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A Load-balance and EEDF based strategy for reducing transmission delay of VoIP services in IEEE 802.16e system
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作者 王立磊 Xu Huimin 《High Technology Letters》 EI CAS 2009年第3期288-293,共6页
To decrease the transmission delay of uplink voice over IP(VoIP)services in IEEE 802.16e sys-tem,a novel strategy which includes a load-balance algorithm and an extended earliest deadline first(EEDF)scheduling algorit... To decrease the transmission delay of uplink voice over IP(VoIP)services in IEEE 802.16e sys-tem,a novel strategy which includes a load-balance algorithm and an extended earliest deadline first(EEDF)scheduling algorithm is proposed.Subsequently,this paper analyzes the performance of the pro-posed strategy in terms of transmission delay of VoIP services,system capacity,throughput and compati-bility with IEEE 802 .16e standard.Finally,simulation experiments are carried out to verify the improve-ment of the proposed strategy.The simulation results match well with the theoretical analysis and showthat the proposed strategy reduces the transmission delay of uplink VoIP services and improves the capaci-ty and throughput.These improvements are remarkable especially when the load of system is heavy. 展开更多
关键词 IEEE 802.16e system load balance EEDF scheduling VolP services
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Fufang E’jiao Jiang’s effect on immunity,hematopoiesis,and angiogenesis via a systematic“compound-effect-target”analysis
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作者 Xiang Li Xiao Xu +14 位作者 Ying Dong Shusheng Fan Xueyang Ren Yuan Zheng Jiamu Ma Feng Zhang Qingyue Deng Xianxian Li Yingyu He Mengyu Sun Wei Liu Mengxia Li Qing Xia Yan Zhang Gaimei She 《Food Science and Human Wellness》 SCIE CAS CSCD 2024年第5期2813-2832,共20页
Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive im... Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets. 展开更多
关键词 Fufang E’jiao Jiang Zebrafish(Danio rerio) Network pharmacology TRANSCRIPTOME BIBLIOMETRICS
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Does Smoking Weaken the Immune System: A Narrative Review
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作者 Anas Malik Radif Alubaidi 《Health》 2024年第6期553-560,共8页
Smoking has a complex impact on the immune system, affecting both innate and adaptive immunity. It can exacerbate pathogenic immune responses and attenuate defensive immunity, leading to a higher susceptibility to inf... Smoking has a complex impact on the immune system, affecting both innate and adaptive immunity. It can exacerbate pathogenic immune responses and attenuate defensive immunity, leading to a higher susceptibility to infections and certain diseases. The chemicals in cigarette smoke, such as nicotine and carbon monoxide, can alter immune cell functions and inflammatory responses. Smoking can also have long-term effects on the immune system, with some changes persisting even after quitting [1]. According to a Penn Medicine Physician, the Medical Oncologist Dr. David Porter, “People who are smokers tend to get sicker from infections”, “It may be that smoking impacts the immune system’s ability to respond appropriately”. Thus, such individuals within smoking exposure history might be considered as immunocompromised due to the altered and weakened immune system. Cigarette smoking is a prevalent habit with far-reaching health implications. Among its many adverse effects, smoking significantly alters the immune system’s functionality [1]. 展开更多
