Objective:In the Ayurvedic system of medicine,body constitution(prakruthi) is said to play a vital role in the disease process as well as in its progression.Free radical toxicity is also involved in the etiopathogenes...Objective:In the Ayurvedic system of medicine,body constitution(prakruthi) is said to play a vital role in the disease process as well as in its progression.Free radical toxicity is also involved in the etiopathogenesis of many disorders.Hence,in the present study an attempt has been made to correlate the body constitution type and the antioxidant status of that prakruthi.Methods:Healthy volunteers from Manipal University Campus, South Karnataka,India were classified into three main human constitutions(prakruthi) and their possible combinations and their serum total antioxidant activity was determined.Results:There was a significant negative correlation of the total antioxidant status with the pitta prakruthi whereas vata and kapha constitutions showed no significant correlation with the total antioxidant status.Conclusion:Ayurveda classifies each individual based on his/her prakruthi into three categories of Doshas:Vata,Pitta and Kapha(collectively known as Tridoshas ). The three Doshas are fundamental regulatory principles responsible for maintaining organism functioning and manifesting those characteristics typifying each individual,that is,in equilibrium Tridoshas signify health and an imbalance leads to disease.Thus,in this study a significantly decreased antioxidant status in the Pitta group would render them more susceptible to damage by oxidative stress.Hence,we suggest that supplementation with antioxidants of herbal(Ayurvedic) origin to such a group would prove to be beneficial - opening up the arena for pharmacogenomics and customized antioxidant drug administration based on the prakruthi of an individual.展开更多
Drugs fulfilling the criterion of a standard drug wil always become panacea provided, if they are used properly. On the other hand, a poorly manufactured drug however used skillfully, will prove to be a poison.Texts o...Drugs fulfilling the criterion of a standard drug wil always become panacea provided, if they are used properly. On the other hand, a poorly manufactured drug however used skillfully, will prove to be a poison.Texts of Ayurveda, do mention hazards of drugs, which are not properly manufactured or administered. Art of drug administration is unique in this ancient medical science that cautions towards concentrating on dose,indications, contra-indications, suitable vehicle, specific diet, certain restrictions etc., while administering medicines in suitable individuals. Though a huge amount of information is available and evidences are being generated on the usefulness of traditional practices in global healthcare; there is a need of generating awareness on Promoting rational use of traditional medicines in particular to Ayurvedic drugs. Conventional researchers wish to work on traditional formulations have to understand traditional principles and involve traditional physicians in their researches in the benefit of mankind.展开更多
In Ayurveda,one can get an assortment of references regarding Yuktivyapashraya Chikitsa(a treatment modality which is based on logic).Ayurveda always has given importance for the treatment by using multiple drugs whic...In Ayurveda,one can get an assortment of references regarding Yuktivyapashraya Chikitsa(a treatment modality which is based on logic).Ayurveda always has given importance for the treatment by using multiple drugs which are of plant origin or mineral origin.Daivavyapashraya Chikitsa(a modality of treatment based on past deeds and pleasing of God)though mentioned as the first line of therapy nowhere in the famous Ayurvedic classics have explained it in detail.For this type of Chikitsa,the causes and the manifestation of the disease are to be analysed by taking the help of other sciences such as astrology.To conduct rituals,one has to be proficient in knowing and chanting hymns.It might be thereason for the less availability of description about Daivavyapashraya Chikitsa in the available Ayurvedic classics.Surprisingly an unpublished manuscript named Kashyapa Samhita deals with it enormously.It is exciting to know that the author of this manuscript has tried to analyse every disease uniquely.This paper deals with the references of Daivavyapasharaya Chikitsa in the available Ayurvedic classics as well as from an unpublished manuscript Kashyapa Samhita.展开更多
