Acupuncture and moxibustion therapy non-specifically raises the pain threshold, relieves regional muscular tension, improves local blood circulation, accelerates elimination of algogenic substances such as acid metabo...Acupuncture and moxibustion therapy non-specifically raises the pain threshold, relieves regional muscular tension, improves local blood circulation, accelerates elimination of algogenic substances such as acid metabolites, and promotes neural regeneration and functional rehabilitation. However, the effects of acupuncture are synthetically influenced by multiple factors, which vary with acu-puncture point, intensity, and manipulation. The present study explored the analgesic effects and mechanisms of specific Sancai acupuncture manipulation for sciatica. Results revealed that Sancai acupuncture manipulation significantly reduced inflammatory factor interleukin-6 expression in the blood serum of rats with sciatica, exhibited anti-inflammatory effects and promoted rehabilitation of injured nerves. In addition, Sancai acupuncture manipulation exhibited superior curative effects over conventional acupuncture manipulation.展开更多
It was found based on the history of acupuncture and records in ancient medicine writings that acupuncture manipulation originated from ancient times,formed in Pre-Qin and Han Dynasties（from the 21 century BC to220 A...It was found based on the history of acupuncture and records in ancient medicine writings that acupuncture manipulation originated from ancient times,formed in Pre-Qin and Han Dynasties（from the 21 century BC to220 AD）,slowly developed in Jin,Sui and Tang Dynasties（256 AD to 907 AD）,and gradually flourished in Song,Jin,and Yuan Dynasties（906 AD to 1368 AD）.It experienced prosperity and decline in the Ming and Qing Dynasties（1368 AD to 1912 AD）,tortuously developed in modern times,and is widely studied in nowadays.展开更多
Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table m...Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table method, 60 SD rats were randomly divided into blank group, model group, grabbing group, paroxetine group and acupuncture group. Except for the blank group, all the rats were established into PTSD models through electric shock and incarceration, with model replication for 7 days in total. The rats were given gavage, acupuncture intervention and grabbing fixation 1 h before modeling, with 6 days as 1 course of treatment. Grabbing treatment was performed for 2 courses, with 12 days in total. After modeling, functional near-infrared spectroscopy（fNIRS） system was adopted to collect and record the changes of concentration of Oxy-Hb, Deoxy-Hb and Total-Hb during 3 min in related brain regions of rats in each group after treatment for 5 consecutive days, and the brain function was evaluated.Results： According to the comparison of the time series of blood-oxygen concentration, there were significant differences between model group and blank group as well as grabbing group and blank group（P〈0.01, P〈0.01）, no significant difference was found between model group and grabbing group（P〈0.05）; there were significant differences between paroxetine group and grabbing group as well as acupuncture group and grabbing group（P〈0.05, P〈0.05）, no significant difference was found between paroxetine group and acupuncture group（P〈0.05）.Conclusion： ＂Liver-soothing and mind-regulating＂ acupuncture manipulation has a benign regulatory effect on the blood-oxygen concentration in cerebral cortex of PTSD rats, which may be the important brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening PTSD.展开更多
Objective To compare the difference of clinical efficacy between acupuncture of lifting and pressing manipulation and conventional acupuncture in motor function recovery of hemiplegic upper limb after stroke, so as to...Objective To compare the difference of clinical efficacy between acupuncture of lifting and pressing manipulation and conventional acupuncture in motor function recovery of hemiplegic upper limb after stroke, so as to provide referential support for clinical application. Method Fifty-nine patients with upper limb hemiplegia after stroke were selected and divided into group A （conventional acupuncture ± lifting and pressing manipulation, 30 cases} and group B （conventional acupuncture, 29 cases} according to random number table method. Upper limb motor function and activity of daily living of patients in the two groups were scored before and after treatment, and the results were analyzed and compared. Results The score of upper limb FugI-Meyer motor function of patients was 22.4 ± 2.83 and 32.97 ± 2.92 before and after treatment in group A, and was 19.89 ± 3.13 and 26.62 ± 3.31 before and after treatment in group B, and the difference between the two groups before and after treatment was significant （P〈0.01}. The score of Barthel index of patients was 60.67 ± 4.65 and 73.00 ± 3.82 before and after treatment in group A, and was 50.52 ± 5.15 and 60.17 ± 4.89 before and after treatment in group B, and the difference between the two groups before and after treatment was not statistcally significant {P〉0.05）. Conclusion Lifting and pressing manipulation combined with conventional acupuncture can better improve upper limb motor function of upper limb paralysis of patients after stroke.展开更多