关键词 SMOKING IMMUNITY Immune system IMMUNOCOMPROMISED E-Cigarettes Hookahs
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PV Capacity Evaluation Using ASTM E2848: Techniques for Accuracy and Reliability in Bifacial Systems
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作者 Gautam Swami Kajal Sheth Dhvanil Patel 《Smart Grid and Renewable Energy》 2024年第9期201-216,共16页
A variety of test methodologies are commonly used to assess if a photovoltaic system can perform in line with expectations generated by a computer simulation. One of the commonly used methodologies across the PV indus... A variety of test methodologies are commonly used to assess if a photovoltaic system can perform in line with expectations generated by a computer simulation. One of the commonly used methodologies across the PV industry is an ASTM E2848. ASTM E2848-13, 2023 test method provides measurement and analysis procedures for determining the capacity of a specific photovoltaic system built in a particular place and in operation under natural sunlight. This test method is mainly used for acceptance testing of newly installed photovoltaic systems, reporting of DC or AC system performance, and monitoring of photovoltaic system performance. The purpose of the PV Capacity Test and modeled energy test is to verify that the integrated system formed from all components of the PV Project has a production capacity that achieves the Guaranteed Capacity and the Guaranteed modeled AEP under measured weather conditions that occur when each PV Capacity Test is conducted. In this paper, we will be discussing ASTM E2848 PV Capacity test plan purpose and scope, methodology, Selection of reporting conditions (RC), data requirements, calculation of results, reporting, challenges, acceptance criteria on pass/fail test results, Cure period, and Sole remedy for EPC contractors for bifacial irradiance. 展开更多
关键词 Photovoltaic system Capacity ASTM E2848 Bifacial PV Modules PV Capacity Testing PVSyst Simulation Solar Energy Performance Regression Modeling
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System Assimilation of E-Skills in Tertiary Institutions to Empower Graduates in South Africa
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作者 Oluwaseun Johnson Awosejo Agnieta Pretorius Tendani Justice Lavhengwa 《Journal of Intelligent Learning Systems and Applications》 2024年第3期222-241,共20页
The value of system assimilation is to improve working relationships between tutors and learners while increasing workflow efficiency among tertiary institutions with low operational costs. E-skills could be described... The value of system assimilation is to improve working relationships between tutors and learners while increasing workflow efficiency among tertiary institutions with low operational costs. E-skills could be described as electronic education development, to assist ICT professionals to reach their future career goals and aim to help users boost their ICT skills. In a society that is expanding, it is also a crucial issue to take into account. Researchers have turned their attention to this topic because of its significance and contribution to the empowerment of graduates