Laser induced breakdown spectroscopy (LIBS) can be used to determine solid, liquid, colloi-dal, and biological samples. It is a promising technique for analysis and characterization of the composition of a broad varie...Laser induced breakdown spectroscopy (LIBS) can be used to determine solid, liquid, colloi-dal, and biological samples. It is a promising technique for analysis and characterization of the composition of a broad variety of objects. This review describes in brief the basic prin-ciples and technological aspects of LIBS, and the most recent progress of the various ap-plications of this technique in biomedicine fields will be reviewed in detail, including bio-aerosols detection and identification, tis-sue analysis, mineral analysis in human body, and detection of zinc in human skin. Finally new approaches and the prospects in bio-medicine fields of LIBS technique are de-scribed.展开更多
Data mining is the process of finding the patterns, associations or relationships among data using different analytical techniques involving the creation of a model and the concluded result will become useful informat...Data mining is the process of finding the patterns, associations or relationships among data using different analytical techniques involving the creation of a model and the concluded result will become useful information or knowledge. The advancement of the new medical deceives and the database management systems create a huge number of data-bases in the biomedicine world. Establishing a methodology for knowledge discovery and management of the large amounts of heterogeneous data has become a major priority of research. This paper introduces some basic data mining techniques, unsupervised learning and supervising learning, and reviews the application of data mining in biomedicine. Applications of the multimedia mining, including text, image, video and web mining are discussed. The key issues faced by the computing professional, medical doctors and clinicians are highlighted. We also state some foreseeable future developments in the field. Although extracting useful information from raw biomedical data is a challenging task, data mining is still a good area of scientific study and remains a promising and rich field for research.展开更多
GENERALAsian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press and aims to set up an acdemic communicating platform for ...GENERALAsian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press and aims to set up an acdemic communicating platform for Chinese and scientists all over the world on tropical biomedicine and related sciences.展开更多
APJTB Monthly Aims&Scope Asian Pacific Journal of Tropical Biomedicine (APJTB) is administrated by Hainan Medical University and sponsored by Hainan Medical University Journal Publisher, and aims to establish an i...APJTB Monthly Aims&Scope Asian Pacific Journal of Tropical Biomedicine (APJTB) is administrated by Hainan Medical University and sponsored by Hainan Medical University Journal Publisher, and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers, especially specialists and scholars of the Asian Pacific region and worldwide on展开更多
Fast and precise diagnostic techniques are required for the treatment of many disorders.Biosensors are one of the diagnostic devices that are applicable in biological and medical sciences.Biosensors could be utilized ...Fast and precise diagnostic techniques are required for the treatment of many disorders.Biosensors are one of the diagnostic devices that are applicable in biological and medical sciences.Biosensors could be utilized to recognize biological molecules with high sensitivity.Biosensors are consisted of different components and have different types.Each type of biosensor is used in a particular field according to its specific features.Nanobodies are a novel class of antibodies with small size,high affinity,and specificity to their target.The unique properties of nanobodies make them appropriate tools for diagnostic applications.In this paper,we review biosensors,and their features and roles in medicine.Antibody/nanobody-based biosensors are also specifically discussed.展开更多
Purpose:To reveal the research hotpots and relationship among three research hot topics in b iomedicine,namely CRISPR,iPS(induced Pluripotent Stem)cell and Synthetic biology.Design/methodology/approach:We set up their...Purpose:To reveal the research hotpots and relationship among three research hot topics in b iomedicine,namely CRISPR,iPS(induced Pluripotent Stem)cell and Synthetic biology.Design/methodology/approach:We set up their keyword co-occurrence networks with using three indicators and information visualization for metric analysis.Findings:The results reveal the main research hotspots in the three topics are different,but the overlapping keywords in the three topics indicate that they are mutually integrated and interacted each other.Research limitations:All analyses use keywords,without any other forms.Practical implications:We try to find the information distribution and structure of these three hot topics for revealing their research status and interactions,and for promoting biomedical developments.Originality/value:We chose the core keywords in three research hot topics in biomedicine by using h-index.展开更多
Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an international academic communicating pl...Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers,especially specialists and scholars of the Asian Pacific region and worldwide on tropical biomedicine research,to prevent and control the prevalence of global tropical disease.展开更多
