Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo,soap,and sunscreen.However,the demand for these gel-based products has led to a surplus production ...Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo,soap,and sunscreen.However,the demand for these gel-based products has led to a surplus production of Aloe vera processing waste.An Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per month.Currently the Aloe vera waste is being disposed to the landfill or used as fertilizer.A sustainable management system for the Aloe vera processing waste should be considered,due to the negative societal and environmental impacts of the currents waste disposal methods.Therefore,this review focuses on various approaches that can be used to valorize Aloe vera waste into value-added products,such as animal and aquaculture feeds,biosorbents,biofuel and natural polymers.Researchers have reported Aloe vera waste for environmental applications biosorbents used for wastewater treatment of various pollutants.Several studies have also reported on the valorization of Aloe vera waste for production of biofuels such as bioethanol,mixed alcohol fuels,biogas and syngas.Aloe vera waste could also be valorized through isolation and synthesis of natural polymers for application in wound dressing,tissue engineering and drug delivery systems.Aloe vera waste valorization was also reviewed through extraction of value-added bioactive compounds such as aloe-emodin,aloin and aloeresin.These value-added bioactive compounds have various applications in the cosmetics(non-steroidal anti-inflammatory,tyrosinase inhibitors)and pharmaceutical(anticancer agent and COVID 19 inhibitors)industry.展开更多
This review summarizes the main chemical composition of Aloe vera flowers and introduces their antioxidant,anti-aging,skin whitening,skin moisturizing,anti-skin irritation,and anti-skin allergy effects.Suggestions for...This review summarizes the main chemical composition of Aloe vera flowers and introduces their antioxidant,anti-aging,skin whitening,skin moisturizing,anti-skin irritation,and anti-skin allergy effects.Suggestions for the application of Aloe v.flowers in cosmetics are provided.展开更多
The search for functional foods with health benefits has increased,and yogurt represents one of these products due to their properties,such as,source of probiotics that favour the gastrointestinal system,contains vita...The search for functional foods with health benefits has increased,and yogurt represents one of these products due to their properties,such as,source of probiotics that favour the gastrointestinal system,contains vitamins,minerals and improves the action of enzymes.Present work investigated bromatological,microbiological,sensorial properties and shelf-life of different yogurt goat milk formulations with Aloe vera and natural sweeteners.The goat yogurt with 99.40%A.vera pulp and 0.60%S.rebaudiana presented the best nutritional composition,being suitable for human consumption representing an innovative product with a great functional potential.The synergy between the ingredients used in the yogurt processing resulted in an innovative product to the market.Goat milk has a lower cost per liter in comparison with cow milk,Aloe vera is accessible due to its fast-vegetative propagation,Stevia Rebaudiana has a great popularity for being a natural sweetener with no calories,and all these products are produced in México.展开更多
Diabetes is a chronic disease that requires a long term management where oxidative stress plays a pivotal role in disease progression and intensifying secondary complications. In spite of all the research on diabetes ...Diabetes is a chronic disease that requires a long term management where oxidative stress plays a pivotal role in disease progression and intensifying secondary complications. In spite of all the research on diabetes and recent advances in diabetes treatments, the reality is that there is no cure for diabetes and its devastating complications. While currently available anti-diabetic therapies are effective in reducing blood glucose level, they are not without associated side effects when they are used for a long term applications. As a result, physicians and patients are inclining more towards to a safer therapy with less serious side effects in the form of medicinal foods and botanical alternatives that are suitable for chronic usage. Aloesin, an Aloe chromone, has previously been formulated with an aloe polysaccharide to give a composition called Loesyn, where it showed significant impact in reducing glycosylated hemoglobin, fasting blood glucose, fructosamine and plasma insulin level in humans. Radical scavenging activities of chromones and polysaccharides from Aloe have also been reported. Here we rationalize the relevance of use of Aloesin alone or in a standardized blend with Aloe polysaccharides, as a potential medical food to manage systemic oxidative stress and/or high blood glucose of diabetes.展开更多
Objective: To investigate the in vitro anticancer effect of Aloe vera(A. vera) and Calligonum comosum(C. comosum) extracts against hepatocellular carcinoma(HepG 2) cells. Methods: Hep G2 cells were tested against diff...Objective: To investigate the in vitro anticancer effect of Aloe vera(A. vera) and Calligonum comosum(C. comosum) extracts against hepatocellular carcinoma(HepG 2) cells. Methods: Hep G2 cells were tested against different doses of A. vera and C. comosum. Viability of the cells was assessed by MTT assay. Evaluation of apoptosis and DNA damage in HepG 2 cells were performed using annexin V apoptosis detection kit. The expression of p53 and anti-apoptotic(Bcl-2) were tested by real time-PCR and flow cytometer analyser. Hematoxylin and eosin stained sections from untreated and treated HepG 2 cells were observed using light microscopy.Results: The IC50 values of A. vera and C. comosum extracts were(10.45 ± 0.31) and(9.60 ± 0.01) μg/mL respectively. The extracts separately increased cytotoxicity against HepG 2 cells in a time and dose dependent manners. Also, it apparently induced apoptosis through increase P53 and decrease Bcl-2 genes expressions.Conclusions: The results indicated that the extracts could have anti-hepatocarcinogenic effect, at least in part, through modulation of apoptosis.展开更多
In adopting tissue culture, effects of rare earth on Physiological and chemical characteristics, proliferation and rootage in aloe were studied. The results indicate that suitable concentration treatment of rare earth...In adopting tissue culture, effects of rare earth on Physiological and chemical characteristics, proliferation and rootage in aloe were studied. The results indicate that suitable concentration treatment of rare earth increases content of reducing sugar and protein, enhances activity intensity of superoxide dismutase (SOD), peroxidase (POD) isozymes and stripes of POD isozymes in the leaves. It also increases rate of proliferation and rootage respectively. The appropriate concentration of rare earth is 20～40 mg·L -1 in proliferation and rootage of aloe.展开更多
