As key components connecting offshore floating production platforms and subsea imports, offshore flexible pipes play significant roles in oil, natural gas, and water injection. It is found that torsional failure is on...As key components connecting offshore floating production platforms and subsea imports, offshore flexible pipes play significant roles in oil, natural gas, and water injection. It is found that torsional failure is one of the failure modes of flexible pipes during transportation and laying. In this paper, a theoretical model(TM) of a flexible pipe section mechanics is established, in which the carcass layer and the pressure armor layer are equivalent to the orthogonal anisotropic layers due to its complex cross-section structure. The calculation results of the TM are consistent with those of a finite element model(FEM), which can accurately describe the torsional response of the flexible pipe.Subsequently, the TM and FEM are used to discuss the influence of boundary conditions on the torsional response.The structure of the flexible pipe is stable when twisted counterclockwise. However, limiting the top axial displacement can improve the axial and radial instability of the tensile armor layer when twisted clockwise. Finally, it is recommended that the flexible pipe can be kept under top fixation during service or installation to avoid torsional failure.展开更多
Understanding the dynamic response of composite material cartridges during the firing process is of great significance for improving their reliability and safety.A theoretical model describing the dynamic response of ...Understanding the dynamic response of composite material cartridges during the firing process is of great significance for improving their reliability and safety.A theoretical model describing the dynamic response of composite material cartridges is established based on the thick-walled cylinder theory and rate-dependent constitutive model of composite materials.The correctness of the theoretical model is validated through finite element simulations of cartridge deformation.The influence of chamber pressure and cartridge wall thickness on the cartridge's deformation process and stress distribution is analyzed.The results indicate that the primary deformation of composite material cartridges inside the chamber is elastic deformation.Compared to metal cartridges,composite material cartridges require higher pressure for touching-chamber and are more prone to developing gaps after unloading to ensure smooth extraction.During the deformation process,the touching-chamber behavior of the cartridge can improve the stress distribution.Under the same chamber pressure,the touching-chamber behavior can reduce the circumferential stress by approximately 30%.The inner wall surface of the cartridge is a critical area that requires attention.The touching-chamber behavior can be facilitated by appropriately reducing the cartridge wall thickness while ensuring overall strength.This study can provide guidance for the optimization design of composite material cartridges.展开更多
The present work aims to assess earthquake-induced earth-retaining(ER)wall displacement.This study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement co...The present work aims to assess earthquake-induced earth-retaining(ER)wall displacement.This study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement concrete facing panels,and gravity-type earth-retaining walls.The finite element(FE)simulations utilized a 3D plane strain condition to model full-scale ER walls and numerous nonlinear dynamics analyses.The seismic performance of differentmodels,which includes reinforcement concrete panels and gravity-type and hollowprecast concrete ER walls,was simulated and examined using the FE approach.It also displays comparative studies such as stress distribution,deflection of the wall,acceleration across the wall height,lateral wall displacement,lateral wall pressure,and backfill plastic strain.Three components of the created ER walls were found throughout this research procedure.One is a granular reinforcement backfill,while the other is a wall-facing panel and base foundation.The dynamic response effects of varied earth-retaining walls have also been studied.It was discovered that the facing panel of the model significantly impacts the earthquake-induced displacement of ER walls.The proposed analytical model’s validity has been evaluated and compared with the reinforcement concrete facing panels,gravity-type ER wall,scientifically available data,and American Association of State Highway and Transportation Officials(AASHTO)guidelines results based on FE simulation.The results of the observations indicate that the hollow prefabricated concrete ER wall is the most feasible option due to its lower displacement and high-stress distribution compared to the two types.The methodology and results of this study establish standards for future analogous investigations and professionals,particularly in light of the increasing computational capabilities of desktop computers.展开更多
As the basic protective element, steel plate had attracted world-wide attention because of frequent threats of explosive loads. This paper reports the relationships between microscopic defects of Q345 steel plate unde...As the basic protective element, steel plate had attracted world-wide attention because of frequent threats of explosive loads. This paper reports the relationships between microscopic defects of Q345 steel plate under the explosive load and its macroscopic dynamics simulation. Firstly, the defect characteristics of the steel plate were investigated by stereoscopic microscope(SM) and scanning electron microscope(SEM). At the macroscopic level, the defect was the formation of cave which was concentrated in the range of 0-3.0 cm from the explosion center, while at the microscopic level, the cavity and void formation were the typical damage characteristics. It also explains that the difference in defect morphology at different positions was the combining results of high temperature and high pressure. Secondly, the variation rules of mechanical properties of steel plate under explosive load were studied. The Arbitrary Lagrange-Euler(ALE) algorithm and multi-material fluid-structure coupling method were used to simulate the explosion process of steel plate. The accuracy of the method was verified by comparing the deformation of the simulation results with the experimental results, the pressure and stress at different positions on the surface of the steel plate were obtained. The simulation results indicated that the critical pressure causing the plate defects may be approximately 2.01 GPa. On this basis, it was found that the variation rules of surface pressure and microscopic defect area of the Q345 steel plate were strikingly similar, and the corresponding mathematical relationship between them was established. Compared with Monomolecular growth fitting models(MGFM) and Logistic fitting models(LFM), the relationship can be better expressed by cubic polynomial fitting model(CPFM). This paper illustrated that the explosive defect characteristics of metal plate at the microscopic level can be explored by analyzing its macroscopic dynamic mechanical response.展开更多
AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive in...AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were examined.RESULTS: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with controls.CONCLUSION: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR.展开更多
We presented a boundary element method using the approximate analytical Green's function given by Sánchez-Sesma et al.Coordinate transform is introduced to extend the method to deal with the model with consta...We presented a boundary element method using the approximate analytical Green's function given by Sánchez-Sesma et al.Coordinate transform is introduced to extend the method to deal with the model with constant-gradient velocity along oblique direction.The method is validated by comparing the numerical results with other independent methods.This method provides a useful tool for analyzing local site effects.We computed seismic response for two series of models.The results in both frequency and time domains are analyzed and show complex amplification patterns.The fundamental mode of resonance is dependent not only on the velocity at the free surface but also on the velocity distribution of the whole basin.For the higher modes of vibration the heterogeneous basin also has its own characteristic.展开更多
The dinoflagellate Prorocentrum minimum,one of the most widespread red tide causing species,affects marine aquaculture and ecosystems worldwide.In this study,ridgetail white prawn Exopalaemon carinicauda were exposed ...The dinoflagellate Prorocentrum minimum,one of the most widespread red tide causing species,affects marine aquaculture and ecosystems worldwide.In this study,ridgetail white prawn Exopalaemon carinicauda were exposed to P.minimum cells(5 × 104 cells mL-1) to investigate its harmful effects on the shrimp.Antioxidant activities and histological changes were used as indicators of health status of the shrimp.In 72 hours,the mortality of E.carinicauda was not affected,but its antioxidant response and histology were statistically different from those of control.Elevated superoxide dismutase(SOD) and glutathione peroxidase(GPX) activities and depressed catalase(CAT) activity were observed in gill;while increased SOD,glutathione S-transferase(GST),CAT activities and modulated GPX activity were observed in hepatopancreas.Thus,antioxidant activities in gill and hepatopancreas seem to respond differentially to harmful alga exposure.Increased malondialdehyde(MDA) content in early a few hours indicates the damage of the antioxidant defense system.Although MDA content recovered to a low level thereafter,a series of histological abnormalities including accumulation or infiltration of hemocytes,tissue lesions and necrosis were discovered in gill and hepatopancreas.Exposure to P.minimum induced sublethal effects on E.carinicauda,including temporary oxidative damage and histological injury.展开更多
[Objectives]To explore the optimal extraction process and the antioxidant activity of flavonoidsof Cacumen platycladi. [Methods]FCPwas obtained from C. platycladi by a new set extraction process of microwave-assisted ...[Objectives]To explore the optimal extraction process and the antioxidant activity of flavonoidsof Cacumen platycladi. [Methods]FCPwas obtained from C. platycladi by a new set extraction process of microwave-assisted extraction,freeze thawing,superfine crushingand freeze drying technology and purification. On the basis of single-factor tests,the quadratic regression parasitism model was established by the extraction amount of total flavonoids with microwave power,alcohol concentration,and liquid-to-solid ratio through the response surface methodology. [Results] The optimal extraction conditions were microwave power of 757 W,alcohol concentration of 69%,liquid-to-solid ratio of21∶ 1,with the optimal extraction yield of 15. 302 9 mg/g. Under the real conditions( microwave power of 800 W,alcohol concentration of69%,liquid-to-solid ratio of 21∶ 1) in our laboratory,the maximum yield of total flavonoids was 15. 9 mg/g,the results fitwell with the prediction of quadratic regression parasitism model. The good antioxidant activity has been determined byscavenging effect of FCP on 1,1-diphenyl-2-picrylhydrazyl( DPPH) radical and superoxide anion free radical with the scavenging yield of 70. 2% and 68. 8% respectively. [Conclusions]All results established a good foundation for furtherdevelopment of C. platycladi products.展开更多
Nonlinear finite element simulation for mechanical response of surface mounted solder joint under different temperature cycling was carried out. Seven sets of parameters were used in order to evaluate the influence of...Nonlinear finite element simulation for mechanical response of surface mounted solder joint under different temperature cycling was carried out. Seven sets of parameters were used in order to evaluate the influence of temperature cycling profile parameters. The results show that temperature cycling history has significant effect on the stress response of the solder joint. Based on the concept of relative damage stress proposed by the authors, it is found that enough high temperature holding time is necessary for designing the temperature cycling profile in accelerated thermal fatigue test.展开更多