in digital education. Many scholars have proposed many methods for integrating e-skills into society with impressive results, but the rising rate of graduate unemployment in South Africa is gradually becoming a big worry in our society. A model based on Activity Theory (AT) and e-skills will be developed in our tertiary institution to equip graduates with skills that will increase their employability and provide more individualized work opportunities as part of this study’s effort to solve this issue. With the use of the Statistical Package for the Social Sciences (SPSS) and Cronbach’s Alpha for validity and reliability testing, the study will create an experimental performance to assess the approach taken to measure e-skills in tertiary institutions to empower graduates in South Africa. The study established that system development and e-skilled models for tertiary institutions are growing gradually, especially in South African institutions, that empower graduates with profitable employability with experiences to improve work operation in the industries. In conclusion, system development and e-skills are very demanding but important to empower graduate employability to determine competency in the professional workforce. 展开更多
关键词 system Integration E-Skills Empower Graduate Tertiary Institution Activity Theory Tertiary Institution
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Security Vulnerability Analyses of Large Language Models (LLMs) through Extension of the Common Vulnerability Scoring System (CVSS) Framework
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作者 Alicia Biju Vishnupriya Ramesh Vijay K. Madisetti 《Journal of Software Engineering and Applications》 2024年第5期340-358,共19页
Large Language Models (LLMs) have revolutionized Generative Artificial Intelligence (GenAI) tasks, becoming an integral part of various applications in society, including text generation, translation, summarization, a... Large Language Models (LLMs) have revolutionized Generative Artificial Intelligence (GenAI) tasks, becoming an integral part of various applications in society, including text generation, translation, summarization, and more. However, their widespread usage emphasizes the critical need to enhance their security posture to ensure the integrity and reliability of their outputs and minimize harmful effects. Prompt injections and training data poisoning attacks are two of the most prominent vulnerabilities in LLMs, which could potentially lead to unpredictable and undesirable behaviors, such as biased outputs, misinformation propagation, and even malicious content generation. The Common Vulnerability Scoring System (CVSS) framework provides a standardized approach to capturing the principal characteristics of vulnerabilities, facilitating a deeper understanding of their severity within the security and AI communities. By extending the current CVSS framework, we generate scores for these vulnerabilities such that organizations can prioritize mitigation efforts, allocate resources effectively, and implement targeted security measures to defend against potential risks. 展开更多
关键词 Common Vulnerability Scoring system (CVSS) Large Language Models (LLMs) DALL-E Prompt Injections Training Data Poisoning CVSS Metrics
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Robust Joint Timing and Frequency Synchronization Algorithm for IEEE802.16e OFDM System
