrolled slope break paleogeomorphology.The strike-slip overprint since the Oligocene is conducive to the formation of a large-scale fault-anticline trap,and the secondary faults in the transfer zone contribute to the hydrocarbon transportation.The conjugate intersection area of the NE-and NW-trending faults offers more opportunity for hydrocarbon migration and accumulation.展开更多
Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated genes.Methods:We conducted a comparative analysis of PRR...Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated genes.Methods:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 isolates.Subsequently,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and DDX58.Results:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the disease.The expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative patients.Expression levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of HFMD.Aspartate aminotransferase was correlated with BST2,MX1 and DDX58 expression levels.Conclusions:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.展开更多
In this article, the transmission dynamics of a Hand-Foot-Mouth disease model with treatment and vaccination interventions are studied. We calculated the basic reproduction number and proved the global stability of di...In this article, the transmission dynamics of a Hand-Foot-Mouth disease model with treatment and vaccination interventions are studied. We calculated the basic reproduction number and proved the global stability of disease-free equilibrium when R0 R0 > 1. Meanwhile, we obtained the optimal control strategies minimizing the cost of intervention and minimizing the infected person. We also give some numerical simulations to verify our theoretical results.展开更多
At present, the water-cooling simulation of the water-cooled magnetic coupler is based on the water-cooled motor and the hydraulic coupler, which cannot accurately characterize the temperature distribution of the rota...At present, the water-cooling simulation of the water-cooled magnetic coupler is based on the water-cooled motor and the hydraulic coupler, which cannot accurately characterize the temperature distribution of the rotating watercooled coupling of the coupler. Focusing on rotating water cooling radiating, the present paper proposes simulating the water cooling temperature field as well as the flow field through the method of combining fluid-solid coupled heat transfer and MRF(Multiphase Reference Frame). In addition, taking an 800 kW magnetic coupling as an example, the paper optimizes the shape, number, cooling water inlet speed? and so on? of the cooling channel. Considering factors such as the complete machine’s temperature, and drag torque, it is proved that the cooling e ect is best when there are 36 involute curved channels and when the inlet speed is 3 m/s. Further, through experiments, the actual temperature values at six di erent positions when 50 kW and 70 kW thermal losses di er are measured. The measured values agree with the simulation results, proving the correctness of the proposed method. Further, data have been collected during the entire experimental procedure? and the variation in the coupling’s temperature is analyzed in depth, with the objective of laying a foundation for the estimation of the inner temperature rise as well as for the optimization of the structural design.展开更多
In order to cool computer chip efficiently with the least noise, a single phase water-cooling radiator for computer chip driven by piezoelectric pump with two parallel-connection chambers is developed. The structure a...In order to cool computer chip efficiently with the least noise, a single phase water-cooling radiator for computer chip driven by piezoelectric pump with two parallel-connection chambers is developed. The structure and work principle of this radiator is described. Material, processing method and design principles of whole radiator are also explained. Finite element analysis （FEA） software, ANSYS, is used to simulate the heat distribution in the radiator. Testing equipments for water-cooling radiator are also listed. By experimental tests, influences of flowrate inside the cooling system and fan on chip cooling are explicated. This water-cooling radiator is proved more efficient than current air-cooling radiator with comparison experiments. During cooling the heater which simulates the working of computer chip with different power, the water-cooling radiator needs shorter time to reach lower steady temperatures than current air-cooling radiator.展开更多
For predicting and controlling the melted depth of bottomelectrode during the process of steelmaking, the water-cooling steel-stick electrode is taken as an example, to analyze the process ofheat transfer, then 3D mat...For predicting and controlling the melted depth of bottomelectrode during the process of steelmaking, the water-cooling steel-stick electrode is taken as an example, to analyze the process ofheat transfer, then 3D mathematical model by control capacity methodis built. At the same time, the measurement on the melted depth ofbottom electrode is conducted which verified the correctness of thebuilt mathematical model. On the base of verification, all kinds ofkey parameters are calculated through the application and a series ofresults are simulated. Finally, the optimum parameters are found andthe service life of bottom electrode is prolonged.展开更多