Our world has demonstrated to he extremely vulnerable.Numerous humanitarian missions in developing countries have revealed the monstrous devastation caused by tropical diseases and malnutrition.Paradoxically,the peopl...Our world has demonstrated to he extremely vulnerable.Numerous humanitarian missions in developing countries have revealed the monstrous devastation caused by tropical diseases and malnutrition.Paradoxically,the people in charge of the political decisions always seem to be far from recognizing this situation when facing the monstrous dose of reality of the transmissible diseases that have predilection for the people in disadvantage.展开更多
Compared with traditional materials,metal-organic framework materials(MOFs)have the characteristics of drug release controllability,degradability,designability and adjustability of composition and structure,excellent ...Compared with traditional materials,metal-organic framework materials(MOFs)have the characteristics of drug release controllability,degradability,designability and adjustability of composition and structure,excellent load capacity,and designability and adjustability of channel shape and size,and have shown a wide range of application value in the field of biomedicine.In this paper,based on the structural characteristics of MOFs,the synthetic design of MOF materials was expounded,and the research achievements of MOF materials in biomedicine in recent years were reviewed.展开更多
APJTB Monthly Aims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an internatio...APJTB Monthly Aims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers,especially specialists and scholars of the Asian Pacific region and worldwide on tropical biomedicine research,to prevent and control the prevalence of global tropical disease.展开更多
APJTB MonthlyAims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an internation...APJTB MonthlyAims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers,especially specialists and scholars of the展开更多
APJTB MonthlyAims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)aims to set up and provide an international academic communication platform for physicians,medical scientists,allied health scientists an...APJTB MonthlyAims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)aims to set up and provide an international academic communication platform for physicians,medical scientists,allied health scientists and public health workers,especially those in the Asian Pacific region and worldwide on tropical biomedicine,infectious diseases and public health,and to meet the growing展开更多
Aims & Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)aims to set up and provide an international academic communication platform for physicians,medical scientists,allied health scientists and public he...Aims & Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)aims to set up and provide an international academic communication platform for physicians,medical scientists,allied health scientists and public health workers,especially those in the Asian Pacific region and worldwide on tropical biomedicine,infectious diseases and public health,and to meet the growing challenges of understanding,preventing and controUing the dramatic global emergence and reemergence of infectious diseases in the Asian Pacific region.展开更多
Nowadays, nanomaterials have become an emerging field that has shown great promise in the development of novel diagnostic, imaging and therapeutic agents for a variety of diseases, including cancer, due to their nanos...Nowadays, nanomaterials have become an emerging field that has shown great promise in the development of novel diagnostic, imaging and therapeutic agents for a variety of diseases, including cancer, due to their nanoscale size effects and increased surface area. In comparison to their larger counterparts, nanomaterials have unique physicochemical and biological properties including size, shape, chemical composition, surface structure and charge, aggregation and agglomeration, and solubility which can affect their interactions with biomolecules and cells. Nanoparticles (NPs) with size-tunable light emission have demonstrated an impressive potential as high-efficiency delivery transporters for biomolecules into cells, being used to produce exceptional images of tumor sites. Moreover, NPs delivery system has been widely applied in pharmaceutical field to enhance absorption of bioactive compounds since they can interact with several phytochemicals by hydrogen bonds and hydrophobic interactions to encapsulate these phytochemicals in NPs and thus enhance aqueous solubility of the chemicals. Moreover, NPs also can prevent against oxidation/degradation of the phytochemicals encapsulated in the gastrointestinal tract and can be taken directly up by epithelial cells in the small intestine resulting in the increase of absorption and bioavailability of phytochemicals. In general, there are two specific fields of utilization of intrinsically active NPs as pharmacologic agents including oxidative-related pathologies and cancer. On the other hand, Redox active NPs have been shown to ameliorate many clinically relevant pathological disorders that implicate oxidative stress, reducing the oxidative burden and alleviating many important symptoms. Such NPs act either in a catalytic way resembling the action of antioxidant enzymes such as catalase and superoxide dismutase, or as activating surfaces to facilitate reactions between the aqueous environment and the reactive oxygen species present at high level in the pathological tissues.展开更多