Manganese(Mn)is one of the essential microelements in all organisms.However,high level of Mn is deleterious to plants.In this study,the effects of exogenous manganese application on mineral element,polyamine(PA)and an...Manganese(Mn)is one of the essential microelements in all organisms.However,high level of Mn is deleterious to plants.In this study,the effects of exogenous manganese application on mineral element,polyamine(PA)and antioxidant accumulation,as well as polyamine metabolic and antioxidant enzyme activities,were investigated in Malus robusta Rehd.,a widely grown apple rootstock.High level of Mn treatments decreased endogenous Mg,Na,K and Ca contents,but increased Zn content,in a Mn-concentration-dependent manner.Polyamine metabolic assays revealed that,except the content of perchloric acid insoluble bound(PIS-bound)spermine,which increased significantly,the contents of putrescine(Put),spermidine(Spd)and spermine(Spm)all decreased progressively,accompanied with the decreased activities of arginine decarboxylase(ADC,EC 4.1.1.19)and ornithine decarboxylase(ODC,EC 4.1.1.17),and the increased activities of diamine oxidase(DAO,EC 1.4.3.6)and polyamine oxidase(PAO,EC 1.5.3.3).Further antioxidant capacity analyses demonstrated that contents of anthocyanin,non-protein thiols(NPT)and soluble sugar,and the activities of guaiacol peroxidase(POD,EC 1.11.1.7),catalase(CAT,EC 1.11.1.6)and superoxide dismutase(SOD,EC 1.15.1.1),also increased upon different concentrations of Mn treatments.Our results suggest that endogenous ion homeostasis is affected by high level of Mn application,and polyamine and antioxidant metabolism is involved in the responses of M.robusta Rehd.plants to high level of Mn stress.展开更多
Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication ...Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 μg MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD50 (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX.展开更多
Many high earth-rockfill dams are constructed in the west of China. The seismic intensity at the dam site is usually very high, thus it is of great importance to ensure the safety of the dam in meizoseismal area. A 3D...Many high earth-rockfill dams are constructed in the west of China. The seismic intensity at the dam site is usually very high, thus it is of great importance to ensure the safety of the dam in meizoseismal area. A 3D FEM model is established to analyze the seismic responses of Shiziping earth-rockfill dam. The nonlinear elastic Duncan-Chang constitutive model and the equivalent viscoelastic constitutive model are used to simulate the static and dynamic stress strain relationships of the dam materials, respectively. Four groups of seismic waves are inputted from the top of the bedrock to analyze the dynamic responses of the dam. The numerical results show that the calculated dynamic magnification factors display a good consistency with the specification values. The site spectrum results in larger acceleration response than the specification spectrum. The analysis of relative dynamic displacement indicates that the displacement at the downstream side of the dam is larger than that at the upstream side. The displacement response reduces from the center of river valley to two banks. The displacement responses corresponding to the specification spectrum are a little smaller than those corresponding to the site spectrum. The analysis of shear stress indicates that a large shear stress area appears in the upstream overburden layer, where the shear stress caused by site waves is larger than that caused by specification waves. The analysis of dynamic principal stress indicates that the minimum dynamic stresses in corridor caused by specification and site waves have little difference. The maximum and minimum dynamic stresses are relatively large at two sides. The largest tensile stress occurs at two sides of the floor of grouting corridor, which may result in the crack near the corridor side. The numerical results present good consistency with the observation data of the grouting corridor in Wenchuan earthquake.展开更多
Male sterility induced by a chemical hybridization agent(CHA) is an important tool for utilizing crop heterosis. Leaves, especially the flag leaves, as CHA initial recipients play a decisive role in inducing male ster...Male sterility induced by a chemical hybridization agent(CHA) is an important tool for utilizing crop heterosis. Leaves, especially the flag leaves, as CHA initial recipients play a decisive role in inducing male sterility. To investigate effects of different treatment times of CHA-SQ-1 used, morphological, biochemical and physiological responses of wheat flag leaves were detected in this study. CHA induced programmed cell death(PCD) as shown in terminal deoxynucleotidyl transferase-mediated d UTP nick end-labelling(TUNEL) and DNA laddering analysis. In the early phase, CHA-SQ-1 triggered organelle changes and PCD in wheat leaves accompanied by excess production of reactive oxygen species( O^-._2and H_2O_2) and down-regulation of the activities of superoxide dismutase(SOD), catalase(CAT) and guaiacol peroxidase(POD). Meanwhile, leaf cell DNAs showed ladder-like patterns on agarose gel, indicating that CHA-SQ-1 led to the activation of the responsible endonuclease. The oxidative stress assays showed that lipid peroxidation was strongly activated and photosynthesis was obviously inhibited in SQ-1-induced leaves. However, CHA contents in wheat leaves gradually reduced along with the time CHA-SQ-1 applied. Young flags returned to an oxidative/antioxidative balance and ultimately developed into mature green leaves. These results provide explanation of the relations between PCD and anther abortion and practical application of CHA for hybrid breeding.展开更多
A new method for optimizing a butterfly-shaped linear ultrasonic motor was proposed to maximize its mechanical output. The finite element analysis technology and response surface methodology were combined together to ...A new method for optimizing a butterfly-shaped linear ultrasonic motor was proposed to maximize its mechanical output. The finite element analysis technology and response surface methodology were combined together to realize the optimal design of the butterfly-shaped linear ultrasonic motor. First, the operation principle of the motor was introduced. Second, the finite element parameterized model of the stator of the motor was built using ANSYS parametric design language and some structure parameters of the stator were selected as design variables. Third, the sample points were selected in design variable space using latin hypercube Design. Through modal analysis and harmonic response analysis of the stator based on these sample points, the target responses were obtained. These sample points and response values were combined together to build a response surface model. Finally, the simplex method was used to find the optimal solution. The experimental results showed that many aspects of the design requirements of the butterfly-shaped linear ultrasonic motor have been fulfilled. The prototype motor fabricated based on the optimal design result exhibited considerably high dynamic performance, such as no-load speed of 873 mm/s, maximal thrust of 27.5 N, maximal efficiency of 43%, and thrust-weight ratio of 45.8.展开更多
Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in l...Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in liquefiable and non-liquefiable soils and their sensitivity to numerical model parameters.A two-dimensional finite element(FE)model is developed to simulate the experiment of a single pile foundation centrifuge in liquefiable soil subjected to earthquake motions and is validated against real-world test results.The differences in soil-pile seismic response of liquefiable and non-liquefiable soils are explored.Specifically,the first-order second-moment method(FOSM)is used for sensitivity analysis of the seismic response.The results show significant differences in seismic response for a soil-pile system between liquefiable and non-liquefiable soil.The seismic responses are found to be significantly larger in liquefiable soil than in non-liquefiable soil.Moreover,the pile bending moment was mainly affected by the kinematic effect in liquefiable soil,while the inertial effect was more significant in non-liquefiable soil.The controlling parameters of seismic response were PGA,soil density,and friction angle in liquefiable soil,while the pile bending moment was mainly controlled by PGA,the friction angle of soil,and shear modulus of loose sand in non-liquefiable soil.展开更多
In order to study the sliding characteristics when the cable is connected with the other rods in the transmission line structures,a linear sliding cable element based on updated Lagrangian formulation and a sliding ca...In order to study the sliding characteristics when the cable is connected with the other rods in the transmission line structures,a linear sliding cable element based on updated Lagrangian formulation and a sliding catenary element considering the out-of-plane stiffness coefficient are put forward.A two-span and a three-span cable structures are taken as examples to verify the sliding cable elements.By comparing the tensions of the two proposed cable elements with the existing research results,the error is less than 1%,which proves the correctness of the proposed elements.The sliding characteristics should be considered in the practical engineering because of the significant difference between the tensions of sliding cable elements and those of cable element without considering sliding.The out-of-plane stiffness coefficient and friction characteristics do not obviously affect the cable tensions.展开更多
The governing equations as well as boundary and initial conditions for nonlinear dynamic response problems of viscous fluid_saturated biphase porous medium model, based on mixture theory, are presented. With Galerkin ...The governing equations as well as boundary and initial conditions for nonlinear dynamic response problems of viscous fluid_saturated biphase porous medium model, based on mixture theory, are presented. With Galerkin weighted residual method the corresponding nonlinear dynamic penalty finite element equation, in which the dependencies of volume fraction and permeation coefficients on deformation are included, is obtained. The iteration solution method of the nonlinear system equation is also discussed. As a numerical example, the dynamic response of a porous medium column under impulsive loading action is analyzed with the developed finite element program. The numerical results demonstrate the efficiency and correctness of the method.展开更多
At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increase...At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein. These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.展开更多
A dynamic finite element method combined with finite element mixed formula for contact problem is used to analyze the dynamic characteristics of gear system. Considering the stiffness excitation, error excitation and ...A dynamic finite element method combined with finite element mixed formula for contact problem is used to analyze the dynamic characteristics of gear system. Considering the stiffness excitation, error excitation and meshing shock excitation, the dynamic finite element model is established for the entire gear system which includes gears, shafts, bearings and gearbox housing. By the software of I-DEAS, the natural frequency, normal mode, dynamic time-domain response, frequency-domain response and one-third octave velocity grade structure borne noise of gear system are studied by the method of theoretical modal analysis and dynamic response analysis. The maximum values of vibration and structure borne noise are occurred at the mesh frequency of output grade gearing.展开更多
基金financially supported by the Natural Science Starting Project of SWPU (Grant No. 2022QHZ002)Sichuan Natural Science Foundation Youth Fund Project (Grant No. 2023NSFC0918)。
文摘As key components connecting offshore floating production platforms and subsea imports, offshore flexible pipes play significant roles in oil, natural gas, and water injection. It is found that torsional failure is one of the failure modes of flexible pipes during transportation and laying. In this paper, a theoretical model(TM) of a flexible pipe section mechanics is established, in which the carcass layer and the pressure armor layer are equivalent to the orthogonal anisotropic layers due to its complex cross-section structure. The calculation results of the TM are consistent with those of a finite element model(FEM), which can accurately describe the torsional response of the flexible pipe.Subsequently, the TM and FEM are used to discuss the influence of boundary conditions on the torsional response.The structure of the flexible pipe is stable when twisted counterclockwise. However, limiting the top axial displacement can improve the axial and radial instability of the tensile armor layer when twisted clockwise. Finally, it is recommended that the flexible pipe can be kept under top fixation during service or installation to avoid torsional failure.