The first major outbreak of the severely complicated hand,foot and mouth disease(HFMD),primarily caused by enterovirus 71,was reported in Taiwan in 1998.HFMD surveillance is needed to assess the spread of HFMD.The par...The first major outbreak of the severely complicated hand,foot and mouth disease(HFMD),primarily caused by enterovirus 71,was reported in Taiwan in 1998.HFMD surveillance is needed to assess the spread of HFMD.The parameters we use in mathematical models are usually classical mathematical parameters,called crisp parameters,which are taken for granted.But any biological or physical phenomenon is best explained by uncertainty.To represent a realistic situation in any mathematical model,fuzzy parameters can be very useful.Many articles have been published on how to control and prevent HFMD from the perspective of public health and statistical modeling.However,few works use fuzzy theory in building models to simulateHFMDdynamics.In this context,we examined anHFMD model with fuzzy parameters.A Non Standard Finite Difference(NSFD)scheme is developed to solve the model.The developed technique retains essential properties such as positivity and dynamic consistency.Numerical simulations are presented to support the analytical results.The convergence and consistency of the proposed method are also discussed.The proposed method converges unconditionally while the many classical methods in the literature do not possess this property.In this regard,our proposed method can be considered as a reliable tool for studying the dynamics of HFMD.展开更多
The water-cooling heat dissipation technology can solve the heat dissipation and noise problems of the calculation plate.Therefore,the structural design of the water-cooling plate directly affects its flow and heat tr...The water-cooling heat dissipation technology can solve the heat dissipation and noise problems of the calculation plate.Therefore,the structural design of the water-cooling plate directly affects its flow and heat transfer characteristics,which restricts the promotion and application of the technology.To this end,the water-cooling plate of a heat dissipation system was taken as the research object,and its flow and heat transfer characteristics were numerical simulated and experimental studied.Through comparative analysis,the rationality of the numerical simulation method was verified.Based on this,three improved schemes of water-cooling plate structure were proposed and numerical simulation was carried out,and the optimal model was verified by experiments.The results of the study show that compared with the original water-cooling plate,the optimized water-cooling plate has increased internal flow velocity and distributes uniformly,increased heat transfer amount by 4.2%,and the average temperature of the calculation plate decreased by 5.3%.展开更多
The Pearl River Mouth Basin(PRMB)is one of the most petroliferous basins on the northern margin of the South China Sea.Knowledge of the thermal history of the PRMB is significant for understanding its tectonic evoluti...The Pearl River Mouth Basin(PRMB)is one of the most petroliferous basins on the northern margin of the South China Sea.Knowledge of the thermal history of the PRMB is significant for understanding its tectonic evolution and for unraveling its poorly studied source-rock maturation history.Our investigations in this study are based on apatite fission-track(AFT)thermochronology analysis of 12 cutting samples from 4 boreholes.Both AFT ages and length data suggested that the PRMB has experienced quite complicated thermal evolution.Thermal history modeling results unraveled four successive events of heating separated by three stages of cooling since the early Middle Eocene.The cooling events occurred approximately in the Late Eocene,early Oligocene,and the Late Miocene,possibly attributed to the Zhuqiong II Event,Nanhai Event,and Dongsha Event,respectively.The erosion amount during the first cooling stage is roughly estimated to be about 455-712 m,with an erosion rate of 0.08-0.12 mm/a.The second erosion-driven cooling is stronger than the first one,with an erosion amount of about 747-814 m and an erosion rate between about 0.13-0.21 mm/a.The erosion amount calculated related to the third cooling event varies from 800 m to 3419 m,which is speculative due to the possible influence of the magmatic activity.展开更多
