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4', 6-Dihydroxy-4-methoxyisoaurone inhibits TNF-α-induced NF-KB activation and expressions of NF-KB-regulated target gene products
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《中国药理学通报》 CAS CSCD 北大核心 2015年第B11期27-27,共1页
The nuclear factor-KB (NF-KB) transcription factors control many physiological processes including in- flammation, immunity, apoptosis, and angiogenesis. In our search for NF-KB inhibitors from natural resources, we... The nuclear factor-KB (NF-KB) transcription factors control many physiological processes including in- flammation, immunity, apoptosis, and angiogenesis. In our search for NF-KB inhibitors from natural resources, we identified 4',6-dihydroxy-4-methoxyisoaurone (ISOA) as an inhibitor of NF-KB activation from the seeds of Tricho- santhes kirilowii. However, the mechanism by which ISOA inhibits NF-KB activation is not fully understood. In the present study, we demonstrated the effect of ISOA on NF-KB activation in TNF-α-stimulated HeLa cells. This com- pound suppressed NF-KB activation through the inhibition of IKB kinase (IKK) activation. ISOA also has an influ- ence on upstream signaling of IKK through the inhibition of expression of adaptor proteins, TNF receptor-associated factor 2 (TRAF2) and receptor interacting protein 1 (RIP1). Consequently, ISOA blocked the phosphorylation and degradation of the inhibitor of NF-KB alpha (IKBα) , and subsequent phosphorylation and nuclear translocation of p65. The suppression of NF-KB activation by ISOA led to the down-regulation of target genes involved in inflam- mation, proliferation, angiogenesis and invasion, as well as potentiation of TNF-α-induced apoptosis at least in part through activation of caspase-8. Taken together, this study extends our understanding on the mechanisms underly- ing the anti-inflammatory and anti-cancer activities of ISOA. Our findings provide new insight into the molecular mechanisms and a potential application of ISOA for inflammatory diseases as well as certain cancers associated with abnormal NF-KB activation. 展开更多
关键词 4' 6-dihydroxy-4-methoxyisoaurone NF-KB IKK IKBΑ P65 apoptosis
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青蕨植物化学成分的研究(英文) 被引量:4
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作者 胡浩斌 郑旭东 《西北植物学报》 CAS CSCD 北大核心 2005年第4期781-785,共5页
从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-meth... 从青蕨根部的乙酸乙酯提取物中分离得到4个化合物.通过化学及波谱分析鉴定其结构为:saucerneolD1,dehydrogoniothalamin2,1-acetoxyl-2-piperonyl-6-[6-methoxyl-piperonyl]-3,7-dioxabicyclo-[3,3,0]-octane3and5,5′-dihydroxy-3-methoxy-6,8,3″,3″-tetramethylpyran-3′,4′flavone-7-O-[β-D-apiofuranosyl-1→6]-β-D-glucopyranoside4.其中化合物4为新化合物,化合物1为首次从该属植物中分离得到. 展开更多
关键词 青蕨 saucerneol D 5 5′-dihydroxy-3-methoxy-6 8 3″ 3″-tetramethylpyran-(3′ 4′)flavone-7-O-[β-D-apiofuranosyl-(1→6)]-β-D-glucopyranoside
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Synthetic Studies of an Analogue of HIV-1 Protease Inhibitors of Didemnaketals:Construction of the C1-C8 Intermediate
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作者 Ping Zhen WANG Yan Xing JIA +1 位作者 Yong Qiang TU Bin WU(Department of Chemistry. National Laboratory of Applied Organic Chemistry,Lanzhou University.Lanzhou 730000) 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第9期749-750,共2页
A convenient and stereoselective approach to the synthesis of(3S. 4R. 6S)- 2-oxo-3, 4-dihydroxy-6-methyl-octanate derivative, a key intermediate for the synthesis of HIV-1 protease inhibitor of didemnaketals analogue,... A convenient and stereoselective approach to the synthesis of(3S. 4R. 6S)- 2-oxo-3, 4-dihydroxy-6-methyl-octanate derivative, a key intermediate for the synthesis of HIV-1 protease inhibitor of didemnaketals analogue, has been developed successfully from L-(-)-menthone. 展开更多
关键词 didemnaketals 2-oxo-3 4-dihydroxy-6-methyl-octanate steroselective synthesis
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A new naphthoquinoneimine derivative from the marine algal-derived endophytic fungus Aspergillus niger EN-13 被引量:7