Interfacial assembly has been intensively investigated in fabricating biomaterials and nanodevices for various applications.Recently,due to the precise sequence programmability,unique molecular recognition ability,and...Interfacial assembly has been intensively investigated in fabricating biomaterials and nanodevices for various applications.Recently,due to the precise sequence programmability,unique molecular recognition ability,and good biocompatibility,deoxyribonucleic acid(DNA)has been explored as superior building blocks to assemble at bio-interface for manipulating biological entities.To the best of our knowledge,the advances in this area have not been systematically summarized.To provide an overview of the area,in this review,the recently developed DNA assembly strategies on bio-interfaces were well summarized,and their representative works are exampled to illustrate how to rationally and elaborately design DNA molecules to realize functional integration and emerging of novel biological functionalities with high controllability and programmability.Furthermore,the biomedical applications of DNA assembly at bio-interface are categorially elaborated.The fascinating and unique advantages of DNA assembly systems are fully discussed in the exemplified applications to show the distinguished perspective of DNA in the future development.At the end of this review,the current limitations and challenges in applications and potential improvement strategies for DNA assembly at bio-interface are fully discussed.The future development direction is deliberated.We envision that this review will help scientists in the interdisciplinary fields gain a more comprehensive understanding of the DNA assembly at bio-interface,and therefore jointly promote the advances in this field.展开更多
Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and c...Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and categorize them into predefined entity types.This process can provide basic support for the automatic construction of knowledge bases.In contrast to general texts,biomedical texts frequently contain numerous nested entities and local dependencies among these entities,presenting significant challenges to prevailing NER models.To address these issues,we propose a novel Chinese nested biomedical NER model based on RoBERTa and Global Pointer(RoBGP).Our model initially utilizes the RoBERTa-wwm-ext-large pretrained language model to dynamically generate word-level initial vectors.It then incorporates a Bidirectional Long Short-Term Memory network for capturing bidirectional semantic information,effectively addressing the issue of long-distance dependencies.Furthermore,the Global Pointer model is employed to comprehensively recognize all nested entities in the text.We conduct extensive experiments on the Chinese medical dataset CMeEE and the results demonstrate the superior performance of RoBGP over several baseline models.This research confirms the effectiveness of RoBGP in Chinese biomedical NER,providing reliable technical support for biomedical information extraction and knowledge base construction.展开更多
Human endogenous retroviruses(HERVs)were formed via ancient integration of exogenous retroviruses into the human genome and are considered to be viral“fossils”.The human genome is embedded with a considerable amount...Human endogenous retroviruses(HERVs)were formed via ancient integration of exogenous retroviruses into the human genome and are considered to be viral“fossils”.The human genome is embedded with a considerable amount of HERVs,witnessing the long-term evolutionary history of the viruses and the host.Most HERVs have lost coding capability during selection but still function in terms of HERV-mediated regulation of host gene expression.In this review,we summarize the roles of HERV activation in response to viral infections and diseases,and emphasize the potential use of HERVs as biomedicine markers in the early diagnosis of diseases such as cancer,which provides a new perspective for the clinical application of HERVs.展开更多
文摘Laser induced breakdown spectroscopy (LIBS) can be used to determine solid, liquid, colloi-dal, and biological samples. It is a promising technique for analysis and characterization of the composition of a broad variety of objects. This review describes in brief the basic prin-ciples and technological aspects of LIBS, and the most recent progress of the various ap-plications of this technique in biomedicine fields will be reviewed in detail, including bio-aerosols detection and identification, tis-sue analysis, mineral analysis in human body, and detection of zinc in human skin. Finally new approaches and the prospects in bio-medicine fields of LIBS technique are de-scribed.
文摘Data mining is the process of finding the patterns, associations or relationships among data using different analytical techniques involving the creation of a model and the concluded result will become useful information or knowledge. The advancement of the new medical deceives and the database management systems create a huge number of data-bases in the biomedicine world. Establishing a methodology for knowledge discovery and management of the large amounts of heterogeneous data has become a major priority of research. This paper introduces some basic data mining techniques, unsupervised learning and supervising learning, and reviews the application of data mining in biomedicine. Applications of the multimedia mining, including text, image, video and web mining are discussed. The key issues faced by the computing professional, medical doctors and clinicians are highlighted. We also state some foreseeable future developments in the field. Although extracting useful information from raw biomedical data is a challenging task, data mining is still a good area of scientific study and remains a promising and rich field for research.
文摘GENERALAsian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press and aims to set up an acdemic communicating platform for Chinese and scientists all over the world on tropical biomedicine and related sciences.