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作者 董国军 戴居丰 魏志成 《Transactions of Tianjin University》 EI CAS 2007年第5期360-364,共5页
Based on the structures of the short preamble and long preamble, which are defined for synchronization in IEEES02.16e specification, the robust synchronization algorithm for IEEES02.16e OFDM system is proposed. The co... Based on the structures of the short preamble and long preamble, which are defined for synchronization in IEEES02.16e specification, the robust synchronization algorithm for IEEES02.16e OFDM system is proposed. The correlations among the sample sequences in the preamble are investigated, especially the correlation between the first sample sequence and the last sample sequence in the long preamble. The conventional joint timing and frequency synchronization algorithm is reviewed based on the short preamble referring to the algorithm proposed by Schmidl, then a robust joint timing and frequency synchronization algorithm is proposed based on the long preamble. The simulations in the multi-path and frequency selective fading channel show that the proposed algorithm has improved the performances of timing metric plateau, timing offset and synchronization acquisition time even when signal-to-noise ratio is less than -5 dB. 展开更多
关键词 IEEE802.16e OFDM SYNCHRONIZATION PREAMBLE correlation estimation training sequence
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Scheduling Algorithm for Multimedia Services in IEEE 802.16e OFDM System
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作者 董国军 戴居丰 《Transactions of Tianjin University》 EI CAS 2008年第1期31-36,共6页
Based on five scheduling types and their QoS requirements defined in IEEE 802.16e specification, this paper proposes a new scheduring algorithm for non-real-time or real-time multimedia services. Taking the performanc... Based on five scheduling types and their QoS requirements defined in IEEE 802.16e specification, this paper proposes a new scheduring algorithm for non-real-time or real-time multimedia services. Taking the performances of efficiency, fairness and complexity into consideration, the proposed algorithm enhances the efficiency of air interface resource at the expense of the short-time unfairness, but ensures the long-time fairness. Moreover, the proposed algorithm introduces an efficient QoS assurance mechanism, which implements the functions of congestion control, queuing management and traffic management. The simulation results based on a simplified traffic model show that the proposed algorithm guarantees better performances of efficiency and fairness than conventional algorithms, without increasing the algorithm complexity. Especially on the occasion of heavy-traffic requirement, the performance of efficiency and fairness can be improved by 50% at most. 展开更多
关键词 IEEE 802.16e scheduling algorithm SUBCHANNEL efficiency FAIRNESS COMPLEXITY
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妊娠高血压疾病不良妊娠结局影响因素分析 被引量:1
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作者 陈静华 周倩珺 +1 位作者 刘应锋 伦桂欢 《中国当代医药》 CAS 2024年第13期54-57,共4页
