Background:In the management of patients with MARV infection,this review article focuses on the potential protective effects of black seeds(Nigella sativa).Methods:To find studies that evaluated various effects of bla...Background:In the management of patients with MARV infection,this review article focuses on the potential protective effects of black seeds(Nigella sativa).Methods:To find studies that evaluated various effects of black seeds(N.sativa)related to signs and symptoms of MARV infection,reference lists and databases such as Medline/Pubmed/PMC,Google Scholar,Science Direct,Ebsco,Scopus,Web of Science,and Embase were searched.Results:In numerous clinical,animal,in-vitro,in-vivo,and in-ovo studies,black seeds(N.sativa)have demonstrated potential antiviral,anti-inflammatory,antioxidant,immunomodulatory,and hepatoprotective properties that may aid in the treatment of MARV-infected patients.Conclusion:In the initial generalization phase of MARV infection,patients may use black seeds(N.sativa)as an adjunctive therapy in addition to symptomatic treatment and supportive care.Future randomized controlled clinical trials would confirm N.sativa’s efficacy and safety in MARV-infected patients.展开更多
Background:The patients with Langya henipavirus(LayV)infection are managed mainly with symptomatic treatment and supportive care.Objective:This review article focuses on the beneficial effects of black seeds(Nigella s...Background:The patients with Langya henipavirus(LayV)infection are managed mainly with symptomatic treatment and supportive care.Objective:This review article focuses on the beneficial effects of black seeds(Nigella sativa)in the management of Langya henipavirus(LayV)infection.Methods:The literature was searched in online databases,including Medline/Pubmed/PMC,Google Scholar,Science Direct,Ebsco,Scopus,Web of Science,Embase,and reference lists,to identify published studies,which established beneficial effects of black seeds(N.sativa)related to signs and symptoms of LayV infection.Results:Black seeds(N.sativa)have shown potential antiviral,bronchodilatory,antihistaminic,antitussive,hepatoprotective,renoprotective,anti-inflammatory,antioxidant,and immunomodulatory properties in various clinical,animal,in-vitro,in-vivo,and in-silico studies,which would help the patients with LayV infection.Conclusion:N.sativa would be a potential herbal candidate in the management of LayV infection along with symptomatic treatment and supportive care,to prevent further deterioration,and hospitalization.The safety and efficacy of N.sativa in patients with LayV infection would further be established by future randomized controlled clinical trials.展开更多
Black seed(Nigella sativa) is an annual flowering plant from Ranunculaceae family, native to southwest Asia. This plant has many food and medicinal uses. The use of its seeds and oil is common for treatment of many di...Black seed(Nigella sativa) is an annual flowering plant from Ranunculaceae family, native to southwest Asia. This plant has many food and medicinal uses. The use of its seeds and oil is common for treatment of many diseases, including rheumatoid arthritis, asthma, inflammatory diseases, diabetes and digestive diseases. The purpose of this study was to provide a comprehensive review on the scientific reports that have been published about N. sativa. The facts and statistics presented in this review article were gathered from the journals accessible in creditable databases such as Science Direct, Medline, Pub Med, Scopus, EBSCO, EMBASE, SID and Iran Medex. The keywords searched in Persian and English books on medicinal plants and traditional medicine, as well as the above reputable databases were "Black seed", "Nigella sativa", "therapeutic effect", and "medicinal plant". The results showed that N. sativa has many biological effects such as anti-inflammatory, anti-hyperlipidemic, anti-microbial, anti-cancer, anti-oxidant, anti-diabetic, anti-hypertensive, and wound healing activities. It also has effects on reproductive, digestive, immune and central nervous systems, such as anticonvulsant and analgesic activities. In summary, it can be used as a valuable plant for production of new drugs for treatment of many diseases.展开更多