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作者 Yi Zhang Xiao Ming Li +1 位作者 Chang Yun Wang Bin Gui Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第8期951-953,共3页
Cultivation of an endophytic fungus Aspergillus niger EN-13 that was isolated from the inner tissue of the marine brown alga Colpomenia sinuosa resulted in the characterization of a new naphthoquinoneimine derivative,... Cultivation of an endophytic fungus Aspergillus niger EN-13 that was isolated from the inner tissue of the marine brown alga Colpomenia sinuosa resulted in the characterization of a new naphthoquinoneimine derivative, namely, 5,7-dihydroxy-2-[1-(4- methoxy-6-oxo-6H-pyran-2-yl)-2-phenylethylamino]-[ 1,4]naphthoquinone. The structure of the new compound was established on the basis of various NMR spectroscopic analyses including 2D NMR techniques, El-MS, and HR-ESI-MS. This compound displayed moderate antifungal activity. 展开更多
关键词 Colpomenia sinuosa Endophytic fungus Aspergillus niger Naphthoquinoneimine 5 7-dihydroxy-2-[1-(4-methoxy-6-oxo-6H-pyran-2-yl)-2-phenylethylamino]-[ 1 4]naphthoquinone
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Syntheses and Crystal Structures of [Na(H_2O)](C_(17)H_(13)O_6SO_3)·2H_2O and [Ni(H_2O)_6](C_(17)H_(13)O_6SO_3)_2·4H_2O 被引量:2
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作者 张尊听 郭亚宁 刘谦光 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2004年第9期971-977,共7页
Two hydrates of sodium 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate ([Na(H2O)](C17H13O6SO3)2H2O, 1) and nickel 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate ([Ni(H2O)6](C17H13O6SO3)24H2O, ... Two hydrates of sodium 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate ([Na(H2O)](C17H13O6SO3)2H2O, 1) and nickel 5,7-dihydroxy-6,4'-dimethoxyisoflavone-3'-sulfonate ([Ni(H2O)6](C17H13O6SO3)24H2O, 2) were syn-thesized and characterized by IR, 1H NMR and X-ray diffraction analyses. The hydrate 1 crystallizes in the mono-clinic system, space group P2(1) with a=0.8201(9) nm, b=0.8030(8) nm, c=1.5361(16) nm, =102.052(12), V=0.9893(18) nm3, Dc=1.579 g/cm3, Z=2, =0.252 nm-1, F(000)=488, R=0.0353, wR=0.0873. The hydrate 2 belongs to triclinic system, space group P-1 with a=0.7411(3) nm, b=0.8333(3) nm, c=1.7448(7) nm, a=86.361(6), 撸?6.389(5), ?=88.999(3), V=1.0731(7) nm3, Dc=1.587 g/cm3, Z=1, =0.649 mm-1, F(000)=534. In the structure of 1, the sodium cation is coordinated by six oxygen atoms and two adjacent ones are bridged by three oxygen atoms to form an octahedron chain. The C—H…p hydrogen bonds exist between two isoflavone molecules in the structure of 2. Meanwhile, hydrogen bonds in two compounds, link themselves to assemble two three-dimensional network structures, respectively. 展开更多
关键词 irisolidon sodium 5 7-dihydroxy-6 4'-dimethoxyisoflavone-3'-sulfonate nickel 5 7-dihydroxy-6 4'- dimethoxyisoflavone-3'-sulfonate crystal structure C—H…p hydrogen bond
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A New Chromone Derivative from Stellera chamaejasme L 被引量:6
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作者 Bao Min FENG Yue Hu PEI Hui Ming HUA 《Chinese Chemical Letters》 SCIE CAS CSCD 2002年第8期738-739,共2页
A new chromone derivative, 3-[1- (2, 4, 6-trihydroxyphenyl) 3-di-(4-hydroxyphenyl) 1-propanone-2-yl] 5,7-dihydroxy-8-di(4-hydroxyphenyl)methyl-4H-1-benzopyran-4-one, named as isomohsenone was isolated from the roots o... A new chromone derivative, 3-[1- (2, 4, 6-trihydroxyphenyl) 3-di-(4-hydroxyphenyl) 1-propanone-2-yl] 5,7-dihydroxy-8-di(4-hydroxyphenyl)methyl-4H-1-benzopyran-4-one, named as isomohsenone was isolated from the roots of Stellera chamaejasme L. together with known chamaechromone. Its structure was determined by the analysis of MS and NMR data, especially 2D NMR spectra. 展开更多
关键词 Stellera chamaejasme L. CHROMONE 3-[1- (2 4 6-trihydroxyphenyl) 3-di-(4-hydroxy- phenyl)-1-propanone-2-yl] 5 7-dihydroxy-8-di-(4-hydroxyphenyl) methyl-4H-1- benzopyran-4- one.