Objective To compare differences in therapeutic effects between acupuncture accelerating qi-flow along meridians （AQF） and conventional acupuncture （CA） in treating periarthritis of shoulder to find better acupunc...Objective To compare differences in therapeutic effects between acupuncture accelerating qi-flow along meridians （AQF） and conventional acupuncture （CA） in treating periarthritis of shoulder to find better acupuncture methods. Methods Sixty-four patients were randomly divided into two groups： group AQF, and group CA with 32 cases in each group. Jiānyú （肩髃 LI 15）, Jiānliáo （肩髎 TE 14）, Jiānzhēn （肩贞 SI 9）, Bìnào （臂臑 LI 14）, Qūchí （曲池 LI 11） and Wàiguān （外关 TE 5） on the affected side were used in both groups, and the two acupuncture methods were respectively used in the two groups for consecutive 2 courses. Pain and moving functions of shoulder and ability in daily life （ADL） were used as indices for evaluating therapeutic effects. Results The total effective rate was 96.9% （31/32） and 81.3% （26/32） in group AQF and group CA, respectively, showing superiority of AQF to CA （P〈0.05）. Scores reflecting pain and moving functions of shoulder and ADL were all improved after treatment in both groups （all P〈0.05）, and the improvement in group AQF was more obvious than those in group CA （all P〈0.05）. Conclusion In treating periarthritis of shoulder, the acupuncture accelerating qi-flow along meridians was better than conventional acupuncture in alleviating pain of the shoulder, improving its moving function and elevating abilities in daily life.展开更多
Objective To observe clinical efficacy of Ch/J：eng Yingyuan manipulation for migraine and its effects on endothelin （ET） and nitric oxide （NO）. Methods One hundred and seventeen cases were randomly divided into a...Objective To observe clinical efficacy of Ch/J：eng Yingyuan manipulation for migraine and its effects on endothelin （ET） and nitric oxide （NO）. Methods One hundred and seventeen cases were randomly divided into a treatment group （59 cases） and a control group （58 cases）. The Chifeng Yingyuan manipulation was applied in the treatment group while oral administration of flunarizine hydrochloride capsules was applied in the control group for consecutive 4 weeks. Before and after the treatment, the clinical efficacy and migraine score in both groups were compared; radioimmunoassay was used to test level of ET while nitrate reductase method was for level of NO. Results Compared between two groups, the total effective rate was 91.5% in the treatment group, which was superior to 70.7% in the control group （P〈0.05）. After the treatment, the migraine scores were both significantly decreased in two groups （P〈0.05, P〈0.01）, which was more obvious in the treatment group （P〈0.05）. The level of ET and NO was significantly changed after treatment （P〈0.05, P〈0.01）. Compared between two groups, the improvement of ET and NO in the treatment group was better than that in the control group （both P〈0.05）. Conclusion The Chifeng Yingyuan manipulation has positive effect on migraine without any adverse reaction, which could maintain cerebrovascular vasomotor function by regulating level of ET and NO in the plasma.展开更多
Many clinical trials and experimental studies claim that sham acupuncture is as effective as traditional Chinese acupuncture. However, these studies have no standard sham acupuncture control and many other factors can...Many clinical trials and experimental studies claim that sham acupuncture is as effective as traditional Chinese acupuncture. However, these studies have no standard sham acupuncture control and many other factors can affect the clinical effect. These factors include needle retention time, treatment frequency, and the total number of treatments needed for satisfactory results, and all can change the clinical effect. The majority of existing acupuncture treatment studies do not consider these factors and lack standard dosage criteria. Therefore, it is still too early to conclude that sham acupuncture is as effective as traditional Chinese acupuncture. This article investigates the factors that influence the curative effect of acupuncture as to help set a standard for acupuncture studies in the future.展开更多
There is worrying about current clinical situation on diagnosis and treatment based on an overall analysis of symptoms and signs in acupuncture. Japanese specialists in the acupuncture field have pointed out that suff...There is worrying about current clinical situation on diagnosis and treatment based on an overall analysis of symptoms and signs in acupuncture. Japanese specialists in the acupuncture field have pointed out that sufficient attention should be paid to its various malpractices. Responding to their questioning, the author put forward some main problems existing and made certain analysis. Diagnosis and treatment based on an overall analysis of symptoms and signs should be expressed in their application according to successive theories, methods, prescriptions, acupoints and techniques. In order to elevate therapeutic effects of acupuncture, forth effort should be put to various aspects, such as clinical skills, functional regularity, indications and affected factors.展开更多
