Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages.However,high elastic modulus can cause stress shielding and lead to bone embrittlement...Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages.However,high elastic modulus can cause stress shielding and lead to bone embrittlement.This study used an electron beam melting method to prepare personalized porous Ti6Al4V(pTi)bone plates.Then,chemical vapor deposition(CVD)technology coats tantalum(Ta)metal on the pTi bone plates.The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone,and no stress shielding occurred.In vitro experiments showed that compared with pTi plates,Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold.To better evaluate the function of the Ta-coated bone plate,animal experiments were conducted using a coat tibia fracture model.Our results showed that the Ta-coated bone plate could effectively fix the fracture.Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation.Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone.Therefore,this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications.展开更多
Low shape matching and high stress shielding rates between bone plate and human bone are not conducive to the primary healing of fracture.In this study,taking the fracture site of the lower one‐third of human tibia a...Low shape matching and high stress shielding rates between bone plate and human bone are not conducive to the primary healing of fracture.In this study,taking the fracture site of the lower one‐third of human tibia as an application case,six types of personalised Ti6Al4V tibial plates with grooved surface were designed and evaluated by reverse en-gineering and finite element analysis.The results showed that the grooved design can reduce the stress shielding rate of bone plate and promote the facture healing.Among the six types of bone plates,the‘OUT-MI’bone plate has the lowest stress shielding rate and the most uniform stress distribution.Meanwhile,with the increasing tibial load during the convalescence,the average stress and maximum axial displacement of the tibial fracture surface increased,which can effectively improve the bone regeneration in the tibial fracture area.Moreover,there was no significant difference in four-point bending performance between the‘OUT-MI’bone plate and the‘STR-BE’bone plate,indicating that the mechanical properties of this bone plate were reliable.The results provide a theoretical basis for the design of fracture fixation plates on clinical treatment.展开更多
Fracture healing progress monitoring techniques attract global research attention due to the importance of selecting the timing of removing the fixation device.To this end,in this research,we present a piezoelectric-b...Fracture healing progress monitoring techniques attract global research attention due to the importance of selecting the timing of removing the fixation device.To this end,in this research,we present a piezoelectric-based smart internal fixation device,in which a piezoelectric sandwich structure is laminated to the surface of a bone plate.In the content,we explain the reasons for utilizing piezoelectric films,elaborate the mechanism of fracture monitoring,and introduce the mechanical parameters of the sensor.The simulation and experimental results show that the electrical output of the device is associated with the elastic modulus of the filler between the tested broken bones when the working load is maintained,indicating that the bone recovery progress could be successfully detected by the developed technique.展开更多
基金supported by the Dalian Science and Technology Innovation Fund Project(No.2018J11CY030).
文摘Metal plates have always been the gold standard in the clinic for internal fracture fixation due to their high strength advantages.However,high elastic modulus can cause stress shielding and lead to bone embrittlement.This study used an electron beam melting method to prepare personalized porous Ti6Al4V(pTi)bone plates.Then,chemical vapor deposition(CVD)technology coats tantalum(Ta)metal on the pTi bone plates.The prepared porous Ta-coated bone plate has an elastic modulus similar to cortical bone,and no stress shielding occurred.In vitro experiments showed that compared with pTi plates,Ta coating significantly enhances the attachment and proliferation of cells on the surface of the scaffold.To better evaluate the function of the Ta-coated bone plate,animal experiments were conducted using a coat tibia fracture model.Our results showed that the Ta-coated bone plate could effectively fix the fracture.Both imaging and histological analysis showed that the Ta-coated bone plate had prominent indirect binding of callus formation.Histological results showed that new bone grew at the interface and formed good osseointegration with the host bone.Therefore,this study provides an alternative to bio-functional Ta-coated bone plates with improved osseointegration and osteogenic functions for orthopaedic applications.
基金This work was supported by the Key R&D project of Sichuan Province(2018JY0552)National Natural Science Foundation of China(No.51,675,447).
文摘Low shape matching and high stress shielding rates between bone plate and human bone are not conducive to the primary healing of fracture.In this study,taking the fracture site of the lower one‐third of human tibia as an application case,six types of personalised Ti6Al4V tibial plates with grooved surface were designed and evaluated by reverse en-gineering and finite element analysis.The results showed that the grooved design can reduce the stress shielding rate of bone plate and promote the facture healing.Among the six types of bone plates,the‘OUT-MI’bone plate has the lowest stress shielding rate and the most uniform stress distribution.Meanwhile,with the increasing tibial load during the convalescence,the average stress and maximum axial displacement of the tibial fracture surface increased,which can effectively improve the bone regeneration in the tibial fracture area.Moreover,there was no significant difference in four-point bending performance between the‘OUT-MI’bone plate and the‘STR-BE’bone plate,indicating that the mechanical properties of this bone plate were reliable.The results provide a theoretical basis for the design of fracture fixation plates on clinical treatment.
基金the National Natural Science Foundation of China(Nos.61803017 and 61827802)in part funded by the Beihang University(Nos.KG12090401 and ZG216S19C8)。
文摘Fracture healing progress monitoring techniques attract global research attention due to the importance of selecting the timing of removing the fixation device.To this end,in this research,we present a piezoelectric-based smart internal fixation device,in which a piezoelectric sandwich structure is laminated to the surface of a bone plate.In the content,we explain the reasons for utilizing piezoelectric films,elaborate the mechanism of fracture monitoring,and introduce the mechanical parameters of the sensor.The simulation and experimental results show that the electrical output of the device is associated with the elastic modulus of the filler between the tested broken bones when the working load is maintained,indicating that the bone recovery progress could be successfully detected by the developed technique.