基金supported by the National Defense National Defense Pre-Research Foundation of China(Grant no.301030102)。
文摘Understanding the dynamic response of composite material cartridges during the firing process is of great significance for improving their reliability and safety.A theoretical model describing the dynamic response of composite material cartridges is established based on the thick-walled cylinder theory and rate-dependent constitutive model of composite materials.The correctness of the theoretical model is validated through finite element simulations of cartridge deformation.The influence of chamber pressure and cartridge wall thickness on the cartridge's deformation process and stress distribution is analyzed.The results indicate that the primary deformation of composite material cartridges inside the chamber is elastic deformation.Compared to metal cartridges,composite material cartridges require higher pressure for touching-chamber and are more prone to developing gaps after unloading to ensure smooth extraction.During the deformation process,the touching-chamber behavior of the cartridge can improve the stress distribution.Under the same chamber pressure,the touching-chamber behavior can reduce the circumferential stress by approximately 30%.The inner wall surface of the cartridge is a critical area that requires attention.The touching-chamber behavior can be facilitated by appropriately reducing the cartridge wall thickness while ensuring overall strength.This study can provide guidance for the optimization design of composite material cartridges.
基金supported by Supported by the Science and Technology Research Program of the Institute of Mountain Hazards and Environment,CAS(IMHE-ZDRW-01)the National Natural Science Foundation of China,China(Grant Numbers:42077275&42271086)the Special Project of Basic Research-Key Project,Yunnan(Grant Number:202301AS070039).
文摘The present work aims to assess earthquake-induced earth-retaining(ER)wall displacement.This study is on the dynamics analysis of various earth-retaining wall designs in hollow precast concrete panels,reinforcement concrete facing panels,and gravity-type earth-retaining walls.The finite element(FE)simulations utilized a 3D plane strain condition to model full-scale ER walls and numerous nonlinear dynamics analyses.The seismic performance of differentmodels,which includes reinforcement concrete panels and gravity-type and hollowprecast concrete ER walls,was simulated and examined using the FE approach.It also displays comparative studies such as stress distribution,deflection of the wall,acceleration across the wall height,lateral wall displacement,lateral wall pressure,and backfill plastic strain.Three components of the created ER walls were found throughout this research procedure.One is a granular reinforcement backfill,while the other is a wall-facing panel and base foundation.The dynamic response effects of varied earth-retaining walls have also been studied.It was discovered that the facing panel of the model significantly impacts the earthquake-induced displacement of ER walls.The proposed analytical model’s validity has been evaluated and compared with the reinforcement concrete facing panels,gravity-type ER wall,scientifically available data,and American Association of State Highway and Transportation Officials(AASHTO)guidelines results based on FE simulation.The results of the observations indicate that the hollow prefabricated concrete ER wall is the most feasible option due to its lower displacement and high-stress distribution compared to the two types.The methodology and results of this study establish standards for future analogous investigations and professionals,particularly in light of the increasing computational capabilities of desktop computers.
基金Science and Technology Project of Fire Rescue Bureau of Ministry of Emergency Management(Grant No.2022XFZD05)S&T Program of Hebei(Grant No.22375419D)National Natural Science Foundation of China(Grant No.11802160).
文摘As the basic protective element, steel plate had attracted world-wide attention because of frequent threats of explosive loads. This paper reports the relationships between microscopic defects of Q345 steel plate under the explosive load and its macroscopic dynamics simulation. Firstly, the defect characteristics of the steel plate were investigated by stereoscopic microscope(SM) and scanning electron microscope(SEM). At the macroscopic level, the defect was the formation of cave which was concentrated in the range of 0-3.0 cm from the explosion center, while at the microscopic level, the cavity and void formation were the typical damage characteristics. It also explains that the difference in defect morphology at different positions was the combining results of high temperature and high pressure. Secondly, the variation rules of mechanical properties of steel plate under explosive load were studied. The Arbitrary Lagrange-Euler(ALE) algorithm and multi-material fluid-structure coupling method were used to simulate the explosion process of steel plate. The accuracy of the method was verified by comparing the deformation of the simulation results with the experimental results, the pressure and stress at different positions on the surface of the steel plate were obtained. The simulation results indicated that the critical pressure causing the plate defects may be approximately 2.01 GPa. On this basis, it was found that the variation rules of surface pressure and microscopic defect area of the Q345 steel plate were strikingly similar, and the corresponding mathematical relationship between them was established. Compared with Monomolecular growth fitting models(MGFM) and Logistic fitting models(LFM), the relationship can be better expressed by cubic polynomial fitting model(CPFM). This paper illustrated that the explosive defect characteristics of metal plate at the microscopic level can be explored by analyzing its macroscopic dynamic mechanical response.
基金Supported by the Basic Research Program of the Korea Science & Engineering Foundation (No. 2009-0068732)the Basic Research Program of the National Research Foundation of Korea (No.2011-0020163)+1 种基金the Bio-Industry Technology Development Program funded by the Korea Institute of Planning & Evaluation for Technology in Food, Agriculture Forestry & Fisheries (No.112005-3)the BK21 Program and by the MRC program of KRF (R13-2005-012-01001-1)
文摘AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were examined.RESULTS: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with controls.CONCLUSION: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR.