目的探讨妊娠高血压疾病患者不良妊娠结局的影响因素。方法选取2020年4月至2022年6月东莞市人民医院收治的71例妊娠高血压疾病患者为研究对象,采用质谱法测定患者维生素A、D及E水平,对妊娠高血压疾病患者不良妊娠结局可能的影响因素进... 目的探讨妊娠高血压疾病患者不良妊娠结局的影响因素。方法选取2020年4月至2022年6月东莞市人民医院收治的71例妊娠高血压疾病患者为研究对象,采用质谱法测定患者维生素A、D及E水平,对妊娠高血压疾病患者不良妊娠结局可能的影响因素进行单因素和多因素分析。结果71例妊娠高血压疾病患者经随访发现19例患者妊娠结局不良,52例患者妊娠结局良好。单因素结果显示,妊娠高血压疾病患者预后与年龄、孕产史、高血压家族史、不良孕史、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)、维生素D、总胆红素无关,差异无统计学意义(P>0.05);与孕前体重指数(BMI)、病情严重程度、血尿酸、24 h尿蛋白定量、维生素A、维生素E比较,差异有统计学意义(P<0.05);多因素logistic回归结果显示,孕前BMI(β=1.213,OR=3.582,95%CI=2.482~6.313)、病情严重程度(β=1.563,OR=6.413,95%CI=5.682~8.452)、血尿酸(β=1.456,OR=4.083,95%CI=3.235~4.572)、24 h尿蛋白定量(β=2.938,OR=1.434,95%CI=1.283~4.394)、维生素A(β=1.691,OR=1.593,95%CI=1.241~1.786)、维生素E(β=1.336,OR=1.246,95%CI=1.187~1.583)是妊娠高血压疾病患者不良预后的独立危险因素,差异有统计学意义(P<0.05)。结论维生素A、D及E水平在妊娠高血压疾病患者中表达异常,其表达水平能反映疾病严重程度,且患者不良妊娠结局受多种因素的影响,不同因素能相互作用及干预,应针对上述可控因素进行干预。 展开更多
关键词 维生素A 维生素D 维生素E 妊娠高血压疾病
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Intrusion Detection System Through Deep Learning in Routing MANET Networks
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作者 Zainab Ali Abbood DoguÇagdaşAtilla Çagatay Aydin 《Intelligent Automation & Soft Computing》 SCIE 2023年第7期269-281,共13页
Deep learning(DL)is a subdivision of machine learning(ML)that employs numerous algorithms,each of which provides various explanations of the data it consumes;mobile ad-hoc networks(MANET)are growing in promi-nence.For... Deep learning(DL)is a subdivision of machine learning(ML)that employs numerous algorithms,each of which provides various explanations of the data it consumes;mobile ad-hoc networks(MANET)are growing in promi-nence.For reasons including node mobility,due to MANET’s potential to provide small-cost solutions for real-world contact challenges,decentralized management,and restricted bandwidth,MANETs are more vulnerable to security threats.When protecting MANETs from attack,encryption and authentication schemes have their limits.However,deep learning(DL)approaches in intrusion detection sys-tems(IDS)can adapt to the changing environment of MANETs and allow a sys-tem to make intrusion decisions while learning about its mobility in the environment.IDSs are a secondary defiance system for mobile ad-hoc networks vs.attacks since they monitor network traffic and report anything unusual.Recently,many scientists have employed deep neural networks(DNNs)to address intrusion detection concerns.This paper used MANET to recognize com-plex patterns by focusing on security standards through efficiency determination and identifying malicious nodes,and mitigating network attacks using the three algorithms presented Cascading Back Propagation Neural Network(CBPNN),Feedforward-Neural-Network(FNN),and Cascading-Back-Propagation-Neural-Network(CBPNN)(FFNN).In addition to Convolutional-Neural-Network(CNN),these primary forms of deep neural network(DNN)building designs are widely used to improve the performance of intrusion detection systems(IDS)and the use of IDS in conjunction with machine learning(ML).Further-more,machine learning(ML)techniques than their statistical and logical methods provide MANET network learning capabilities and encourage adaptation to differ-ent environments.Compared with another current model,The proposed model has better average receiving packet(ARP)and end-to-end(E2E)performance.The results have been obtained from CBP,FFNN and CNN 74%,82%and 85%,respectively,by the time(27,18,and 17 s). 展开更多
关键词 ARP CBPNN CNN DNN DL E2E FFNN IDS ML MANET security
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儿童过敏性鼻炎伴食物过敏原检测阳性的临床特征分析