The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, ...The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.展开更多
Objective: To explore the new sources of novel bioactive compounds having pharmaceutical and agricultural interest and to search the endophytic actinobacteria from medicinal plants. Methods: NAF-1 an endophyte actinob...Objective: To explore the new sources of novel bioactive compounds having pharmaceutical and agricultural interest and to search the endophytic actinobacteria from medicinal plants. Methods: NAF-1 an endophyte actinobacteria was isolated from leaves of medicinal plant Aloe vera collected in Marrakesh, Morocco using Bennett agar as selective medium. NAF-1 was tested for its antimicrobial activity against five pathogenic bacteria such as Staphylococcus aureus PIC 53156, Micrococcus luteus ATCC381, Bacillus subtilis ATCC 14579, Pseudomonas aeruginosa DSM 50090 and Escherichia coli ATCC 8739 and four human clinic fungi belonging to the Candida, Aspergillus and Microsporum genera. Several antioxidant activities were studied such as DPPH free radical scavenging, β-carotene and linoleic acid and reducing power assays. The total of phenol and flavonoid was also calculated. Using Artemia salina shrimp assay, the cytotoxicity of NAF-1 crude extract was determined. Results: The results revealed that the actinobacteria showed a high activity(≥20 mm) against only Gram positive bacteria but it had a moderate activity(between 13 and 15 mm) against Human clinic fungi. The isolate also exhibited a LD50 of 14.20 μg/mL in the cytotoxicity assay. The result showed that the crude extract presented an interesting free radical-scavenging activity with IC50 value of(5.58 ± 0.26) μg/mL and a high value of phenolic and flavonoid compounds with(15.41 ± 0.18) μg GAE/mg extract and(11.41± 0.06) μg QE/mg extract respectively. Moreover, the taxonomic position of our endophyte actinobacteria using the morphological and physiological criteria and using 16 S r RNA gene sequence(polyphasic approach) showed that the NAF-1 isolate was similar to Streptomyces hydrogenans which was never described as an endophyte actinobacteria. Conclusions: This isolated strain appears promising resources of bioactive agents and can be exploited to produce therapeutic agents active against pathogenic disease.展开更多
AIM:To evaluate the protective effects of Aloe vera on gastric injury in rats with indomethacin(IMN)-induced gastropathy.METHODS:Male Sprague-Dawley rats were randomly divided into three groups.Group 1(control,n=6)was...AIM:To evaluate the protective effects of Aloe vera on gastric injury in rats with indomethacin(IMN)-induced gastropathy.METHODS:Male Sprague-Dawley rats were randomly divided into three groups.Group 1(control,n=6)was given distilled water(DW)orally.Group 2(IMN,n=6)was given oral IMN(150 mg/kg)dissolved in5%sodium bicarbonate(Na HCO3-)at time 0 and 4 h.Group 3(Aloe vera-treated,n=6)was given oral Aloevera(150 mg/kg)dissolved in DW and IMN at time 0and 4 h.Eight hours later,the stomach was removed to determine gastric malondialdehyde(MDA),the number of interleukin(IL)-18 positive stained cells(%)by immunohistochemistry,and for histopathological examination.Then,the serum was collected to determine tumor necrosis factor(TNF)-αand cytokineinduced neutrophil chemoattractant(CINC)-1 by sandwich enzyme linked immunosorbent assay method.RESULTS:In the IMN group,serum TNF-α,CINC-1and gastric MDA were significantly increased when compared to the control group(27.78±1.52 pg/m L vs 85.07±49.11 pg/m L,P=0.009;104.55±45.80pg/m L vs 1054.70±20.38 pg/m L,and 1.74±0.21nmol/mg vs 9.36±1.07 nmol/mg protein,P=0.000,respectively).The mean level of TNF-α,CINC-1 and gastric MDA in the Aloe vera-treated group were improved as compared with the IMN group(85.07±49.11 pg/m L vs 35.19±1.61 pg/m L,P=0.021;1054.70±20.38 pg/m L vs 813.56±239.04 pg/m L,P=0.025;and 9.36±1.07 nmol/mg vs 2.67±0.64 nmol/mg protein,P=0.000,respectively).The number of IL-18 positive stained cells(%)in the gastric epithelial cells of the IMN group was significantly higher than the control group(5.01%±3.73%vs 30.67%±2.03%,P=0.000,respectively).In contrast,Aloe vera treatment decreased the number of IL-18 positive stained cells(%)significantly when compared with the IMN group(30.67%±2.03%vs 13.21%±1.10%,P=0.000,respectively).Most rats in the IMN group developed moderate to severe gastric inflammation and erosions.The gastric erosions and neutrophil infiltration scores were significantly reduced in the Aloe veratreated group.CONCLUSION:Aloe vera attenuated IMN-induced gastropathy in rats by the reduction of oxidative stress,inflammation,and improvement of gastrichistopathology.展开更多
BACKGROUND Aloe vera exerts several biological activities,such as,anti-inflammatory,antioxidant,and antimicrobial effects.It was recently shown to reduce insulin resistance and triglyceride level.We hypothesized that ...BACKGROUND Aloe vera exerts several biological activities,such as,anti-inflammatory,antioxidant,and antimicrobial effects.It was recently shown to reduce insulin resistance and triglyceride level.We hypothesized that aloe vera would have beneficial effects in alleviating non-alcoholic steatohepatitis(NASH)in rats.AIM To examine the therapeutic effects of aloe vera in NASH rats.METHODS All rats were randomly divided into 3 groups(n=6 in each group).Rats in the control group were fed ad libitum with a standard diet for 8 wk.Rats in the NASH group were fed ad libitum with a high-fat high-fructose diet(HFHFD)for 8 wk.Rats in the aloe vera group were fed ad libitum with a HFHFD and aloe vera in dimethylsulfoxide(50 mg/kg)by gavage daily for 8 wk.Liver samples were collected at the end of the treatment period.RESULTS Hepatic malondialdehyde(MDA)levels increased significantly in the NASH group as compared with the control group(377±77 nmol/mg vs 129±51 nmol/mg protein,respectively,P<0.001).Glutathione(GSH)levels were significantly lower in the NASH group than the control group(9±2 nmol/mg vs 24±8 nmol/mg protein,respectively,P=0.001).The expression of interleukin-18 (IL-18), nuclear factor-kappa β, and caspase-3 increased, while peroxisomeproliferator-activated receptor gamma decreased in the NASH group comparedwith the controls. Following aloe vera administration, MDA levels decreased (199± 35 nmol/mg protein) and GSH increased (18 ± 4 nmol/mg protein) markedly.Steatosis, hepatocyte ballooning, lobular inflammation and increased hepatocyteapoptosis were observed in the NASH group. Aloe vera treatment attenuatedthese changes in liver histology.CONCLUSIONAloe vera attenuated oxidative stress, hepatic inflammation and hepatocyteapoptosis, thus improving liver pathology in rats with NASH.展开更多