Objective： To study the impact of De-qi （得气%, obtaining qi） and psychological factors on the efficacy of acupuncture treatment for primary dysmenorrhea, with an attempt to explore the relationship among De-qi, ps...Objective： To study the impact of De-qi （得气%, obtaining qi） and psychological factors on the efficacy of acupuncture treatment for primary dysmenorrhea, with an attempt to explore the relationship among De-qi, psychological factors, and clinical efficacy. Methods： The patients with primary dysmenorrhea were randomly assigned to a group of acupuncture with manual manipulation （manipulation group, n=67） and an acupuncture group without manipulation （non-manipulation group, n=64）. Pain intensity and pain duration were used as measures for evaluating the therapeutic efficacy of the acupuncture treatment. De-qi, the sensations a patient experienced during the acupuncture treatment, was scored on a 4-point scale by the subjects. In addition, the psychological factors, including belief in acupuncture, the level of nervousness, anxiety, and depression, were quantitatively assessed. The personality of the subject was assessed using the Eysenck personality questionnaire （EPQ） and 16 personality factor questionnaire （16PF）. Results： Complete data were obtained from 120 patients, 60 patients in each group. There were statistically significant differences in pain intensity （W=2410.0, P〈0.01 ） and pain duration （W=3181.0, P〈0.01） between the two groups. The number of De-qi acupoints （W=1150.5, P〈0.01） and the average intensity of De-qi （W=1141.0, P〈0.01） were significantly higher in the manipulation group as compared with their non-manipulation counterparts. The correlation coefficients between De-qi and therapeutic efficacy of acupuncture were greater than those between psychological factors and therapeutic efficacy. Conclusions： Compared with the psychological factors, De-qi contributed more to the pain-relieving effect of acupuncture in subjects with primary dysmenorrhea. Moreover, manual manipulation is a prerequisite for eliciting and enhancing the De-qi sensations, and De-qi is critical for achieving therapeutic effects.展开更多
Objective： To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods： From March 2017 throu...Objective： To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods： From March 2017 through to September 2017, 60 outpatients of knee joint pain were collected from the Acupuncture-Moxibustion Department. They were randomly divided into the group A（treated with scraping combined with collateral bloodletting therapy） and the group B（treated with the simple needling therapy of acupuncture）, 30 cases in each one. Once treatment was given every day and10 times consist of one course, two courses of treatment were required. At the end of treatment, the visual analogue scale（VAS） was adopted to evaluate the pain index, tenderness index and the overall effect of the patients in the two groups. Based on the Lysholm knee scale, the scores were compared in the patients of the two groups before and after treatment.Results： The total effective rate was 96.7% in the group A and was 86.7% in the group B, indicating the significant difference（P〈0.05）. VAS value was 3.03 ± 0.62 in the group A and was 3.67 ± 0.74 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）. The Lysholm knee score was 89.2 ± 4.8 in the group A and was 82.4 ± 2.6 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）.Conclusion： The scraping combined with collateral bloodletting therapy is significant in the efficacy on knee joint pain and feasible in the clinical guidance.展开更多
Objective To introduce a new acupoint that has a good analgesic effect clinically. Methods According to the discovery, clinical exploration and clinical practice of Neimadian （内麻点） point, local anatomy, positioni...Objective To introduce a new acupoint that has a good analgesic effect clinically. Methods According to the discovery, clinical exploration and clinical practice of Neimadian （内麻点） point, local anatomy, positioning, manipulation, clinical application, precautions for manipulation and handling of adverse reactions of Nei madian point were summarized. Results After acupuncture at Neimadian point with continuous stimulation, it was shown that the level of serum β-endorphin increased significantly, while the level of angiotensin II was unchanged, indicating that acupuncture at Neimadian point has a good analgesic effect. Conclusion Acupuncture at Neimadian point can be used for clinical treatment of acute and chronic pain.展开更多
基金the Science and Technology Development Program of High Institutes of Liaoning Provincial Educational Department,No.2007T118
文摘Acupuncture and moxibustion therapy non-specifically raises the pain threshold, relieves regional muscular tension, improves local blood circulation, accelerates elimination of algogenic substances such as acid metabolites, and promotes neural regeneration and functional rehabilitation. However, the effects of acupuncture are synthetically influenced by multiple factors, which vary with acu-puncture point, intensity, and manipulation. The present study explored the analgesic effects and mechanisms of specific Sancai acupuncture manipulation for sciatica. Results revealed that Sancai acupuncture manipulation significantly reduced inflammatory factor interleukin-6 expression in the blood serum of rats with sciatica, exhibited anti-inflammatory effects and promoted rehabilitation of injured nerves. In addition, Sancai acupuncture manipulation exhibited superior curative effects over conventional acupuncture manipulation.