Two experiments were conducted to determine the nitrogen-corrected apparent metabolizable energy(AMEn) of differently processed meals from Juncea(Brassica juncea), yellow and black seeded canola(Brassica napus), with ...Two experiments were conducted to determine the nitrogen-corrected apparent metabolizable energy(AMEn) of differently processed meals from Juncea(Brassica juncea), yellow and black seeded canola(Brassica napus), with or without supplementation of multi-carbohydrase enzymes(Enz) in diets for broiler chickens. The first experiment was a 3×2×2 factorial arrangement with the main factors being seed type(yellow [Yellow] or black [B1] canola seeds and Juncea seeds), processed at two temperatures(high temperature desolventized-toasted [HTDT] at 95℃ or low temperature desolventized-toasted[LTDT] at 57℃), with or without Enz. In Exp. 1, a total of 384 one-day-old male broiler chicks were randomly assigned to 64 battery cages, with 6 birds/cage. The second experiment was a 2×2×2 factorial arrangement with the main factors being seed type(Yellow or black [B2]), seed source(Scott,Saskatchewan or Truro, Nova Scotia) and Enz(with or without) supplementation. A total of 264 one-dayold male broiler chicks were randomly assigned to 44 battery cages, with 6 birds per cage. In Exp, 1 and 2,all birds were fed a common starter diet from 1 to 14 days of age. From d 15 to 21, the birds were fed one of the test treatments, a basal grower diet or the basal grower diet replaced with 30% test ingredient with celite(0.8%) added as an inert marker. Excreta was collected on d 20 and 21. In Exp. 1, there were no interactions(P > 0.05) among seed type, processing temperature and Enz. Processing temperature and dietary Enz did not affect(P > 0.05) AMEn of different canola meals. The AMEn of prepress solvent extracted canola and juncea meals(PSEM) from Yellow(11.2 MJ/kg) was higher(P < 0.05) than B1(10.2 MJ/kg) and Juncea(10.2 MJ/kg). In Exp. 2, there were no interactions(P > 0.05) among seed color,location and Enz. Supplementation of dietary Enz did not affect(P > 0.05) AMEn of different cold press canola meals. The AMEn of cold press canola meals(CPM) from Yellow(14.7 MJ/kg) was higher(P < 0.05)compared with B2(12.2 MJ/kg). In conclusion, among the different processing methods of oil extraction,meals derived from yellow seeded canola had higher AMEn than B seeded canola and Juncea.展开更多
Many different techniques may be used to remove industrial pollutants from wastewater. Adsorption using activated carbon has been reported to be an effective method. This work proposes the use of a vegetable residue(b...Many different techniques may be used to remove industrial pollutants from wastewater. Adsorption using activated carbon has been reported to be an effective method. This work proposes the use of a vegetable residue(black sapote seeds) as a raw material for its synthesis. These carbons were chemically activated using phosphoric acid and carbonized at 673 and 873 K. Adsorption isotherms were constructed for the textile dyes on the carbons, and this data was treated using Langmuir’s equation to quantitatively describe the adsorption process. The synthesized carbons were characterized using FTIR, EA, SEM, Nitrogen adsorption(specific surface areas of 879 and 652 m2·g-1), and their points of zero charge(2.1 and 2.3). It was possible to adsorb both heavy metals and textile dyes present in aqueous solutions and wastewaters using these activated carbons. Heavy metals were adsorbed almost completely by both carbons. Cationic dyes where adsorbed(58–59.8 mg·g-1) in greater amounts compared to anionic dyes(10–58.8 mg·g-1). The amount of anionic dyes adsorbed increased almost 30% by changing the pH of the solutions. One of the carbons was thermally regenerated on three occasions without losing its adsorption capacity and it was proved in a flow system.展开更多
Black locust (Robinia pseudoacacia L.) is one of the most important stand-forming tree species in Hungary and its importance is increasing in many countries. The main aim of the discussed new selection programme is to...Black locust (Robinia pseudoacacia L.) is one of the most important stand-forming tree species in Hungary and its importance is increasing in many countries. The main aim of the discussed new selection programme is to identify black locust clones with good performance and good form for setting up clonal seed orchards. As a result of selection programme 16 new black locust clones have been improved. In spring 2002 a black locust seed orchard was established with the newly selected clones. About 40% of the plants can be considered to belong to the height growth rate class 1 and 2. Hungary was the first country where micropropagated black locust planting material was used for seed orchard establishment.展开更多