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A new alkaloid from Castanea mollissima Blume 被引量:4
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作者 Dong Song Zhang Hui Yuan Gao +2 位作者 Xiao Mei Song Zhi Shu Tang Li Jun Wu 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第7期832-834,共3页
A new alkaloid, named 6-(2',3'-dihydroxy-4'-hydroxymethyl-tetrahydro-furan-1'-yl)cyclopentadiene[c]pyrrole-1,3-diol, was isolated from the seeds of Castanea mollissima Blume. The structure was elucidated based o... A new alkaloid, named 6-(2',3'-dihydroxy-4'-hydroxymethyl-tetrahydro-furan-1'-yl)cyclopentadiene[c]pyrrole-1,3-diol, was isolated from the seeds of Castanea mollissima Blume. The structure was elucidated based on spectroscopic evidence including 2D NMR techniques. 展开更多
关键词 Castanea mollissima Blume ALKALOID 6-(2' 3'-dihydroxy-4'-hydroxylmethyl-tetrahydro-furan-1'-yl)cyclopentadiene[c]pyrrole-1 3-diol
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New flavan and unusual chalcone glycosides from Drypetes parvifolia 被引量:1
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作者 Viviane Nadège Nenkep Jovita Chi Shirri +5 位作者 Hanh Trinh Van-Dufat Falindor Sipepnou Philippe Vérité Elisabeth Seguin Francois Tillequin Jean Wandji 《Chinese Chemical Letters》 SCIE CAS CSCD 2008年第8期943-946,共4页
Two new compounds 7-hydroxy-5-O-(β-D-glucopyranoside) flavan (1) and (Z)-4',6'-dihydroxy-2'-O-(β-D-glucopyranoside) chalcone (2), along with eight known compounds, were isolated from the stem bark of Dr... Two new compounds 7-hydroxy-5-O-(β-D-glucopyranoside) flavan (1) and (Z)-4',6'-dihydroxy-2'-O-(β-D-glucopyranoside) chalcone (2), along with eight known compounds, were isolated from the stem bark of Drypetes parvifolia (Euphorbiaceae). Their structures were established on the basis of spectroscopic analysis and chemical evidence. 展开更多
关键词 Drypetes parvifolia Flavonoid glycosides 7-Hydroxy-5-O-(β-D-glucopyranoside) flavan (Z)-4 6-dihydroxy-2'-O-(β-D-glucopyr-anoside) chalcone
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A new germacranolide from Carpesium cernuum
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作者 曹建新 潘远江 +4 位作者 许重阳 黄利夏 马淑红 代常亮 高婉婉 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2005年第7期640-642,共3页
As a part of our interest in biologically active germacranolides from the genus Carpesium (Compositae), we have investigated the constituents of Carpesium cernuum. This paper reports the isolation and structural elu... As a part of our interest in biologically active germacranolides from the genus Carpesium (Compositae), we have investigated the constituents of Carpesium cernuum. This paper reports the isolation and structural elucidation of a new germacranolide, cernolide A (Compound 1), from the herb. The structure of Compound 1 was determined as 2α,3β-dihydroxy-9-angeloxygermacra-4-en-6,12-olide on the basis of spectral evidence. The skeleton of Compound 1 was elucidation by IR, MS, ^1H and ^13C NMR, COSY, HMQC and HMBC experiments. The stereochemistry of Compound 1 was deduced by ROESY spectral data. Finally, the procedures of extraction and isolation were described in detail. 展开更多
关键词 Carpesium cernuum COMPOSITAE SESQUITERPENOID -dihydroxy-9-angeloxygermacra-4-en-6 12-olide
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A New Flavone Glycoside from Isodon enanderianus
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作者 Zhi NA Shuang Xi MEI +2 位作者 Chao Ming LI Zhong Wen LIN Han Dong SUN 《Chinese Chemical Letters》 SCIE CAS CSCD 2001年第3期233-234,共2页
A new flavone glycoside, 5,8-dihydroxy-4',6,7-trimethoxyflavone 8-O-(-D-glucopyranoside 1, together with three known flavonoids, pedalitin 2, cirsimartin 3 and genkwanin 4, were isolated from the aerial parts of I... A new flavone glycoside, 5,8-dihydroxy-4',6,7-trimethoxyflavone 8-O-(-D-glucopyranoside 1, together with three known flavonoids, pedalitin 2, cirsimartin 3 and genkwanin 4, were isolated from the aerial parts of Isodon enanderianus. Their structures were determined on the basis of spectral data. 展开更多
关键词 Isodon enanderianus flavonoid flavone glycoside 5 8-dihydroxy-4 6 7-trimethoxyflavone 8-O-(-D-glucopyranoside.