文摘APJTB Monthly Aims&Scope Asian Pacific Journal of Tropical Biomedicine (APJTB) is administrated by Hainan Medical University and sponsored by Hainan Medical University Journal Publisher, and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers, especially specialists and scholars of the Asian Pacific region and worldwide on
基金Pasteur Institute of Iran for supporting the current article
文摘Fast and precise diagnostic techniques are required for the treatment of many disorders.Biosensors are one of the diagnostic devices that are applicable in biological and medical sciences.Biosensors could be utilized to recognize biological molecules with high sensitivity.Biosensors are consisted of different components and have different types.Each type of biosensor is used in a particular field according to its specific features.Nanobodies are a novel class of antibodies with small size,high affinity,and specificity to their target.The unique properties of nanobodies make them appropriate tools for diagnostic applications.In this paper,we review biosensors,and their features and roles in medicine.Antibody/nanobody-based biosensors are also specifically discussed.
基金the National Natural Science Foundation of China Grant 71673131 for financial support
文摘Purpose:To reveal the research hotpots and relationship among three research hot topics in b iomedicine,namely CRISPR,iPS(induced Pluripotent Stem)cell and Synthetic biology.Design/methodology/approach:We set up their keyword co-occurrence networks with using three indicators and information visualization for metric analysis.Findings:The results reveal the main research hotspots in the three topics are different,but the overlapping keywords in the three topics indicate that they are mutually integrated and interacted each other.Research limitations:All analyses use keywords,without any other forms.Practical implications:We try to find the information distribution and structure of these three hot topics for revealing their research status and interactions,and for promoting biomedical developments.Originality/value:We chose the core keywords in three research hot topics in biomedicine by using h-index.
文摘Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers,especially specialists and scholars of the Asian Pacific region and worldwide on tropical biomedicine research,to prevent and control the prevalence of global tropical disease.
文摘Our world has demonstrated to he extremely vulnerable.Numerous humanitarian missions in developing countries have revealed the monstrous devastation caused by tropical diseases and malnutrition.Paradoxically,the people in charge of the political decisions always seem to be far from recognizing this situation when facing the monstrous dose of reality of the transmissible diseases that have predilection for the people in disadvantage.
基金Supported by Subproject of Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine(GXZYKF2019-7).
文摘Compared with traditional materials,metal-organic framework materials(MOFs)have the characteristics of drug release controllability,degradability,designability and adjustability of composition and structure,excellent load capacity,and designability and adjustability of channel shape and size,and have shown a wide range of application value in the field of biomedicine.In this paper,based on the structural characteristics of MOFs,the synthetic design of MOF materials was expounded,and the research achievements of MOF materials in biomedicine in recent years were reviewed.
文摘APJTB Monthly Aims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers,especially specialists and scholars of the Asian Pacific region and worldwide on tropical biomedicine research,to prevent and control the prevalence of global tropical disease.
文摘APJTB MonthlyAims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)is administrated by Hainan Medical University and sponsored by Asian Pacific Tropical Medicine Press,and aims to establish an international academic communicating platform for researchers of tropical biomedicine and public health workers,especially specialists and scholars of the
文摘APJTB MonthlyAims&Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)aims to set up and provide an international academic communication platform for physicians,medical scientists,allied health scientists and public health workers,especially those in the Asian Pacific region and worldwide on tropical biomedicine,infectious diseases and public health,and to meet the growing
文摘Aims & Scope Asian Pacific Journal of Tropical Biomedicine(APJTB)aims to set up and provide an international academic communication platform for physicians,medical scientists,allied health scientists and public health workers,especially those in the Asian Pacific region and worldwide on tropical biomedicine,infectious diseases and public health,and to meet the growing challenges of understanding,preventing and controUing the dramatic global emergence and reemergence of infectious diseases in the Asian Pacific region.