基金Supported by National Natural Science Foundation of China:81001551
文摘It was found based on the history of acupuncture and records in ancient medicine writings that acupuncture manipulation originated from ancient times,formed in Pre-Qin and Han Dynasties（from the 21 century BC to220 AD）,slowly developed in Jin,Sui and Tang Dynasties（256 AD to 907 AD）,and gradually flourished in Song,Jin,and Yuan Dynasties（906 AD to 1368 AD）.It experienced prosperity and decline in the Ming and Qing Dynasties（1368 AD to 1912 AD）,tortuously developed in modern times,and is widely studied in nowadays.
基金Supported by Regional fund project of 2014 National Natural Science Foundation of China:814607442013 Gansu Provincial Natural Science Foundation:1308RJZA150~~
文摘Objective： To explore the brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening post-traumatic stress disorder（PTSD）.Methods： According to random number table method, 60 SD rats were randomly divided into blank group, model group, grabbing group, paroxetine group and acupuncture group. Except for the blank group, all the rats were established into PTSD models through electric shock and incarceration, with model replication for 7 days in total. The rats were given gavage, acupuncture intervention and grabbing fixation 1 h before modeling, with 6 days as 1 course of treatment. Grabbing treatment was performed for 2 courses, with 12 days in total. After modeling, functional near-infrared spectroscopy（fNIRS） system was adopted to collect and record the changes of concentration of Oxy-Hb, Deoxy-Hb and Total-Hb during 3 min in related brain regions of rats in each group after treatment for 5 consecutive days, and the brain function was evaluated.Results： According to the comparison of the time series of blood-oxygen concentration, there were significant differences between model group and blank group as well as grabbing group and blank group（P〈0.01, P〈0.01）, no significant difference was found between model group and grabbing group（P〈0.05）; there were significant differences between paroxetine group and grabbing group as well as acupuncture group and grabbing group（P〈0.05, P〈0.05）, no significant difference was found between paroxetine group and acupuncture group（P〈0.05）.Conclusion： ＂Liver-soothing and mind-regulating＂ acupuncture manipulation has a benign regulatory effect on the blood-oxygen concentration in cerebral cortex of PTSD rats, which may be the important brain function mechanism of ＂liver-soothing and mind-regulating＂ acupuncture manipulation in intervening PTSD.
文摘Objective To compare the difference of clinical efficacy between acupuncture of lifting and pressing manipulation and conventional acupuncture in motor function recovery of hemiplegic upper limb after stroke, so as to provide referential support for clinical application. Method Fifty-nine patients with upper limb hemiplegia after stroke were selected and divided into group A （conventional acupuncture ± lifting and pressing manipulation, 30 cases} and group B （conventional acupuncture, 29 cases} according to random number table method. Upper limb motor function and activity of daily living of patients in the two groups were scored before and after treatment, and the results were analyzed and compared. Results The score of upper limb FugI-Meyer motor function of patients was 22.4 ± 2.83 and 32.97 ± 2.92 before and after treatment in group A, and was 19.89 ± 3.13 and 26.62 ± 3.31 before and after treatment in group B, and the difference between the two groups before and after treatment was significant （P〈0.01}. The score of Barthel index of patients was 60.67 ± 4.65 and 73.00 ± 3.82 before and after treatment in group A, and was 50.52 ± 5.15 and 60.17 ± 4.89 before and after treatment in group B, and the difference between the two groups before and after treatment was not statistcally significant {P〉0.05）. Conclusion Lifting and pressing manipulation combined with conventional acupuncture can better improve upper limb motor function of upper limb paralysis of patients after stroke.