基金supported by the National Science Foundation of China(Nos. D40444002 and D40521002)National Key Basic Research Program(No.2006CB705803)
文摘We presented a boundary element method using the approximate analytical Green's function given by Sánchez-Sesma et al.Coordinate transform is introduced to extend the method to deal with the model with constant-gradient velocity along oblique direction.The method is validated by comparing the numerical results with other independent methods.This method provides a useful tool for analyzing local site effects.We computed seismic response for two series of models.The results in both frequency and time domains are analyzed and show complex amplification patterns.The fundamental mode of resonance is dependent not only on the velocity at the free surface but also on the velocity distribution of the whole basin.For the higher modes of vibration the heterogeneous basin also has its own characteristic.
基金supported by the Special Fund for Agro-scientific Research in the Public Interest of China(No.2060302201515013)the Scientific and Technological Innovation Project Financially Supported by Qingdao National Laboratory for Marine Science and Technology(No.2015ASKJ02)
文摘The dinoflagellate Prorocentrum minimum,one of the most widespread red tide causing species,affects marine aquaculture and ecosystems worldwide.In this study,ridgetail white prawn Exopalaemon carinicauda were exposed to P.minimum cells(5 × 104 cells mL-1) to investigate its harmful effects on the shrimp.Antioxidant activities and histological changes were used as indicators of health status of the shrimp.In 72 hours,the mortality of E.carinicauda was not affected,but its antioxidant response and histology were statistically different from those of control.Elevated superoxide dismutase(SOD) and glutathione peroxidase(GPX) activities and depressed catalase(CAT) activity were observed in gill;while increased SOD,glutathione S-transferase(GST),CAT activities and modulated GPX activity were observed in hepatopancreas.Thus,antioxidant activities in gill and hepatopancreas seem to respond differentially to harmful alga exposure.Increased malondialdehyde(MDA) content in early a few hours indicates the damage of the antioxidant defense system.Although MDA content recovered to a low level thereafter,a series of histological abnormalities including accumulation or infiltration of hemocytes,tissue lesions and necrosis were discovered in gill and hepatopancreas.Exposure to P.minimum induced sublethal effects on E.carinicauda,including temporary oxidative damage and histological injury.
基金Sponsored by Qing Lan Project of Jiangsu Province(2016)Jiangsu Key Lab of Biomass-based Green Fuels and Chemicals(JSBGFC12010)+1 种基金Excellent Scientific and Technological Innovation Team of Universities in Jiangsu Province(2017-31)Nanjing Polytechnic Institute NHKY-2017-09
文摘[Objectives]To explore the optimal extraction process and the antioxidant activity of flavonoidsof Cacumen platycladi. [Methods]FCPwas obtained from C. platycladi by a new set extraction process of microwave-assisted extraction,freeze thawing,superfine crushingand freeze drying technology and purification. On the basis of single-factor tests,the quadratic regression parasitism model was established by the extraction amount of total flavonoids with microwave power,alcohol concentration,and liquid-to-solid ratio through the response surface methodology. [Results] The optimal extraction conditions were microwave power of 757 W,alcohol concentration of 69%,liquid-to-solid ratio of21∶ 1,with the optimal extraction yield of 15. 302 9 mg/g. Under the real conditions( microwave power of 800 W,alcohol concentration of69%,liquid-to-solid ratio of 21∶ 1) in our laboratory,the maximum yield of total flavonoids was 15. 9 mg/g,the results fitwell with the prediction of quadratic regression parasitism model. The good antioxidant activity has been determined byscavenging effect of FCP on 1,1-diphenyl-2-picrylhydrazyl( DPPH) radical and superoxide anion free radical with the scavenging yield of 70. 2% and 68. 8% respectively. [Conclusions]All results established a good foundation for furtherdevelopment of C. platycladi products.
文摘Nonlinear finite element simulation for mechanical response of surface mounted solder joint under different temperature cycling was carried out. Seven sets of parameters were used in order to evaluate the influence of temperature cycling profile parameters. The results show that temperature cycling history has significant effect on the stress response of the solder joint. Based on the concept of relative damage stress proposed by the authors, it is found that enough high temperature holding time is necessary for designing the temperature cycling profile in accelerated thermal fatigue test.
基金This work was jointly supported by the following grants:The National Natural Science Foundation of China(31701866 and 31870576)The Youth Fund of Shandong Natural Science Foundation(ZR2016CQ27)+1 种基金The National Key R&D Program of China(2019YFD1000500)the Key R&D project of Shandong Province(2018GNC110007).
文摘Manganese(Mn)is one of the essential microelements in all organisms.However,high level of Mn is deleterious to plants.In this study,the effects of exogenous manganese application on mineral element,polyamine(PA)and antioxidant accumulation,as well as polyamine metabolic and antioxidant enzyme activities,were investigated in Malus robusta Rehd.,a widely grown apple rootstock.High level of Mn treatments decreased endogenous Mg,Na,K and Ca contents,but increased Zn content,in a Mn-concentration-dependent manner.Polyamine metabolic assays revealed that,except the content of perchloric acid insoluble bound(PIS-bound)spermine,which increased significantly,the contents of putrescine(Put),spermidine(Spd)and spermine(Spm)all decreased progressively,accompanied with the decreased activities of arginine decarboxylase(ADC,EC 4.1.1.19)and ornithine decarboxylase(ODC,EC 4.1.1.17),and the increased activities of diamine oxidase(DAO,EC 1.4.3.6)and polyamine oxidase(PAO,EC 1.5.3.3).Further antioxidant capacity analyses demonstrated that contents of anthocyanin,non-protein thiols(NPT)and soluble sugar,and the activities of guaiacol peroxidase(POD,EC 1.11.1.7),catalase(CAT,EC 1.11.1.6)and superoxide dismutase(SOD,EC 1.15.1.1),also increased upon different concentrations of Mn treatments.Our results suggest that endogenous ion homeostasis is affected by high level of Mn application,and polyamine and antioxidant metabolism is involved in the responses of M.robusta Rehd.plants to high level of Mn stress.