Aloe vera, a short-stemmed shrub is described as a “wonder plant”, due to its vast uses in various medical products. Since many decades, extensive research has revealed that the pharmacological active ingredients ar...Aloe vera, a short-stemmed shrub is described as a “wonder plant”, due to its vast uses in various medical products. Since many decades, extensive research has revealed that the pharmacological active ingredients are distributed in both the gel and rind of the Aloe vera leaves. A. vera is very popular in cosmetic and pharmaceutical industries and it is needed in large quantities with higher fractions of important constituents. To satisfy the market demand, intervention of microbial community seems to be a promising approach, which helps to increase the growth and metabolites along with plant fitness. Piriformospora indica is a root colonizing endophytic fungus, having unique plant growth-promoting properties. It helps the plant to acquire more nutrients from soil even under extreme physical and nutrient stress conditions. It interacts with a wide range of hosts. Interaction of P. indica with A. vera resulted in overall increase in plant biomass and greater shoot and root length, as well as number of shoots and roots as compared to control under both in vitro and in vivo environment conditions. Apart from that, the photosynthetic pigments (Chl a, Chl b and total Chl) and aloin content were observed significantly higher in A. vera plantlets colonized with symbiotic endophyte. The antioxidant activities were also tested and found significantly higher as compared to control plants. This imparts the potential of P. indica, to resist the plants against phyto-pathogenic microbes. P. indica has been proved as a potential candidate to enhance the biomass production along with various value additions in the form of active ingredients in A. vera.展开更多
The objective of the study was to evaluate the anti-diabetic activities of methanol extracts of Aloe camperi (AC), Meriandra dianthera (MD) and a polyherbal drug (PH) in diabetes induced Wistar albino rats. A single d...The objective of the study was to evaluate the anti-diabetic activities of methanol extracts of Aloe camperi (AC), Meriandra dianthera (MD) and a polyherbal drug (PH) in diabetes induced Wistar albino rats. A single dose of alloxan monohydrate (150 mg/kg, i.p.) was used to induce diabetes mellitus (DM). Diabetes was confirmed by the elevated blood glucose levels determined after 72 h of induction. Animals with mean fasting blood glucose (FBG) level more than 200 mg/dl were recruited for the experiment. The herbal extracts at doses of 200 and 400 mg/kg and standard drugmetformin (5 mg/kg) were administered orally to the diabetic rats for 21 days and the FBG level was estimated on 0, 7, 14 and 21 days. The herbal extracts showed dose-dependent fall in FBG levels and the result exhibited very significant (P < 0.001) decreases in FBG level by the end of the experimental day as compared to the diabetic control. The highest antihyperglycemic effect was observed by MD extract at 400 mg/kg and was comparable to the standard drug. Oral glucose tolerance test (OGTT) was also conducted on normal rats and thus glucose at 2 g/kg per body weight was loaded via oral gavage to all groups 30 min after extract administration. All the groups showed significant increase (P P The hyperglycemia with glucose challenge was significantly brought down (P < 0.001) by all herbal extracts at 60 and 120 min relative to the negative control. Moreover, acute oral toxicity tests was conducted based on the protocols of OECD-425 and thus the LD50 of the herbal extracts was estimated to be greater than 2000 mg/kg. Statistical analysis was performed using One-Way ANOVA followed by Dunnett’s test for multiple comparisons, and values of P < 0.05 were considered as statistically significant.展开更多
Nutrigenomic studies were conducted to uncover the mechanism of action for the hypoglycemic and insulin sensitizing effects of UP780. From high fat diet-induced obesity mouse model for UP780, livers and white adipose ...Nutrigenomic studies were conducted to uncover the mechanism of action for the hypoglycemic and insulin sensitizing effects of UP780. From high fat diet-induced obesity mouse model for UP780, livers and white adipose tissues (WAT) from groups of lean control, high fat diet (HFD), and HFD treated with UP780 were collected for microarray study. Microarray generated gene expression changes were applied to Ingenuity Pathway Analysis for changes in canonical metabolic and signaling pathways. Microarray was validated by quantitative reverse transcriptase-polymerase chain reaction (QPCR), Western blots, liver triglyceride, liver cholesterol, liver steatosis, and insulin ELISA. UP780 treatment decreased liver gene expressions for multiple enzymes involved in fatty acid biosynthesis and triglyceride production. UP780 treatment increased gene expressions globally for the insulin receptor signaling pathway in WAT. Both liver triglyceride and liver cholesterol levels were significantly reduced by UP780 over HFD. The reduction of liver fat was confirmed by microscopic analysis of liver steatosis. Finally, UP780 significantly decreased fasting plasma insulin level over HFD. The mechanism of action for UP780 indicated a reduction of liver fat accumulation and an enhancement in adipose tissue insulin signaling pathway. This provided mechanistic explanation for the in vivo UP780 effects of enhanced insulin sensitiveity and decreased blood glucose in mouse diabetes and prediabetes models.展开更多
We have developed a novel methodology for the determination of Aloins A and B in Aloe vera plant extract and commercial Aloe vera product formulations using HPLC method. The result shows good sensitivity and accuracy ...We have developed a novel methodology for the determination of Aloins A and B in Aloe vera plant extract and commercial Aloe vera product formulations using HPLC method. The result shows good sensitivity and accuracy which can be utilized for the scientific validation of bioactive compounds present in the commercial formulations.展开更多
Objective:Aloe Vera gel(AVG) has a prominent role as a contemporary folk remedy.The Non-healed chronic ulcers of 16 non-responders to conventional treatment were treated with AVG for which the clinical efficacy was st...Objective:Aloe Vera gel(AVG) has a prominent role as a contemporary folk remedy.The Non-healed chronic ulcers of 16 non-responders to conventional treatment were treated with AVG for which the clinical efficacy was studied.Methods:This study included 16 patients having chronic ulcer(9 males and 7 females) with mean age of 41.8±14.6 who following failure treatment to conventional therapy,were dispensed AVG to apply. AVG is consisted from gel part of Aloe Vera plant plus one preservative material,in this study ECG jelly. The patients were assessed as responder whenever intensity of inflammation,the number and /or the size of ulcers have been reduced.Results:The period of time till healing(complete or reduction in size of ulcer), were from 5 to 160 days with mean of 31.2±36.4 days.The mean time of decreasing for secreting,swelling and redness was from 5-11 days.Spearman coefficient of correlation,showed no significant correlation between first size and depth of ulcer and timing till 50%reduction in size of ulcer.Conclusion:All patients had been treated with conventional treatment all to no avail.There were some full thickness ulcer which at the end of treatment we observed an improvement and normal skin for those ulcers.There was a minor complication like itching in one patient but no leading to stop treatment.These findings suggest that AVG is an excellent and safer choice than current conventional therapeutic management of chronic ulcers.展开更多