文摘Objective To compare differences in therapeutic effects between acupuncture accelerating qi-flow along meridians （AQF） and conventional acupuncture （CA） in treating periarthritis of shoulder to find better acupuncture methods. Methods Sixty-four patients were randomly divided into two groups： group AQF, and group CA with 32 cases in each group. Jiānyú （肩髃 LI 15）, Jiānliáo （肩髎 TE 14）, Jiānzhēn （肩贞 SI 9）, Bìnào （臂臑 LI 14）, Qūchí （曲池 LI 11） and Wàiguān （外关 TE 5） on the affected side were used in both groups, and the two acupuncture methods were respectively used in the two groups for consecutive 2 courses. Pain and moving functions of shoulder and ability in daily life （ADL） were used as indices for evaluating therapeutic effects. Results The total effective rate was 96.9% （31/32） and 81.3% （26/32） in group AQF and group CA, respectively, showing superiority of AQF to CA （P〈0.05）. Scores reflecting pain and moving functions of shoulder and ADL were all improved after treatment in both groups （all P〈0.05）, and the improvement in group AQF was more obvious than those in group CA （all P〈0.05）. Conclusion In treating periarthritis of shoulder, the acupuncture accelerating qi-flow along meridians was better than conventional acupuncture in alleviating pain of the shoulder, improving its moving function and elevating abilities in daily life.
文摘Objective To observe clinical efficacy of Ch/J：eng Yingyuan manipulation for migraine and its effects on endothelin （ET） and nitric oxide （NO）. Methods One hundred and seventeen cases were randomly divided into a treatment group （59 cases） and a control group （58 cases）. The Chifeng Yingyuan manipulation was applied in the treatment group while oral administration of flunarizine hydrochloride capsules was applied in the control group for consecutive 4 weeks. Before and after the treatment, the clinical efficacy and migraine score in both groups were compared; radioimmunoassay was used to test level of ET while nitrate reductase method was for level of NO. Results Compared between two groups, the total effective rate was 91.5% in the treatment group, which was superior to 70.7% in the control group （P〈0.05）. After the treatment, the migraine scores were both significantly decreased in two groups （P〈0.05, P〈0.01）, which was more obvious in the treatment group （P〈0.05）. The level of ET and NO was significantly changed after treatment （P〈0.05, P〈0.01）. Compared between two groups, the improvement of ET and NO in the treatment group was better than that in the control group （both P〈0.05）. Conclusion The Chifeng Yingyuan manipulation has positive effect on migraine without any adverse reaction, which could maintain cerebrovascular vasomotor function by regulating level of ET and NO in the plasma.
基金Supported by the National Basic Research Program of China(No.2012CB518505)National Industry of Traditional Chinese Medicine Scientific Research(No.201207001-10)
文摘Many clinical trials and experimental studies claim that sham acupuncture is as effective as traditional Chinese acupuncture. However, these studies have no standard sham acupuncture control and many other factors can affect the clinical effect. These factors include needle retention time, treatment frequency, and the total number of treatments needed for satisfactory results, and all can change the clinical effect. The majority of existing acupuncture treatment studies do not consider these factors and lack standard dosage criteria. Therefore, it is still too early to conclude that sham acupuncture is as effective as traditional Chinese acupuncture. This article investigates the factors that influence the curative effect of acupuncture as to help set a standard for acupuncture studies in the future.