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作者 胡慧敏 张媛 +5 位作者 黄东生 谷易轩 朱霞 张伟令 张谊 徐琛 《中国医刊》 CAS 2024年第9期982-985,共4页
目的总结过敏性鼻炎(AR)伴食物过敏原检测阳性患儿的临床特征,为制订AR儿童的饮食及营养方案提供依据。方法本研究为回顾性分析,选取2021年1月至2022年12月于首都医科大学附属北京同仁医院变态反应科就诊的330例AR伴食物过敏原检测阳性... 目的总结过敏性鼻炎(AR)伴食物过敏原检测阳性患儿的临床特征,为制订AR儿童的饮食及营养方案提供依据。方法本研究为回顾性分析,选取2021年1月至2022年12月于首都医科大学附属北京同仁医院变态反应科就诊的330例AR伴食物过敏原检测阳性患儿为研究对象。收集患儿血清过敏原检测结果,包括血清总免疫球蛋白E(IgE)以及13种食物过敏原的血清特异性免疫球蛋白E(sIgE),分析其临床特征和食物过敏原分布特点。结果330例AR伴食物过敏原检测阳性患儿中男性209例(63.33%),女性121例(36.67%);中位就诊年龄5岁,按年龄进行分组,其中<3岁组17例,3~<6岁组155例和≥6岁组158例,年龄≥6岁患儿占比最高(47.88%)。血清总IgE为4~4674 kUA/L,中位数167 kUA/L,其中检测结果升高者(≥60 kUA/L)占78.18%。99例患儿吸入性过敏原筛查阴性,231例患儿吸入性过敏原筛查阳性,吸入性过敏原筛查阴性患儿的血清总IgE升高比例(51.52%)低于吸入性过敏原筛查阳性患儿(89.61%),差异有统计学意义(P<0.05);不同年龄患儿血清总IgE升高比例比较差异有统计学意义(P<0.05),≥6岁组血清总IgE升高比例最高(51.94%),其次是3~<6岁组(42.64%)。食物过敏原阳性检出率最高的3种食物分别是牛奶(72.42%)、蛋清/蛋白(22.42%)和水果类(13.94%);对不同年龄、性别患儿的食物过敏原分布进行比较,结果显示女性患儿的蛋清/蛋白阳性率高于男性,蛋清/蛋白阳性率在<3岁年龄患儿中最高,其次是3~<6岁,最低的是≥6岁,差异均有统计学意义(P<0.05)。结论儿童AR伴食物过敏原检测阳性以男性患儿更为多见,牛奶、蛋清/蛋白及水果类为主要食物过敏原,且女性患儿及年龄<3岁患儿的蛋清/蛋白阳性率最高。 展开更多
关键词 过敏性鼻炎 食物过敏原 免疫球蛋白E 儿童 特异性免疫球蛋白E
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牛病毒性腹泻病毒E2蛋白的真核表达及间接ELISA抗体检测方法的建立 被引量:1
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作者 刘丹 黄小洁 +5 位作者 吴华伟 孙淼 陈延飞 秦义娴 侯力丹 薛麒 《动物医学进展》 北大核心 2024年第4期51-56,共6页
为建立检测牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)抗体的间接ELISA方法,利用昆虫细胞真核表达系统成功表达E2蛋白,将纯化后的E2蛋白作为包被抗原,用方阵滴定方法对影响ELISA的各个因素进行优化,并进行特异性、敏感性和重... 为建立检测牛病毒性腹泻病毒(Bovine viral diarrhea virus,BVDV)抗体的间接ELISA方法,利用昆虫细胞真核表达系统成功表达E2蛋白,将纯化后的E2蛋白作为包被抗原,用方阵滴定方法对影响ELISA的各个因素进行优化,并进行特异性、敏感性和重复性试验。结果表明,在昆虫细胞中表达了BVDV E2蛋白,Western blot证实目的蛋白可与BVDV阳性血清发生特异性反应。ELISA优化结果显示,E2蛋白最佳包被浓度为0.5μg/mL,最佳封闭液为1%明胶,最佳血清稀释度为1∶400,最佳血清作用方式为37℃作用30 min,酶标抗体的最佳作用方式为1∶2000稀释、37℃作用30 min,最佳底物作用时间为室温20 min,阳性临界值为OD 450≥0.423。与血清中和试验法进行比较,总符合率为97.8%,板内和板间重复性试验的变异系数均小于10%。该方法与牛常见病毒阳性血清均无交叉反应。说明建立的间接ELISA抗体检测方法特异性、敏感性和重复性良好,可用于大批量样本的临床检测和流行病学研究。 展开更多
关键词 牛病毒性腹泻病毒 E2蛋白 间接ELISA 抗体检测
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人参皂苷Rg3通过调控E2F1对人胃癌SGC-7901细胞生物行为学的影响 被引量:1
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作者 王建新 王琳茜 +3 位作者 朱波 时沛 孙义长 韩立 《中国药理学通报》 CAS CSCD 北大核心 2024年第5期853-858,共6页
目的探究人参皂苷Rg3通过调控E2F1对人胃癌SGC-7901细胞生物行为学的影响。方法MTT测定不同浓度人参皂苷Rg3(0、80、160、320μmol·L^(-1))对细胞增殖影响;流式细胞术测定不同浓度人参皂苷Rg3对细胞凋亡的影响;划痕愈合实验和Trans... 目的探究人参皂苷Rg3通过调控E2F1对人胃癌SGC-7901细胞生物行为学的影响。方法MTT测定不同浓度人参皂苷Rg3(0、80、160、320μmol·L^(-1))对细胞增殖影响;流式细胞术测定不同浓度人参皂苷Rg3对细胞凋亡的影响;划痕愈合实验和Transwell实验测定不同浓度人参皂苷Rg3对细胞迁移及侵袭的影响;Western blot测定不同浓度人参皂苷Rg3对E2F1、MMP-2、MMP-9、BCL-2、Bax表达的影响。结果80、160、320μmol·L^(-1)人参皂苷Rg3组细胞存活率与空白对照组比较明显降低,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞凋亡率与空白对照组比较明显增加,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞迁移数目与空白对照组比较明显降低,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞侵袭数目与空白对照组比较明显降低,且呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组E2F1 mRNA与E2F1蛋白表达量相较空白对照组明显减少且,呈浓度依赖性(P<0.05)。80、160、320μmol·L^(-1)人参皂苷Rg3组细胞中MMP-2、MMP-9、BCL-2蛋白表达量与空白对照组比较明显降低,BCL-2与空白对照组比较明显升高,且呈浓度依赖性(P<0.05)。结论人参皂苷Rg3能降低胃癌SGC-7901细胞增殖能力,抑制细胞迁移及侵袭能力,同时还促进SGC-7901细胞凋亡,且具有浓度依赖性,其作用机制可能通过E2F1因子下调MMP-2、MMP-9、BCL-2表达,上调Bax表达有关。 展开更多
关键词 人参皂苷RG3 E2F1 胃癌 增殖 迁移和侵袭 凋亡
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载脂蛋白E联合临床相关指标预测阿尔兹海默病模型的建立与验证
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作者 吴天晨 杨卉 +1 位作者 梁艳 杨永刚 《中国卫生统计》 CSCD 北大核心 2024年第1期23-27,共5页
