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Two new α,β-unsaturated butyrolactone derivatives from Pleione bulbocodioides 被引量:2
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作者 Xin Qiao Liu Wen Yuan Gao +2 位作者 Yuan Qiang Guo Tie Jun Zhang Lu Lu Yan 《Chinese Chemical Letters》 SCIE CAS CSCD 2007年第9期1075-1077,共3页
Two new α,β-unsaturated butyrolactone derivatives, 4-(4″-hydroxybenzyl)-3-(3′-hydroxy-phenethyl)furan-2(5H)-one (1) and 3-(3′-hydroxyphenethyl)furan-2(5H)-one (2), together with one known phenolic compound (3), w... Two new α,β-unsaturated butyrolactone derivatives, 4-(4″-hydroxybenzyl)-3-(3′-hydroxy-phenethyl)furan-2(5H)-one (1) and 3-(3′-hydroxyphenethyl)furan-2(5H)-one (2), together with one known phenolic compound (3), were isolated from the tubers of Pleione bulbocodioides (Franch.) Rolfe. Their structures were elucidated by analysis of spectroscopic data. 展开更多
关键词 Pleione bulbocodioides α β-Unsaturated butyrolactone Phenolic compound
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Structures and Antiviral Activities of Butyrolactone Derivatives Isolated from Aspergillus terreus MXH-23 被引量:2
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作者 MA Xinhua ZHU Tianjiao +3 位作者 GU Qianqun XI Rui WANG Wei LI Dehai 《Journal of Ocean University of China》 SCIE CAS 2014年第6期1067-1070,共4页
A new butyrolactone derivative,namely butyrolactone Ⅷ (1),and six known butyrolactones (2-7) were separated from the ethyl acetate (EtOAc) extract of the fermentation broth of a fungus,Aspergillus terreus MXH-2... A new butyrolactone derivative,namely butyrolactone Ⅷ (1),and six known butyrolactones (2-7) were separated from the ethyl acetate (EtOAc) extract of the fermentation broth of a fungus,Aspergillus terreus MXH-23.The chemical structures of these metabolites were identified by analyzing their nuclear magnetic resonance (NMR) and mass spectrometry (MS).Known butyrolactone derivatives contain an α,β-unsaturated γ-lactone ring with α-hydroxyl and y-benzyl,and butyrolactone Ⅷ (1) was the first butyrolactones contains α-benzyl and γ-hydroxyl on α,β-unsaturated lactone ring.All of the butyrolactone derivatives were tested for their anti-influenza (H 1N 1) effects.Derivatives 4 and 7 showed moderate antiviral activities while the newly-identified,derivative 1,did not. 展开更多
关键词 sponge-derived fungus secondary metabolite butyrolactone anti-influenza activity
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Synthesis and Characterization of Multi-block(β)±butyrolactone(BL)-ethylene Oxide(EO) Copolymer
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《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1998年第1期104-109,共6页
SynthesisandCharacterizationofMulti-block(β)±butyrolactone(BL)-ethyleneOxide(EO)CopolymerCHENXian-hai(NSFB... SynthesisandCharacterizationofMulti-block(β)±butyrolactone(BL)-ethyleneOxide(EO)CopolymerCHENXian-hai(NSFBiodegradablePolymer... 展开更多
关键词 EO OXIDE COPOLYMER butyrolactone ETHYLENE BL
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Synthesis of Z and E-(2',5'-dimethoxyphenyl)-methylene-butyrolactones
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作者 Yong Ying JIANG2 Zhi Yun LIN Li Ya ZHU1 (1Dept. Of medicinal chemistry, College of pharmacy, Rutgers University, Piscataway, NJ, U.S.A. Institute of Materia Medica, Peking Union Medical College and) Chinese Academy of Medical Sciences, Beijing 100050 《Chinese Chemical Letters》 SCIE CAS CSCD 2000年第2期109-110,共2页
A pair of Z and E isomers of cyclization of γ-ketoacid 7, which was prepared in six steps from 2,5-dimethoxyphenyl acetic acid 1, gave a pair of Z(20%) and E (4%) isomers of (2,5-dimethoxyphenyl)-methylene-butyrolact... A pair of Z and E isomers of cyclization of γ-ketoacid 7, which was prepared in six steps from 2,5-dimethoxyphenyl acetic acid 1, gave a pair of Z(20%) and E (4%) isomers of (2,5-dimethoxyphenyl)-methylene-butyrolactones 展开更多
关键词 butyrolactone γ-keto-acid LACTONIZATION ferric sulfate hydrate.
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Development of the SCNT Embryo from Butyrolactone Ⅰ Prematured Bovine Oocytes
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作者 Zhou Jia-bo Zhang Li +3 位作者 Cao Xiao-zhang Yue Kui-zhong Liu Di Yue Shun-li 《Journal of Northeast Agricultural University(English Edition)》 CAS 2012年第2期42-46,共5页
The somatic cell nuclear transfer (SCNT) technique has been applied successfully in a range of mammalian species giving rise to offspring, however, the efficiency of development to term has remained low. Oocyte meio... The somatic cell nuclear transfer (SCNT) technique has been applied successfully in a range of mammalian species giving rise to offspring, however, the efficiency of development to term has remained low. Oocyte meiotic arrest is an important option to make the SCNT more flexible and increase the number of cloned embryos produced. This paper showed that the use of butyrolactone I to arrest the meiotic division for 24 h prior to in vitro maturation (IVM) provided bovine oocytes capability of supporting development of blastocysts as efficiently as non arrested oocytes. In the SCNT group, cleavage rates were not affected by prematuration when adding butyrolactone I during IVM (57.9% vs. 62.4%; control vs. 10 μmol.L^-1 butyrolactone I), developmental rates to biastocyst were unaffected (22.0% vs. 20.3%; control vs. 10 μmol.L^-1 butyrolactone I, p〉0.05) by the addition ofbutyrolactone I during IVM in cloned embryos. Moreover, the total cell numbers of blastocyst were not affected by butyrolactone I (total nucleus numbers, 132±16.5 vs. 128±19.4, p〉0.05). In conclusion, the SCNT embryos from butyrolactone I- prematured bovine oocytes had the same developmental potential as the non treated one. The present study provided a method for laboratories of in vitro embryos production, mainly those working on the SCNT, where prematuration could be used to iiacrease the flexibility of the procedure. 展开更多
关键词 BOVINE OOCYTE prematuration butyrolactone I
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Conformational Analysis of γ-Butyrolactones by Nuclear Magnetic Resonance Spectroscopy
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作者 Fu An KANG and Cheng Lie YIN (Department of Chemistry Beijing Normal University , Beijing 100875) 《Chinese Chemical Letters》 SCIE CAS CSCD 1997年第10期885-888,共4页
A series of trans-4, 5-disubstituted -γ-butyrolactones are found to assume two different envelope conformations by means of nuclear magnetic resonance spectroscopy.
