In this paper, a two level finite difference scheme of Crank-Nicholson type is constructed and used to numerically investigate nonlinear temperature distribution in biological tissues described by bioheat transfer equ...In this paper, a two level finite difference scheme of Crank-Nicholson type is constructed and used to numerically investigate nonlinear temperature distribution in biological tissues described by bioheat transfer equation of Pennes’ type. For the equation under consideration, the thermal conductivity is either depth-dependent or tem-perature-dependent, while blood perfusion is temperature-dependent. In both cases of depth- dependent and temperature-dependent thermal conductivity, it is shown that blood perfusion decreases the temperature of the living tissue. Our numerical simulations show that neither the localization nor the magnitude of peak tempera-ture is affected by surface temperature;however, the width of peak temperature increases with surface temperature.展开更多
This paper presents a 2D simulation of transient heat transfer in the human eye using appropriate boundary conditions.The mathematical model governing bioheat transfer in the human eye is discussed and the existence a...This paper presents a 2D simulation of transient heat transfer in the human eye using appropriate boundary conditions.The mathematical model governing bioheat transfer in the human eye is discussed and the existence and uniqueness of the solution are proven.Four methods based on finite element method and nonoverlapping domain decomposition method to obtain transient heat transfer in the human eye are presented and described in details.After conducting numerous simulations using realistic parameters obtained from the open literature and after comparison with measurements reported by previous experimental studies,all proposed methods gave an accurate representation of transient heat transfer in the human eye.The results obtained by the domain decomposition of the human eye into four subdomains are found to be the closest to reality.展开更多
Based on the Pennes’ bioheat transfer equation, a simplified one-dimensional bioheat transfer model of the cylindrical living tissues in the steady state has been set up for application in limb and whole body heat tr...Based on the Pennes’ bioheat transfer equation, a simplified one-dimensional bioheat transfer model of the cylindrical living tissues in the steady state has been set up for application in limb and whole body heat transfer studies, and by using the Bessel’s equation, its corresponding analytic solution has been derived in this paper. With the obtained analytic solution, the effects of the thermal conductivity, the blood perfusion, the metabolic heat generation, and the coefficient of heat transfer on the temperature distribution in living tissues are analyzed. The results show that the derived analytic solution is useful to easily and accurately study the thermal behavior of the biological system, and can be extended to such applications as parameter measurement, temperature field reconstruction and clinical treatment.展开更多
An algebraically explicit analytical solution with heat wave effect is derived for the non-Fourier bioheat transfer Chen-Holmes model. Besides its important theoreti-cal meaning (for example, to expand the understandi...An algebraically explicit analytical solution with heat wave effect is derived for the non-Fourier bioheat transfer Chen-Holmes model. Besides its important theoreti-cal meaning (for example, to expand the understanding of heat wave phenomena in living tissues), this analytical solu-tion is also valuable as the benchmark solution to check the numerical calculation and to develop various numerical computational approaches.展开更多
A basic bioheat transfer equation based upon porous medium model was derived by Wang et al. in 1993 to improve the Pennes equation in common use previously. A steady one-dimensional general analytical solution of this...A basic bioheat transfer equation based upon porous medium model was derived by Wang et al. in 1993 to improve the Pennes equation in common use previously. A steady one-dimensional general analytical solution of this new equation was given by Wang et al. later under the condition of constant coefficients and rectangular coordinates. This analytical solution compared well with experimental data. In order to expand the understanding of the new equation, an unsteady one-dimensional particular analytical solution展开更多
The aim of this study is to develop a model of fluid and heat transfer in a biological tissue taking into account the exact structure of the related microvascular network,and to analyze the influence of structural cha...The aim of this study is to develop a model of fluid and heat transfer in a biological tissue taking into account the exact structure of the related microvascular network,and to analyze the influence of structural changes of such a network induced by diabetes.A cubic region representing local skin tissue is selected as the computational domain,which in turn includes two intravascular and extravascular sub-domains.To save computational resources,the capillary network is reduced to a 1D pipeline model and embedded into the extravascular region.On the basis of the immersed boundary method(IBM)strategy,fluid and heat fluxes across a capillary wall are distributed to the surrounding tissue nodes by a delta function.We consider both steady and periodic blood pressure conditions at the entrances of the capillary network.Under steady blood pressure conditions,both the interstitial fluid pressure and tissue temperature around the capillary network are larger than those in other places.When the periodic blood pressure condition is considered,tissue temperature tends to fluctuate with the same frequency of the forcing,but the related waveform displays a smaller amplitude and a certain time(phase)delay.When the connectivity of capillary network is diminished,the capacity of blood redistribution through the capillary network becomes weaker and a subset of the vessel branches lose blood flow,which further aggravates the amplitude attenuation and time delay of the skin temperature fluctuation.展开更多
Analytically solving a three-dimensional （3-D） bioheat transfer problem with phase change during a freezing process is extremely difficult but theoretically important. The moving heat source model and the Green func...Analytically solving a three-dimensional （3-D） bioheat transfer problem with phase change during a freezing process is extremely difficult but theoretically important. The moving heat source model and the Green function method are introduced to deal with the cryopreservation process of in vitro biomaterials. Exact solutions for the 3-D temperature transients of tissues under various boundary conditions, such as totally convective cooling, totally fixed temperature cooling and a hybrid between them on tissue surfaces, are obtained. Furthermore, the cryosurgical process in living tissues subject to freezing by a single or multiple cryoprobes is also analytically solved. A closed-form analytical solution to the bioheat phase change process is derived by considering contributions from blood perfusion heat transfer, metabolic heat generation, and heat sink of a cryoprobe. The present method is expected to have significant value for analytically solving complex bioheat transfer problems with phase change.展开更多
文摘In this paper, a two level finite difference scheme of Crank-Nicholson type is constructed and used to numerically investigate nonlinear temperature distribution in biological tissues described by bioheat transfer equation of Pennes’ type. For the equation under consideration, the thermal conductivity is either depth-dependent or tem-perature-dependent, while blood perfusion is temperature-dependent. In both cases of depth- dependent and temperature-dependent thermal conductivity, it is shown that blood perfusion decreases the temperature of the living tissue. Our numerical simulations show that neither the localization nor the magnitude of peak tempera-ture is affected by surface temperature;however, the width of peak temperature increases with surface temperature.