目的 以载脂蛋白E(ApoE)为基础,结合阿尔茨海默病发病危险因素及临床常见指标,构建阿尔兹海默病发病风险的临床预测模型。方法 从南京市中医院大数据平台中,检索时间为2019年1月至2021年1月两年时间内,阿尔兹海默病患者61例,模糊匹配健... 目的 以载脂蛋白E(ApoE)为基础,结合阿尔茨海默病发病危险因素及临床常见指标,构建阿尔兹海默病发病风险的临床预测模型。方法 从南京市中医院大数据平台中,检索时间为2019年1月至2021年1月两年时间内,阿尔兹海默病患者61例,模糊匹配健康体检者111例。利用LASSO回归筛选危险因素,构建logistic回归预测模型,10折交叉进行区分度验证,bootstrap法进行校准度验证,临床决策曲线评判预测模型的临床指导性,最后以列线图可视化呈现临床预测模型。结果 筛选出12个变量,最终纳入4个危险因素:年龄、游离三碘甲状腺素(FT3)、性别、ApoE。全样本ROC曲线下面积为0.879,10折交叉9次验证后ROC曲线下平均面积为0.864;采用Bootstrap法抽样及Hosmer-Lemeshow校准度检验,结果χ^(2)=6.496,P=0.592>0.05。临床决策曲线阈值概率区间为1%~88.6%。结论 利用年龄、游离三碘甲状腺素、性别、 ApoE构建的临床预测模型对患者进行个体化评估,可以预警阿尔兹海默病,开展早期预防干预,减缓该病的发生发展。 展开更多
关键词 痴呆 阿尔兹海默病 预测模型 载脂蛋白E
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创伤性颅脑损伤患者血清锌、维生素E与病情程度及预后的关系
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作者 张春满 梁晨 +4 位作者 曹慧琴 杨延庆 胡国良 折刚刚 韦玮 《疑难病杂志》 CAS 2024年第8期902-907,共6页
目的探讨创伤性颅脑损伤(TBI)患者血清锌、维生素E与病情程度及预后的关系。方法选取2020年1月—2023年8月延安大学附属医院神经外科收治的TBI患者135例为TBI组,根据格拉斯哥昏迷量表(GCS)评分分为轻度TBI亚组(GCS评分13~15分,54例)、中... 目的探讨创伤性颅脑损伤(TBI)患者血清锌、维生素E与病情程度及预后的关系。方法选取2020年1月—2023年8月延安大学附属医院神经外科收治的TBI患者135例为TBI组,根据格拉斯哥昏迷量表(GCS)评分分为轻度TBI亚组(GCS评分13~15分,54例)、中度TBI亚组(GCS评分9~12分,45例)、重度TBI亚组(GCS评分3~8分,36例),再根据患者90 d预后分为不良预后亚组(35例)和良好预后亚组(100例),另选同期体检健康者100例为健康对照组。采用锌比色法与高效液相色谱法检测血清锌、维生素E水平;比较TBI组与健康对照组和不同病情程度TBI患者血清锌、维生素E水平;采用Spearman相关系数分析血清锌、维生素E水平与GCS评分的相关性;多因素Logistic回归分析影响TBI患者不良预后的因素;绘制受试者工作特征(ROC)曲线评价血清锌、维生素E水平对TBI患者90 d死亡的预测价值。结果与健康对照组比较,TBI组血清锌、维生素E水平降低(t/P=10.836/<0.001、10.160/<0.001);不同病情程度TBI患者血清锌、维生素E水平比较,轻度TBI亚组>中度TBI亚组>重度TBI亚组(F/P=41.858/<0.001、104.911/<0.001)。135例TBI患者90 d不良预后发生率为25.93%(35/135);血清锌、维生素E水平与GCS评分均呈正相关(r s=0.709/<0.001、0.698/<0.001);GCS评分增加、血清锌升高、维生素E升高为TBI患者不良预后的独立保护因素[OR(95%CI)=0.809(0.690~0.950)、0.706(0.590~0.845)、0.726(0.599~0.880)],基底池异常、中线移位≥5 mm为TBI患者不良预后的独立危险因素[OR(95%CI)=5.989(1.492~24.036)、3.378(1.045~10.922)];血清锌、维生素E水平及二者联合预测TBI患者不良预后的AUC分别为0.783、0.774、0.856,二者联合的AUC大于血清锌、维生素E水平单独预测(Z/P=2.580/0.010、2.727/0.006)。结论TBI患者血清锌、维生素E水平降低,与病情程度加重和预后不良有关,二者联合对TBI患者不良预后有良好的预测价值。 展开更多
关键词 创伤性颅脑损伤 血清锌 维生素E 病情程度 预后
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沧州市中心医院2233例吸入性变应原血清学检测结果分析
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作者 刘卫卫 温博深 +5 位作者 苏小明 黄艳 申梦梦 贾玉静 王斌 李建房 《中国耳鼻咽喉头颈外科》 CSCD 2024年第3期156-160,共5页
目的回顾性分析2022年沧州市中心医院就诊患者的18种常见吸入性变应原的血清检测结果,了解该地区吸入性变应原的流行情况,为过敏性疾病的预防、诊断和治疗提供依据。方法以沧州市中心医院2022年1~12月进行变应原sIgE检测的2233例患者为... 目的回顾性分析2022年沧州市中心医院就诊患者的18种常见吸入性变应原的血清检测结果,了解该地区吸入性变应原的流行情况,为过敏性疾病的预防、诊断和治疗提供依据。方法以沧州市中心医院2022年1~12月进行变应原sIgE检测的2233例患者为研究对象,对患者变应原情况进行统计分析。结果吸入性变应原sIgE阳性率为59.43%,前5位的吸入性变应原依次为粉尘螨(28.08%)、屋尘(23.20%)、屋尘螨(22.21%)、艾蒿(16.44%)和猫上皮(12.32%)。男性和女性患者各类变应原阳性率均无显著性差异(P>0.05)。不同年龄组的阳性率差异具有统计学意义(P<0.01),其中1~10岁组的阳性率最高。除1~10岁组中阳性率最高的吸入性变应原为屋尘以外,其他年龄组阳性率最高的变应原均为粉尘螨。秋季就诊的阳性检出率最高。结论沧州地区疑诊过敏性疾病患者变应原sIgE阳性主要变应原为粉尘螨、屋尘、屋尘螨、艾蒿和猫上皮。变应原sIgE阳性检出率在不同季节、不同年龄段患者中存在明显差异,不同性别患者的变应原sIgE阳性率无显著差异。研究结果可以为河北沧州地区过敏性疾病的防治提供重要参考。 展开更多
关键词 变应原 免疫球蛋白E 沧州市 吸入性变应原
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电化教育实践建立“政产学研用”协同发展机制 被引量:1
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作者 李运林 郭绍青 +4 位作者 刘繁华 徐福荫 陈庆贵 张学波 钟丽霞 《电化教育研究》 CSSCI 北大核心 2024年第3期5-9,17,共6页
从电化教育专业创建发展的实践中,回顾电化教育发展的历程,用系统科学协同论观点,建立“政产学研用”协同发展机制,即政——事物的管理系统;产——事物的产业系统;学——事物的学科教学系统;研——事物的科研系统;用——事物的事业系统... 从电化教育专业创建发展的实践中,回顾电化教育发展的历程,用系统科学协同论观点,建立“政产学研用”协同发展机制,即政——事物的管理系统;产——事物的产业系统;学——事物的学科教学系统;研——事物的科研系统;用——事物的事业系统。该机制可以促进教育技术学科发展,同时对中国式现代化建设与发展有重大作用。 展开更多
关键词 电化教育实践 电化教育系统 “政产学研用” 协同发展 机制
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LncRNA ZEB1-AS1和LncRNA SOX2OT在糖尿病肾病患者中的表达及与肾功能的相关性研究 被引量:1