EV71-type virus is one of the main pathogens causing the occurrence of hand,foot and mouth disease(HFMD),and VP1 protein,a factor that directly determines the antigenicity of the virus,has been isolated.The tomato was...EV71-type virus is one of the main pathogens causing the occurrence of hand,foot and mouth disease(HFMD),and VP1 protein,a factor that directly determines the antigenicity of the virus,has been isolated.The tomato was selected as a bioreactor for the production of an edible EV71 vaccine designed for the VP1 capsid protein.Using molecular biology techniques,the fusion gene EV71-VP1 was cut from vector PGEX-4T-2,a vector containing the p2300-EV71 gene with CaMV35S promoter and TL regulatory elements was constructed,and the hypocotyl and cotyledons of tomato were transformed using Agrobacterium(EHA105)-mediated method,screened,elongated and rooted,and finally 20 resistant tomato plants were obtained.Five transgenic positive seedlings were obtained by digestion and PCR assay,among which three plants were detected by RT-PCR to be capable of transcriptional translation at the RNA level.The experimental results aimed to explore new material support for the preparation of transgenic plant oral vaccines against EV71 infection and provide a theoretical basis for accelerating the development of transgenic plant vaccines in the future.展开更多
Objective:To explore the effect of mindfulness meditation on patients with burning mouth syndrome.Methods:60 patients with burning mouth syndrome in our hospital who were treated from January 2021 to December 2022 wer...Objective:To explore the effect of mindfulness meditation on patients with burning mouth syndrome.Methods:60 patients with burning mouth syndrome in our hospital who were treated from January 2021 to December 2022 were selected for this study.The patients were divided into two groups of thirty cases each using the randomized numerical table method.The observation underwent psychological intervention and mindfulness meditation training,while the control group only received symptomatic care.The condition of the patients of both groups was observed and compared.Results:Upon receiving treatment,the patients in the observation group had lower Hamilton Anxiety(HAM-A)scores,and Hamilton Depression(HAMD)scores compared to the control group(P<0.05).The visual analog scale(VAS)scores of the observation group were also lower than those of the control group(P<0.05).Moreover,the efficacy of the nursing intervention in the observation group was higher than that of the control group(P<0.05).Conclusion:Psychological intervention and mindfulness meditation training can effectively improve the clinical symptoms of patients with burning mouth syndrome.Therefore,this treatment method should be popularized.展开更多
基金Supported by the CNOOC Major Technology Project During the 14th FIVE-YEAR PLAN PERIOD(KJGG2022-0403)CNOOC Major Technology Project(KJZH-2021-0003-00).
文摘Based on the practice of oil and gas exploration in the Huizhou Sag of the Pearl River Mouth Basin,the geochemical indexes of source rocks were measured,the reservoir development morphology was restored,the rocks and minerals were characterized microscopically,the measured trap sealing indexes were compared,the biomarker compounds of crude oil were extracted,the genesis of condensate gas was identified,and the reservoir-forming conditions were examined.On this basis,the Paleogene Enping Formation in the Huizhou 26 subsag was systematically analyzed for the potential of oil and gas resources,the development characteristics of large-scale high-quality conglomerate reservoirs,the trapping effectiveness of faults,the hydrocarbon migration and accumulation model,and the formation conditions and exploration targets of large-and medium-sized glutenite-rich oil and gas fields.The research results were obtained in four aspects.First,the Paleogene Wenchang Formation in the Huizhou 26 subsag develops extensive and thick high-quality source rocks of semi-deep to deep lacustrine subfacies,which have typical hydrocarbon expulsion characteristics of"great oil generation in the early stage and huge gas expulsion in the late stage",providing a sufficient material basis for hydrocarbon accumulation in the Enping Formation.Second,under the joint control of the steep slope zone and transition zone of the fault within the sag,the large-scale near-source glutenite reservoirs are highly heterogeneous,with the development scale dominated hierarchically by three factors(favorable facies zone,particle component,and microfracture).The(subaqueous)distributary channels near the fault system,with equal grains,a low mud content(<5%),and a high content of feldspar composition,are conducive to the development of sweet spot reservoirs.Third,the strike-slip pressurization trap covered by stable lake flooding mudstone is a necessary condition for oil and gas preservation,and the NE and nearly EW faults obliquely to the principal stress have the best control on traps.Fourth,the spatiotemporal configuration of high-quality source rocks,fault transport/sealing,and glutenite reservoirs controls the degree of hydrocarbon enrichment.From top to bottom,three hydrocarbon accumulation units,i.e.low-fill zone,transition zone,and high-fill zone,are recognized.The main area of the channel in the nearly pressurized source-connecting fault zone is favorable for large-scale hydrocarbon enrichment.The research results suggest a new direction for the exploration of large-scale glutenite-rich reservoirs in the Enping Formation of the Pearl River Mouth Basin,and present a major breakthrough in oil and gas exploration.
