目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论...目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论量、保存量、被引频次、推荐量与Altmetrics评分、h指数、学术迹T之间的相关性以及对单篇论文的评价效果。结果:阅览量、下载量、讨论量与被引频次、h指数有正相关性,推荐量与h指数、学术迹无关。Altmetrics评分与阅览量、下载量和讨论量呈中度相关性,与被引频次呈弱相关。结论:PLo S ALMs是一个多维评价,应该应用多指标测度,才能体现研究成果的综合实力。展开更多
BACKGROUND Alström syndrome(AS,OMIM ID 203800)is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients.In the Chinese population,there are few reports on the clinical...BACKGROUND Alström syndrome(AS,OMIM ID 203800)is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients.In the Chinese population,there are few reports on the clinical manifestations and pathogenesis of AS.This is the first report on the association between AS and Graves’hyperthyroidism.CASE SUMMARY An 8-year-old Chinese girl was diagnosed with AS.Two years later,Graves’hyperthyroidism developed with progressive liver dysfunction.The patient’s clinical data were collected;DNA from peripheral blood of the proband,parents and sibling was collected for gene mutation detection using the second-generation sequencing method and gene panel for diabetes.The association between the patient’s genotype and clinical phenotype was analyzed.She carried the pathogenic compound heterozygous mutation of ALMS1(c.2296_2299del4 and c.11460C>A).These stop-gain mutations likely caused truncation of the ALMS1 protein.CONCLUSION The manifestation of hyperthyroidism may suggest rapid progression of AS.展开更多
Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovar...Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.展开更多
In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in Zhu(J Sci Comput 88:46,2021)for the design of a regularization term.Due to this new second...In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in Zhu(J Sci Comput 88:46,2021)for the design of a regularization term.Due to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image contrast.The augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed algorithm.Numerical experiments are presented to demonstrate the features of the proposed model.展开更多
2019年11月24日,2019/2020赛季ALMS亚洲勒芒系列赛(ASIAN LE MANS SERIES)迎来了上海揭幕战。2019/20赛季亚洲勒芒系列赛有着令人振奋的比赛阵容,也带来了精彩的演艺,而米其林作为该赛事的官方轮胎供应商以及技术合作伙伴,以米其林轮胎...2019年11月24日,2019/2020赛季ALMS亚洲勒芒系列赛(ASIAN LE MANS SERIES)迎来了上海揭幕战。2019/20赛季亚洲勒芒系列赛有着令人振奋的比赛阵容,也带来了精彩的演艺,而米其林作为该赛事的官方轮胎供应商以及技术合作伙伴,以米其林轮胎出色的性能表现为车手们护航,开启全新征程。展开更多
As an alternative of Internet protocol(IP)multicast,application layer multicast(ALM)is widely used with the advantage of simplicity and flexibility.However,the existing problems of large transmission delay and poor st...As an alternative of Internet protocol(IP)multicast,application layer multicast(ALM)is widely used with the advantage of simplicity and flexibility.However,the existing problems of large transmission delay and poor stability limit the application and development.In this article,to solve these problems,an ALM model based on node potential(NP)and topological index(TI)is proposed.The proposed model considers the factors of node capability and node distance in constructing and maintaining multicast tree to reduce transmission delay and increase stability,and thus it improves the application level in real-time multimedia multicast.The computer simulations prove that the proposed model reduces the ALM transmission delay,increases multicast tree stability effectively,and improves the ALM performance,and therefore it is suitable to apply in large-scale real-time multimedia environment.展开更多