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作者 何德娇 凌娜 +3 位作者 李正翔 乔玲 张淼淼 夏露 《疑难病杂志》 CAS 2024年第7期809-813,共5页
目的探究长链非编码RNA锌指E盒结合同源盒蛋白1反义链1(LncRNA ZEB1-AS1)和长链非编码RNA性别决定相关基因簇2重叠转录本(LncRNA SOX2OT)在糖尿病肾病(DN)患者中的表达及与肾功能的相关性。方法选取于2021年11月—2023年12月在武汉大学... 目的探究长链非编码RNA锌指E盒结合同源盒蛋白1反义链1(LncRNA ZEB1-AS1)和长链非编码RNA性别决定相关基因簇2重叠转录本(LncRNA SOX2OT)在糖尿病肾病(DN)患者中的表达及与肾功能的相关性。方法选取于2021年11月—2023年12月在武汉大学人民医院肾内科收治的DN患者106例为DN组,并根据24 h尿蛋白定量(24 h Upro)水平分为正常蛋白尿亚组43例(<30 mg)、微量蛋白尿亚组39例(30~<300 mg)、大量蛋白尿亚组24例(≥300 mg),另选取同期医院单纯糖尿病患者106例作对照组,检测患者血清LncRNA ZEB1-AS1、LncRNA SOX2OT水平;Pearson法分析LncRNA ZEB1-AS1和LncRNA SOX2OT与肾功能指标的相关性;Logistic分析影响DN患者肾功能损伤的因素。结果DN组血清LncRNA ZEB1-AS1、LncRNA SOX2OT水平低于对照组(t=11.471、10.257,P均<0.001)。血清LncRNA ZEB1-AS1、LncRNA SOX2OT比较,正常尿蛋白亚组>微量尿蛋白亚组>大量尿蛋白亚组(F=58.720、117.722,P均<0.001),BUN、SCr、UA水平比较,正常尿蛋白亚组<微量尿蛋白亚组<大量尿蛋白亚组,差异均有统计学意义(F=122.493、595.589、53.178,P均<0.001);LncRNA ZEB1-AS1、LncRNA SOX2OT分别与BUN、SCr、UA呈负相关(r=-0.487、-0.498、-0.521,-0.527、-0.515、-0.534,P均<0.001);Logistic回归分析显示,糖尿病病程长及高BUN、SCr、UA水平是影响DN患者肾功能损伤的危险因素[OR(95%CI)=1.672(1.128~2.479)、2.839(1.534~5.253)、2.754(1.512~5.017)、2.693(1.464~4.954)],高LncRNA ZEB1-AS1、LncRNA SOX2OT是保护因素[OR(95%CI)=0.875(0.798~0.959)、0.898(0.832~0.969)]。结论血清LncRNA ZEB1-AS1、LncRNA SOX2OT水平与DN患者肾功能有关,可能是评估DN患者肾功能的潜在指标。 展开更多
关键词 糖尿病肾病 长链非编码RNA锌指E盒结合同源盒蛋白1反义链1 长链非编码RNA性别决定相关基因簇2重叠转录本 肾功能 相关性
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以“教学之道”御“教学之术”——以认知为目标的教学新范式 被引量:1
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作者 赵宏 杜小勇 郭蕴 《中国大学教学》 CSSCI 北大核心 2024年第5期10-15,66,共7页
面对高校师生陷入“内卷”困境,以及AI等新技术的快速发展对当下教育教学提出的新挑战,本文汲取中华优秀传统文化中的哲学智慧,把“教学之道”作为真正有效教学的根基,基于布卢姆教育目标分类构建了适合我国的知识、能力和认知三维教育... 面对高校师生陷入“内卷”困境,以及AI等新技术的快速发展对当下教育教学提出的新挑战,本文汲取中华优秀传统文化中的哲学智慧,把“教学之道”作为真正有效教学的根基,基于布卢姆教育目标分类构建了适合我国的知识、能力和认知三维教育目标,并分析当下教育重心已由“知识+能力”向“能力+认知”偏移。在问题逻辑认知模式的成果导向教育(POT-OBE)基础上,提出了一种以提升“能力+认知”为目标的“5E”教学范式。教学实践表明,“5E”在提升学生的解决问题能力、创新意识和认知模式等方面效果明显,能够为师生摆脱教与学的内卷迷茫找到一个突破口,为AI冲击下的教育学科摆脱实质“停滞”提供一个思路。 展开更多
关键词 教学之道 教育目标 认知 POT-OBE “5E”教学范式
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栀子苷调节PI3K/AKT/mTOR信号通路在动脉粥样硬化形成过程中对Th17/Treg功能的影响 被引量:2
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作者 吴佳 吴进 +1 位作者 肖凯 凌超 《中西医结合心脑血管病杂志》 2024年第5期817-822,共6页
目的:观察栀子苷对载脂蛋白E缺乏(ApoE^(-/-))小鼠Th17/调节性T(Treg)细胞失衡的影响及其作用机制。方法:将50只纯合子ApoE^(-/-)雌性小鼠随机分为对照组、模型组和栀子苷低剂量组、栀子苷中剂量组、栀子苷高剂量组。对照组小鼠喂养普... 目的:观察栀子苷对载脂蛋白E缺乏(ApoE^(-/-))小鼠Th17/调节性T(Treg)细胞失衡的影响及其作用机制。方法:将50只纯合子ApoE^(-/-)雌性小鼠随机分为对照组、模型组和栀子苷低剂量组、栀子苷中剂量组、栀子苷高剂量组。对照组小鼠喂养普通饲料,模型组和栀子苷组小鼠喂养高脂饲料。从第8周开始,栀子苷各剂量组每日灌胃栀子苷(25、50、100 mg/kg),连续8周。试验结束时,采用油红O染色评估主动脉及其根部动脉粥样硬化(AS)病变面积比。采用定量逆转录聚合酶链式反应(RT-PCR)分析主动脉组织肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-6、IL-17A和IL-10 mRNA表达;采用流式细胞仪分析脾脏中Th17和Treg细胞百分比;蛋白免疫印迹法(Western Blot)检测主动脉组织磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路相关蛋白表达。结果:油红O染色病变显示,栀子苷中剂量组、栀子苷高剂量组病变百分比低于模型组(P<0.05)。与对照组比较,模型组主动脉TNF-α、IL-6和IL-17A mRNA表达水平升高(P<0.05);栀子苷各剂量组主动脉TNF-α、IL-6和IL-17A mRNA表达水平降低(P<0.05)。与对照组比较,模型组主动脉抗炎细胞因子IL-10 mRNA表达水平降低(P<0.05);栀子苷各剂量组主动脉抗炎细胞因子IL-10 mRNA表达水平升高(P<0.05)。与对照组比较,模型组小鼠脾脏中Th17细胞百分比升高,Treg细胞百分比降低(P<0.05)。栀子苷处理恢复了AS小鼠Th17和Treg细胞的平衡。栀子苷抑制PI3K的表达及AKT和mTOR的磷酸化,MHY1485(mTOR活化剂)减弱了栀子苷对T细胞分化的影响。结论:栀子苷抗AS作用机制可能与抑制PI3K/AKT/mTOR信号引起的Treg细胞增多和Th17细胞减少有关。 展开更多
关键词 动脉粥样硬化 栀子苷 载脂蛋白E缺乏 Th17/调节性T细胞 磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路 小鼠 实验研究
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