Background:Non-communicable or lifestyle diseases replaced infectious diseases at the end of the 20th century as the primary burden of disease worldwide,marking the epidemiological transition.The industrial revolution...Background:Non-communicable or lifestyle diseases replaced infectious diseases at the end of the 20th century as the primary burden of disease worldwide,marking the epidemiological transition.The industrial revolution and technological advancements,as well as packaged processed foods,have greatly affected lifestyle,causing adverse health effects through chronic,low-level,and systemic inflammation known as“metaflammation”.The main contributors to lifestyle-related diseases are poor eating habits,physical inactivity,poor posture,and a disturbed biological clock.The study on lifestyle changes indicates that comprehensive lifestyle changes can prevent disease and reverse the progression of diseases like diabetes,heart disease,stroke,prostatic cancer and breast cancer.The concept of disease prevention is getting wider acceptability owing credit to early disease detection,better treatment modalities and reduced financial implications.However,the possible harms of over-testing and over-medicalization have led to the propagation of Quaternary prevention strategies.Ayurveda,too propagates the principle of health preservation,promotion,and disease prevention,along with early diagnosis and holistic disease management strategies,incorporating dietary and lifestyle components such as Dinacharya(daily regimen practices),Ritucharya(seasonal regimen practice).This paper critically explores the scientific relevance behind these ascribed daily regimen practices(Dinacharya)and their suitability as a quaternary prevention strategy and presents it for dialogue and research to the scientific community.Method:The classical texts of Ayurveda and the internet search engines were explored with keywords of relevant terms such as“research”“benefit”and“role in health”combined with the Ayurveda daily regimen terms and their English equivalents as provided in brackets and their different combinations and permutations,along with net surfing and hand search.The relevant articles were stored and screened for relevance and the matter is presented systematically for scientific deliberation principal findings–Ayurveda recognized the temporal effects of chronobiological cycles on human health and accordingly devised the daily regimen schedule,delineating the principles for healthy living and harmonization.The daily regimen practices of Ayurveda like timely sleeping,waking up early in the morning,proper defecation,massage,exercise,occupation,social bonding,appropriate dietary practices,etc.adopt a system biology approach with synchronization of chronobiological cycles,mind-body integration,system performance,and epigenetics,apart from other possible approaches and have considerable scientific evidence for the effectiveness as a quaternary prevention strategy.Conclusion:The adoption of these practices in the daily routine may play a crucial role in health preservation and disease prevention at all levels of preventive domains.However,prospective large scale,long-duration randomized controlled trials are yet needed to scientifically further establish the validity of the same.展开更多
Visha(POISON)are the substances which when administered prove fatal either sooner or later.This fatality is due to the qualities of visha that are exactly opposite to the nature of oja which is the vital component of ...Visha(POISON)are the substances which when administered prove fatal either sooner or later.This fatality is due to the qualities of visha that are exactly opposite to the nature of oja which is the vital component of life and causes destruction of life.Though they are previewed as visha,the same qualities can be utilized in the treat-ment after proper shodhana,which alters basic toxic properties like vyavaayi,vikasi,sookshma and yogavahi.Thus many visha are used in the formulations in order to increase the potency,bioavailability,therapeutic values.Hence Ayurveda highlights that when visha is utilized in a proper way can become the best medicine.Though basically they are visha,when properly administered along with pathyas they act as vishaghna,rasayana in many conditions.The present paper discusses about use of vi-sha in the making of formulations which are indicated in the untreated,chronic,auto immune diseases and also in acute management.展开更多
