This observational prospective study was conducted on 25 patients who had received a full 3-dose COVID-19 vaccination scheme with a follow-up ranging from 12 to 19 months after the last injection. The aim of the study...This observational prospective study was conducted on 25 patients who had received a full 3-dose COVID-19 vaccination scheme with a follow-up ranging from 12 to 19 months after the last injection. The aim of the study was focused on a single biological indicator the anti-spike IgG antibody titer. The age of the patients ranged from 51 to 85 years old. 15 out 25 patients (60%) presented a comorbidity. Our data showed a persistent positive anti-spike IgG antibodies titer ranging from 105 to 5680 BAU/mL (mean: 2661 BAU/mL) in all patients. In view of these results, systematic administration of a SARS-CoV-2 vaccine booster is questionable and should be individually tailored according to the patient medical condition and the anti-spike IgG antibody level.展开更多
Spiking neural P systems with anti-spikes （ASN P systems） are variant forms of spiking neural P systems, which are inspired by inhibitory impulses/spikes or inhibitory synapses. The typical feature of ASN P systems ...Spiking neural P systems with anti-spikes （ASN P systems） are variant forms of spiking neural P systems, which are inspired by inhibitory impulses/spikes or inhibitory synapses. The typical feature of ASN P systems is when a neuron contains both spikes and anti-spikes, spikes and anti-spikes wil immediately annihilate each other in a maximal way. In this paper, a restricted variant of ASN P systems, cal ed ASN P systems without anni-hilating priority, is considered, where the annihilating rule is used as the standard rule, i.e., it is not obligatory to use in the neuron associated with both spikes and anti-spikes. If the annihilating rule is used in a neuron, the annihilation wil consume one time unit. As a result, such systems using two categories of spiking rules （identified by （a, a） and （a,a^-）） can achieve Turing completeness as number accepting devices.展开更多
Background:Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures.Such studies are scarce in Egypt,thus we conducted this study to e...Background:Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures.Such studies are scarce in Egypt,thus we conducted this study to explore risk factors for SARS-CoV-2 seropositivity.Methods:This survey included 2919 participants from 10 Egyptian governorates.Sera were tested for SARS-CoV-2 spike(S)and nucleocapsid(N)antibodies.Univariate and multivariate analyses were performed to identify associated factors and predictors of seropositivity regarding sociodemographic factors,clinical data,and personal practices of participants.A subgroup analysis was performed to investigate the occupational risks of seropositivity.Results:Seropositivity was recorded in 1564 participants(53.6%).Independent predictors of seropositivity in-cluded non-smokers(aOR=1.817;95%CI:1.407-2.346,p=0.000),having blood group A(aOR=1.231;95%CI:1.016-1.493,p=0.034),a history of COVID-19 infection(aOR=2.997;95%CI:2.176-4.127,p=0.000),COVID-19 vaccination(aOR=4.349;95%CI:2.798-6.759,p=0.000),higher crowding index(aOR=1.229;95%CI:1.041-1.451,p=0.015),anosmia and/or ageusia(aOR=3.453;95%CI:2.661-4.481,p=0.000)and history of fever(aOR=1.269;95%CI:1.033-1.560,p=0.023).Healthcare worker and Obesity/overweight were additional significant predictors of seropositivity among the working participants(aOR=1.760;95%CI:1.301-2.381,p=0.000 and aOR=1.384;95%CI:1.059-1.808,p=0.019,respectively).Additional factors showing association with seropositivity in the univariate analysis were:female gender,age group(15-39 years),higher educational level(preparatory and above),lack of environmental disinfection and having roommates at the workplace.There was a positive correlation between the titers of both antibodies.Age was weakly corre-lated with anti-S titer,while anti-N was significantly correlated with the number of protective measures applied by the participants.Both antibodies were significantly correlated with adult BMI,while both were significantly negatively correlated with the smoking index.Conclusions:SARS-CoV-2 seropositivity was associated with some personal and behavioral and occupation-related factors.Fever and anosmia and/or ageusia were the symptoms mostly associated with seropositivity.展开更多
文摘This observational prospective study was conducted on 25 patients who had received a full 3-dose COVID-19 vaccination scheme with a follow-up ranging from 12 to 19 months after the last injection. The aim of the study was focused on a single biological indicator the anti-spike IgG antibody titer. The age of the patients ranged from 51 to 85 years old. 15 out 25 patients (60%) presented a comorbidity. Our data showed a persistent positive anti-spike IgG antibodies titer ranging from 105 to 5680 BAU/mL (mean: 2661 BAU/mL) in all patients. In view of these results, systematic administration of a SARS-CoV-2 vaccine booster is questionable and should be individually tailored according to the patient medical condition and the anti-spike IgG antibody level.
