To preliminarily determine the appropriate dosage of carboplatin （CBP） at AUC of 5 mg-M1^-1·min^-1 in the combination chemotherapy for Chinese senile patients with non-small cell lung cancer （NSCLC）. Thirty-f...To preliminarily determine the appropriate dosage of carboplatin （CBP） at AUC of 5 mg-M1^-1·min^-1 in the combination chemotherapy for Chinese senile patients with non-small cell lung cancer （NSCLC）. Thirty-five Chinese senile patients with NSCLC in advanced stage （Ⅲ/Ⅳ） were given 96 cycles of combination chemotherapy. Chemotherapy schedules included Taxol＋CBP, Gemzar＋CBP and NVB＋CBE The dose of CBP was at 5 mg.mL^-1·min^-1 of area under the concentration-time curve （AUC）. Side effects and quality of life were observed before and after the chemotherapy. Myelosuppression was severe and commonly observed. Grade 3/4 of granulocytopenia was found in 47.9% （46/96） of the patients and grade 3/4 of thrombocytopenia was noted in 28.1% （27/96） of the subjects. However, other side effects were slight. The mean score of quality of life （QOL）, according to the criteria of QOL for Chinese cancer patients had reduced 6.8. At 5 mg.mL^-1·min^-1 by AUC, the hematological toxicity of CBP was severe and it had some negative effects on the QOL. The administration of CBP at 5 mg.mL^-1·min^-1 by AUC may be too high for Chinese senile patients with non-small cell lung cancer.展开更多
Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity...Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)(</=800 mgm(-2)h(-1)),and reduced DI(MTX)(</=1000 mgm(-2)wk(-1))were significantly correlated with low AUC(MTX)values.Seven pa-展开更多
The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is necessary.This study uses maximum e...The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is necessary.This study uses maximum entropy(MaxEnt)modeling to forecast the likelihood of Leucaena leucocephala(Lam.)de Wit invasion in Saudi Arabia under present and future climate change scenarios.Utilizing the MaxEnt modeling,we integrated climatic and soil data to predict habitat suitability for the invasive species.We conducted a detailed analysis of the distribution patterns of the species,using climate variables and ecological factors.We focused on the important influence of temperature seasonality,temperature annual range,and precipitation seasonality.The distribution modeling used robust measures of area under the curve(AUC)and receiver-operator characteristic(ROC)curves,to map the invasion extent,which has a high level of accuracy in identifying appropriate habitats.The complex interaction that influenced the invasion of L.leucocephala was highlighted by the environmental parameters using Jackknife test.Presently,the actual geographic area where L.leucocephala was found in Saudi Arabia was considerably smaller than the theoretical maximum range,suggesting that it had the capacity to expand further.The MaxEnt model exhibited excellent prediction accuracy and produced reliable results based on the data from the ROC curve.Precipitation and temperature were the primary factors influencing the potential distribution of L.leucocephala.Currently,an estimated area of 216,342 km^(2)in Saudi Arabia was at a high probability of invasion by L.leucocephala.We investigated the potential for increased invasion hazards in the future due to climate change scenarios(Shared Socioeconomic Pathways(SSPs)245 and 585).The analysis of key climatic variables,including temperature seasonality and annual range,along with soil properties such as clay composition and nitrogen content,unveiled their substantial influence on the distribution dynamic of L.leucocephala.Our findings indicated a significant expansion of high risk zones.High-risk zones for L.leucocephala invasion in the current climate conditions had notable expansions projected under future climate scenarios,particularly evident in southern Makkah,Al Bahah,Madina,and Asir areas.The results,backed by thorough spatial studies,emphasize the need to reduce the possible ecological impacts of climate change on the spread of L.leucocephala.Moreover,the study provides valuable strategic insights for the management of invasion,highlighting the intricate relationship between climate change,habitat appropriateness,and the risks associated with invasive species.Proactive techniques are suggested to avoid and manage the spread of L.leucocephala,considering its high potential for future spread.This study enhances the overall comprehension of the dynamics of invasive species by combining modeling techniques with ecological knowledge.It also provides valuable information for decision-making to implement efficient conservation and management strategies in response to changing environmental conditions.展开更多