Objective:To evaluate the anti-inflammatory potential of peptide/polypeptide fraction of Aloe vera through in vitro and in vivo studies.Methods:The peptide/polypeptide fraction from Aloe vera was obtained through tric...Objective:To evaluate the anti-inflammatory potential of peptide/polypeptide fraction of Aloe vera through in vitro and in vivo studies.Methods:The peptide/polypeptide fraction from Aloe vera was obtained through trichloroacetic acid precipitation.The anti-inflammatory property of the peptide/polypeptide fraction was tested by protein denaturation,membrane stabilization assays.The effect of the fraction on RAW 264.7 cell viability was examined by MTT assays.The nitric oxide level was determined through Griess reagent.TNF-αand IL-6 levels were estimated using ELISA kits.In vivo studies were carried out in male Wistar rats through injection of Freund’s adjuvant in the hind paw.Paw edema was measured through the Vernier scale and levels of alanine aminotransferase,aspartate transaminase,TNF-α,IL-6,and secretory phospholipase A2 were estimated through their respective kits after fourteen days of treatment.Graph Pad Prism6 was used for analyzing the results.Results:The peptide/polypeptide extract inhibited protein denaturation with an IC50 value of(218.9±15.6)μg/m L and stabilized the membrane of red blood cells with an IC50 value of(275.9±19.1)μg/m L.The extract showed no changes in cell morphology or cytotoxicity up to the concentration of 20μg/mL in MTT assays.The peptide/polypeptide fraction markedly reduced the levels of proinflammatory markers and mediators in both in vitro and in vivo studies.Conclusions:The results indicate that the peptide/polypeptide fraction of Aloe vera has antiinflammatory property through inhibition of inflammatory markers and mediators responsible for NF-κB and mitogen-activated protein kinase pathways.展开更多
Background: Aloe vera has been used by many civilizations throughout history due to the numerous properties attributed. Gastro oesophageal reflux disease is a common disorder with consequences for the patient’s healt...Background: Aloe vera has been used by many civilizations throughout history due to the numerous properties attributed. Gastro oesophageal reflux disease is a common disorder with consequences for the patient’s health related quality of life. Aims: The purpose of this study was to assess the benefits of the Aloe vera in 80 patients with gastro oesophageal reflux. Methods: This is probably the first randomised and double-blind trail ever performed on this subject. The study included eight weeks of treatment with milk enriched with Aloe vera or placebo. Data of diet (frequency questionnaire), symptoms (gastrointestinal symptom rating scale) and quality of life (quality of life in reflux and disease) were obtained. Results: So far, there has been hardly any proof that Aloe vera decreases symptoms of reflux disease;on the contrary, a lower percentage of remission of pain is observed among the Aloe vera group. As long as its effectiveness has not been proven properly, the use of Aloe vera in reflux disease cannot be recommend. Conclusion: Aloe vera does not have a beneficial effect on reflux disease under the study conditions.展开更多
The purpose of this study was to evaluate the ability of aqueous extract of Aloe barbadensis Miller (Aloe vera) on oxidative damage and Anion Exchanger 1 (AE1, also known as Band 3) expression in human erythrocytes ex...The purpose of this study was to evaluate the ability of aqueous extract of Aloe barbadensis Miller (Aloe vera) on oxidative damage and Anion Exchanger 1 (AE1, also known as Band 3) expression in human erythrocytes exposed to the water soluble free radical initiator 2.2’-azobis-2-amidinopropano dihydrochloride (AAPH). In addition, total phenolic compounds in the extracts were determined as catechin equivalent and the various antioxidant activities were compared to natural and synthetic standard antioxidants such as BHA and ascorbic acid. Since Aloe vera extract did not cause a consumption of the cytosolic antioxidant, glutathione (GSH) when it was direct incubated with GSH in basic aerated aqueous solution, this indicates that Aloe vera extract does not proceed auto oxidation at this experimental condition. Furthermore, Aloe vera extract prevent the consumption of GSH, in radical treated RBCs. It also inhibit consumption of GSH when it was direct incubated with AAPH. Aloe vera gel extract inhibits the generation of diphenyl-2-picrylhy-drazyl (DPPH) and the scavenging activity was increased in a dose dependent manner. Aloe vera extract was shown the similar reducing power than standards BHT and ascorbic acid. Biochemical analysis by SDS-PAGE and western blotting showed that AAPH-induced oxidative stress increased the susceptibility of AE1 to proteolytic degradation. Of note, our data evidenced that Aloe vera treatment was able to partially restore the normal RBC membrane protein profiles in a dose-dependent manner. These results clearly demonstrate the antioxidative activity of Aloe vera gel extract that might be ascribed to a synergistic action of the bioactive compounds contained therein.展开更多
Nano-encapsulation is a platform which offers a promising application for control release and the delivery of drugs in pharmaceuticals and antioxidant/ antimicrobial in food systems. Poly (lactic-co-glycolide acid) (P...Nano-encapsulation is a platform which offers a promising application for control release and the delivery of drugs in pharmaceuticals and antioxidant/ antimicrobial in food systems. Poly (lactic-co-glycolide acid) (PLGA) is a biodegradable and biocompatible co-polymer of lactic acid and glycolic acid which is used for synthesizing food based polymeric nanoparticles (NP). The aim of this study was to evaluate the morphological and physicochemical properties and the controlled release of bioactive components derived from Aloe vera gel loaded PLGA NP. The results shows the mean hydrodynamic diameter of the unloaded NP is 103 nm which is significantly (p < 0.01) smaller than the loaded freeze dried powered gel (FDG) (147 nm) and liquid gel (LG) (221 nm) and the particle size distribution given by the Poly-dispersity Index were 0.2, 0.2 and 0.3, respectively. The zeta potential for unloaded, FDG and LG NP were ±60, ±28 and ±22 mV, respectively, hence were electrokinetically stable NP. No significant (p > 0.05) inhibition of the antioxidant potential was observed with loaded NP. The entrapment efficiency for the FDG synthesized was 87%, and the burst effect was observed after 4 h as a result of the encapsulation effect. The release kinetics of bioactive is govern by the combination of mass diffusion and capillary action.展开更多