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New Flavonoid Glycoside from Thalictrum przewalskii
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作者 Shi Chun YU Qing Li WU +1 位作者 Li Wei WANG Pei Gen XIAO(Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094.) 《Chinese Chemical Letters》 SCIE CAS CSCD 1999年第4期295-296,共2页
A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was de... A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was determined on basis of spectroscopic evidences. 展开更多
关键词 THALICTRUM Thalictrum przewalskii flavonoid glycoside 5 7-dihydroxy-4 '-methoxyflavonoid 7-O-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside
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Isolation and structural elucidation of cytotoxic compounds from the root bark of Diospyros quercina (Baill.) endemic to Madagascar
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作者 Fatiany Pierre Ruphin Robijaona Baholy +3 位作者 Randrianarivo Emmanuel Raharisololalao Amelie Marie-Therese Martin Ngbolua Koto-te-Nyiwa 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2014年第3期169-175,共7页
Objective:To isolate and characterize the cytotoxic compounds from Diospyros quercina(Baill.)G.E.Schatz&Lowry(Ebenaceae).Methods:An ethno-botanical survey was conducted in the south of Madagascar from July to Augu... Objective:To isolate and characterize the cytotoxic compounds from Diospyros quercina(Baill.)G.E.Schatz&Lowry(Ebenaceae).Methods:An ethno-botanical survey was conducted in the south of Madagascar from July to August 2010.Bio-guided fractionation assay was carried out on the root bark of Diospyros quercina,using cytotoxicity bioassay on murine P388 leukemia cell lines as model.The structures of the cytotoxic compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry.Results:Biological experiments resulted in the isolation of three bioactive pure compounds(named TR-21,TR-22,and TR-23)which exhibited very good in vitro cytotoxic activities with the IC_(50)values of(0.017 5±0.0060)μg/mL,(0.089±0.005)μg/mL and(1.027±0.070)μg/mL respectively.Thus,they support the claims of traditional healers and suggest the possible correlation between the chemical composition of this plant and its wide use in Malagasy folk medicine to treat cancer.Conclusions:The ability of isolated compounds in this study to inhibit cell growth may represent a rational explanation for the use of Diospyros quercina root bark in treating cancer by Malagasy traditional healers.Further studies are,therefore,necessary to evaluate the in vivo antineoplastic activity of these cytotoxic compounds as effective anticancer drugs. 展开更多
