以4-氨基-3-甲基苯甲酸为起始原料,经混酸硝化反应、正丁酸酐酰化反应和甲醇酯化反应等三步合成目标产物3-甲基-4-正丁酰氨基-5-硝基苯甲酸甲酯.其中间产物和目标产物的化学结构均经1 H NMR、13 C NMR、MS等方法进行了表征.实验过程中...以4-氨基-3-甲基苯甲酸为起始原料,经混酸硝化反应、正丁酸酐酰化反应和甲醇酯化反应等三步合成目标产物3-甲基-4-正丁酰氨基-5-硝基苯甲酸甲酯.其中间产物和目标产物的化学结构均经1 H NMR、13 C NMR、MS等方法进行了表征.实验过程中还对各步反应条件进行了优化,各步在最佳反应条件下总产率可达72.6%.该合成路线简单易行,容易实现工业化生产,具有很好的应用价值.展开更多
The thermal decomposition of 2-(4-methoxycarbonylphenyl)-5-nitryl-6-hydroxybenzoxazole(MNB) in N2 atmosphere was studied by thermogravimetry(TG) and differential thermogravimetry(DTG).It is a sequential process.The mo...The thermal decomposition of 2-(4-methoxycarbonylphenyl)-5-nitryl-6-hydroxybenzoxazole(MNB) in N2 atmosphere was studied by thermogravimetry(TG) and differential thermogravimetry(DTG).It is a sequential process.The molecular bond orders were calculated by GAMESS method and the IR spectra of MNB and its intermediates in thermal decomposition at various temperatures were determined.The mechanism of the thermal decomposition has been discussed,the C-N bond breakdown and the nitro group elimination occurred in the initial step of the decomposition.The thermal decomposition kinetic parameters such as apparent activation energy E=115.5kJ·mol-1,pre-exponential factor A = 1.698×1010 min-1 and apparent reaction order n = 0 were obtained according to test data.展开更多
文摘以4-氨基-3-甲基苯甲酸为起始原料,经混酸硝化反应、正丁酸酐酰化反应和甲醇酯化反应等三步合成目标产物3-甲基-4-正丁酰氨基-5-硝基苯甲酸甲酯.其中间产物和目标产物的化学结构均经1 H NMR、13 C NMR、MS等方法进行了表征.实验过程中还对各步反应条件进行了优化,各步在最佳反应条件下总产率可达72.6%.该合成路线简单易行,容易实现工业化生产,具有很好的应用价值.
文摘The thermal decomposition of 2-(4-methoxycarbonylphenyl)-5-nitryl-6-hydroxybenzoxazole(MNB) in N2 atmosphere was studied by thermogravimetry(TG) and differential thermogravimetry(DTG).It is a sequential process.The molecular bond orders were calculated by GAMESS method and the IR spectra of MNB and its intermediates in thermal decomposition at various temperatures were determined.The mechanism of the thermal decomposition has been discussed,the C-N bond breakdown and the nitro group elimination occurred in the initial step of the decomposition.The thermal decomposition kinetic parameters such as apparent activation energy E=115.5kJ·mol-1,pre-exponential factor A = 1.698×1010 min-1 and apparent reaction order n = 0 were obtained according to test data.
