目的:探讨通窍胶囊联合布地奈德对分泌性中耳炎(SOM)患者听力及血清水通道蛋白(AQP)-1、AQP-4水平的影响。方法:选取2015年4月至2016年8月延安大学咸阳医院收治的SOM患者114例,按照随机数字表法分为对照组(n=56)和观察组(n=58),对照组...目的:探讨通窍胶囊联合布地奈德对分泌性中耳炎(SOM)患者听力及血清水通道蛋白(AQP)-1、AQP-4水平的影响。方法:选取2015年4月至2016年8月延安大学咸阳医院收治的SOM患者114例,按照随机数字表法分为对照组(n=56)和观察组(n=58),对照组患者给予常规治疗和布地奈德鼓室注射治疗,观察组在对照组基础上给予通窍胶囊治疗,观察并比较两组患者治疗前、后在0.5 k Hz、1 k Hz、2 k Hz频率下的气导阈值及血清AQP-1、AQP-4水平的变化。结果:治疗前,两组患者各个频率下的气导阈值比较差异均无统计学意义(均P>0.05);观察组治疗后在0.5 k Hz、1 k Hz、2 k Hz频率下的气导阈值均明显低于对照组(均P<0.01)。观察组治疗后血清AQP-1水平为(11.02±1.04)μg/L,明显高于对照组的(7.26±0.34)μg/L(P<0.01),而两组血清AQP-4水平比较差异无统计学意义(P>0.05)。结论:通窍胶囊联合布地奈德治疗SOM,可有效改善患者听力,提高患者血清AQP-1水平,改善耳道分泌情况。展开更多
目的:探讨颅内压参数联合血清小窝蛋白-1(caveolin-1)、水通道蛋白4(AQP-4)对高血压脑出血(HICH)患者术后预后不良的预测价值。方法:选择2020年1月至2022年1月河北省胸科医院收治的106例HICH患者,术后随访3个月,根据格拉斯哥预后(GOS)...目的:探讨颅内压参数联合血清小窝蛋白-1(caveolin-1)、水通道蛋白4(AQP-4)对高血压脑出血(HICH)患者术后预后不良的预测价值。方法:选择2020年1月至2022年1月河北省胸科医院收治的106例HICH患者,术后随访3个月,根据格拉斯哥预后(GOS)评分将患者分为预后良好组(55例),预后不良组(51例)。术后监测颅内压参数[压力反应指数(PRx)、平均颅内压波幅(MWA)、20 mm Hg阈值下颅内压剂量(Dicp20)],检测血清caveolin-1、AQP-4水平。多因素Logistic回归分析HICH患者术后预后不良的因素。受试者工作特征曲线(ROC)分析颅内压参数联合血清caveolin-1、AQP-4预测HICH患者术后预后不良的价值。结果:预后不良组PRx、MWA、Dicp20以及血清caveolin-1、AQP-4水平高于预后良好组(P<0.05)。低术前格拉斯哥昏迷评分(GCS)评分、高PRx、高Dicp20、高caveolin-1、高AQP-4是HICH患者术后预后不良的危险因素(P<0.05)。联合PRx、Dicp20、caveolin-1和AQP-4预测HICH患者术后3个月预后不良的的曲线下面积为0.823,大于PRx、Dicp20、caveolin-1和AQP-4单独预测。结论:高PRx、Dicp20、caveolin-1、AQP4是HICH患者术后预后不良的危险因素,联合颅内压参数PRx、Dicp20及血清caveolin-1、AQP4预测HICH患者术后预后不良具有较高的价值。展开更多
Objective To investigate the changes of aquaporin （AQP-1） expressions on peritonea in liver cirrhotic rats with ascites,and to study the correlation between AQP-1 expressions and ascites form.Methods32 healthy Sprag...Objective To investigate the changes of aquaporin （AQP-1） expressions on peritonea in liver cirrhotic rats with ascites,and to study the correlation between AQP-1 expressions and ascites form.Methods32 healthy Sprague-Dawley（SD） rats were divided into two groups randomly, 20 rats were used to produce liver cirrhotic models induced with phenobarbitol sodium and CCl4. The distribution and protein expressions of AQP-1 on the rats′ peritonea were measured with immunohistochemistry assay, and the expressions of APQ-1 mRNA were tested with relative GAPDH quantitative RT-PCR. Results （1）The expressions of AQP-1 were mainly on the endothelial cells of capillary vessels and venules on the rats′ peritonea, and also on mesothelial cells. （2）There was no statistically significant difference between the expressions of AQP-1 protein and mRNA in the two groups on the early stage of liver cirrhosis. （3） Downregulations of the expressions of AQP-1 protein and mRNA were observed in B group on the advanced cirrhotic stage.Conclusion Expressions of AQP-1 were downregulated on the peritonea of rats with decompensated liver cirrhosis, which may play a role in the formation of ascites. The changes of AQP-1 Expressions on peritoneal mesothelial cells which were fewer than those on the endothelial cells may be few relations to ascites form.展开更多