文摘Objective: To study the application effect of mouth-opening training sticks combined with oral massage on patients with mouth-opening difficulty after treatment for head and neck cancer. Methods: Using convenient sampling, 60 patients with mouth-opening difficulty after treatment for head and neck cancer admitted to the Oncology Department from February 2022 to October 2023 were selected for a 2-week exercise and nursing program. The patients were divided into a control group (February 1, 2022 to November 30, 2022) and an observation group (December 1, 2022 to October 31, 2023), with 30 patients in each group. The control group underwent routine mouth-opening functional exercises combined with cork for oral support training, while the observation group underwent routine mouth-opening functional exercises combined with oral massage and mouth-opening training sticks for oral support training. The mouth-opening degree, mouth-opening difficulty level, comfort level, compliance, and quality of life were observed in both groups. Results: Before the intervention, there were no statistically significant differences in mouth-opening degree and mouth-opening difficulty level between the two groups (P > 0.05). After the intervention, the mouth-opening degree, mouth-opening difficulty level, oral comfort level, compliance, and QLICP-HN scores in the observation group were all better than those in the control group, with statistically significant differences (P < 0.05). Conclusion: The combination of mouth-opening training sticks and oral massage with mouth-opening functional exercises can effectively improve the degree of mouth-opening difficulty, enhance oral comfort, increase compliance with mouth-opening exercises, and improve quality of life.
基金Supported by the National Natural Science Foundation of China(91528303)CNOOC Technology Project(2021-KT-YXKY-05).
文摘The coupling relationship between shelf-edge deltas and deep-water fan sand bodies is a hot and cutting-edge field of international sedimentology and deep-water oil and gas exploration.Based on the newly acquired high-resolution 3D seismic,logging and core data of Pearl River Mouth Basin(PRMB),this paper dissected the shelf-edge delta to deep-water fan(SEDDF)depositional system in the Oligocene Zhuhai Formation of Paleogene in south subsag of Baiyun Sag,and revealed the complex coupling relationship from the continental shelf edge to deep-water fan sedimentation and its genetic mechanisms.The results show that during the deposition of the fourth to first members of the Zhuhai Formation,the scale of the SEDDF depositional system in the study area showed a pattern of first increasing and then decreasing,with deep-water fan developed in the third to first members and the largest plane distribution scale developed in the late stage of the second member.Based on the development of SEDDF depositional system along the source direction,three types of coupling relationships are divided,namely,deltas that are linked downdip to fans,deltas that lack downdip fans and fans that lack updip coeval deltas,with different depositional characteristics and genetic mechanisms.(1)Deltas that are linked downdip to fans:with the development of shelf-edge deltas in the shelf area and deep-water fans in the downdip slope area,and the strong source supply and relative sea level decline are the two key factors which control the development of this type of source-to-sink(S2S).The development of channels on the continental shelf edge is conducive to the formation of this type of S2S system even with weak source supply and high sea level.(2)Deltas that lack downdip fans:with the development of shelf edge deltas in shelf area,while deep water fans are not developed in the downdip slope area.The lack of“sources”and“channels”,and fluid transformation are the three main reasons for the formation of this type of S2S system.(3)Fans that lack updip coeval deltas:with the development of deep-water fans in continental slope area and the absence of updip coeval shelf edge deltas,which is jointly controlled by the coupling of fluid transformation at the shelf edge and the“channels”in the continental slope area.