Our aim in this paper is to interest retinal eye specialists in preventing dry macula degeneration by a special flurry vector field through open or closed curved surfaces. The flux of vector fields through surfaces is...Our aim in this paper is to interest retinal eye specialists in preventing dry macula degeneration by a special flurry vector field through open or closed curved surfaces. The flux of vector fields through surfaces is based on vector element area and volume element. Therefore, we explain a few geometrical derivations of area and volume elements in curved orthogonal coordinate systems. We hope that by derivation of a spatial vector field flurry against drusen through open or closed surfaces due to the Gauss theorem might select drusen under eye retina cells without destroying the cells and prevent macula degeneration. A changed flurry of a magnetic or electric vector field through a closed line causes an electric or magnetic vector field on the surface closed by the line. We also hope that derivation by Stokes’ and Greens’ theorems, with the help of iron, might help eye cells to get in life.展开更多
Climate change is the most serious causes and has a direct impact on biodiversity.According to the world’s biodiversity conservation organization,rep-tile species are most affected since their biological and ecologic...Climate change is the most serious causes and has a direct impact on biodiversity.According to the world’s biodiversity conservation organization,rep-tile species are most affected since their biological and ecological qualities are directly linked to climate.Due to a lack of time frame in existing works,conser-vation adoption affects the performance of existing works.The proposed research presents a knowledge-driven Decision Support System(DSS)including the assisted translocation to adapt to future climate change to conserving from its extinction.The Dynamic approach is used to develop a knowledge-driven DSS using machine learning by applying an ecological and biological variable that characterizes the model and mitigation processes for species.However,the frame-work demonstrates the huge difference in the estimated significance of climate change,the model strategy helps to recognize the probable risk of threatened spe-cies translocation to future climate change.The proposed system is evaluated using various performance metrics and this framework can comfortably adapt to the decisions support to reintroduce the species for conservation in the future.展开更多
Using Picard's theorem and the Leray-Schauder fixed point theorem to reinvestigate the area-preserving convex curve flow in the plane which is considered as a coupled system and thus different from the setting han...Using Picard's theorem and the Leray-Schauder fixed point theorem to reinvestigate the area-preserving convex curve flow in the plane which is considered as a coupled system and thus different from the setting handled by Gage.展开更多
An approach is presented for computing integral values, such as areas and volumes of revo-lution . of regions bounded by rational plane B zier curves. The method approximates rational curveswith polynomial curves, an...An approach is presented for computing integral values, such as areas and volumes of revo-lution . of regions bounded by rational plane B zier curves. The method approximates rational curveswith polynomial curves, and then computes the integral values on those polynomial curves. Errorbounds are provided. For high precision, this new algorithm performs much more quickly than con-ventional numerical methods.展开更多
基金a grant from a key research program of the Education Bureau of Hubei Province (D2006-02-002).
文摘To preliminarily determine the appropriate dosage of carboplatin （CBP） at AUC of 5 mg-M1^-1·min^-1 in the combination chemotherapy for Chinese senile patients with non-small cell lung cancer （NSCLC）. Thirty-five Chinese senile patients with NSCLC in advanced stage （Ⅲ/Ⅳ） were given 96 cycles of combination chemotherapy. Chemotherapy schedules included Taxol＋CBP, Gemzar＋CBP and NVB＋CBE The dose of CBP was at 5 mg.mL^-1·min^-1 of area under the concentration-time curve （AUC）. Side effects and quality of life were observed before and after the chemotherapy. Myelosuppression was severe and commonly observed. Grade 3/4 of granulocytopenia was found in 47.9% （46/96） of the patients and grade 3/4 of thrombocytopenia was noted in 28.1% （27/96） of the subjects. However, other side effects were slight. The mean score of quality of life （QOL）, according to the criteria of QOL for Chinese cancer patients had reduced 6.8. At 5 mg.mL^-1·min^-1 by AUC, the hematological toxicity of CBP was severe and it had some negative effects on the QOL. The administration of CBP at 5 mg.mL^-1·min^-1 by AUC may be too high for Chinese senile patients with non-small cell lung cancer.
文摘Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)(</=800 mgm(-2)h(-1)),and reduced DI(MTX)(</=1000 mgm(-2)wk(-1))were significantly correlated with low AUC(MTX)values.Seven pa-
基金the Researchers Supporting Project(RSP2024R347),King Saud University,Riyadh,Saudi Arabia.