With nearly 5,000,000 Indians dying due to medical negligence every year.there is a circular relationship between nature and humankind because human concepts are nature’s concepts. Human technological and economic in...With nearly 5,000,000 Indians dying due to medical negligence every year.there is a circular relationship between nature and humankind because human concepts are nature’s concepts. Human technological and economic inventiveness is no more than nature’s way of acting upon itself and shaping its own future. The outcome could be glorious success or disastrous failure - in either case, nature acting through humankind bears partial responsibility for the outcome. A basic knowledge of how judicial forums deal with the cases relating to medical negligence is of absolute necessity for doctors. The need for such knowledge is more now than before in light of higher premium being placed by the Indian forums on the value of human life and su ffering, and perhaps rightly so. Judicial forums, while seeking to identify delinquents and delinquency in the cases of medical negligence, actually aim at striking a careful balance between the autonomy of a doctor to make judgments and the rights of a patient to be dealt with fairly.Agadatantra one among eight branches of ayurveda has given good references in regard to medcal ethics and also how to overcome the burden of medical negligence merely by identifying the treating doctor.展开更多
Background:Unique cutaneous manifestations simulating viral infection like intense itching,rashes,maculo popular eruptions etc are noted.Etiological factors,underlying pathology,prevalence,whether it manifests in init...Background:Unique cutaneous manifestations simulating viral infection like intense itching,rashes,maculo popular eruptions etc are noted.Etiological factors,underlying pathology,prevalence,whether it manifests in initial stage or post covid or if it predicts associated severity,linked symptoms,later complications,adverse drug reactions and many other associated issues need to be reported and evaluated.Method:Reporting five cases with varied cutaneous manifestations during July 2020 from India.Frostbite like skin lesion,maculo papular eruptions in two cases,two rash like manifestations were considered and managed by Ayurveda.Patient who lived in same house as covid infected person,travelled from red zone,who tested positive for COVID-19 infection.Results:Itching and redness were the predominant symptoms which reduced quickly in 6 to 8 hours,eruptions gradually reduced in 3 to 6 days.Conclusions:Cutaneous mani-festations during the pandemic suspected or confirmed COVID-19 infection 5 cases reported from India,managed by Ayurveda indicates post COVID-19 needs to be managed to improve quality of life and prevent further complications.展开更多
Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, ...Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care.展开更多
Rasayana tantra is one of the eight specialties of Ayurveda.It is a specialized practice in the form of rejuvenative recipes,dietary regimen,special health promoting behaviour and drugs.Properly administered Rasayana ...Rasayana tantra is one of the eight specialties of Ayurveda.It is a specialized practice in the form of rejuvenative recipes,dietary regimen,special health promoting behaviour and drugs.Properly administered Rasayana can bestow the human being with several benefits like longevity,memory,intelligence,freedom from diseases,youthful age,excellence of luster,complexion and voice,optimum strength of physique and sense organs,respectability and brilliance.Various types of plant based Rasayana recipes are mentioned in Ayurveda. Review of the current literature available on Rasayanas indicates that anti-oxidant and immunomodulation are the most studied activities of the Rasayana drugs.Querying in Pubmed database on Rasayanas reveals that single plants as well as poly herbal formulations have been researched on.This article reviews the basics of Rasayana therapy and the published research on different Rasayana drugs for specific health conditions.It also provides the possible directions for future research.展开更多
Shodhana(purification/detoxification)is an important aspect of Ayurveda.It has been described in several important pieces of literature.In this study,we performed shodhana process on Langali(Gloriosa superba Linn.)tub...Shodhana(purification/detoxification)is an important aspect of Ayurveda.It has been described in several important pieces of literature.In this study,we performed shodhana process on Langali(Gloriosa superba Linn.)tubers of family Liliaceae,a semi-woody herbaceous climber with significant therapeutic properties.We compared the unprocessed(before purification)and processed(after purification)samples based on the phytochemical,physicochemical,and chromatographic study,including HPTLC,HPLC,GC-MS and LC-MS.Significant changes were observed in profiling after the shodhana process.This plant contains colchicine,known for its toxic effects,particularly cardiotoxicity.Therefore,we quantified colchicine in the unprocessed and processed samples of Gloriosa superba Linn.tubers using HPLC method.Results showed that the percentage of colchicine was reduced by 13.67%in chloroform extract and 20.97%in ethanol extracts after the shodhana process.展开更多