文摘Nowadays, nanomaterials have become an emerging field that has shown great promise in the development of novel diagnostic, imaging and therapeutic agents for a variety of diseases, including cancer, due to their nanoscale size effects and increased surface area. In comparison to their larger counterparts, nanomaterials have unique physicochemical and biological properties including size, shape, chemical composition, surface structure and charge, aggregation and agglomeration, and solubility which can affect their interactions with biomolecules and cells. Nanoparticles (NPs) with size-tunable light emission have demonstrated an impressive potential as high-efficiency delivery transporters for biomolecules into cells, being used to produce exceptional images of tumor sites. Moreover, NPs delivery system has been widely applied in pharmaceutical field to enhance absorption of bioactive compounds since they can interact with several phytochemicals by hydrogen bonds and hydrophobic interactions to encapsulate these phytochemicals in NPs and thus enhance aqueous solubility of the chemicals. Moreover, NPs also can prevent against oxidation/degradation of the phytochemicals encapsulated in the gastrointestinal tract and can be taken directly up by epithelial cells in the small intestine resulting in the increase of absorption and bioavailability of phytochemicals. In general, there are two specific fields of utilization of intrinsically active NPs as pharmacologic agents including oxidative-related pathologies and cancer. On the other hand, Redox active NPs have been shown to ameliorate many clinically relevant pathological disorders that implicate oxidative stress, reducing the oxidative burden and alleviating many important symptoms. Such NPs act either in a catalytic way resembling the action of antioxidant enzymes such as catalase and superoxide dismutase, or as activating surfaces to facilitate reactions between the aqueous environment and the reactive oxygen species present at high level in the pathological tissues.
基金supported in part by the National Natural Science Foundation of China(Nos.31971305 and 21905196)Fundamental Research Funds for the Central University(Nos.buctrc201915 and XK1802-8).
文摘Interfacial assembly has been intensively investigated in fabricating biomaterials and nanodevices for various applications.Recently,due to the precise sequence programmability,unique molecular recognition ability,and good biocompatibility,deoxyribonucleic acid(DNA)has been explored as superior building blocks to assemble at bio-interface for manipulating biological entities.To the best of our knowledge,the advances in this area have not been systematically summarized.To provide an overview of the area,in this review,the recently developed DNA assembly strategies on bio-interfaces were well summarized,and their representative works are exampled to illustrate how to rationally and elaborately design DNA molecules to realize functional integration and emerging of novel biological functionalities with high controllability and programmability.Furthermore,the biomedical applications of DNA assembly at bio-interface are categorially elaborated.The fascinating and unique advantages of DNA assembly systems are fully discussed in the exemplified applications to show the distinguished perspective of DNA in the future development.At the end of this review,the current limitations and challenges in applications and potential improvement strategies for DNA assembly at bio-interface are fully discussed.The future development direction is deliberated.We envision that this review will help scientists in the interdisciplinary fields gain a more comprehensive understanding of the DNA assembly at bio-interface,and therefore jointly promote the advances in this field.
基金supported by the Outstanding Youth Team Project of Central Universities(QNTD202308)the Ant Group through CCF-Ant Research Fund(CCF-AFSG 769498 RF20220214).
文摘Named Entity Recognition(NER)stands as a fundamental task within the field of biomedical text mining,aiming to extract specific types of entities such as genes,proteins,and diseases from complex biomedical texts and categorize them into predefined entity types.This process can provide basic support for the automatic construction of knowledge bases.In contrast to general texts,biomedical texts frequently contain numerous nested entities and local dependencies among these entities,presenting significant challenges to prevailing NER models.To address these issues,we propose a novel Chinese nested biomedical NER model based on RoBERTa and Global Pointer(RoBGP).Our model initially utilizes the RoBERTa-wwm-ext-large pretrained language model to dynamically generate word-level initial vectors.It then incorporates a Bidirectional Long Short-Term Memory network for capturing bidirectional semantic information,effectively addressing the issue of long-distance dependencies.Furthermore,the Global Pointer model is employed to comprehensively recognize all nested entities in the text.We conduct extensive experiments on the Chinese medical dataset CMeEE and the results demonstrate the superior performance of RoBGP over several baseline models.This research confirms the effectiveness of RoBGP in Chinese biomedical NER,providing reliable technical support for biomedical information extraction and knowledge base construction.
基金supported by the National Science and Technology Major Project(Grant No.2018ZX10301101)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA13010500)the CAS Pioneer Hundred Talents Program to JC。
文摘Human endogenous retroviruses(HERVs)were formed via ancient integration of exogenous retroviruses into the human genome and are considered to be viral“fossils”.The human genome is embedded with a considerable amount of HERVs,witnessing the long-term evolutionary history of the viruses and the host.Most HERVs have lost coding capability during selection but still function in terms of HERV-mediated regulation of host gene expression.In this review,we summarize the roles of HERV activation in response to viral infections and diseases,and emphasize the potential use of HERVs as biomedicine markers in the early diagnosis of diseases such as cancer,which provides a new perspective for the clinical application of HERVs.
