Objective: To explore the molecular biological mechanism of Arnebia root oil promoting wound surface healing by observing histological change and bFGF expression in wound surface tissue as well as wound surface healin...Objective: To explore the molecular biological mechanism of Arnebia root oil promoting wound surface healing by observing histological change and bFGF expression in wound surface tissue as well as wound surface healing rate. Methods: Raw surface in patients were randomly divided into 2 groups. Experimental group was treated by Arnebia root oil and control group was treated by petrolatum gauze, then the tissular structure of raw surface was observed by histology, histochemistry. electron microscope and raw surface healing rates was compared either. bFGF expression in wound surface tissue was also evaluated by Western-blot. Results: Raw surface healing rate of experimental group and control group had obvious difference(P<0. 05). Raw surface of experimental group had more fibroblast, collagen and blood capillary. bFGF was expressed in both groups, and the level of bFGF expression in experimental group was higher than that in control group in every period. There were significant differences between 2 groups in gray-density value ( P<0. 05). Being as an internal control, no significant change was found for β-actin expression, although it occured in various phases. Conclusion: Arnebia root oil plays an important regulative role in the course of healing of wound and it can promote skin raw surface repair and accelerate wound surface healing, which are caused by enhancing bFGF in the wound tissue.展开更多
目的综合评价紫草油治疗压疮的效果。方法计算机检索PubMed、MEDLINE、Web of Knowledge、CINAHL、Springer、EBSCO、中国生物医学文献数据库、中国知网、万方数据库、中国科技期刊数据库中使用紫草油治疗压疮的随机对照试验,由2名研究...目的综合评价紫草油治疗压疮的效果。方法计算机检索PubMed、MEDLINE、Web of Knowledge、CINAHL、Springer、EBSCO、中国生物医学文献数据库、中国知网、万方数据库、中国科技期刊数据库中使用紫草油治疗压疮的随机对照试验,由2名研究人员筛选和提取资料,运用RevMan 5.3软件进行Meta分析。结果共纳入16篇随机对照试验(761例患者)。Meta分析结果显示,有效率存在统计学意义[OR=5.48,95%CI(3.47,8.66),P<0.01],有效时间存在统计学意义[MD=-5.53,95%CI(-6.10,-4.65),P<0.01]。结论紫草油治疗压疮具有良好的效果,值得临床推广。展开更多
文摘Objective: To explore the molecular biological mechanism of Arnebia root oil promoting wound surface healing by observing histological change and bFGF expression in wound surface tissue as well as wound surface healing rate. Methods: Raw surface in patients were randomly divided into 2 groups. Experimental group was treated by Arnebia root oil and control group was treated by petrolatum gauze, then the tissular structure of raw surface was observed by histology, histochemistry. electron microscope and raw surface healing rates was compared either. bFGF expression in wound surface tissue was also evaluated by Western-blot. Results: Raw surface healing rate of experimental group and control group had obvious difference(P<0. 05). Raw surface of experimental group had more fibroblast, collagen and blood capillary. bFGF was expressed in both groups, and the level of bFGF expression in experimental group was higher than that in control group in every period. There were significant differences between 2 groups in gray-density value ( P<0. 05). Being as an internal control, no significant change was found for β-actin expression, although it occured in various phases. Conclusion: Arnebia root oil plays an important regulative role in the course of healing of wound and it can promote skin raw surface repair and accelerate wound surface healing, which are caused by enhancing bFGF in the wound tissue.
文摘目的综合评价紫草油治疗压疮的效果。方法计算机检索PubMed、MEDLINE、Web of Knowledge、CINAHL、Springer、EBSCO、中国生物医学文献数据库、中国知网、万方数据库、中国科技期刊数据库中使用紫草油治疗压疮的随机对照试验,由2名研究人员筛选和提取资料,运用RevMan 5.3软件进行Meta分析。结果共纳入16篇随机对照试验(761例患者)。Meta分析结果显示,有效率存在统计学意义[OR=5.48,95%CI(3.47,8.66),P<0.01],有效时间存在统计学意义[MD=-5.53,95%CI(-6.10,-4.65),P<0.01]。结论紫草油治疗压疮具有良好的效果,值得临床推广。
