Background:Euphorbia prostrata Ait.is an annual herb widely distributed in the southern region of China with great medical values on Anti-inflammation,insect repellent,treatment of diarrhea.Despite its extensive uses ...Background:Euphorbia prostrata Ait.is an annual herb widely distributed in the southern region of China with great medical values on Anti-inflammation,insect repellent,treatment of diarrhea.Despite its extensive uses as a traditional Chinese medicine,no systematic research on the identification of E.prostrata has been reported.Methods:The study aimed to establish an accurate identification system for E.prostrata through traditional pharmacognostical methods,including botanical origin,morphological characters,medicinal material characters,microscopic characters,physicochemical parameters determination,phytochemical screening,and DNA barcoding analysis.Results:Physicochemical results show that this plant likely contains flavonoids,anthraquinones,and other substances.The ITS loci of the nuclear genome and psbA-trnH loci of the chloroplast genome were selected and evaluated,which were the most variable loci.Conclusion:The findings of this study are expected to contribute to the development of species identification,as well as provide references for authenticity identification,genetic relationship analysis,and further utilization of E.prostrata.展开更多
文摘Background:Euphorbia prostrata Ait.is an annual herb widely distributed in the southern region of China with great medical values on Anti-inflammation,insect repellent,treatment of diarrhea.Despite its extensive uses as a traditional Chinese medicine,no systematic research on the identification of E.prostrata has been reported.Methods:The study aimed to establish an accurate identification system for E.prostrata through traditional pharmacognostical methods,including botanical origin,morphological characters,medicinal material characters,microscopic characters,physicochemical parameters determination,phytochemical screening,and DNA barcoding analysis.Results:Physicochemical results show that this plant likely contains flavonoids,anthraquinones,and other substances.The ITS loci of the nuclear genome and psbA-trnH loci of the chloroplast genome were selected and evaluated,which were the most variable loci.Conclusion:The findings of this study are expected to contribute to the development of species identification,as well as provide references for authenticity identification,genetic relationship analysis,and further utilization of E.prostrata.
文摘自身免疫性甲状腺炎(Autoimmune Thyroiditis,AIT)是一种常见的器官特异性自身免疫性疾病,临床以桥本甲状腺炎(Hashimoto Thyroiditis,HT)最为多见,属中医“瘿病”范畴。AIT患者普遍存在维生素D缺乏的现象,且缺乏程度与病情严重性相关,补充维生素D有助于降低甲状腺抗体水平、改善免疫失衡、延缓向甲状腺机能减退的进展。重点阐述了AIT发病机制与维生素D体内代谢的密切相关性,维生素D受体(Vitamin D Receptor,VDR)的表达是活性维生素D发挥免疫调控作用的决定因素。探究AIT中医病机,“脾者,主为卫”,脾失之卫、免疫调控异常、防御病邪能力下降为其主要病机,卫气亏虚、气行不畅、痰瘀壅结颈前为发病关键。维生素D作为脾所运化之精微物质,为后天免疫系统的完善奠定了物质基础,是发挥免疫调控作用的重要组成部分。临证治疗应以“运脾强卫”理论为指导,采用升清、散精、祛湿之法,健运脾气,调节维生素D代谢,纠正AIT免疫紊乱。