基金supported by the Key Project of CAS titled "The effects of regenerative organic pollutant microcystins on the safety of aquatic food"the National Natural Science Foundation of China (No. 30700077)
文摘Objective To investigate the hispathological characteristics and antioxidant responses in liver of silver carp after intraperitoneal administration of microcystins (MCs) for further understanding hepatic intoxication and antioxidation mechanism in fish. Methods Phytoplanktivorous silver carp was injected intraperitoneally (i.p.) with extracted hepatotoxic microcystins (mainly MC-RR and -LR) at a dose of 1000 μg MC-LReq./kg body weight, and liver histopathological changes and antioxidant responses were studied at 1, 3, 12, 24, and 48 h, respectively, after injection. Results The damage to liver structure and the activities of hepatic antioxidant enzymes including catalase (CAT), superoxide dismutase (SOD), and glutathione peroxide (GPX) were increased in a time-dependent manner. Conclusion In terms of clinical and histological signs of intoxication and LD50 (i.p.) dose of MC-LR, silver carp appears rather resistant to MCs exposure than other fishes. Also, the significantly increased SOD activity in the liver of silver carp suggests a higher degree of response to MCs exposure than CAT and GPX.
基金Foundation item： Project（IRTl125） supported by the Program for Changjiang Scholars and Innovative Research Team in Universities of China Project（B13024） supported by the ＂111＂ Project Project（BK2012811） supported by the Natural Science Foundation of Jiangsu Province, China
文摘Many high earth-rockfill dams are constructed in the west of China. The seismic intensity at the dam site is usually very high, thus it is of great importance to ensure the safety of the dam in meizoseismal area. A 3D FEM model is established to analyze the seismic responses of Shiziping earth-rockfill dam. The nonlinear elastic Duncan-Chang constitutive model and the equivalent viscoelastic constitutive model are used to simulate the static and dynamic stress strain relationships of the dam materials, respectively. Four groups of seismic waves are inputted from the top of the bedrock to analyze the dynamic responses of the dam. The numerical results show that the calculated dynamic magnification factors display a good consistency with the specification values. The site spectrum results in larger acceleration response than the specification spectrum. The analysis of relative dynamic displacement indicates that the displacement at the downstream side of the dam is larger than that at the upstream side. The displacement response reduces from the center of river valley to two banks. The displacement responses corresponding to the specification spectrum are a little smaller than those corresponding to the site spectrum. The analysis of shear stress indicates that a large shear stress area appears in the upstream overburden layer, where the shear stress caused by site waves is larger than that caused by specification waves. The analysis of dynamic principal stress indicates that the minimum dynamic stresses in corridor caused by specification and site waves have little difference. The maximum and minimum dynamic stresses are relatively large at two sides. The largest tensile stress occurs at two sides of the floor of grouting corridor, which may result in the crack near the corridor side. The numerical results present good consistency with the observation data of the grouting corridor in Wenchuan earthquake.
基金supported by the National High Technology Research and Development Program of China (2011AA10A106)the National Natural Science Foundation of China (31171611, 31371697)+1 种基金the Technological Innovation and Over Planning Projects of Shaanxi Province, China (2014KTZB02-01-02, 2011KTZB02-01-01)the Projects Opening Up New Function of Precision Instrument of Northwest A&F University, China (dysb130210)
文摘Male sterility induced by a chemical hybridization agent(CHA) is an important tool for utilizing crop heterosis. Leaves, especially the flag leaves, as CHA initial recipients play a decisive role in inducing male sterility. To investigate effects of different treatment times of CHA-SQ-1 used, morphological, biochemical and physiological responses of wheat flag leaves were detected in this study. CHA induced programmed cell death(PCD) as shown in terminal deoxynucleotidyl transferase-mediated d UTP nick end-labelling(TUNEL) and DNA laddering analysis. In the early phase, CHA-SQ-1 triggered organelle changes and PCD in wheat leaves accompanied by excess production of reactive oxygen species( O^-._2and H_2O_2) and down-regulation of the activities of superoxide dismutase(SOD), catalase(CAT) and guaiacol peroxidase(POD). Meanwhile, leaf cell DNAs showed ladder-like patterns on agarose gel, indicating that CHA-SQ-1 led to the activation of the responsible endonuclease. The oxidative stress assays showed that lipid peroxidation was strongly activated and photosynthesis was obviously inhibited in SQ-1-induced leaves. However, CHA contents in wheat leaves gradually reduced along with the time CHA-SQ-1 applied. Young flags returned to an oxidative/antioxidative balance and ultimately developed into mature green leaves. These results provide explanation of the relations between PCD and anther abortion and practical application of CHA for hybrid breeding.