基金The National Natural Science Foundation of China under contract No.42276066the Key Research and Development Program(International Science and Technology Cooperation Development Program)of Hainan Province under contract No.GHYF2022009the Youth Innovation Promotion Association of CAS under contract No.2018401.
文摘Based on high-resolution 3D seismic data acquired in the Pearl(Zhujiang)River Mouth Basin of the northern South China Sea,this study investigated the geometry,spatial extension,and throw distribution of the post-rift normal fault through detailed seismic interpretation and fault modeling.A total of 289 post-rift normal faults were identified in the study area and can be classified into four types:(1)isolated normal faults above the carbonate platform;(2)isolated normal faults cutting through the carbonate platform;(3)conjugate normal faults,and(4)connecting normal faults.Throw distribution analysis on the fault planes show that the vertical throw profiles of most normal fault exhibit flat-topped profiles.Isolated normal faults above the carbonate platform exhibit roughly concentric ellipses with maximum throw zones in the central section whereas the normal faults cutting through the carbonate platform miss the lowermost section due to the chaotic seismic reflections in the interior of the carbonate platform.The vertical throws of conjugate normal faults anomalously decrease toward their intersection region on the fault plane whereas the connecting normal faults present two maximum throw zones in the central section of the fault plane.According to the symmetric elliptical distribution model of fault throw,an estimation was made indicating that normal faults cutting through the carbonate platform extended downward between-1308 s and-1780 s(two-way travel time)in depth and may not penetrate the entire Liuhua carbonate platform.Moreover,it is observed that the distribution of karst caves on the top of the carbonate platform disaccord with those of hydrocarbon reservoirs and the post-rift normal faults cutting through the carbonate platform in the study area.We propose that these karst caves formed most probably by corrosive fluids derived from magmatic activities during the Dongsha event,rather than pore waters or hydrocarbons.
基金Supported by the National Natural Science Foundation of China(Nos.42302155,42072169,42072235)the Natural Science Foundation of Shandong Province(No.ZR2023QD016)+2 种基金the China Postdoctoral Science Foundation(No.2022M713461)the Qingdao Postdoctoral Application Research Funds(No.QDBSH20220202067)the Fundamental Research Funds for the Central Universities(No.22CX06005A)。
文摘A transfer zone in rift basins preserves important information on regional tectonic evolution and plays significant roles in hydrocarbon accumulation.Based on the systematic analysis of 3D seismic data and hydrocarbon accumulation conditions,the geometry,kinematics,and reservoir control of a large synthetic overlapping transfer zone in the south of the Wenchang A subsag in the Zhujiang(Pearl)River Mouth basin were investigated.Results indicate that the development and evolution of the transfer zone was controlled by the interaction between pre-existing faults and regional stress transformation.The intense rifting of the main faults of the transfer zone controlled the development of source rocks and faultcontrolled slope break paleogeomorphology.The strike-slip overprint since the Oligocene is conducive to the formation of a large-scale fault-anticline trap,and the secondary faults in the transfer zone contribute to the hydrocarbon transportation.The conjugate intersection area of the NE-and NW-trending faults offers more opportunity for hydrocarbon migration and accumulation.
文摘Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated genes.Methods:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 isolates.Subsequently,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and DDX58.Results:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the disease.The expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative patients.Expression levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of HFMD.Aspartate aminotransferase was correlated with BST2,MX1 and DDX58 expression levels.Conclusions:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.
文摘In this article, the transmission dynamics of a Hand-Foot-Mouth disease model with treatment and vaccination interventions are studied. We calculated the basic reproduction number and proved the global stability of disease-free equilibrium when R0 R0 > 1. Meanwhile, we obtained the optimal control strategies minimizing the cost of intervention and minimizing the infected person. We also give some numerical simulations to verify our theoretical results.
