The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping ...The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu_（1.94） S and Bi_2S_3 nanocrystals into a biocompatible poly（amino acid） matrix with size of^85 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites（NCs） are tunable toward both high photothermal conversion efficiency（~31%） and excellent CT imaging capability（27.8 HU g L^（-1））. These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multifunctional theranostics towards simultaneous strong CT signal and excellent PTT.展开更多
基金upported in part by the National Natural Science Foundation of China(21475007 and 21675009)the Fundamental Research Funds for the Central Universities(buctrc201608 and buctrc201720)
文摘The doping of radiocontrast agent such as bismuth（Bi） in copper chalcogenide nanocrystals for computed tomography（CT） imaging guided photothermal therapy（PTT） has drawn increasing attention. However, the doping of Bi often suffers from the weak CT signal due to the low Bi doping concentration and deteriorates the PTT efficacy of copper chalcogenides. Here we report a multifunctional nanoprobe by encapsulating both Cu_（1.94） S and Bi_2S_3 nanocrystals into a biocompatible poly（amino acid） matrix with size of^85 nm for CT imaging guided PTT. The amount of nanocrystals and the ratio of Cu1.94S-to-Bi2S3 in the multifunctional nanocomposites（NCs） are tunable toward both high photothermal conversion efficiency（~31%） and excellent CT imaging capability（27.8 HU g L^（-1））. These NCs demonstrate excellent effects for photothermal ablation of tumors after intratumoral injection on 4T1 tumor-bearing mice. Our study may provide a facile strategy for the fabrication of multifunctional theranostics towards simultaneous strong CT signal and excellent PTT.