Black cumin (Nigella sativa L.;Family-Ranunculaceae) is an important spice crop. Mature seeds are consumed for edible and medical purposes and also used as a food additive and flavour. Seed of black cumin has great po...Black cumin (Nigella sativa L.;Family-Ranunculaceae) is an important spice crop. Mature seeds are consumed for edible and medical purposes and also used as a food additive and flavour. Seed of black cumin has great potentiality as spice crop due to nutritive and medicinal values. The experiments were carried out at Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur during 2011 to 2012 to determine optimum planting time for seed production of black cumin. The experiment was two factorials. Factor A: 4 genotypes were V1: Exotic, Iran;V2: BARI kalozira-1;V3: Local, Faridpur and V4: Local, Natore. Factor B: sowing date: D1: 16 October;D2: 1 November;D3: 16 November and D4: 1 December. Therefore, treatment combinations were 16 in total. So, in 3 replications total plot was 48. Result revealed that significantly the highest 2.37 t/ha in V1, followed by V2 (1.96 t/ha). V2 and V3 (1.97 t/ha) were statistically similar and maximum yield was obtained from D2 (2.65 t/ha). In combined effect, maximum yield 3.00 t/ha was obtained in V1D2.. Investigation on time of sowing revealed that performance of black cumin was better in earlier sowings (16 October, 1 November) than later ones. The highest yield (4g plant-1;2.65 tha-1) was obtained when the crop was sown on 1 November. Among the genotypes, the exotic one with sowing in 1 November gave the highest seed yield (4.54 g·plant-1;3.00 t·ha-1).展开更多
The objective of this study was to investigate the correlations between antioxidations and the contents of the total phenolics and anthocyanin in 127 accessions of black soybean. A T-test, a fast clustering procedure,...The objective of this study was to investigate the correlations between antioxidations and the contents of the total phenolics and anthocyanin in 127 accessions of black soybean. A T-test, a fast clustering procedure, and a correlation coefficient analysis were used for experimentation. The variation ranges of the total antioxidant capacity (TAC), the total phenolics, and anthocyanin contents in 127 black soybean accessions were 0.44-3.56, 7.05-74.82, and 0.22-1.87 mg g-1, respectively, displaying significant genotype differences. The major differences in TAC, the total phenolics, and the anthocyanin contents existed among various types of accessions from geographical regions. The differences between the accessions from black and yellow soybeans, spring and autumn, summer and autumn, Dongbeichun and Nanfangchun, Dongbeichun and Nanfangxia, Beifangchun and Nanfangchun, and Beifangchun and Nanfangxia were significant at 0.01 or 0.05 levels, respectively. The general tendency was that the TAC, the total phenolics, and the anthocyanin contents of Beifangchun accessions were higher than that of Dongbeichun ones, while that of Nanfangchun accessions were the worst. 127 black soybean accessions could be clustered into 6 clusters, which consisted of 3, 24, 20, 31, 37, and 12 accessions, respectively. The most significant (P < 0.01) correlations existed respectively between the TAC and the total phenolics content, and the TAC and the anthocyanin content of black soybean. The results showed that the total phenolics and anthocyanin in black soybean seed coat were the important antioxidation substances.展开更多