基金Supported by China Coal Science and Technology Group Technology Innovation Fund Major Project(Grand No.2018ZD002)China Coal Science and Technology Group Technology Innovation Fund Youth Project(Grand No.2018-2-QN010)
文摘At present, the water-cooling simulation of the water-cooled magnetic coupler is based on the water-cooled motor and the hydraulic coupler, which cannot accurately characterize the temperature distribution of the rotating watercooled coupling of the coupler. Focusing on rotating water cooling radiating, the present paper proposes simulating the water cooling temperature field as well as the flow field through the method of combining fluid-solid coupled heat transfer and MRF(Multiphase Reference Frame). In addition, taking an 800 kW magnetic coupling as an example, the paper optimizes the shape, number, cooling water inlet speed? and so on? of the cooling channel. Considering factors such as the complete machine’s temperature, and drag torque, it is proved that the cooling e ect is best when there are 36 involute curved channels and when the inlet speed is 3 m/s. Further, through experiments, the actual temperature values at six di erent positions when 50 kW and 70 kW thermal losses di er are measured. The measured values agree with the simulation results, proving the correctness of the proposed method. Further, data have been collected during the entire experimental procedure? and the variation in the coupling’s temperature is analyzed in depth, with the objective of laying a foundation for the estimation of the inner temperature rise as well as for the optimization of the structural design.
基金This project is supported by National Hi-tech Research and Development Program of China (863 Program, No. 2002AA404250)National Natural Science Foundation of China (No. 50575093).
文摘In order to cool computer chip efficiently with the least noise, a single phase water-cooling radiator for computer chip driven by piezoelectric pump with two parallel-connection chambers is developed. The structure and work principle of this radiator is described. Material, processing method and design principles of whole radiator are also explained. Finite element analysis （FEA） software, ANSYS, is used to simulate the heat distribution in the radiator. Testing equipments for water-cooling radiator are also listed. By experimental tests, influences of flowrate inside the cooling system and fan on chip cooling are explicated. This water-cooling radiator is proved more efficient than current air-cooling radiator with comparison experiments. During cooling the heater which simulates the working of computer chip with different power, the water-cooling radiator needs shorter time to reach lower steady temperatures than current air-cooling radiator.
文摘For predicting and controlling the melted depth of bottomelectrode during the process of steelmaking, the water-cooling steel-stick electrode is taken as an example, to analyze the process ofheat transfer, then 3D mathematical model by control capacity methodis built. At the same time, the measurement on the melted depth ofbottom electrode is conducted which verified the correctness of thebuilt mathematical model. On the base of verification, all kinds ofkey parameters are calculated through the application and a series ofresults are simulated. Finally, the optimum parameters are found andthe service life of bottom electrode is prolonged.
文摘The first major outbreak of the severely complicated hand,foot and mouth disease(HFMD),primarily caused by enterovirus 71,was reported in Taiwan in 1998.HFMD surveillance is needed to assess the spread of HFMD.The parameters we use in mathematical models are usually classical mathematical parameters,called crisp parameters,which are taken for granted.But any biological or physical phenomenon is best explained by uncertainty.To represent a realistic situation in any mathematical model,fuzzy parameters can be very useful.Many articles have been published on how to control and prevent HFMD from the perspective of public health and statistical modeling.However,few works use fuzzy theory in building models to simulateHFMDdynamics.In this context,we examined anHFMD model with fuzzy parameters.A Non Standard Finite Difference(NSFD)scheme is developed to solve the model.The developed technique retains essential properties such as positivity and dynamic consistency.Numerical simulations are presented to support the analytical results.The convergence and consistency of the proposed method are also discussed.The proposed method converges unconditionally while the many classical methods in the literature do not possess this property.In this regard,our proposed method can be considered as a reliable tool for studying the dynamics of HFMD.