Burn victims around the world are forced to a life of long lasting morbidity and high mortality rate. Although physiotherapy and occupational therapy subside the painful side of morbidity after severe skin burns, pati...Burn victims around the world are forced to a life of long lasting morbidity and high mortality rate. Although physiotherapy and occupational therapy subside the painful side of morbidity after severe skin burns, patients are under huge financial pressure in order to return to health. Various treatment plans are used for severe burn injuries. Aloe Vera Gel is introduced recently as an alternative management for burn injuries through betterment of granulation tissue formation and epithelialization. Moreover, numerous studies reported Aloe Vera healing effect on chronic wounds by manipulating collagen layout. This study aims to present the therapeutic impact of Aloe Vera Gel on chronic skin burns of a 17-year-old female who was referred to our department because of rejected skin graft.展开更多
文摘Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo,soap,and sunscreen.However,the demand for these gel-based products has led to a surplus production of Aloe vera processing waste.An Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per month.Currently the Aloe vera waste is being disposed to the landfill or used as fertilizer.A sustainable management system for the Aloe vera processing waste should be considered,due to the negative societal and environmental impacts of the currents waste disposal methods.Therefore,this review focuses on various approaches that can be used to valorize Aloe vera waste into value-added products,such as animal and aquaculture feeds,biosorbents,biofuel and natural polymers.Researchers have reported Aloe vera waste for environmental applications biosorbents used for wastewater treatment of various pollutants.Several studies have also reported on the valorization of Aloe vera waste for production of biofuels such as bioethanol,mixed alcohol fuels,biogas and syngas.Aloe vera waste could also be valorized through isolation and synthesis of natural polymers for application in wound dressing,tissue engineering and drug delivery systems.Aloe vera waste valorization was also reviewed through extraction of value-added bioactive compounds such as aloe-emodin,aloin and aloeresin.These value-added bioactive compounds have various applications in the cosmetics(non-steroidal anti-inflammatory,tyrosinase inhibitors)and pharmaceutical(anticancer agent and COVID 19 inhibitors)industry.
文摘This review summarizes the main chemical composition of Aloe vera flowers and introduces their antioxidant,anti-aging,skin whitening,skin moisturizing,anti-skin irritation,and anti-skin allergy effects.Suggestions for the application of Aloe v.flowers in cosmetics are provided.
文摘The search for functional foods with health benefits has increased,and yogurt represents one of these products due to their properties,such as,source of probiotics that favour the gastrointestinal system,contains vitamins,minerals and improves the action of enzymes.Present work investigated bromatological,microbiological,sensorial properties and shelf-life of different yogurt goat milk formulations with Aloe vera and natural sweeteners.The goat yogurt with 99.40%A.vera pulp and 0.60%S.rebaudiana presented the best nutritional composition,being suitable for human consumption representing an innovative product with a great functional potential.The synergy between the ingredients used in the yogurt processing resulted in an innovative product to the market.Goat milk has a lower cost per liter in comparison with cow milk,Aloe vera is accessible due to its fast-vegetative propagation,Stevia Rebaudiana has a great popularity for being a natural sweetener with no calories,and all these products are produced in México.
文摘Diabetes is a chronic disease that requires a long term management where oxidative stress plays a pivotal role in disease progression and intensifying secondary complications. In spite of all the research on diabetes and recent advances in diabetes treatments, the reality is that there is no cure for diabetes and its devastating complications. While currently available anti-diabetic therapies are effective in reducing blood glucose level, they are not without associated side effects when they are used for a long term applications. As a result, physicians and patients are inclining more towards to a safer therapy with less serious side effects in the form of medicinal foods and botanical alternatives that are suitable for chronic usage. Aloesin, an Aloe chromone, has previously been formulated with an aloe polysaccharide to give a composition called Loesyn, where it showed significant impact in reducing glycosylated hemoglobin, fasting blood glucose, fructosamine and plasma insulin level in humans. Radical scavenging activities of chromones and polysaccharides from Aloe have also been reported. Here we rationalize the relevance of use of Aloesin alone or in a standardized blend with Aloe polysaccharides, as a potential medical food to manage systemic oxidative stress and/or high blood glucose of diabetes.
文摘Objective: To investigate the in vitro anticancer effect of Aloe vera(A. vera) and Calligonum comosum(C. comosum) extracts against hepatocellular carcinoma(HepG 2) cells. Methods: Hep G2 cells were tested against different doses of A. vera and C. comosum. Viability of the cells was assessed by MTT assay. Evaluation of apoptosis and DNA damage in HepG 2 cells were performed using annexin V apoptosis detection kit. The expression of p53 and anti-apoptotic(Bcl-2) were tested by real time-PCR and flow cytometer analyser. Hematoxylin and eosin stained sections from untreated and treated HepG 2 cells were observed using light microscopy.Results: The IC50 values of A. vera and C. comosum extracts were(10.45 ± 0.31) and(9.60 ± 0.01) μg/mL respectively. The extracts separately increased cytotoxicity against HepG 2 cells in a time and dose dependent manners. Also, it apparently induced apoptosis through increase P53 and decrease Bcl-2 genes expressions.Conclusions: The results indicated that the extracts could have anti-hepatocarcinogenic effect, at least in part, through modulation of apoptosis.
文摘In adopting tissue culture, effects of rare earth on Physiological and chemical characteristics, proliferation and rootage in aloe were studied. The results indicate that suitable concentration treatment of rare earth increases content of reducing sugar and protein, enhances activity intensity of superoxide dismutase (SOD), peroxidase (POD) isozymes and stripes of POD isozymes in the leaves. It also increases rate of proliferation and rootage respectively. The appropriate concentration of rare earth is 20～40 mg·L -1 in proliferation and rootage of aloe.