Sesamum indicum has various biological effects,and this study aimed to investigate its hypolipidemic effect.A hyperlipidemia rat model was established by feeding rats with high-fat diets in this study,then the hyperli...Sesamum indicum has various biological effects,and this study aimed to investigate its hypolipidemic effect.A hyperlipidemia rat model was established by feeding rats with high-fat diets in this study,then the hyperlipidemia rats were fed with different doses of black and white sesame seeds and black and white sesame kernels.The serum and liver biochemical indicators of the rats were determined,and liver pathology analysis was conducted to evaluate the hypolipidemic effect of sesame.The results showed that the blood lipid of SD(Sprague-Dawley)rats fed with high-fat diet for three weeks was higher than 200 mg/d L,indicating that the hyperlipidemia rat model was successfully established.At the same dose,the final body weights of the rats of white sesame seed and kernel groups were higher than those of the black sesame seed and kernel groups;and the weights of the black and white sesame seed groups were lower than those of the black and white sesame kernel groups.The liver indexes of the normal control group and the experimental groups were significantly lower than the model control group(P<0.05),indicating that black and white sesame seed and kernel could reduce the lipid accumulation on the liver.The malondialdehyde(MDA)values of the liver in the normal control group and the experimental groups were significantly lower than that in the model control group(P<0.05).The total antioxidant capacity(T-AOC),high density lipoprotein cholesterol(HDL-C),glutathione peroxidase(GSH-Px)and total superoxide dismutase(T-SOD)in the liver of each experimental group were significantly higher than those in the model control group(P<0.05).Based on the above results as well as pathological observation and analysis,we found that the black and white sesame seeds and kernels could improve fatty liver lesions and lipid metabolism disorder and could reduce lipid accumulation on the liver,thereby protecting the liver from damage and reducing the risk of fatty liver.Moreover,black and white sesame seeds,black and white sesame kernels can reduce the levels of total cholesterol(TC)and triglyceride(TG)in serum,and high dose of black sesame seeds(30%black sesame seeds)and low dose of black sesame kernels(10%black sesame kernels)were more beneficial for the recovery of hyperlipidemia and fatty liver.The above results indicated that black and white sesame has hypolipidemic effect.展开更多
Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on ...Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.展开更多
文摘Background:In the management of patients with MARV infection,this review article focuses on the potential protective effects of black seeds(Nigella sativa).Methods:To find studies that evaluated various effects of black seeds(N.sativa)related to signs and symptoms of MARV infection,reference lists and databases such as Medline/Pubmed/PMC,Google Scholar,Science Direct,Ebsco,Scopus,Web of Science,and Embase were searched.Results:In numerous clinical,animal,in-vitro,in-vivo,and in-ovo studies,black seeds(N.sativa)have demonstrated potential antiviral,anti-inflammatory,antioxidant,immunomodulatory,and hepatoprotective properties that may aid in the treatment of MARV-infected patients.Conclusion:In the initial generalization phase of MARV infection,patients may use black seeds(N.sativa)as an adjunctive therapy in addition to symptomatic treatment and supportive care.Future randomized controlled clinical trials would confirm N.sativa’s efficacy and safety in MARV-infected patients.
文摘Background:The patients with Langya henipavirus(LayV)infection are managed mainly with symptomatic treatment and supportive care.Objective:This review article focuses on the beneficial effects of black seeds(Nigella sativa)in the management of Langya henipavirus(LayV)infection.Methods:The literature was searched in online databases,including Medline/Pubmed/PMC,Google Scholar,Science Direct,Ebsco,Scopus,Web of Science,Embase,and reference lists,to identify published studies,which established beneficial effects of black seeds(N.sativa)related to signs and symptoms of LayV infection.Results:Black seeds(N.sativa)have shown potential antiviral,bronchodilatory,antihistaminic,antitussive,hepatoprotective,renoprotective,anti-inflammatory,antioxidant,and immunomodulatory properties in various clinical,animal,in-vitro,in-vivo,and in-silico studies,which would help the patients with LayV infection.Conclusion:N.sativa would be a potential herbal candidate in the management of LayV infection along with symptomatic treatment and supportive care,to prevent further deterioration,and hospitalization.The safety and efficacy of N.sativa in patients with LayV infection would further be established by future randomized controlled clinical trials.
