In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-N...In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-NBP-5 displayed the strongest activity in inhibiting the arachidonic acid(AA)- and adenosine diphosphate(ADP)-induced platelet aggregation in vitro, with 3.8- and 7.0-fold more effectiveness than(S)-NBP, respectively. Furthermore, NOSH-NBP-5 could release moderate levels of NO and H2 S, which would be beneficial in improving cardiovascular and cerebral circulation. Moreover, NOSH-NBP-5 could release(S)-NBP when incubated with rat brain homogenate. In conclusion, these findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke.展开更多
Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered fro...Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered from atypical initial symptoms.Here,in this case report,a 12-year-old patient was initially diagnosed as encephalitis.However,it was later noticed that this was a misdiagnosis for the following reasons:the echocardiography showed a vegetation attached to his mitral valves;the cranial magnetic resonance imaging showed lesions that were consistent with a cardioembolic distribution.The final diagnosis was IE.展开更多
基金supported by the National Natural Science Foundation for Young Scientists of China(Nos:21502071 and 21302068)the Natural Science Foundation of Jiangsu Province,China(Nos:BK20140154 and BK20130127)the Fundamental Research Funds for the Central Universities(Nos:JUSRP51411B and JUSRP51629B)
文摘In the present study, a series of novel nitric oxide-hydrogen sulfide releasing derivatives of(S)-3-n-butylphthalide((S)-NBP) were designed, synthesized, and evaluated as potential antiplatelet agents. Compound NOSH-NBP-5 displayed the strongest activity in inhibiting the arachidonic acid(AA)- and adenosine diphosphate(ADP)-induced platelet aggregation in vitro, with 3.8- and 7.0-fold more effectiveness than(S)-NBP, respectively. Furthermore, NOSH-NBP-5 could release moderate levels of NO and H2 S, which would be beneficial in improving cardiovascular and cerebral circulation. Moreover, NOSH-NBP-5 could release(S)-NBP when incubated with rat brain homogenate. In conclusion, these findings may provide new insights into the development of novel antiplatelet agents for the treatment of thrombosis-related ischemic stroke.
文摘Infective endocarditis(IE)is caused by infection of the endocardial surface of heart.It typically affects one or more heart valves,the mural endocardium,or a septal defect.In recent years,many IE patients suffered from atypical initial symptoms.Here,in this case report,a 12-year-old patient was initially diagnosed as encephalitis.However,it was later noticed that this was a misdiagnosis for the following reasons:the echocardiography showed a vegetation attached to his mitral valves;the cranial magnetic resonance imaging showed lesions that were consistent with a cardioembolic distribution.The final diagnosis was IE.