文摘The plant Aloe vera is used in Ayurvedic, Homoeopathic and Allopathic streams of medicine, and not only tribal community but also most of the people for food and medicine. The plant leaves contains numerous vitamins, minerals, enzymes, amino acids, natural sugars and other bioactive compounds with emollient, purgative, anti-microbial, anti inflammatory, antioxidant, aphrodisiac, anti-helmenthic, antifungal, antiseptic and cosmetic values for health care. This plant has potential to cure sunburns, burns and minor cuts, and even skin cancer. The external use in cosmetic primarily acts as skin healer and prevents injury of epithelial tissues, cures acne and gives a youthful glow to skin, also acts as extremely powerful laxative.
文摘Objective: To explore the new sources of novel bioactive compounds having pharmaceutical and agricultural interest and to search the endophytic actinobacteria from medicinal plants. Methods: NAF-1 an endophyte actinobacteria was isolated from leaves of medicinal plant Aloe vera collected in Marrakesh, Morocco using Bennett agar as selective medium. NAF-1 was tested for its antimicrobial activity against five pathogenic bacteria such as Staphylococcus aureus PIC 53156, Micrococcus luteus ATCC381, Bacillus subtilis ATCC 14579, Pseudomonas aeruginosa DSM 50090 and Escherichia coli ATCC 8739 and four human clinic fungi belonging to the Candida, Aspergillus and Microsporum genera. Several antioxidant activities were studied such as DPPH free radical scavenging, β-carotene and linoleic acid and reducing power assays. The total of phenol and flavonoid was also calculated. Using Artemia salina shrimp assay, the cytotoxicity of NAF-1 crude extract was determined. Results: The results revealed that the actinobacteria showed a high activity(≥20 mm) against only Gram positive bacteria but it had a moderate activity(between 13 and 15 mm) against Human clinic fungi. The isolate also exhibited a LD50 of 14.20 μg/mL in the cytotoxicity assay. The result showed that the crude extract presented an interesting free radical-scavenging activity with IC50 value of(5.58 ± 0.26) μg/mL and a high value of phenolic and flavonoid compounds with(15.41 ± 0.18) μg GAE/mg extract and(11.41± 0.06) μg QE/mg extract respectively. Moreover, the taxonomic position of our endophyte actinobacteria using the morphological and physiological criteria and using 16 S r RNA gene sequence(polyphasic approach) showed that the NAF-1 isolate was similar to Streptomyces hydrogenans which was never described as an endophyte actinobacteria. Conclusions: This isolated strain appears promising resources of bioactive agents and can be exploited to produce therapeutic agents active against pathogenic disease.
基金Supported by 90th Anniversary Fund of Chulalongkorn University(Ratchada phiseksomphot Endowment Fund)The Grant of Ratchadaphiseksomphot,Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand
文摘AIM:To evaluate the protective effects of Aloe vera on gastric injury in rats with indomethacin(IMN)-induced gastropathy.METHODS:Male Sprague-Dawley rats were randomly divided into three groups.Group 1(control,n=6)was given distilled water(DW)orally.Group 2(IMN,n=6)was given oral IMN(150 mg/kg)dissolved in5%sodium bicarbonate(Na HCO3-)at time 0 and 4 h.Group 3(Aloe vera-treated,n=6)was given oral Aloevera(150 mg/kg)dissolved in DW and IMN at time 0and 4 h.Eight hours later,the stomach was removed to determine gastric malondialdehyde(MDA),the number of interleukin(IL)-18 positive stained cells(%)by immunohistochemistry,and for histopathological examination.Then,the serum was collected to determine tumor necrosis factor(TNF)-αand cytokineinduced neutrophil chemoattractant(CINC)-1 by sandwich enzyme linked immunosorbent assay method.RESULTS:In the IMN group,serum TNF-α,CINC-1and gastric MDA were significantly increased when compared to the control group(27.78±1.52 pg/m L vs 85.07±49.11 pg/m L,P=0.009;104.55±45.80pg/m L vs 1054.70±20.38 pg/m L,and 1.74±0.21nmol/mg vs 9.36±1.07 nmol/mg protein,P=0.000,respectively).The mean level of TNF-α,CINC-1 and gastric MDA in the Aloe vera-treated group were improved as compared with the IMN group(85.07±49.11 pg/m L vs 35.19±1.61 pg/m L,P=0.021;1054.70±20.38 pg/m L vs 813.56±239.04 pg/m L,P=0.025;and 9.36±1.07 nmol/mg vs 2.67±0.64 nmol/mg protein,P=0.000,respectively).The number of IL-18 positive stained cells(%)in the gastric epithelial cells of the IMN group was significantly higher than the control group(5.01%±3.73%vs 30.67%±2.03%,P=0.000,respectively).In contrast,Aloe vera treatment decreased the number of IL-18 positive stained cells(%)significantly when compared with the IMN group(30.67%±2.03%vs 13.21%±1.10%,P=0.000,respectively).Most rats in the IMN group developed moderate to severe gastric inflammation and erosions.The gastric erosions and neutrophil infiltration scores were significantly reduced in the Aloe veratreated group.CONCLUSION:Aloe vera attenuated IMN-induced gastropathy in rats by the reduction of oxidative stress,inflammation,and improvement of gastrichistopathology.
基金Supported by the Grant of Ratchadaphiseksomphot,Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand,No.RA59/035.
文摘BACKGROUND Aloe vera exerts several biological activities,such as,anti-inflammatory,antioxidant,and antimicrobial effects.It was recently shown to reduce insulin resistance and triglyceride level.We hypothesized that aloe vera would have beneficial effects in alleviating non-alcoholic steatohepatitis(NASH)in rats.AIM To examine the therapeutic effects of aloe vera in NASH rats.METHODS All rats were randomly divided into 3 groups(n=6 in each group).Rats in the control group were fed ad libitum with a standard diet for 8 wk.Rats in the NASH group were fed ad libitum with a high-fat high-fructose diet(HFHFD)for 8 wk.Rats in the aloe vera group were fed ad libitum with a HFHFD and aloe vera in dimethylsulfoxide(50 mg/kg)by gavage daily for 8 wk.Liver samples were collected at the end of the treatment period.RESULTS Hepatic malondialdehyde(MDA)levels increased significantly in the NASH group as compared with the control group(377±77 nmol/mg vs 129±51 nmol/mg protein,respectively,P<0.001).Glutathione(GSH)levels were significantly lower in the NASH group than the control group(9±2 nmol/mg vs 24±8 nmol/mg protein,respectively,P=0.001).The expression of interleukin-18 (IL-18), nuclear factor-kappa β, and caspase-3 increased, while peroxisomeproliferator-activated receptor gamma decreased in the NASH group comparedwith the controls. Following aloe vera administration, MDA levels decreased (199± 35 nmol/mg protein) and GSH increased (18 ± 4 nmol/mg protein) markedly.Steatosis, hepatocyte ballooning, lobular inflammation and increased hepatocyteapoptosis were observed in the NASH group. Aloe vera treatment attenuatedthese changes in liver histology.CONCLUSIONAloe vera attenuated oxidative stress, hepatic inflammation and hepatocyteapoptosis, thus improving liver pathology in rats with NASH.