梵语-龟兹语双语医学文书PK AS 2B共载有3颂药方,其内容与古印度阿育吠陀医学典籍《百医方》相对应。其中有1颂药方为治风方,属于阿育吠陀医学经典药方,同类药方还见于其他多部医典。该方治风理念既包含阿育吠陀医学思想,又包含佛教医...梵语-龟兹语双语医学文书PK AS 2B共载有3颂药方,其内容与古印度阿育吠陀医学典籍《百医方》相对应。其中有1颂药方为治风方,属于阿育吠陀医学经典药方,同类药方还见于其他多部医典。该方治风理念既包含阿育吠陀医学思想,又包含佛教医学理念;同时该药方的梵语部分和龟兹语部分并不一一对应,反映出古代龟兹地区的医学在接受外来医药文化过程中的融合与创新。展开更多
Traditional Indian medicine or Ayurveda(阿育吠陀)and Traditional Chinese Medicine remain the most ancient yet living traditions.These are the two great traditional medicines with rich philosophical,experiential,and ex...Traditional Indian medicine or Ayurveda(阿育吠陀)and Traditional Chinese Medicine remain the most ancient yet living traditions.These are the two great traditional medicines with rich philosophical,experiential,and experimental basis.Both the systems have been developed and enriched by thousands of years of practices,observations,and experiences.As India and China are neighbors,some exchange of medical ideas and practices might have occurred between the two nations since ancient times.Therefore,when the two traditional medicines are examined closely,many similarities become apparent in the theories and practices along with individual differences.展开更多
目的:本研究旨在制作《阿育吠陀梵语汉语词汇表》。方法:提取The Ayurvedic Pharmacopoeia of India(API,《印度阿育吠陀药典》)和The Ayurvedic Formulary of India(AFI,《印度阿育吠陀处方集》)中阿育吠陀梵语词汇及其英文或拉丁学名...目的:本研究旨在制作《阿育吠陀梵语汉语词汇表》。方法:提取The Ayurvedic Pharmacopoeia of India(API,《印度阿育吠陀药典》)和The Ayurvedic Formulary of India(AFI,《印度阿育吠陀处方集》)中阿育吠陀梵语词汇及其英文或拉丁学名的对照翻译,并翻译成汉语,制作《阿育吠陀梵语汉语词汇表》。结果:完成《阿育吠陀梵语汉语词汇表》,以梵语字母为序;收载阿育吠陀词汇1 743条,其中医学词汇913条,药学词汇791条,医学和药学共用词汇12条,其它词汇27个。词条均由拉丁体梵语、英语或拉丁学名和汉语三部分组成,其中病名附英文对照,生物种药物名附拉丁学名对照。罗列了阿育吠陀三病素、三果药材、药物的特性和作用的梵语和汉语,总结了阿育吠陀梵语词根;阿育吠陀病名的英译体现了传统医学特色和现代研究水平,但专业性和规范性有待提高。结论:《阿育吠陀梵语汉语词汇表》的素材来源可靠,可为我国学者研究阿育吠陀理论和破解处方组成搭建基础和平台。展开更多
Objective:To evaluate the hypoglycemic effect of Brassica juncea(seeds) on streptozotocin induced diabetic male albino rats.Methods:Hypoglycemic activity of Brassica juncea(seeds)aqueous extract at a dose of 250,350 a...Objective:To evaluate the hypoglycemic effect of Brassica juncea(seeds) on streptozotocin induced diabetic male albino rats.Methods:Hypoglycemic activity of Brassica juncea(seeds)aqueous extract at a dose of 250,350 and 450 mg/kg body weight was evaluated.Adult male Swiss albino rats of six numbers in each group was undertaken for study and evaluated.Results:The serum insulin levels were recorded a significant depletion in all groups,short term as well as long term diabetic animals,when compared to that of normal animals.A significant dosage dependent augmenting effect of the seed extract on the serum insulin was recorded in both short term as well as long term groups.Conclusions:The aqueous seed extract of Brassica juncea has potent hypoglycemic activity in male albino rat.展开更多
基金supported by the seed money grant from Kasturba Medical College.Manipal University, Manipal - 576104
文摘Objective:In the Ayurvedic system of medicine,body constitution(prakruthi) is said to play a vital role in the disease process as well as in its progression.Free radical toxicity is also involved in the etiopathogenesis of many disorders.Hence,in the present study an attempt has been made to correlate the body constitution type and the antioxidant status of that prakruthi.Methods:Healthy volunteers from Manipal University Campus, South Karnataka,India were classified into three main human constitutions(prakruthi) and their possible combinations and their serum total antioxidant activity was determined.Results:There was a significant negative correlation of the total antioxidant status with the pitta prakruthi whereas vata and kapha constitutions showed no significant correlation with the total antioxidant status.Conclusion:Ayurveda classifies each individual based on his/her prakruthi into three categories of Doshas:Vata,Pitta and Kapha(collectively known as Tridoshas ). The three Doshas are fundamental regulatory principles responsible for maintaining organism functioning and manifesting those characteristics typifying each individual,that is,in equilibrium Tridoshas signify health and an imbalance leads to disease.Thus,in this study a significantly decreased antioxidant status in the Pitta group would render them more susceptible to damage by oxidative stress.Hence,we suggest that supplementation with antioxidants of herbal(Ayurvedic) origin to such a group would prove to be beneficial - opening up the arena for pharmacogenomics and customized antioxidant drug administration based on the prakruthi of an individual.