“Alme ardeb” is a conventional beverage made from sugar and tamarind, season with other ingredients and highly prized by the population of the northern regions of Cameroon. Despite the importance of this traditional...“Alme ardeb” is a conventional beverage made from sugar and tamarind, season with other ingredients and highly prized by the population of the northern regions of Cameroon. Despite the importance of this traditional drink, the manufacturing process and quality attributes are still unknown. As such, a study was undertaken to describe the manufacturing process and characterise the quality of “Alme ardeb”. A survey was conducted in the Diamaré division of the Far north region. An ethnographical technique accompanied with semi-structured questionnaires and interviewing were used for collecting data needed to elaborate the production process. Forty-nine (49) samples of “Alme ardeb” were taken from 49 women producers in the different sites representing 10 samples per site and the sensory, physicochemical, phytochemical and microbiological properties were assessed according referenced techniques. The field survey reveals that the production of “Alme ardeb” is conventional and rudimentary involving two classical units of operation, caramelisation and boiling. The pH and titratable acidity of “Alme ardeb” were insignificant (p ≥ 0.05) except for the soluble solids, electrical conductivity and total sugar. The pH is acidic ranging between 4.06 ± 0.01 and 4.74 ± 0.05 with an oscillating titratable acidity ranging from 0.61% ± 0.022% to 0.65% ± 0.01% and an average soluble solids content of about 10.74 °Brix. Similarly, the total sugar content varies between 51.25 ± 0.18g·L<sup>-1</sup> and 61.37 ± 0.18 g·L<sup>-1</sup> with a conductivity that fluctuates around 351 μS·cm<sup>-1</sup> and 707 μS·cm<sup>-1</sup>. In addition, the average polyphenol, flavonoid and tannin contents were 2.2g EAG·L<sup>-1</sup>, 0.58 g·EQL<sup>-1</sup> and 0.36 g·ECL<sup>-1</sup> respectively, with a free radical scavenging capacity of 52.18%. The beverage revealed a complete absence of Salmonella with a doubtful hygienic quality. The total aerobic plate count varied from (4.1 ± 0.014) × 10<sup>4</sup> CFU·mL<sup>-1</sup> to (8.2 ± 0.007) × 10<sup>7</sup> CFU·mL<sup>-1</sup>, total coliforms from (4.3 ± 0.6) × 10<sup>2</sup> CFU·mL<sup>-1</sup> to (1.05 ± 0.7) × 10<sup>5</sup> CFU·mL<sup>-1</sup>, faecal coliforms from non-detected to (4.1 ± 0.07) × 10<sup>2</sup> CFU·mL<sup>-1</sup> and the fungal flora ranged from 0.0 to (6.5 ± 0.7) × 10<sup>3</sup> CFU·mL<sup>-1</sup>. However, the panelists judged the beverage as being acidic with a brownish colour and a sweet caramelized taste. Consequently, the beverage was highly palatable and consumed with an overall score that went from 13.48 ± 3.32 to 15.81 ± 4.47.展开更多
文摘目的:比较分析PLo S ALMs与Altmetrics评分、单篇论文学术评价指标之间的相关性及对单篇论文的评价效度。方法:以PLo S系列期刊PLo S Biology、PLo S Medicine为例,基于PLo S ALMs论文层面计量指标数据,分析比较其阅览量、下载量、讨论量、保存量、被引频次、推荐量与Altmetrics评分、h指数、学术迹T之间的相关性以及对单篇论文的评价效果。结果:阅览量、下载量、讨论量与被引频次、h指数有正相关性,推荐量与h指数、学术迹无关。Altmetrics评分与阅览量、下载量和讨论量呈中度相关性,与被引频次呈弱相关。结论:PLo S ALMs是一个多维评价,应该应用多指标测度,才能体现研究成果的综合实力。
文摘BACKGROUND Alström syndrome(AS,OMIM ID 203800)is a rare disease involving multiple organs in children and is mostly reported in non-Chinese patients.In the Chinese population,there are few reports on the clinical manifestations and pathogenesis of AS.This is the first report on the association between AS and Graves’hyperthyroidism.CASE SUMMARY An 8-year-old Chinese girl was diagnosed with AS.Two years later,Graves’hyperthyroidism developed with progressive liver dysfunction.The patient’s clinical data were collected;DNA from peripheral blood of the proband,parents and sibling was collected for gene mutation detection using the second-generation sequencing method and gene panel for diabetes.The association between the patient’s genotype and clinical phenotype was analyzed.She carried the pathogenic compound heterozygous mutation of ALMS1(c.2296_2299del4 and c.11460C>A).These stop-gain mutations likely caused truncation of the ALMS1 protein.CONCLUSION The manifestation of hyperthyroidism may suggest rapid progression of AS.
基金jointly supported by the National Key Research and Development Program of China(2018YFC1002104 to L.W.,2018YFC1004904 to B.-L.W.and J.F.,2016YFC1000500 to H.Y.W.and W.F.T.)the National Natural Science Foundation of China([81930036,31521003,31771669]to H.Y.W.)+1 种基金the Commission for Science and Technology of Shanghai Municipality(17JC1400902to H.Y.W.)the MDA-CHB Research Grant to B.-L.W。
文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity.