文摘Aloe vera, a short-stemmed shrub is described as a “wonder plant”, due to its vast uses in various medical products. Since many decades, extensive research has revealed that the pharmacological active ingredients are distributed in both the gel and rind of the Aloe vera leaves. A. vera is very popular in cosmetic and pharmaceutical industries and it is needed in large quantities with higher fractions of important constituents. To satisfy the market demand, intervention of microbial community seems to be a promising approach, which helps to increase the growth and metabolites along with plant fitness. Piriformospora indica is a root colonizing endophytic fungus, having unique plant growth-promoting properties. It helps the plant to acquire more nutrients from soil even under extreme physical and nutrient stress conditions. It interacts with a wide range of hosts. Interaction of P. indica with A. vera resulted in overall increase in plant biomass and greater shoot and root length, as well as number of shoots and roots as compared to control under both in vitro and in vivo environment conditions. Apart from that, the photosynthetic pigments (Chl a, Chl b and total Chl) and aloin content were observed significantly higher in A. vera plantlets colonized with symbiotic endophyte. The antioxidant activities were also tested and found significantly higher as compared to control plants. This imparts the potential of P. indica, to resist the plants against phyto-pathogenic microbes. P. indica has been proved as a potential candidate to enhance the biomass production along with various value additions in the form of active ingredients in A. vera.
文摘The objective of the study was to evaluate the anti-diabetic activities of methanol extracts of Aloe camperi (AC), Meriandra dianthera (MD) and a polyherbal drug (PH) in diabetes induced Wistar albino rats. A single dose of alloxan monohydrate (150 mg/kg, i.p.) was used to induce diabetes mellitus (DM). Diabetes was confirmed by the elevated blood glucose levels determined after 72 h of induction. Animals with mean fasting blood glucose (FBG) level more than 200 mg/dl were recruited for the experiment. The herbal extracts at doses of 200 and 400 mg/kg and standard drugmetformin (5 mg/kg) were administered orally to the diabetic rats for 21 days and the FBG level was estimated on 0, 7, 14 and 21 days. The herbal extracts showed dose-dependent fall in FBG levels and the result exhibited very significant (P < 0.001) decreases in FBG level by the end of the experimental day as compared to the diabetic control. The highest antihyperglycemic effect was observed by MD extract at 400 mg/kg and was comparable to the standard drug. Oral glucose tolerance test (OGTT) was also conducted on normal rats and thus glucose at 2 g/kg per body weight was loaded via oral gavage to all groups 30 min after extract administration. All the groups showed significant increase (P P The hyperglycemia with glucose challenge was significantly brought down (P < 0.001) by all herbal extracts at 60 and 120 min relative to the negative control. Moreover, acute oral toxicity tests was conducted based on the protocols of OECD-425 and thus the LD50 of the herbal extracts was estimated to be greater than 2000 mg/kg. Statistical analysis was performed using One-Way ANOVA followed by Dunnett’s test for multiple comparisons, and values of P < 0.05 were considered as statistically significant.
文摘Nutrigenomic studies were conducted to uncover the mechanism of action for the hypoglycemic and insulin sensitizing effects of UP780. From high fat diet-induced obesity mouse model for UP780, livers and white adipose tissues (WAT) from groups of lean control, high fat diet (HFD), and HFD treated with UP780 were collected for microarray study. Microarray generated gene expression changes were applied to Ingenuity Pathway Analysis for changes in canonical metabolic and signaling pathways. Microarray was validated by quantitative reverse transcriptase-polymerase chain reaction (QPCR), Western blots, liver triglyceride, liver cholesterol, liver steatosis, and insulin ELISA. UP780 treatment decreased liver gene expressions for multiple enzymes involved in fatty acid biosynthesis and triglyceride production. UP780 treatment increased gene expressions globally for the insulin receptor signaling pathway in WAT. Both liver triglyceride and liver cholesterol levels were significantly reduced by UP780 over HFD. The reduction of liver fat was confirmed by microscopic analysis of liver steatosis. Finally, UP780 significantly decreased fasting plasma insulin level over HFD. The mechanism of action for UP780 indicated a reduction of liver fat accumulation and an enhancement in adipose tissue insulin signaling pathway. This provided mechanistic explanation for the in vivo UP780 effects of enhanced insulin sensitiveity and decreased blood glucose in mouse diabetes and prediabetes models.
文摘We have developed a novel methodology for the determination of Aloins A and B in Aloe vera plant extract and commercial Aloe vera product formulations using HPLC method. The result shows good sensitivity and accuracy which can be utilized for the scientific validation of bioactive compounds present in the commercial formulations.
文摘Objective:Aloe Vera gel(AVG) has a prominent role as a contemporary folk remedy.The Non-healed chronic ulcers of 16 non-responders to conventional treatment were treated with AVG for which the clinical efficacy was studied.Methods:This study included 16 patients having chronic ulcer(9 males and 7 females) with mean age of 41.8±14.6 who following failure treatment to conventional therapy,were dispensed AVG to apply. AVG is consisted from gel part of Aloe Vera plant plus one preservative material,in this study ECG jelly. The patients were assessed as responder whenever intensity of inflammation,the number and /or the size of ulcers have been reduced.Results:The period of time till healing(complete or reduction in size of ulcer), were from 5 to 160 days with mean of 31.2±36.4 days.The mean time of decreasing for secreting,swelling and redness was from 5-11 days.Spearman coefficient of correlation,showed no significant correlation between first size and depth of ulcer and timing till 50%reduction in size of ulcer.Conclusion:All patients had been treated with conventional treatment all to no avail.There were some full thickness ulcer which at the end of treatment we observed an improvement and normal skin for those ulcers.There was a minor complication like itching in one patient but no leading to stop treatment.These findings suggest that AVG is an excellent and safer choice than current conventional therapeutic management of chronic ulcers.
