目的用微波辐射催化法合成苯并咪唑并喹喔啉衍生物。方法在120 W微波辐射条件下,以碘化亚铜和脯氨酸锂为催化剂,N-对甲苯磺酰基-2-碘苯胺和2-氯甲基苯并咪唑在110℃二甲基甲酰胺中反应30min得到苯并咪唑并喹喔啉及其衍生物。结果发现一...目的用微波辐射催化法合成苯并咪唑并喹喔啉衍生物。方法在120 W微波辐射条件下,以碘化亚铜和脯氨酸锂为催化剂,N-对甲苯磺酰基-2-碘苯胺和2-氯甲基苯并咪唑在110℃二甲基甲酰胺中反应30min得到苯并咪唑并喹喔啉及其衍生物。结果发现一种合成苯并咪唑并喹喔啉衍生物的新方法,获得7个相应的苯并咪唑并喹喔啉化合物,均已通过1 H NMR、13 C NMR和质谱确认结构,最高收率为94%。结论微波辐射法Cu+/脯氨酸锂催化合成吡咯[1,2-α]喹喔啉,与传统方法比较,具有时间短、收率高的优点。展开更多
The title compound [ClCH2(C7H6N2)]NO3 has been prepared and characterized by elemental analysis and X-ray studies. It crystallizes in the monoclinic system, space group P21/n with a = 7.4189(3), b =15.3064(6), c = 9.2...The title compound [ClCH2(C7H6N2)]NO3 has been prepared and characterized by elemental analysis and X-ray studies. It crystallizes in the monoclinic system, space group P21/n with a = 7.4189(3), b =15.3064(6), c = 9.2657(3) ? b = 102.449(2)? C8H8ClN3O3, Mr = 229.62, V = 1027.44(7) 3, Z = 4, Dc = 1.484 g/cm3, F(000) = 472, = 0.363 mm-1, R = 0.0671 and wR = 0.1546. The crystal structure consists of discrete 2-chloromethyl-1H-benzimidazole cations and NO3- anions. The benzimidazole ring with the conjunction carbon atom C(1) is fairly planar, with the deviation from the least plane through the ring atoms is smaller than 0.010(3) ? The analytical results of crystal structure show that three different non-covalent interactions in the compound, NH…O intermolecular hydrogen bonds, CH…O interaction and p-p stacking interaction, play an important role in the crystal packing.展开更多
文摘目的用微波辐射催化法合成苯并咪唑并喹喔啉衍生物。方法在120 W微波辐射条件下,以碘化亚铜和脯氨酸锂为催化剂,N-对甲苯磺酰基-2-碘苯胺和2-氯甲基苯并咪唑在110℃二甲基甲酰胺中反应30min得到苯并咪唑并喹喔啉及其衍生物。结果发现一种合成苯并咪唑并喹喔啉衍生物的新方法,获得7个相应的苯并咪唑并喹喔啉化合物,均已通过1 H NMR、13 C NMR和质谱确认结构,最高收率为94%。结论微波辐射法Cu+/脯氨酸锂催化合成吡咯[1,2-α]喹喔啉,与传统方法比较,具有时间短、收率高的优点。
基金the Natural Science Foundation of Shandong province (No. Y2002B06)the Outstanding Adult-Young Scientific Research Encouraging Foundation of Shandong province (No. O1BS18)
文摘The title compound [ClCH2(C7H6N2)]NO3 has been prepared and characterized by elemental analysis and X-ray studies. It crystallizes in the monoclinic system, space group P21/n with a = 7.4189(3), b =15.3064(6), c = 9.2657(3) ? b = 102.449(2)? C8H8ClN3O3, Mr = 229.62, V = 1027.44(7) 3, Z = 4, Dc = 1.484 g/cm3, F(000) = 472, = 0.363 mm-1, R = 0.0671 and wR = 0.1546. The crystal structure consists of discrete 2-chloromethyl-1H-benzimidazole cations and NO3- anions. The benzimidazole ring with the conjunction carbon atom C(1) is fairly planar, with the deviation from the least plane through the ring atoms is smaller than 0.010(3) ? The analytical results of crystal structure show that three different non-covalent interactions in the compound, NH…O intermolecular hydrogen bonds, CH…O interaction and p-p stacking interaction, play an important role in the crystal packing.