文摘Drugs fulfilling the criterion of a standard drug wil always become panacea provided, if they are used properly. On the other hand, a poorly manufactured drug however used skillfully, will prove to be a poison.Texts of Ayurveda, do mention hazards of drugs, which are not properly manufactured or administered. Art of drug administration is unique in this ancient medical science that cautions towards concentrating on dose,indications, contra-indications, suitable vehicle, specific diet, certain restrictions etc., while administering medicines in suitable individuals. Though a huge amount of information is available and evidences are being generated on the usefulness of traditional practices in global healthcare; there is a need of generating awareness on Promoting rational use of traditional medicines in particular to Ayurvedic drugs. Conventional researchers wish to work on traditional formulations have to understand traditional principles and involve traditional physicians in their researches in the benefit of mankind.
文摘In Ayurveda,one can get an assortment of references regarding Yuktivyapashraya Chikitsa(a treatment modality which is based on logic).Ayurveda always has given importance for the treatment by using multiple drugs which are of plant origin or mineral origin.Daivavyapashraya Chikitsa(a modality of treatment based on past deeds and pleasing of God)though mentioned as the first line of therapy nowhere in the famous Ayurvedic classics have explained it in detail.For this type of Chikitsa,the causes and the manifestation of the disease are to be analysed by taking the help of other sciences such as astrology.To conduct rituals,one has to be proficient in knowing and chanting hymns.It might be thereason for the less availability of description about Daivavyapashraya Chikitsa in the available Ayurvedic classics.Surprisingly an unpublished manuscript named Kashyapa Samhita deals with it enormously.It is exciting to know that the author of this manuscript has tried to analyse every disease uniquely.This paper deals with the references of Daivavyapasharaya Chikitsa in the available Ayurvedic classics as well as from an unpublished manuscript Kashyapa Samhita.
文摘Background:Non-communicable or lifestyle diseases replaced infectious diseases at the end of the 20th century as the primary burden of disease worldwide,marking the epidemiological transition.The industrial revolution and technological advancements,as well as packaged processed foods,have greatly affected lifestyle,causing adverse health effects through chronic,low-level,and systemic inflammation known as“metaflammation”.The main contributors to lifestyle-related diseases are poor eating habits,physical inactivity,poor posture,and a disturbed biological clock.The study on lifestyle changes indicates that comprehensive lifestyle changes can prevent disease and reverse the progression of diseases like diabetes,heart disease,stroke,prostatic cancer and breast cancer.The concept of disease prevention is getting wider acceptability owing credit to early disease detection,better treatment modalities and reduced financial implications.However,the possible harms of over-testing and over-medicalization have led to the propagation of Quaternary prevention strategies.Ayurveda,too propagates the principle of health preservation,promotion,and disease prevention,along with early diagnosis and holistic disease management strategies,incorporating dietary and lifestyle components such as Dinacharya(daily regimen practices),Ritucharya(seasonal regimen practice).This paper critically explores the scientific relevance behind these ascribed daily regimen practices(Dinacharya)and their suitability as a quaternary prevention strategy and presents it for dialogue and research to the scientific community.Method:The classical texts of Ayurveda and the internet search engines were explored with keywords of relevant terms such as“research”“benefit”and“role in health”combined with the Ayurveda daily regimen terms and their English equivalents as provided in brackets and their different combinations and permutations,along with net surfing and hand search.The relevant articles were stored and screened for relevance and the matter is presented systematically for scientific deliberation principal findings–Ayurveda recognized the temporal effects of chronobiological cycles on human health and accordingly devised the daily regimen schedule,delineating the principles for healthy living and harmonization.The daily regimen practices of Ayurveda like timely sleeping,waking up early in the morning,proper defecation,massage,exercise,occupation,social bonding,appropriate dietary practices,etc.adopt a system biology approach with synchronization of chronobiological cycles,mind-body integration,system performance,and epigenetics,apart from other possible approaches and have considerable scientific evidence for the effectiveness as a quaternary prevention strategy.Conclusion:The adoption of these practices in the daily routine may play a crucial role in health preservation and disease prevention at all levels of preventive domains.However,prospective large scale,long-duration randomized controlled trials are yet needed to scientifically further establish the validity of the same.