文摘This paper presents a 2D simulation of transient heat transfer in the human eye using appropriate boundary conditions.The mathematical model governing bioheat transfer in the human eye is discussed and the existence and uniqueness of the solution are proven.Four methods based on finite element method and nonoverlapping domain decomposition method to obtain transient heat transfer in the human eye are presented and described in details.After conducting numerous simulations using realistic parameters obtained from the open literature and after comparison with measurements reported by previous experimental studies,all proposed methods gave an accurate representation of transient heat transfer in the human eye.The results obtained by the domain decomposition of the human eye into four subdomains are found to be the closest to reality.
文摘Based on the Pennes’ bioheat transfer equation, a simplified one-dimensional bioheat transfer model of the cylindrical living tissues in the steady state has been set up for application in limb and whole body heat transfer studies, and by using the Bessel’s equation, its corresponding analytic solution has been derived in this paper. With the obtained analytic solution, the effects of the thermal conductivity, the blood perfusion, the metabolic heat generation, and the coefficient of heat transfer on the temperature distribution in living tissues are analyzed. The results show that the derived analytic solution is useful to easily and accurately study the thermal behavior of the biological system, and can be extended to such applications as parameter measurement, temperature field reconstruction and clinical treatment.
基金This work was supported by the National Natural Science Foundation of China(Grant No.50246003 and its succeeding foundation)the Major State Basic Research Development Program of China(Grant No.G20000263).
文摘An algebraically explicit analytical solution with heat wave effect is derived for the non-Fourier bioheat transfer Chen-Holmes model. Besides its important theoreti-cal meaning (for example, to expand the understanding of heat wave phenomena in living tissues), this analytical solu-tion is also valuable as the benchmark solution to check the numerical calculation and to develop various numerical computational approaches.
基金Project supported by the National Natural Science Foundation of China.
文摘A basic bioheat transfer equation based upon porous medium model was derived by Wang et al. in 1993 to improve the Pennes equation in common use previously. A steady one-dimensional general analytical solution of this new equation was given by Wang et al. later under the condition of constant coefficients and rectangular coordinates. This analytical solution compared well with experimental data. In order to expand the understanding of the new equation, an unsteady one-dimensional particular analytical solution
基金This study was supported by National Natural Science Foundation of China(NSFC No.51576033)Dalian Innovative Funding of Science and Technology(2018J12SN076)NSFC No 11602053.
文摘The aim of this study is to develop a model of fluid and heat transfer in a biological tissue taking into account the exact structure of the related microvascular network,and to analyze the influence of structural changes of such a network induced by diabetes.A cubic region representing local skin tissue is selected as the computational domain,which in turn includes two intravascular and extravascular sub-domains.To save computational resources,the capillary network is reduced to a 1D pipeline model and embedded into the extravascular region.On the basis of the immersed boundary method(IBM)strategy,fluid and heat fluxes across a capillary wall are distributed to the surrounding tissue nodes by a delta function.We consider both steady and periodic blood pressure conditions at the entrances of the capillary network.Under steady blood pressure conditions,both the interstitial fluid pressure and tissue temperature around the capillary network are larger than those in other places.When the periodic blood pressure condition is considered,tissue temperature tends to fluctuate with the same frequency of the forcing,but the related waveform displays a smaller amplitude and a certain time(phase)delay.When the connectivity of capillary network is diminished,the capacity of blood redistribution through the capillary network becomes weaker and a subset of the vessel branches lose blood flow,which further aggravates the amplitude attenuation and time delay of the skin temperature fluctuation.
基金Project supported by the National Natural Science Foundation of China (No. 50776097)
文摘Analytically solving a three-dimensional （3-D） bioheat transfer problem with phase change during a freezing process is extremely difficult but theoretically important. The moving heat source model and the Green function method are introduced to deal with the cryopreservation process of in vitro biomaterials. Exact solutions for the 3-D temperature transients of tissues under various boundary conditions, such as totally convective cooling, totally fixed temperature cooling and a hybrid between them on tissue surfaces, are obtained. Furthermore, the cryosurgical process in living tissues subject to freezing by a single or multiple cryoprobes is also analytically solved. A closed-form analytical solution to the bioheat phase change process is derived by considering contributions from blood perfusion heat transfer, metabolic heat generation, and heat sink of a cryoprobe. The present method is expected to have significant value for analytically solving complex bioheat transfer problems with phase change.