文摘Black seed(Nigella sativa) is an annual flowering plant from Ranunculaceae family, native to southwest Asia. This plant has many food and medicinal uses. The use of its seeds and oil is common for treatment of many diseases, including rheumatoid arthritis, asthma, inflammatory diseases, diabetes and digestive diseases. The purpose of this study was to provide a comprehensive review on the scientific reports that have been published about N. sativa. The facts and statistics presented in this review article were gathered from the journals accessible in creditable databases such as Science Direct, Medline, Pub Med, Scopus, EBSCO, EMBASE, SID and Iran Medex. The keywords searched in Persian and English books on medicinal plants and traditional medicine, as well as the above reputable databases were "Black seed", "Nigella sativa", "therapeutic effect", and "medicinal plant". The results showed that N. sativa has many biological effects such as anti-inflammatory, anti-hyperlipidemic, anti-microbial, anti-cancer, anti-oxidant, anti-diabetic, anti-hypertensive, and wound healing activities. It also has effects on reproductive, digestive, immune and central nervous systems, such as anticonvulsant and analgesic activities. In summary, it can be used as a valuable plant for production of new drugs for treatment of many diseases.
基金the Canola Council of Canada Project # 2.2.1Nova Scotia Technology Development Project # Dev26-008+1 种基金Poultry Industry Council Project #PIC 238Advancing Canadian Agriculture and Agri-Food (ACAAF) Project # NS0107 for funding support
文摘Two experiments were conducted to determine the nitrogen-corrected apparent metabolizable energy(AMEn) of differently processed meals from Juncea(Brassica juncea), yellow and black seeded canola(Brassica napus), with or without supplementation of multi-carbohydrase enzymes(Enz) in diets for broiler chickens. The first experiment was a 3×2×2 factorial arrangement with the main factors being seed type(yellow [Yellow] or black [B1] canola seeds and Juncea seeds), processed at two temperatures(high temperature desolventized-toasted [HTDT] at 95℃ or low temperature desolventized-toasted[LTDT] at 57℃), with or without Enz. In Exp. 1, a total of 384 one-day-old male broiler chicks were randomly assigned to 64 battery cages, with 6 birds/cage. The second experiment was a 2×2×2 factorial arrangement with the main factors being seed type(Yellow or black [B2]), seed source(Scott,Saskatchewan or Truro, Nova Scotia) and Enz(with or without) supplementation. A total of 264 one-dayold male broiler chicks were randomly assigned to 44 battery cages, with 6 birds per cage. In Exp, 1 and 2,all birds were fed a common starter diet from 1 to 14 days of age. From d 15 to 21, the birds were fed one of the test treatments, a basal grower diet or the basal grower diet replaced with 30% test ingredient with celite(0.8%) added as an inert marker. Excreta was collected on d 20 and 21. In Exp. 1, there were no interactions(P > 0.05) among seed type, processing temperature and Enz. Processing temperature and dietary Enz did not affect(P > 0.05) AMEn of different canola meals. The AMEn of prepress solvent extracted canola and juncea meals(PSEM) from Yellow(11.2 MJ/kg) was higher(P < 0.05) than B1(10.2 MJ/kg) and Juncea(10.2 MJ/kg). In Exp. 2, there were no interactions(P > 0.05) among seed color,location and Enz. Supplementation of dietary Enz did not affect(P > 0.05) AMEn of different cold press canola meals. The AMEn of cold press canola meals(CPM) from Yellow(14.7 MJ/kg) was higher(P < 0.05)compared with B2(12.2 MJ/kg). In conclusion, among the different processing methods of oil extraction,meals derived from yellow seeded canola had higher AMEn than B seeded canola and Juncea.
基金VIEP-BUAP,Mexico for their financial support during the development of the project PECA-ING-17-GCONACYT,Mexico for scholarship number 596493.