文摘Visha(POISON)are the substances which when administered prove fatal either sooner or later.This fatality is due to the qualities of visha that are exactly opposite to the nature of oja which is the vital component of life and causes destruction of life.Though they are previewed as visha,the same qualities can be utilized in the treat-ment after proper shodhana,which alters basic toxic properties like vyavaayi,vikasi,sookshma and yogavahi.Thus many visha are used in the formulations in order to increase the potency,bioavailability,therapeutic values.Hence Ayurveda highlights that when visha is utilized in a proper way can become the best medicine.Though basically they are visha,when properly administered along with pathyas they act as vishaghna,rasayana in many conditions.The present paper discusses about use of vi-sha in the making of formulations which are indicated in the untreated,chronic,auto immune diseases and also in acute management.
文摘With nearly 5,000,000 Indians dying due to medical negligence every year.there is a circular relationship between nature and humankind because human concepts are nature’s concepts. Human technological and economic inventiveness is no more than nature’s way of acting upon itself and shaping its own future. The outcome could be glorious success or disastrous failure - in either case, nature acting through humankind bears partial responsibility for the outcome. A basic knowledge of how judicial forums deal with the cases relating to medical negligence is of absolute necessity for doctors. The need for such knowledge is more now than before in light of higher premium being placed by the Indian forums on the value of human life and su ffering, and perhaps rightly so. Judicial forums, while seeking to identify delinquents and delinquency in the cases of medical negligence, actually aim at striking a careful balance between the autonomy of a doctor to make judgments and the rights of a patient to be dealt with fairly.Agadatantra one among eight branches of ayurveda has given good references in regard to medcal ethics and also how to overcome the burden of medical negligence merely by identifying the treating doctor.
文摘Background:Unique cutaneous manifestations simulating viral infection like intense itching,rashes,maculo popular eruptions etc are noted.Etiological factors,underlying pathology,prevalence,whether it manifests in initial stage or post covid or if it predicts associated severity,linked symptoms,later complications,adverse drug reactions and many other associated issues need to be reported and evaluated.Method:Reporting five cases with varied cutaneous manifestations during July 2020 from India.Frostbite like skin lesion,maculo papular eruptions in two cases,two rash like manifestations were considered and managed by Ayurveda.Patient who lived in same house as covid infected person,travelled from red zone,who tested positive for COVID-19 infection.Results:Itching and redness were the predominant symptoms which reduced quickly in 6 to 8 hours,eruptions gradually reduced in 3 to 6 days.Conclusions:Cutaneous mani-festations during the pandemic suspected or confirmed COVID-19 infection 5 cases reported from India,managed by Ayurveda indicates post COVID-19 needs to be managed to improve quality of life and prevent further complications.
基金Indian National Science Academy for granting visiting scientist fellowship in 2019 for learning in silico studies in AyurvedaAIIA, New Delhi for laboratory support。
文摘Coalescence of traditional medicine Ayurveda and in silico technology is a rigor for supplementary development of future-ready effective traditional medicine. Ayurveda is a popular traditional medicine in South Asia, emanating worldwide for the treatment of metabolic disorders and chronic illness. Techniques of in silico biology are not much explored for the investigation of a variety of bioactive phytochemicals of Ayurvedic herbs. Drug repurposing, reverse pharmacology, and polypharmacology in Ayurveda are areas in silico explorations that are needed to understand the rich repertoire of herbs, minerals, herbo-minerals, and assorted Ayurvedic formulations. This review emphasizes exploring the concept of Ayurveda with in silico approaches and the need for Ayurinformatics studies. It also provides an overview of in silico studies done on phytoconstituents of some important Ayurvedic plants, the utility of in silico studies in Ayurvedic phytoconstituents/formulations, limitations/challenges, and prospects of in silico studies in Ayurveda. This article discusses the convergence of in silico work, especially in the least explored field of Ayurveda. The focused coalesce of these two domains could present a predictive combinatorial platform to enhance translational research magnitude. In nutshell, it could provide new insight into an Ayurvedic drug discovery involving an in silico approach that could not only alleviate the process of traditional medicine research but also enhance its effectiveness in addressing health care.
基金Supported by the Department of Science and Technology, Government of India,to establish a"National R&D Facility for Rasayana products in Indian System of Medicines"under Drugs&Pharmaceuticals Research Programme(DPRP)
文摘Rasayana tantra is one of the eight specialties of Ayurveda.It is a specialized practice in the form of rejuvenative recipes,dietary regimen,special health promoting behaviour and drugs.Properly administered Rasayana can bestow the human being with several benefits like longevity,memory,intelligence,freedom from diseases,youthful age,excellence of luster,complexion and voice,optimum strength of physique and sense organs,respectability and brilliance.Various types of plant based Rasayana recipes are mentioned in Ayurveda. Review of the current literature available on Rasayanas indicates that anti-oxidant and immunomodulation are the most studied activities of the Rasayana drugs.Querying in Pubmed database on Rasayanas reveals that single plants as well as poly herbal formulations have been researched on.This article reviews the basics of Rasayana therapy and the published research on different Rasayana drugs for specific health conditions.It also provides the possible directions for future research.