文摘Objective:To evaluate the anti-inflammatory potential of peptide/polypeptide fraction of Aloe vera through in vitro and in vivo studies.Methods:The peptide/polypeptide fraction from Aloe vera was obtained through trichloroacetic acid precipitation.The anti-inflammatory property of the peptide/polypeptide fraction was tested by protein denaturation,membrane stabilization assays.The effect of the fraction on RAW 264.7 cell viability was examined by MTT assays.The nitric oxide level was determined through Griess reagent.TNF-αand IL-6 levels were estimated using ELISA kits.In vivo studies were carried out in male Wistar rats through injection of Freund’s adjuvant in the hind paw.Paw edema was measured through the Vernier scale and levels of alanine aminotransferase,aspartate transaminase,TNF-α,IL-6,and secretory phospholipase A2 were estimated through their respective kits after fourteen days of treatment.Graph Pad Prism6 was used for analyzing the results.Results:The peptide/polypeptide extract inhibited protein denaturation with an IC50 value of(218.9±15.6)μg/m L and stabilized the membrane of red blood cells with an IC50 value of(275.9±19.1)μg/m L.The extract showed no changes in cell morphology or cytotoxicity up to the concentration of 20μg/mL in MTT assays.The peptide/polypeptide fraction markedly reduced the levels of proinflammatory markers and mediators in both in vitro and in vivo studies.Conclusions:The results indicate that the peptide/polypeptide fraction of Aloe vera has antiinflammatory property through inhibition of inflammatory markers and mediators responsible for NF-κB and mitogen-activated protein kinase pathways.
文摘Background: Aloe vera has been used by many civilizations throughout history due to the numerous properties attributed. Gastro oesophageal reflux disease is a common disorder with consequences for the patient’s health related quality of life. Aims: The purpose of this study was to assess the benefits of the Aloe vera in 80 patients with gastro oesophageal reflux. Methods: This is probably the first randomised and double-blind trail ever performed on this subject. The study included eight weeks of treatment with milk enriched with Aloe vera or placebo. Data of diet (frequency questionnaire), symptoms (gastrointestinal symptom rating scale) and quality of life (quality of life in reflux and disease) were obtained. Results: So far, there has been hardly any proof that Aloe vera decreases symptoms of reflux disease;on the contrary, a lower percentage of remission of pain is observed among the Aloe vera group. As long as its effectiveness has not been proven properly, the use of Aloe vera in reflux disease cannot be recommend. Conclusion: Aloe vera does not have a beneficial effect on reflux disease under the study conditions.
文摘The purpose of this study was to evaluate the ability of aqueous extract of Aloe barbadensis Miller (Aloe vera) on oxidative damage and Anion Exchanger 1 (AE1, also known as Band 3) expression in human erythrocytes exposed to the water soluble free radical initiator 2.2’-azobis-2-amidinopropano dihydrochloride (AAPH). In addition, total phenolic compounds in the extracts were determined as catechin equivalent and the various antioxidant activities were compared to natural and synthetic standard antioxidants such as BHA and ascorbic acid. Since Aloe vera extract did not cause a consumption of the cytosolic antioxidant, glutathione (GSH) when it was direct incubated with GSH in basic aerated aqueous solution, this indicates that Aloe vera extract does not proceed auto oxidation at this experimental condition. Furthermore, Aloe vera extract prevent the consumption of GSH, in radical treated RBCs. It also inhibit consumption of GSH when it was direct incubated with AAPH. Aloe vera gel extract inhibits the generation of diphenyl-2-picrylhy-drazyl (DPPH) and the scavenging activity was increased in a dose dependent manner. Aloe vera extract was shown the similar reducing power than standards BHT and ascorbic acid. Biochemical analysis by SDS-PAGE and western blotting showed that AAPH-induced oxidative stress increased the susceptibility of AE1 to proteolytic degradation. Of note, our data evidenced that Aloe vera treatment was able to partially restore the normal RBC membrane protein profiles in a dose-dependent manner. These results clearly demonstrate the antioxidative activity of Aloe vera gel extract that might be ascribed to a synergistic action of the bioactive compounds contained therein.
文摘Nano-encapsulation is a platform which offers a promising application for control release and the delivery of drugs in pharmaceuticals and antioxidant/ antimicrobial in food systems. Poly (lactic-co-glycolide acid) (PLGA) is a biodegradable and biocompatible co-polymer of lactic acid and glycolic acid which is used for synthesizing food based polymeric nanoparticles (NP). The aim of this study was to evaluate the morphological and physicochemical properties and the controlled release of bioactive components derived from Aloe vera gel loaded PLGA NP. The results shows the mean hydrodynamic diameter of the unloaded NP is 103 nm which is significantly (p < 0.01) smaller than the loaded freeze dried powered gel (FDG) (147 nm) and liquid gel (LG) (221 nm) and the particle size distribution given by the Poly-dispersity Index were 0.2, 0.2 and 0.3, respectively. The zeta potential for unloaded, FDG and LG NP were ±60, ±28 and ±22 mV, respectively, hence were electrokinetically stable NP. No significant (p > 0.05) inhibition of the antioxidant potential was observed with loaded NP. The entrapment efficiency for the FDG synthesized was 87%, and the burst effect was observed after 4 h as a result of the encapsulation effect. The release kinetics of bioactive is govern by the combination of mass diffusion and capillary action.
文摘Burn victims around the world are forced to a life of long lasting morbidity and high mortality rate. Although physiotherapy and occupational therapy subside the painful side of morbidity after severe skin burns, patients are under huge financial pressure in order to return to health. Various treatment plans are used for severe burn injuries. Aloe Vera Gel is introduced recently as an alternative management for burn injuries through betterment of granulation tissue formation and epithelialization. Moreover, numerous studies reported Aloe Vera healing effect on chronic wounds by manipulating collagen layout. This study aims to present the therapeutic impact of Aloe Vera Gel on chronic skin burns of a 17-year-old female who was referred to our department because of rejected skin graft.