文摘There is worrying about current clinical situation on diagnosis and treatment based on an overall analysis of symptoms and signs in acupuncture. Japanese specialists in the acupuncture field have pointed out that sufficient attention should be paid to its various malpractices. Responding to their questioning, the author put forward some main problems existing and made certain analysis. Diagnosis and treatment based on an overall analysis of symptoms and signs should be expressed in their application according to successive theories, methods, prescriptions, acupoints and techniques. In order to elevate therapeutic effects of acupuncture, forth effort should be put to various aspects, such as clinical skills, functional regularity, indications and affected factors.
基金Supported by the National Basic Research Program of China (973 program,No.2006CB504502)
文摘Objective： To study the impact of De-qi （得气%, obtaining qi） and psychological factors on the efficacy of acupuncture treatment for primary dysmenorrhea, with an attempt to explore the relationship among De-qi, psychological factors, and clinical efficacy. Methods： The patients with primary dysmenorrhea were randomly assigned to a group of acupuncture with manual manipulation （manipulation group, n=67） and an acupuncture group without manipulation （non-manipulation group, n=64）. Pain intensity and pain duration were used as measures for evaluating the therapeutic efficacy of the acupuncture treatment. De-qi, the sensations a patient experienced during the acupuncture treatment, was scored on a 4-point scale by the subjects. In addition, the psychological factors, including belief in acupuncture, the level of nervousness, anxiety, and depression, were quantitatively assessed. The personality of the subject was assessed using the Eysenck personality questionnaire （EPQ） and 16 personality factor questionnaire （16PF）. Results： Complete data were obtained from 120 patients, 60 patients in each group. There were statistically significant differences in pain intensity （W=2410.0, P〈0.01 ） and pain duration （W=3181.0, P〈0.01） between the two groups. The number of De-qi acupoints （W=1150.5, P〈0.01） and the average intensity of De-qi （W=1141.0, P〈0.01） were significantly higher in the manipulation group as compared with their non-manipulation counterparts. The correlation coefficients between De-qi and therapeutic efficacy of acupuncture were greater than those between psychological factors and therapeutic efficacy. Conclusions： Compared with the psychological factors, De-qi contributed more to the pain-relieving effect of acupuncture in subjects with primary dysmenorrhea. Moreover, manual manipulation is a prerequisite for eliciting and enhancing the De-qi sensations, and De-qi is critical for achieving therapeutic effects.
基金Supported by Natural Science Foundation of 2017 Anhui University of Traditional Chinese Medicine:2017zrzd002
文摘Objective： To observe the clinical efficacy of knee joint pain treated with scraping combined with collateral bloodletting therapy in comparison with the routine acupuncture techniques.Methods： From March 2017 through to September 2017, 60 outpatients of knee joint pain were collected from the Acupuncture-Moxibustion Department. They were randomly divided into the group A（treated with scraping combined with collateral bloodletting therapy） and the group B（treated with the simple needling therapy of acupuncture）, 30 cases in each one. Once treatment was given every day and10 times consist of one course, two courses of treatment were required. At the end of treatment, the visual analogue scale（VAS） was adopted to evaluate the pain index, tenderness index and the overall effect of the patients in the two groups. Based on the Lysholm knee scale, the scores were compared in the patients of the two groups before and after treatment.Results： The total effective rate was 96.7% in the group A and was 86.7% in the group B, indicating the significant difference（P〈0.05）. VAS value was 3.03 ± 0.62 in the group A and was 3.67 ± 0.74 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）. The Lysholm knee score was 89.2 ± 4.8 in the group A and was 82.4 ± 2.6 in the group B after treatment, indicating that difference is statistically significant（P〈0.05）.Conclusion： The scraping combined with collateral bloodletting therapy is significant in the efficacy on knee joint pain and feasible in the clinical guidance.
文摘Objective To introduce a new acupoint that has a good analgesic effect clinically. Methods According to the discovery, clinical exploration and clinical practice of Neimadian （内麻点） point, local anatomy, positioning, manipulation, clinical application, precautions for manipulation and handling of adverse reactions of Nei madian point were summarized. Results After acupuncture at Neimadian point with continuous stimulation, it was shown that the level of serum β-endorphin increased significantly, while the level of angiotensin II was unchanged, indicating that acupuncture at Neimadian point has a good analgesic effect. Conclusion Acupuncture at Neimadian point can be used for clinical treatment of acute and chronic pain.