文摘The presence of invasive plant species poses a substantial ecological impact,thus comprehensive evaluation of their potential range and risk under the influence of climate change is necessary.This study uses maximum entropy(MaxEnt)modeling to forecast the likelihood of Leucaena leucocephala(Lam.)de Wit invasion in Saudi Arabia under present and future climate change scenarios.Utilizing the MaxEnt modeling,we integrated climatic and soil data to predict habitat suitability for the invasive species.We conducted a detailed analysis of the distribution patterns of the species,using climate variables and ecological factors.We focused on the important influence of temperature seasonality,temperature annual range,and precipitation seasonality.The distribution modeling used robust measures of area under the curve(AUC)and receiver-operator characteristic(ROC)curves,to map the invasion extent,which has a high level of accuracy in identifying appropriate habitats.The complex interaction that influenced the invasion of L.leucocephala was highlighted by the environmental parameters using Jackknife test.Presently,the actual geographic area where L.leucocephala was found in Saudi Arabia was considerably smaller than the theoretical maximum range,suggesting that it had the capacity to expand further.The MaxEnt model exhibited excellent prediction accuracy and produced reliable results based on the data from the ROC curve.Precipitation and temperature were the primary factors influencing the potential distribution of L.leucocephala.Currently,an estimated area of 216,342 km^(2)in Saudi Arabia was at a high probability of invasion by L.leucocephala.We investigated the potential for increased invasion hazards in the future due to climate change scenarios(Shared Socioeconomic Pathways(SSPs)245 and 585).The analysis of key climatic variables,including temperature seasonality and annual range,along with soil properties such as clay composition and nitrogen content,unveiled their substantial influence on the distribution dynamic of L.leucocephala.Our findings indicated a significant expansion of high risk zones.High-risk zones for L.leucocephala invasion in the current climate conditions had notable expansions projected under future climate scenarios,particularly evident in southern Makkah,Al Bahah,Madina,and Asir areas.The results,backed by thorough spatial studies,emphasize the need to reduce the possible ecological impacts of climate change on the spread of L.leucocephala.Moreover,the study provides valuable strategic insights for the management of invasion,highlighting the intricate relationship between climate change,habitat appropriateness,and the risks associated with invasive species.Proactive techniques are suggested to avoid and manage the spread of L.leucocephala,considering its high potential for future spread.This study enhances the overall comprehension of the dynamics of invasive species by combining modeling techniques with ecological knowledge.It also provides valuable information for decision-making to implement efficient conservation and management strategies in response to changing environmental conditions.
文摘Our aim in this paper is to interest retinal eye specialists in preventing dry macula degeneration by a special flurry vector field through open or closed curved surfaces. The flux of vector fields through surfaces is based on vector element area and volume element. Therefore, we explain a few geometrical derivations of area and volume elements in curved orthogonal coordinate systems. We hope that by derivation of a spatial vector field flurry against drusen through open or closed surfaces due to the Gauss theorem might select drusen under eye retina cells without destroying the cells and prevent macula degeneration. A changed flurry of a magnetic or electric vector field through a closed line causes an electric or magnetic vector field on the surface closed by the line. We also hope that derivation by Stokes’ and Greens’ theorems, with the help of iron, might help eye cells to get in life.
文摘Climate change is the most serious causes and has a direct impact on biodiversity.According to the world’s biodiversity conservation organization,rep-tile species are most affected since their biological and ecological qualities are directly linked to climate.Due to a lack of time frame in existing works,conser-vation adoption affects the performance of existing works.The proposed research presents a knowledge-driven Decision Support System(DSS)including the assisted translocation to adapt to future climate change to conserving from its extinction.The Dynamic approach is used to develop a knowledge-driven DSS using machine learning by applying an ecological and biological variable that characterizes the model and mitigation processes for species.However,the frame-work demonstrates the huge difference in the estimated significance of climate change,the model strategy helps to recognize the probable risk of threatened spe-cies translocation to future climate change.The proposed system is evaluated using various performance metrics and this framework can comfortably adapt to the decisions support to reintroduce the species for conservation in the future.
文摘Using Picard's theorem and the Leray-Schauder fixed point theorem to reinvestigate the area-preserving convex curve flow in the plane which is considered as a coupled system and thus different from the setting handled by Gage.
文摘An approach is presented for computing integral values, such as areas and volumes of revo-lution . of regions bounded by rational plane B zier curves. The method approximates rational curveswith polynomial curves, and then computes the integral values on those polynomial curves. Errorbounds are provided. For high precision, this new algorithm performs much more quickly than con-ventional numerical methods.