基金Projects(51275235, 50975135) supported by the National Natural Science Foundation of ChinaProject(U0934004) supported by the Natural Science Foundation of Guangdong Province, ChinaProject(2011CB707602) supported by the National Basic Research Program of China
文摘A new method for optimizing a butterfly-shaped linear ultrasonic motor was proposed to maximize its mechanical output. The finite element analysis technology and response surface methodology were combined together to realize the optimal design of the butterfly-shaped linear ultrasonic motor. First, the operation principle of the motor was introduced. Second, the finite element parameterized model of the stator of the motor was built using ANSYS parametric design language and some structure parameters of the stator were selected as design variables. Third, the sample points were selected in design variable space using latin hypercube Design. Through modal analysis and harmonic response analysis of the stator based on these sample points, the target responses were obtained. These sample points and response values were combined together to build a response surface model. Finally, the simplex method was used to find the optimal solution. The experimental results showed that many aspects of the design requirements of the butterfly-shaped linear ultrasonic motor have been fulfilled. The prototype motor fabricated based on the optimal design result exhibited considerably high dynamic performance, such as no-load speed of 873 mm/s, maximal thrust of 27.5 N, maximal efficiency of 43%, and thrust-weight ratio of 45.8.
基金National Science Foundation for Excellent Young Scholars of China under Grant No.51722801National Natural Science Foundation of China under Grant Nos.51808006 and 52078016。
文摘Case history investigations have shown that pile foundations are more critically damaged in liquefiable soils than non-liquefiable soils.This study examines the differences in seismic response of pile foundations in liquefiable and non-liquefiable soils and their sensitivity to numerical model parameters.A two-dimensional finite element(FE)model is developed to simulate the experiment of a single pile foundation centrifuge in liquefiable soil subjected to earthquake motions and is validated against real-world test results.The differences in soil-pile seismic response of liquefiable and non-liquefiable soils are explored.Specifically,the first-order second-moment method(FOSM)is used for sensitivity analysis of the seismic response.The results show significant differences in seismic response for a soil-pile system between liquefiable and non-liquefiable soil.The seismic responses are found to be significantly larger in liquefiable soil than in non-liquefiable soil.Moreover,the pile bending moment was mainly affected by the kinematic effect in liquefiable soil,while the inertial effect was more significant in non-liquefiable soil.The controlling parameters of seismic response were PGA,soil density,and friction angle in liquefiable soil,while the pile bending moment was mainly controlled by PGA,the friction angle of soil,and shear modulus of loose sand in non-liquefiable soil.
基金Project(51308193)supported by the National Natural Science Foundation of ChinaProject(SGKJ[2007]116)supported by the Science and Technology Program of State Grid Corporation of China
文摘In order to study the sliding characteristics when the cable is connected with the other rods in the transmission line structures,a linear sliding cable element based on updated Lagrangian formulation and a sliding catenary element considering the out-of-plane stiffness coefficient are put forward.A two-span and a three-span cable structures are taken as examples to verify the sliding cable elements.By comparing the tensions of the two proposed cable elements with the existing research results,the error is less than 1%,which proves the correctness of the proposed elements.The sliding characteristics should be considered in the practical engineering because of the significant difference between the tensions of sliding cable elements and those of cable element without considering sliding.The out-of-plane stiffness coefficient and friction characteristics do not obviously affect the cable tensions.
文摘The governing equations as well as boundary and initial conditions for nonlinear dynamic response problems of viscous fluid_saturated biphase porous medium model, based on mixture theory, are presented. With Galerkin weighted residual method the corresponding nonlinear dynamic penalty finite element equation, in which the dependencies of volume fraction and permeation coefficients on deformation are included, is obtained. The iteration solution method of the nonlinear system equation is also discussed. As a numerical example, the dynamic response of a porous medium column under impulsive loading action is analyzed with the developed finite element program. The numerical results demonstrate the efficiency and correctness of the method.
文摘At 8 weeks after intragastric administration of icariin to senescence-accelerated mice (P8 strain), Morris water maze results showed that escape latency was shortened, and the number of platform crossings was increased. Immunohistochemical staining and western blot assay detected significantly increased levels of cyclic adenosine monophosphate response element binding protein. These results suggest that icariin upregulates phosphorylated cyclic adenosine monophosphate response element binding protein levels and improves learning and memory functions in hippocampus of the senescence-accelerated mouse.
基金Funded by the Natural Science Foundation of China (No. 50675232)the Natural Science Foundation of CQ CSTC (2006BB3008)
文摘A dynamic finite element method combined with finite element mixed formula for contact problem is used to analyze the dynamic characteristics of gear system. Considering the stiffness excitation, error excitation and meshing shock excitation, the dynamic finite element model is established for the entire gear system which includes gears, shafts, bearings and gearbox housing. By the software of I-DEAS, the natural frequency, normal mode, dynamic time-domain response, frequency-domain response and one-third octave velocity grade structure borne noise of gear system are studied by the method of theoretical modal analysis and dynamic response analysis. The maximum values of vibration and structure borne noise are occurred at the mesh frequency of output grade gearing.
