Objective:To investigate the clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma.Methods: A total of 56 patients with acute attack of bronchial asthma who were treated in ...Objective:To investigate the clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma.Methods: A total of 56 patients with acute attack of bronchial asthma who were treated in our hospital between January 2015 and January 2018 were selected as the research subjects, and the therapies were reviewed and used to divide the patients into the control group (n=30) who received conventional inhalant therapy and the interferon group (n=26) who received interferon combined with inhalant therapy. Control group received salbutamol aerosol inhalation, and interferon group received interferon combined with salbutamol aerosol inhalation. The differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were compared between the two groups immediately after admission and after 48 h of treatment.Results:Immediately after admission, the differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were not statistically significant between the two groups of patients. After 48 h of treatment, serum inflammatory factors IL-8, IL-17, IL-18, IL-25, IL-27 and IL-33 levels of interferon group were lower than those of control group;airway remodeling indexes VEGF, MMP-9 and TIMP1 levels were lower than those of control group;immunoglobulins IgA, IgG and IgM levels were higher than those of control group whereas IgE level was lower than that of control group.Conclusion:interferon combined with inhalant therapy can effectively reduce systemic inflammatory response, inhibit airway remodeling and optimize humoral immune function in patients with acute attack of bronchial asthma.展开更多
OBJECTIVE: To observe the effects of Suhuang Zhike Capsules on lung function and peripheral blood eosinophil count (EOS) and exhaled nitric oxide (eNO) in patients with acute asthma attack.METHODS: A total of 80 patie...OBJECTIVE: To observe the effects of Suhuang Zhike Capsules on lung function and peripheral blood eosinophil count (EOS) and exhaled nitric oxide (eNO) in patients with acute asthma attack.METHODS: A total of 80 patients with acute exacerbation of bronchial asthma admitted to Huai'an Cancer Hospital from January 2017 to January 2018 were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was given conventional treatment with western medicine,and the observation group was given Suhuang Zhike Capsules on the basis of the treatment method of the control group.After 1 week of treatment,the improvement of individual symptoms (cough,wheezing,wheezing rale),lung function [1 second forced expiratory volume (FEV1),forced expiratory volume occupational capacity of vital capacity (FVC) in 1 second and peak expiratory flow (PEF)] and peripheral blood EOS and eNO levels and efficacy before and after the treatment were observed and assessed.RESULTS: The total effective rate of the observation group was 92.5%,which was significantly higher than the total effective rate of the control group (75.0%)(P < 0.05).The cough,wheezing and wheezing scores of the 2 groups were significantly decreased after treatment (P < 0.05).The scores of the above symptoms were significantly lower in the observation group than in the control group (P < 0.05).The FEV1,FVC and PEF were significantly increased after treatment (P < 0.05),and the above lung functions in the observation group were significantly higher than the control group (all P < 0.05).The EOS and eNO levels in the peripheral blood of the 2 groups were significantly decreased after treatment (P < 0.05),and the EOS and eNO levels in the peripheral blood in the observation group were significantly lower than those in the control group (P < 0.05).CONCLUSION: Suhuang Zhike Capsules can reduce the levels of EOS and eNO in peripheral blood of patients with acute asthma attack,improve the lung function of patients,relieve the clinical symptoms and improve the prognosis.展开更多
文摘Objective:To investigate the clinical effect of interferon combined with inhalant therapy for acute attack of bronchial asthma.Methods: A total of 56 patients with acute attack of bronchial asthma who were treated in our hospital between January 2015 and January 2018 were selected as the research subjects, and the therapies were reviewed and used to divide the patients into the control group (n=30) who received conventional inhalant therapy and the interferon group (n=26) who received interferon combined with inhalant therapy. Control group received salbutamol aerosol inhalation, and interferon group received interferon combined with salbutamol aerosol inhalation. The differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were compared between the two groups immediately after admission and after 48 h of treatment.Results:Immediately after admission, the differences in serum levels of inflammatory factors, airway remodeling indexes and immunoglobulins were not statistically significant between the two groups of patients. After 48 h of treatment, serum inflammatory factors IL-8, IL-17, IL-18, IL-25, IL-27 and IL-33 levels of interferon group were lower than those of control group;airway remodeling indexes VEGF, MMP-9 and TIMP1 levels were lower than those of control group;immunoglobulins IgA, IgG and IgM levels were higher than those of control group whereas IgE level was lower than that of control group.Conclusion:interferon combined with inhalant therapy can effectively reduce systemic inflammatory response, inhibit airway remodeling and optimize humoral immune function in patients with acute attack of bronchial asthma.
文摘OBJECTIVE: To observe the effects of Suhuang Zhike Capsules on lung function and peripheral blood eosinophil count (EOS) and exhaled nitric oxide (eNO) in patients with acute asthma attack.METHODS: A total of 80 patients with acute exacerbation of bronchial asthma admitted to Huai'an Cancer Hospital from January 2017 to January 2018 were randomly divided into an observation group and a control group,with 40 cases in each group.The control group was given conventional treatment with western medicine,and the observation group was given Suhuang Zhike Capsules on the basis of the treatment method of the control group.After 1 week of treatment,the improvement of individual symptoms (cough,wheezing,wheezing rale),lung function [1 second forced expiratory volume (FEV1),forced expiratory volume occupational capacity of vital capacity (FVC) in 1 second and peak expiratory flow (PEF)] and peripheral blood EOS and eNO levels and efficacy before and after the treatment were observed and assessed.RESULTS: The total effective rate of the observation group was 92.5%,which was significantly higher than the total effective rate of the control group (75.0%)(P < 0.05).The cough,wheezing and wheezing scores of the 2 groups were significantly decreased after treatment (P < 0.05).The scores of the above symptoms were significantly lower in the observation group than in the control group (P < 0.05).The FEV1,FVC and PEF were significantly increased after treatment (P < 0.05),and the above lung functions in the observation group were significantly higher than the control group (all P < 0.05).The EOS and eNO levels in the peripheral blood of the 2 groups were significantly decreased after treatment (P < 0.05),and the EOS and eNO levels in the peripheral blood in the observation group were significantly lower than those in the control group (P < 0.05).CONCLUSION: Suhuang Zhike Capsules can reduce the levels of EOS and eNO in peripheral blood of patients with acute asthma attack,improve the lung function of patients,relieve the clinical symptoms and improve the prognosis.