文摘The water-cooling heat dissipation technology can solve the heat dissipation and noise problems of the calculation plate.Therefore,the structural design of the water-cooling plate directly affects its flow and heat transfer characteristics,which restricts the promotion and application of the technology.To this end,the water-cooling plate of a heat dissipation system was taken as the research object,and its flow and heat transfer characteristics were numerical simulated and experimental studied.Through comparative analysis,the rationality of the numerical simulation method was verified.Based on this,three improved schemes of water-cooling plate structure were proposed and numerical simulation was carried out,and the optimal model was verified by experiments.The results of the study show that compared with the original water-cooling plate,the optimized water-cooling plate has increased internal flow velocity and distributes uniformly,increased heat transfer amount by 4.2%,and the average temperature of the calculation plate decreased by 5.3%.
基金This study is financially supported by the National Natural Science Foundation of China(42072181).
文摘The Pearl River Mouth Basin(PRMB)is one of the most petroliferous basins on the northern margin of the South China Sea.Knowledge of the thermal history of the PRMB is significant for understanding its tectonic evolution and for unraveling its poorly studied source-rock maturation history.Our investigations in this study are based on apatite fission-track(AFT)thermochronology analysis of 12 cutting samples from 4 boreholes.Both AFT ages and length data suggested that the PRMB has experienced quite complicated thermal evolution.Thermal history modeling results unraveled four successive events of heating separated by three stages of cooling since the early Middle Eocene.The cooling events occurred approximately in the Late Eocene,early Oligocene,and the Late Miocene,possibly attributed to the Zhuqiong II Event,Nanhai Event,and Dongsha Event,respectively.The erosion amount during the first cooling stage is roughly estimated to be about 455-712 m,with an erosion rate of 0.08-0.12 mm/a.The second erosion-driven cooling is stronger than the first one,with an erosion amount of about 747-814 m and an erosion rate between about 0.13-0.21 mm/a.The erosion amount calculated related to the third cooling event varies from 800 m to 3419 m,which is speculative due to the possible influence of the magmatic activity.
基金Supported by the Natural Science Foundation of Heilongjiang Province(LH2021C032)。
文摘EV71-type virus is one of the main pathogens causing the occurrence of hand,foot and mouth disease(HFMD),and VP1 protein,a factor that directly determines the antigenicity of the virus,has been isolated.The tomato was selected as a bioreactor for the production of an edible EV71 vaccine designed for the VP1 capsid protein.Using molecular biology techniques,the fusion gene EV71-VP1 was cut from vector PGEX-4T-2,a vector containing the p2300-EV71 gene with CaMV35S promoter and TL regulatory elements was constructed,and the hypocotyl and cotyledons of tomato were transformed using Agrobacterium(EHA105)-mediated method,screened,elongated and rooted,and finally 20 resistant tomato plants were obtained.Five transgenic positive seedlings were obtained by digestion and PCR assay,among which three plants were detected by RT-PCR to be capable of transcriptional translation at the RNA level.The experimental results aimed to explore new material support for the preparation of transgenic plant oral vaccines against EV71 infection and provide a theoretical basis for accelerating the development of transgenic plant vaccines in the future.
文摘Objective:To explore the effect of mindfulness meditation on patients with burning mouth syndrome.Methods:60 patients with burning mouth syndrome in our hospital who were treated from January 2021 to December 2022 were selected for this study.The patients were divided into two groups of thirty cases each using the randomized numerical table method.The observation underwent psychological intervention and mindfulness meditation training,while the control group only received symptomatic care.The condition of the patients of both groups was observed and compared.Results:Upon receiving treatment,the patients in the observation group had lower Hamilton Anxiety(HAM-A)scores,and Hamilton Depression(HAMD)scores compared to the control group(P<0.05).The visual analog scale(VAS)scores of the observation group were also lower than those of the control group(P<0.05).Moreover,the efficacy of the nursing intervention in the observation group was higher than that of the control group(P<0.05).Conclusion:Psychological intervention and mindfulness meditation training can effectively improve the clinical symptoms of patients with burning mouth syndrome.Therefore,this treatment method should be popularized.
