Cancer is one of the most dangerous diseaseswith highmortality.One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill ...Cancer is one of the most dangerous diseaseswith highmortality.One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and technicians.In our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer patients.Medical image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction problem.We proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and augmentation.In strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the architecture.The output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation doses.Our experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation therapy.The results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is 1.78.In addition,we also conducted a comparison with the results of another study in the same context of using the loss function.展开更多
针对低剂量CT图像质量退化问题,提出了一种基于投影域数据恢复的低剂量CT优质重建方法。新方法首先通过非线性Anscombe变换将满足Poisson分布的投影域数据转化Gaussian型分布,然后利用针对Anscombe变换的Gaussian型数据进行自适应Block-...针对低剂量CT图像质量退化问题,提出了一种基于投影域数据恢复的低剂量CT优质重建方法。新方法首先通过非线性Anscombe变换将满足Poisson分布的投影域数据转化Gaussian型分布,然后利用针对Anscombe变换的Gaussian型数据进行自适应Block-Matchingand 3D filtering(BM3D)滤波,最后通过对Anscombe逆变换数据执行传统的滤波反投影(Filtered Back Projec-tion,FBP)CT重建。由于Anscombe变换数据的方差已知,且所用BM3D滤波无需人工设置滤波参数,使得方法可实现自适应低剂量CT图像重建。仿真和临床低剂量CT数据的实验表明,方法具有良好的重建鲁棒性,其重建图像的噪声和伪影可同时得到有效抑制。展开更多
基金sponsored by the Institute of Information Technology(Vietnam Academy of Science and Technology)with Project Code“CS24.01”.
文摘Cancer is one of the most dangerous diseaseswith highmortality.One of the principal treatments is radiotherapy by using radiation beams to destroy cancer cells and this workflow requires a lot of experience and skill from doctors and technicians.In our study,we focused on the 3D dose prediction problem in radiotherapy by applying the deeplearning approach to computed tomography(CT)images of cancer patients.Medical image data has more complex characteristics than normal image data,and this research aims to explore the effectiveness of data preprocessing and augmentation in the context of the 3D dose prediction problem.We proposed four strategies to clarify our hypothesis in different aspects of applying data preprocessing and augmentation.In strategies,we trained our custom convolutional neural network model which has a structure inspired by the U-net,and residual blocks were also applied to the architecture.The output of the network is added with a rectified linear unit(Re-Lu)function for each pixel to ensure there are no negative values,which are absurd with radiation doses.Our experiments were conducted on the dataset of the Open Knowledge-Based Planning Challenge which was collected from head and neck cancer patients treatedwith radiation therapy.The results of four strategies showthat our hypothesis is rational by evaluating metrics in terms of the Dose-score and the Dose-volume histogram score(DVH-score).In the best training cases,the Dose-score is 3.08 and the DVH-score is 1.78.In addition,we also conducted a comparison with the results of another study in the same context of using the loss function.
文摘针对低剂量CT图像质量退化问题,提出了一种基于投影域数据恢复的低剂量CT优质重建方法。新方法首先通过非线性Anscombe变换将满足Poisson分布的投影域数据转化Gaussian型分布,然后利用针对Anscombe变换的Gaussian型数据进行自适应Block-Matchingand 3D filtering(BM3D)滤波,最后通过对Anscombe逆变换数据执行传统的滤波反投影(Filtered Back Projec-tion,FBP)CT重建。由于Anscombe变换数据的方差已知,且所用BM3D滤波无需人工设置滤波参数,使得方法可实现自适应低剂量CT图像重建。仿真和临床低剂量CT数据的实验表明,方法具有良好的重建鲁棒性,其重建图像的噪声和伪影可同时得到有效抑制。