文摘In this work,we propose a second-order model for image denoising by employing a novel potential function recently developed in Zhu(J Sci Comput 88:46,2021)for the design of a regularization term.Due to this new second-order derivative based regularizer,the model is able to alleviate the staircase effect and preserve image contrast.The augmented Lagrangian method(ALM)is utilized to minimize the associated functional and convergence analysis is established for the proposed algorithm.Numerical experiments are presented to demonstrate the features of the proposed model.
文摘2019年11月24日,2019/2020赛季ALMS亚洲勒芒系列赛(ASIAN LE MANS SERIES)迎来了上海揭幕战。2019/20赛季亚洲勒芒系列赛有着令人振奋的比赛阵容,也带来了精彩的演艺,而米其林作为该赛事的官方轮胎供应商以及技术合作伙伴,以米其林轮胎出色的性能表现为车手们护航,开启全新征程。
基金National Natural Science Foundation of China(Nos.71171045 and 61801107)。
文摘As an alternative of Internet protocol(IP)multicast,application layer multicast(ALM)is widely used with the advantage of simplicity and flexibility.However,the existing problems of large transmission delay and poor stability limit the application and development.In this article,to solve these problems,an ALM model based on node potential(NP)and topological index(TI)is proposed.The proposed model considers the factors of node capability and node distance in constructing and maintaining multicast tree to reduce transmission delay and increase stability,and thus it improves the application level in real-time multimedia multicast.The computer simulations prove that the proposed model reduces the ALM transmission delay,increases multicast tree stability effectively,and improves the ALM performance,and therefore it is suitable to apply in large-scale real-time multimedia environment.
文摘“Alme ardeb” is a conventional beverage made from sugar and tamarind, season with other ingredients and highly prized by the population of the northern regions of Cameroon. Despite the importance of this traditional drink, the manufacturing process and quality attributes are still unknown. As such, a study was undertaken to describe the manufacturing process and characterise the quality of “Alme ardeb”. A survey was conducted in the Diamaré division of the Far north region. An ethnographical technique accompanied with semi-structured questionnaires and interviewing were used for collecting data needed to elaborate the production process. Forty-nine (49) samples of “Alme ardeb” were taken from 49 women producers in the different sites representing 10 samples per site and the sensory, physicochemical, phytochemical and microbiological properties were assessed according referenced techniques. The field survey reveals that the production of “Alme ardeb” is conventional and rudimentary involving two classical units of operation, caramelisation and boiling. The pH and titratable acidity of “Alme ardeb” were insignificant (p ≥ 0.05) except for the soluble solids, electrical conductivity and total sugar. The pH is acidic ranging between 4.06 ± 0.01 and 4.74 ± 0.05 with an oscillating titratable acidity ranging from 0.61% ± 0.022% to 0.65% ± 0.01% and an average soluble solids content of about 10.74 °Brix. Similarly, the total sugar content varies between 51.25 ± 0.18g·L<sup>-1</sup> and 61.37 ± 0.18 g·L<sup>-1</sup> with a conductivity that fluctuates around 351 μS·cm<sup>-1</sup> and 707 μS·cm<sup>-1</sup>. In addition, the average polyphenol, flavonoid and tannin contents were 2.2g EAG·L<sup>-1</sup>, 0.58 g·EQL<sup>-1</sup> and 0.36 g·ECL<sup>-1</sup> respectively, with a free radical scavenging capacity of 52.18%. The beverage revealed a complete absence of Salmonella with a doubtful hygienic quality. The total aerobic plate count varied from (4.1 ± 0.014) × 10<sup>4</sup> CFU·mL<sup>-1</sup> to (8.2 ± 0.007) × 10<sup>7</sup> CFU·mL<sup>-1</sup>, total coliforms from (4.3 ± 0.6) × 10<sup>2</sup> CFU·mL<sup>-1</sup> to (1.05 ± 0.7) × 10<sup>5</sup> CFU·mL<sup>-1</sup>, faecal coliforms from non-detected to (4.1 ± 0.07) × 10<sup>2</sup> CFU·mL<sup>-1</sup> and the fungal flora ranged from 0.0 to (6.5 ± 0.7) × 10<sup>3</sup> CFU·mL<sup>-1</sup>. However, the panelists judged the beverage as being acidic with a brownish colour and a sweet caramelized taste. Consequently, the beverage was highly palatable and consumed with an overall score that went from 13.48 ± 3.32 to 15.81 ± 4.47.