基金supported by the National Natural Science Foundation of China(6103300361100145+1 种基金91130034)the China Postdoctoral Science Foundation(2014M550389)
文摘Spiking neural P systems with anti-spikes （ASN P systems） are variant forms of spiking neural P systems, which are inspired by inhibitory impulses/spikes or inhibitory synapses. The typical feature of ASN P systems is when a neuron contains both spikes and anti-spikes, spikes and anti-spikes wil immediately annihilate each other in a maximal way. In this paper, a restricted variant of ASN P systems, cal ed ASN P systems without anni-hilating priority, is considered, where the annihilating rule is used as the standard rule, i.e., it is not obligatory to use in the neuron associated with both spikes and anti-spikes. If the annihilating rule is used in a neuron, the annihilation wil consume one time unit. As a result, such systems using two categories of spiking rules （identified by （a, a） and （a,a^-）） can achieve Turing completeness as number accepting devices.
基金supported financially by the Science and Technology Development Fund(STDF),EgyptProject No.43834.
文摘Background:Population-based studies on the determinants of COVID-19 seroprevalence constitute a cornerstone in guiding appropriate preventive measures.Such studies are scarce in Egypt,thus we conducted this study to explore risk factors for SARS-CoV-2 seropositivity.Methods:This survey included 2919 participants from 10 Egyptian governorates.Sera were tested for SARS-CoV-2 spike(S)and nucleocapsid(N)antibodies.Univariate and multivariate analyses were performed to identify associated factors and predictors of seropositivity regarding sociodemographic factors,clinical data,and personal practices of participants.A subgroup analysis was performed to investigate the occupational risks of seropositivity.Results:Seropositivity was recorded in 1564 participants(53.6%).Independent predictors of seropositivity in-cluded non-smokers(aOR=1.817;95%CI:1.407-2.346,p=0.000),having blood group A(aOR=1.231;95%CI:1.016-1.493,p=0.034),a history of COVID-19 infection(aOR=2.997;95%CI:2.176-4.127,p=0.000),COVID-19 vaccination(aOR=4.349;95%CI:2.798-6.759,p=0.000),higher crowding index(aOR=1.229;95%CI:1.041-1.451,p=0.015),anosmia and/or ageusia(aOR=3.453;95%CI:2.661-4.481,p=0.000)and history of fever(aOR=1.269;95%CI:1.033-1.560,p=0.023).Healthcare worker and Obesity/overweight were additional significant predictors of seropositivity among the working participants(aOR=1.760;95%CI:1.301-2.381,p=0.000 and aOR=1.384;95%CI:1.059-1.808,p=0.019,respectively).Additional factors showing association with seropositivity in the univariate analysis were:female gender,age group(15-39 years),higher educational level(preparatory and above),lack of environmental disinfection and having roommates at the workplace.There was a positive correlation between the titers of both antibodies.Age was weakly corre-lated with anti-S titer,while anti-N was significantly correlated with the number of protective measures applied by the participants.Both antibodies were significantly correlated with adult BMI,while both were significantly negatively correlated with the smoking index.Conclusions:SARS-CoV-2 seropositivity was associated with some personal and behavioral and occupation-related factors.Fever and anosmia and/or ageusia were the symptoms mostly associated with seropositivity.