文摘Shodhana(purification/detoxification)is an important aspect of Ayurveda.It has been described in several important pieces of literature.In this study,we performed shodhana process on Langali(Gloriosa superba Linn.)tubers of family Liliaceae,a semi-woody herbaceous climber with significant therapeutic properties.We compared the unprocessed(before purification)and processed(after purification)samples based on the phytochemical,physicochemical,and chromatographic study,including HPTLC,HPLC,GC-MS and LC-MS.Significant changes were observed in profiling after the shodhana process.This plant contains colchicine,known for its toxic effects,particularly cardiotoxicity.Therefore,we quantified colchicine in the unprocessed and processed samples of Gloriosa superba Linn.tubers using HPLC method.Results showed that the percentage of colchicine was reduced by 13.67%in chloroform extract and 20.97%in ethanol extracts after the shodhana process.
文摘梵语-龟兹语双语医学文书PK AS 2B共载有3颂药方,其内容与古印度阿育吠陀医学典籍《百医方》相对应。其中有1颂药方为治风方,属于阿育吠陀医学经典药方,同类药方还见于其他多部医典。该方治风理念既包含阿育吠陀医学思想,又包含佛教医学理念;同时该药方的梵语部分和龟兹语部分并不一一对应,反映出古代龟兹地区的医学在接受外来医药文化过程中的融合与创新。
基金Shanghai Planning of Philosophy and Science:2018ZJX007。
文摘Traditional Indian medicine or Ayurveda(阿育吠陀)and Traditional Chinese Medicine remain the most ancient yet living traditions.These are the two great traditional medicines with rich philosophical,experiential,and experimental basis.Both the systems have been developed and enriched by thousands of years of practices,observations,and experiences.As India and China are neighbors,some exchange of medical ideas and practices might have occurred between the two nations since ancient times.Therefore,when the two traditional medicines are examined closely,many similarities become apparent in the theories and practices along with individual differences.
文摘目的:本研究旨在制作《阿育吠陀梵语汉语词汇表》。方法:提取The Ayurvedic Pharmacopoeia of India(API,《印度阿育吠陀药典》)和The Ayurvedic Formulary of India(AFI,《印度阿育吠陀处方集》)中阿育吠陀梵语词汇及其英文或拉丁学名的对照翻译,并翻译成汉语,制作《阿育吠陀梵语汉语词汇表》。结果:完成《阿育吠陀梵语汉语词汇表》,以梵语字母为序;收载阿育吠陀词汇1 743条,其中医学词汇913条,药学词汇791条,医学和药学共用词汇12条,其它词汇27个。词条均由拉丁体梵语、英语或拉丁学名和汉语三部分组成,其中病名附英文对照,生物种药物名附拉丁学名对照。罗列了阿育吠陀三病素、三果药材、药物的特性和作用的梵语和汉语,总结了阿育吠陀梵语词根;阿育吠陀病名的英译体现了传统医学特色和现代研究水平,但专业性和规范性有待提高。结论:《阿育吠陀梵语汉语词汇表》的素材来源可靠,可为我国学者研究阿育吠陀理论和破解处方组成搭建基础和平台。
文摘Objective:To evaluate the hypoglycemic effect of Brassica juncea(seeds) on streptozotocin induced diabetic male albino rats.Methods:Hypoglycemic activity of Brassica juncea(seeds)aqueous extract at a dose of 250,350 and 450 mg/kg body weight was evaluated.Adult male Swiss albino rats of six numbers in each group was undertaken for study and evaluated.Results:The serum insulin levels were recorded a significant depletion in all groups,short term as well as long term diabetic animals,when compared to that of normal animals.A significant dosage dependent augmenting effect of the seed extract on the serum insulin was recorded in both short term as well as long term groups.Conclusions:The aqueous seed extract of Brassica juncea has potent hypoglycemic activity in male albino rat.