关键词 DIOSPYROS quercinia Cytotoxic activities Isodiospyrin 6’-Ethoxy-1’ 3’-dihydroxy-4 6-dimethyl-1 2’-binaphthyl-2 5’3 8’tetraones (E)-5 6-Dimethyl-2-(2-methyl-3-(prop-1-enyl) phenyl)-2H-Chromene Madagascar
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桂枝茯苓胶囊化学成分研究(VI) 被引量:12
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作者 谢雪 张宏达 +6 位作者 温建辉 宋亚玲 王雪晶 赵祎武 黄文哲 王振中 萧伟 《中草药》 CAS CSCD 北大核心 2016年第21期3795-3797,共3页
目的对桂枝茯苓胶囊内容物正丁醇和醋酸乙酯萃取部位进行化学成分研究。方法采用多种色谱方法对桂枝茯苓胶囊内容物的正丁醇和醋酸乙酯萃取部位进行分离纯化,根据理化性质和波谱数据鉴定其结构。结果从醋酸乙酯和正丁醇层分离得到10个... 目的对桂枝茯苓胶囊内容物正丁醇和醋酸乙酯萃取部位进行化学成分研究。方法采用多种色谱方法对桂枝茯苓胶囊内容物的正丁醇和醋酸乙酯萃取部位进行分离纯化,根据理化性质和波谱数据鉴定其结构。结果从醋酸乙酯和正丁醇层分离得到10个化合物,分别鉴定为对羟基苯甲酸(1)、反式邻甲氧基桂皮酸(2)、反式桂皮酸(3)、对香豆酸(4)、2,5-dihydroxy-4-methylaeetophenone(5)、没食子酸乙酯(6);从正丁醇层分离得到4个化合物,分别为香草酸(7)、原儿茶酸(8)、affinoside(9)、benzyl-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside(10)。结论化合物1~10均为首次从该复方中分离得到。 展开更多
关键词 桂枝茯苓胶囊 对香豆酸 2 5-dihydroxy-4-methylacetophenone 原儿茶酸 affinoside benzyl-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside
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湖北麦冬地下部分化学成分 被引量:5
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作者 梁冰倩 胡正芳 戚进 《中国实验方剂学杂志》 CAS CSCD 北大核心 2018年第19期37-41,共5页
目的:研究百合科山麦冬属植物湖北麦冬Liriope spicata var.prolifera地下部分的化学成分,进一步丰富该植物的化学信息并为其开发和利用提供理论指导。方法:采用60%乙醇对湖北麦冬地下部分进行提取,综合利用大孔吸附树脂,正、反向硅胶... 目的:研究百合科山麦冬属植物湖北麦冬Liriope spicata var.prolifera地下部分的化学成分,进一步丰富该植物的化学信息并为其开发和利用提供理论指导。方法:采用60%乙醇对湖北麦冬地下部分进行提取,综合利用大孔吸附树脂,正、反向硅胶,小孔树脂(MCI)及葡聚糖凝胶等柱色谱法对提取物进行分离和纯化,并根据化合物的理化性质及谱学数据鉴定其结构。结果:从湖北麦冬地下部分共分离并鉴定了12个化合物,其中包括4个黄酮类成分(化合物1~4),4个酚类及苯甲酸类衍生物(化合物5~8),2个酰胺类生物碱(化合物9,10)及2个其他类成分(化合物11,12)。分别鉴定为2',4,4'-三羟基查耳酮(1),木犀草素(2),槲皮苷(3),3,5-dihydroxy-7-methoxy-6-methyl-3-(4-hydroxybenzyl)chroman-4-one(4),2,6-二甲氧基-4-硝基苯酚(5),烯丙基焦儿茶酚(6),3,4-dihydroxyallylbenzene 4-O-[α-L-rhamnopyranosyl(1→6)]-β-D-glucopyranoside(7),丁香酸(8),E-阿魏酰酪胺(9),反式对羟基桂皮酸(10),(1S,4S,5R,6R,7S,10S)-1,4,6-trihydroxyeudesmane-6-O-β-Dglucopyranoside(11)和5-羟甲基糠醛(12)。结论:其中化合物1~3,5~8及化合物10~12均为首次从山麦冬属植物中分离得到,化合物4和9为首次从该植物中分离得到。 展开更多
关键词 湖北麦冬 化学成分 结构鉴定 3 5-dihydroxy-7-methoxy-6-methyl-3-(4-hydroxybenzyl)chroman-4-one E-阿魏酰酪胺
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Two new guaianolide-type sesquiterpenoids from Kadsura interior 被引量:4
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作者 Ke Dong Jian-Xin Pu +2 位作者 Xue Du Xiao-Nian Li Han-Dong Sun 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第2期111-113,共3页
Received 22 November 2012 Received in revised form 25 December 2012 Accepted 2B December 2012 Available online 4 February 2013
关键词 Kadsura interior4 8 -dihydroxy-1 a 5a-H-guaia-6 10( 14)-dien4β 10β-Trihydroxy-1a.5a-H-guaia-6-enX-ray technique
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