Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists ...Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the bowel.Although there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.展开更多
Most of the rich philosophical and scientific concepts which nurtured the Chinese thought we know today, were developed during the troubled final end of the era before ours, from V to II centuries. After reading reput...Most of the rich philosophical and scientific concepts which nurtured the Chinese thought we know today, were developed during the troubled final end of the era before ours, from V to II centuries. After reading reputed sinologists’ work on the cosmological origin and subsequent evolution of the Chinese concept of parallelism-pairing in poetry, literature, mathematic and other disciplines and since it is a tradition that all branches of knowledge in China are based on the development of those initiatory thoughts, the author asked herself if such knowing on the cosmological genesis of the parallelism concept could also be applied to Chinese medicine, science that describes its coupled structures and functions in pairs, simply based on yinyang, matrix of all pairings. Therefore, this paper proposes to apply those foundations, to explain the pairing of dynamisms in medicine. This work starts out from the oracular inscriptions in ancient times, cosmological basis of these ideas and their applications to Chinese literature and from there translates this approach to the study of the pairings described by Chinese medicine, and thanks to which (qi xue) blood-energy circulation occurs in human beings. Organic and functional pairs described by Chinese medicine are the basic element to understand the concept of health and disease, and this paper is about the cosmological roots of those pairings, the cosmic resonance influence and the numerology influence in them, and the whole is illustrated both through the description of the (obverse-reverse) biao li pair, different from (inside-outside) nei wai, and the functional relationship between these two couples.展开更多
文摘Pulmonary abnormalities,dysfunction or hyper-reactivity occurs in association with inflammatory bowel disease(IBD) more frequently than previously recognized.Emerging evidence suggests that subtle inflammation exists in the airways among IBD patients even in the absence of any bronchopulmonary symptoms,and with normal pulmonary functions. The pulmonary impairment is more pronounced in IBD patients with active disease than in those in remission. A growing number of case reports show that the IBD patients develop rapidly progressive respiratory symptoms after colectomy,with failure to isolate bacterial pathogens on repeated sputum culture,and often request oral corticosteroid therapy. All the above evidence indicates that the inflammatory changes in both the intestine and lung during IBD. Clinical or subclinical pulmonary inflammation accompanies the main inflammation of the bowel.Although there are clinical and epidemiological reports of chronic inflammation of the pulmonary and intestinal mucosa in IBD,the detailed mechanisms of pulmonaryintestinal crosstalk remain unknown. The lung has no anatomical connection with the main inflammatory site of the bowel. Why does the inflammatory process shift from the gastrointestinal tract to the airways? The clinical and subclinical pulmonary abnormalities,dysfunction,or hyper-reactivity among IBD patients need further evaluation. Here,we give an overview of the concordance between chronic inflammatory reactions in the airways and the gastrointestinal tract. A better understanding of the possible mechanism of the crosstalk among the distant organs will be beneficial in identifying therapeutic strategies for mucosal inflammatory diseases such as IBD and allergy.
文摘Most of the rich philosophical and scientific concepts which nurtured the Chinese thought we know today, were developed during the troubled final end of the era before ours, from V to II centuries. After reading reputed sinologists’ work on the cosmological origin and subsequent evolution of the Chinese concept of parallelism-pairing in poetry, literature, mathematic and other disciplines and since it is a tradition that all branches of knowledge in China are based on the development of those initiatory thoughts, the author asked herself if such knowing on the cosmological genesis of the parallelism concept could also be applied to Chinese medicine, science that describes its coupled structures and functions in pairs, simply based on yinyang, matrix of all pairings. Therefore, this paper proposes to apply those foundations, to explain the pairing of dynamisms in medicine. This work starts out from the oracular inscriptions in ancient times, cosmological basis of these ideas and their applications to Chinese literature and from there translates this approach to the study of the pairings described by Chinese medicine, and thanks to which (qi xue) blood-energy circulation occurs in human beings. Organic and functional pairs described by Chinese medicine are the basic element to understand the concept of health and disease, and this paper is about the cosmological roots of those pairings, the cosmic resonance influence and the numerology influence in them, and the whole is illustrated both through the description of the (obverse-reverse) biao li pair, different from (inside-outside) nei wai, and the functional relationship between these two couples.