文摘目的:探讨通窍胶囊联合布地奈德对分泌性中耳炎(SOM)患者听力及血清水通道蛋白(AQP)-1、AQP-4水平的影响。方法:选取2015年4月至2016年8月延安大学咸阳医院收治的SOM患者114例,按照随机数字表法分为对照组(n=56)和观察组(n=58),对照组患者给予常规治疗和布地奈德鼓室注射治疗,观察组在对照组基础上给予通窍胶囊治疗,观察并比较两组患者治疗前、后在0.5 k Hz、1 k Hz、2 k Hz频率下的气导阈值及血清AQP-1、AQP-4水平的变化。结果:治疗前,两组患者各个频率下的气导阈值比较差异均无统计学意义(均P>0.05);观察组治疗后在0.5 k Hz、1 k Hz、2 k Hz频率下的气导阈值均明显低于对照组(均P<0.01)。观察组治疗后血清AQP-1水平为(11.02±1.04)μg/L,明显高于对照组的(7.26±0.34)μg/L(P<0.01),而两组血清AQP-4水平比较差异无统计学意义(P>0.05)。结论:通窍胶囊联合布地奈德治疗SOM,可有效改善患者听力,提高患者血清AQP-1水平,改善耳道分泌情况。
文摘目的:探讨颅内压参数联合血清小窝蛋白-1(caveolin-1)、水通道蛋白4(AQP-4)对高血压脑出血(HICH)患者术后预后不良的预测价值。方法:选择2020年1月至2022年1月河北省胸科医院收治的106例HICH患者,术后随访3个月,根据格拉斯哥预后(GOS)评分将患者分为预后良好组(55例),预后不良组(51例)。术后监测颅内压参数[压力反应指数(PRx)、平均颅内压波幅(MWA)、20 mm Hg阈值下颅内压剂量(Dicp20)],检测血清caveolin-1、AQP-4水平。多因素Logistic回归分析HICH患者术后预后不良的因素。受试者工作特征曲线(ROC)分析颅内压参数联合血清caveolin-1、AQP-4预测HICH患者术后预后不良的价值。结果:预后不良组PRx、MWA、Dicp20以及血清caveolin-1、AQP-4水平高于预后良好组(P<0.05)。低术前格拉斯哥昏迷评分(GCS)评分、高PRx、高Dicp20、高caveolin-1、高AQP-4是HICH患者术后预后不良的危险因素(P<0.05)。联合PRx、Dicp20、caveolin-1和AQP-4预测HICH患者术后3个月预后不良的的曲线下面积为0.823,大于PRx、Dicp20、caveolin-1和AQP-4单独预测。结论:高PRx、Dicp20、caveolin-1、AQP4是HICH患者术后预后不良的危险因素,联合颅内压参数PRx、Dicp20及血清caveolin-1、AQP4预测HICH患者术后预后不良具有较高的价值。
文摘Objective To investigate the changes of aquaporin （AQP-1） expressions on peritonea in liver cirrhotic rats with ascites,and to study the correlation between AQP-1 expressions and ascites form.Methods32 healthy Sprague-Dawley（SD） rats were divided into two groups randomly, 20 rats were used to produce liver cirrhotic models induced with phenobarbitol sodium and CCl4. The distribution and protein expressions of AQP-1 on the rats′ peritonea were measured with immunohistochemistry assay, and the expressions of APQ-1 mRNA were tested with relative GAPDH quantitative RT-PCR. Results （1）The expressions of AQP-1 were mainly on the endothelial cells of capillary vessels and venules on the rats′ peritonea, and also on mesothelial cells. （2）There was no statistically significant difference between the expressions of AQP-1 protein and mRNA in the two groups on the early stage of liver cirrhosis. （3） Downregulations of the expressions of AQP-1 protein and mRNA were observed in B group on the advanced cirrhotic stage.Conclusion Expressions of AQP-1 were downregulated on the peritonea of rats with decompensated liver cirrhosis, which may play a role in the formation of ascites. The changes of AQP-1 Expressions on peritoneal mesothelial cells which were fewer than those on the endothelial cells may be few relations to ascites form.