关键词 Conformational Analysis of butyrolactones by Nuclear Magnetic Resonance Spectroscopy
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Butyrolactones,inhibitors of 5-lipoxygenase from fungal metabolites 被引量:1
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作者 王福生 可爱兵 +8 位作者 朱京童 李业英 路新华 郑智慧 张华 马瑛 任晓 王亚婷 赵宝华 《Journal of Chinese Pharmaceutical Sciences》 CAS 2010年第4期251-255,共5页
In our ongoing search for new inhibitors of 5-lipoxygenase(5-LOX) from microbial resources,Aspergillus F06Z-509 was found to produce active components.Three active compounds named F06Z-509-A,B and C were obtained an... In our ongoing search for new inhibitors of 5-lipoxygenase(5-LOX) from microbial resources,Aspergillus F06Z-509 was found to produce active components.Three active compounds named F06Z-509-A,B and C were obtained and identified as butyrolactoneⅡ,ⅠandⅢby NMR and MS data analyses.They showed inhibitory activity against 5-LOX with IC50 of 21.43, 22.51 and 11.83μg/mL,respectively.Butyrolactones are shown to be inhibitors of 5-LOX for the first time. 展开更多
关键词 5-Lipoxygenase inhibitors butyrolactoneS Fungal metabolites
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1,6-Asymmetric induction: a higher enantioselective synthesis of γ-butyrolactone
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作者 DING Yu LI Ja-Yao WANG Lai-Xi 《Chinese Journal of Chemistry》 SCIE CAS CSCD 1991年第6期543-546,共0页
A novel 1,6-asymmetric induction has been observed in the iodolactonization of γ,δ-unsa- turated amides. The optically active γ-butyrolactone was synthesized by employing iodolactonization reaction as a key step.
关键词 a higher enantioselective synthesis of Asymmetric induction butyrolactone
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细胞周期蛋白依赖性激酶抑制剂 被引量:6
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作者 罗蕴 胡永洲 《中国现代应用药学》 CAS CSCD 北大核心 2003年第5期360-363,共4页
目的 系统介绍细胞周期蛋白依赖性激酶 (CDK)抑制剂的抗肿瘤作用。方法 对近几年国外有关CDK抑制剂的发现、构效研究及临床试验等文献进行检索和综述。结果 olomoucine,roscovitine等三取代嘌呤类化合物 ,flavopiridol及butyrolac t... 目的 系统介绍细胞周期蛋白依赖性激酶 (CDK)抑制剂的抗肿瘤作用。方法 对近几年国外有关CDK抑制剂的发现、构效研究及临床试验等文献进行检索和综述。结果 olomoucine,roscovitine等三取代嘌呤类化合物 ,flavopiridol及butyrolac tone三类化合物具有明显的CDK抑制活性 ,对多种人类肿瘤均有疗效 ,且不良反应小。结论 细胞周期蛋白依赖性激酶(CDK) 展开更多
关键词 细胞周期 细胞周期蛋白依赖性激酶抑制剂 肿瘤治疗olomoucine ROSCOVITINE FLAVOPIRIDOL butyrolactone
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Synthesis of Cyclopropylamine with Phase Transfer Catalysis
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作者 YI Jian-ming TANG Kuo-wen +1 位作者 REN Bi-ye XIONG Hai-ying 《Journal of Central South University》 SCIE EI CAS 2000年第2期81-83,共3页
Cyclopropylamine is synthesized with γ butyrolactone and isopropanol by five steps of ring opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation. Cyclization and hydrolysis are key steps ... Cyclopropylamine is synthesized with γ butyrolactone and isopropanol by five steps of ring opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation. Cyclization and hydrolysis are key steps in the process, and Phase Transfer Catalysis (PTC) is used in the two steps respectively. In the cyclization reaction, because solid liquid PTC, sodium hydroxide is applied instead of expensive sodium alcoholate, the reaction can be carried out in mild conditions. The optimum re action conditions are as follows: 0.03∶1∶1.5 mole ratio of BTEAC to ester to sodium hydroxide, reacting at 50 ℃ for 2 h with yield of 92%. Hydrolysis of isopropyl cyclopropanecarboxylate is accelerated by liquid liquid PTC, and the order of catalytic activity is BTEAC>BTMAC>CTMAB>TBAB. The results show that the new synthesis method is superior to those from literature and feasible for production with simple routes, mild reaction conditions, cheap materials and total yield of 52.6%. 展开更多
关键词 CYCLOPROPYLAMINE SYNTHESIS γ butyrolactone PHASE TRANSFER CATALYSIS
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