文摘Many different techniques may be used to remove industrial pollutants from wastewater. Adsorption using activated carbon has been reported to be an effective method. This work proposes the use of a vegetable residue(black sapote seeds) as a raw material for its synthesis. These carbons were chemically activated using phosphoric acid and carbonized at 673 and 873 K. Adsorption isotherms were constructed for the textile dyes on the carbons, and this data was treated using Langmuir’s equation to quantitatively describe the adsorption process. The synthesized carbons were characterized using FTIR, EA, SEM, Nitrogen adsorption(specific surface areas of 879 and 652 m2·g-1), and their points of zero charge(2.1 and 2.3). It was possible to adsorb both heavy metals and textile dyes present in aqueous solutions and wastewaters using these activated carbons. Heavy metals were adsorbed almost completely by both carbons. Cationic dyes where adsorbed(58–59.8 mg·g-1) in greater amounts compared to anionic dyes(10–58.8 mg·g-1). The amount of anionic dyes adsorbed increased almost 30% by changing the pH of the solutions. One of the carbons was thermally regenerated on three occasions without losing its adsorption capacity and it was proved in a flow system.
文摘Black locust (Robinia pseudoacacia L.) is one of the most important stand-forming tree species in Hungary and its importance is increasing in many countries. The main aim of the discussed new selection programme is to identify black locust clones with good performance and good form for setting up clonal seed orchards. As a result of selection programme 16 new black locust clones have been improved. In spring 2002 a black locust seed orchard was established with the newly selected clones. About 40% of the plants can be considered to belong to the height growth rate class 1 and 2. Hungary was the first country where micropropagated black locust planting material was used for seed orchard establishment.
文摘Black cumin (Nigella sativa L.;Family-Ranunculaceae) is an important spice crop. Mature seeds are consumed for edible and medical purposes and also used as a food additive and flavour. Seed of black cumin has great potentiality as spice crop due to nutritive and medicinal values. The experiments were carried out at Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur during 2011 to 2012 to determine optimum planting time for seed production of black cumin. The experiment was two factorials. Factor A: 4 genotypes were V1: Exotic, Iran;V2: BARI kalozira-1;V3: Local, Faridpur and V4: Local, Natore. Factor B: sowing date: D1: 16 October;D2: 1 November;D3: 16 November and D4: 1 December. Therefore, treatment combinations were 16 in total. So, in 3 replications total plot was 48. Result revealed that significantly the highest 2.37 t/ha in V1, followed by V2 (1.96 t/ha). V2 and V3 (1.97 t/ha) were statistically similar and maximum yield was obtained from D2 (2.65 t/ha). In combined effect, maximum yield 3.00 t/ha was obtained in V1D2.. Investigation on time of sowing revealed that performance of black cumin was better in earlier sowings (16 October, 1 November) than later ones. The highest yield (4g plant-1;2.65 tha-1) was obtained when the crop was sown on 1 November. Among the genotypes, the exotic one with sowing in 1 November gave the highest seed yield (4.54 g·plant-1;3.00 t·ha-1).
基金This work was supported by the National Natural Science Foundation of China （30200171）.
文摘The objective of this study was to investigate the correlations between antioxidations and the contents of the total phenolics and anthocyanin in 127 accessions of black soybean. A T-test, a fast clustering procedure, and a correlation coefficient analysis were used for experimentation. The variation ranges of the total antioxidant capacity (TAC), the total phenolics, and anthocyanin contents in 127 black soybean accessions were 0.44-3.56, 7.05-74.82, and 0.22-1.87 mg g-1, respectively, displaying significant genotype differences. The major differences in TAC, the total phenolics, and the anthocyanin contents existed among various types of accessions from geographical regions. The differences between the accessions from black and yellow soybeans, spring and autumn, summer and autumn, Dongbeichun and Nanfangchun, Dongbeichun and Nanfangxia, Beifangchun and Nanfangchun, and Beifangchun and Nanfangxia were significant at 0.01 or 0.05 levels, respectively. The general tendency was that the TAC, the total phenolics, and the anthocyanin contents of Beifangchun accessions were higher than that of Dongbeichun ones, while that of Nanfangchun accessions were the worst. 127 black soybean accessions could be clustered into 6 clusters, which consisted of 3, 24, 20, 31, 37, and 12 accessions, respectively. The most significant (P < 0.01) correlations existed respectively between the TAC and the total phenolics content, and the TAC and the anthocyanin content of black soybean. The results showed that the total phenolics and anthocyanin in black soybean seed coat were the important antioxidation substances.
基金supported by the Construction of Modern Agricultural Industrial Technology System(CARS14-1-29)。
文摘Sesamum indicum has various biological effects,and this study aimed to investigate its hypolipidemic effect.A hyperlipidemia rat model was established by feeding rats with high-fat diets in this study,then the hyperlipidemia rats were fed with different doses of black and white sesame seeds and black and white sesame kernels.The serum and liver biochemical indicators of the rats were determined,and liver pathology analysis was conducted to evaluate the hypolipidemic effect of sesame.The results showed that the blood lipid of SD(Sprague-Dawley)rats fed with high-fat diet for three weeks was higher than 200 mg/d L,indicating that the hyperlipidemia rat model was successfully established.At the same dose,the final body weights of the rats of white sesame seed and kernel groups were higher than those of the black sesame seed and kernel groups;and the weights of the black and white sesame seed groups were lower than those of the black and white sesame kernel groups.The liver indexes of the normal control group and the experimental groups were significantly lower than the model control group(P<0.05),indicating that black and white sesame seed and kernel could reduce the lipid accumulation on the liver.The malondialdehyde(MDA)values of the liver in the normal control group and the experimental groups were significantly lower than that in the model control group(P<0.05).The total antioxidant capacity(T-AOC),high density lipoprotein cholesterol(HDL-C),glutathione peroxidase(GSH-Px)and total superoxide dismutase(T-SOD)in the liver of each experimental group were significantly higher than those in the model control group(P<0.05).Based on the above results as well as pathological observation and analysis,we found that the black and white sesame seeds and kernels could improve fatty liver lesions and lipid metabolism disorder and could reduce lipid accumulation on the liver,thereby protecting the liver from damage and reducing the risk of fatty liver.Moreover,black and white sesame seeds,black and white sesame kernels can reduce the levels of total cholesterol(TC)and triglyceride(TG)in serum,and high dose of black sesame seeds(30%black sesame seeds)and low dose of black sesame kernels(10%black sesame kernels)were more beneficial for the recovery of hyperlipidemia and fatty liver.The above results indicated that black and white sesame has hypolipidemic effect.
文摘Nigella sativa L. (Black seed), is a traditional herbal medicine that has been used for many purposes. The present study was designed to investigate the effects of hydro-alcoholic extract of nigella sativa L. (NS) on performance of Forced Swimming Test (FST), blood biochemical parameters related to fatigue and thyroid functions. Therefore, Blood Urea Nitrogen (BUN), Creatine Kinase (CK), Lactic Dehydrogenase (LDH), and Total Protein (TP), triiodothyronine T3, thyroxin T4 and TSH tests were investigated. Thirty five male adult mice were randomly divided into five groups: three NS-fed groups, one fluoxetine treated group and one control group. Three NS experimental groups received hydro-alcoholic extract of NS at doses of 50, 100 and 200 mg/kg orally for two weeks. Immobility time decreased in all NS groups compared with control group. Administration of NS significantly increased the concentration of T3 and T4 of the treatment groups. On the contrary, the amount of BUN, CK, LDH, TP and TSH decreased. In conclusion, black seed extract at the experimented doses showed anti-depressant, anti-fatigue and hyperthyroid effects.
