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Antioxidant and lipoxygenase inhibitory properties of a novel flavonoid from Pistacia chinensis Bunge and its molecular docking analysis
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作者 Abdur Rauf Zuneera Akram +6 位作者 Naveed Muhammad Najla AlMasoud Taghrid Saad Alomar Saima Naz Abdul Wadood Chandni Hayat Marcello Iriti 《Traditional Medicine Research》 2025年第2期30-36,共7页
Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and diabetes.The study was conducted to investigate the antioxidant and ... Background:Pistacia chinensis Bunge has been traditionally used to manage various conditions,including asthma,pain,inflammation,hepatoprotection,and diabetes.The study was conducted to investigate the antioxidant and anti-lipoxygenase(LOX)properties of the isolated compound 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one from Pistacia chinensis.Methods:LOX assay and antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl(DPPH)assay were performed.Molecular docking studies were conducted using a molecular operating environment.Results:The LOX assay revealed significant inhibitory effects at 0.2µM concentration,with an IC50 value of 37.80µM.The antioxidant effect demonstrated dose-dependency across 5 to 100µg/mL concentrations,reaching 93.09%at 100µg/mL,comparable to ascorbic acid’s 95.43%effect.Molecular docking studies highlighted strong interactions with the lipoxygenase enzyme,presenting an excellent docking score of-10.98 kcal/mol.Conclusion:These findings provide valuable insights into Pistacia chinensis’chemical components and biological effects,reinforcing its traditional medicinal applications. 展开更多
关键词 Pistacia chinensis bunge ANTIOXIDANT DPPH assay antilipoxygenase docking analysis
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Mechanism prediction of Astragalus mongholicus Bunge and Angelica sinensis Diels in treating interstitial lung disease based on network pharmacology and molecular docking
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作者 Jun Du Jian Hao Wei Wei 《TMR药理学研究》 2023年4期1-9,共9页
Objective:To investigate the mechanism by which Astragalus mongholicus Bunge(AM),and Angelica sinensis Diels(AS)act in interstitial lung disease(ILD)based on computational prediction.Methods:We screened the ingredient... Objective:To investigate the mechanism by which Astragalus mongholicus Bunge(AM),and Angelica sinensis Diels(AS)act in interstitial lung disease(ILD)based on computational prediction.Methods:We screened the ingredients of AM and AS in PubMed,the Web of Science,China National Knowledge Infrastructure(CNKI)Databases,etc.Then obtained the potential effective components.By sharing the same molecular with ILD,we got the possible target genes for ILD treatment and constructed components–targets–disease network with Cytoscape software.The CTD(Comparative Toxicogenomics Database)database was used for GO and KEGG enrichment analysis of these target genes.Results:59 active ingredients that can be druggable were chosen from AM,67 active ingredients were chosen from AS.77 overlapping target genes for AM and ILD and 36 overlapping target genes for AS and ILD were acquired.The hub targets of AM were PTGS2,PTGS1,CDK2,MAOA,ESR1,TOP2A,GSK3B,ESR2,PPARG,NOS2,The hub targets of AS were PTGS2,GABRA1,PTGS1,CHRM1,SLC6A2,ADRA1B,ADRAIA,ADRB2,CHRM3,GABRA2,CHRM2.Quercetin,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,and 5-Hydroxycoumarin were the main active ingredients which have more effective targets.Prediction of the protein-protein interaction network showed PTGS2,GSK3B,PPARG,etc.,were the important predicted targets.The enriched KEGG pathways,including the Immune System,Metabolism of lipids and lipoproteins,Cytokine Signaling in the Immune system,Generic Transcription Pathway,The interleukin pathway,Metabolism of proteins,PI3K-Akt signaling pathway,Metabolic pathways,Innate Immune System,Neuroactive ligand-receptor interaction,Metabolism,GPCR downstream signaling,Amine ligand-binding receptors,Class A/1,Calcium signaling pathway.Molecular docking showed that quercetin,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,5-Hydroxycoumarin had good binding activities with PTGS2 and GSK3B,which mainly mediated PI3K/Akt and other important signaling pathways in the pathogenesis of ILD.Conclusion:The components in AS and AM share some common targets,such as PTGS2.AM and AS may ameliorate ILD through the PI3K-Akt signaling pathway which is mediated by GSK3B.PTGS2,PPARG may also be vital target genes in the treatment of ILD with AM and AS. 展开更多
关键词 Astragalus mongholicus bunge Angelica sinensis Diels computational prediction interstitial lung disease PI3K-Akt signaling pathways
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基于四种常用机器学习的梭梭(Haloxylon ammod-endron(C.A.Mey)Bunge)适宜生境分布研究
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作者 朱妮 郭彦龙 《生态科学》 CSCD 2023年第4期190-199,共10页
梭梭Haloxylon ammodendron (C.A.Mey) Bunge是适应中亚荒漠生境的耐寒、抗旱、耐盐碱C4植物,预测该物种地理分布范围以及未来不同气候变化情景下该物种适宜生境分布的变化,对于我国荒漠区生态环境保护具有重要意义。利用收集的梭梭分... 梭梭Haloxylon ammodendron (C.A.Mey) Bunge是适应中亚荒漠生境的耐寒、抗旱、耐盐碱C4植物,预测该物种地理分布范围以及未来不同气候变化情景下该物种适宜生境分布的变化,对于我国荒漠区生态环境保护具有重要意义。利用收集的梭梭分布数据与33个环境因子,基于四种常用的机器学习算法组成的组合模型对该物种适宜生境在我国西北干旱区的分布进行了预测。结果表明:(1)不同的模型算法的结果在空间上具有较高的一致性,但其分布细节具有一定的差异性。(2)梭梭在我国的适宜生境面积约为0.91×10^(6) km^(2),主要分布在新疆的准噶尔盆地和塔里木盆地边缘,甘肃河西走廊地区,内蒙古巴丹吉林、乌兰布和、腾格里沙漠和库布齐沙漠的西部,青海省柴达木盆地等地区。(3)未来气候变化对该物种适宜生境分布的影响取决于升温幅度,但是在大部分的增温情景中,该物种的适宜生境变化较小。(4)高适宜生境面积为0.19×10^(6) km^(2),应该作为梭梭原生产地保护以及人工种植的重点区域。(5)集成多模型结果的组合物种分布模型能够在一定程度上减少模型的不确定性,增加模型的精度。在环境条件限制性较高的干旱区,加入土壤因素能够有效提高物种分布模型的建模科学性和合理性。 展开更多
关键词 梭梭(Haloxylon ammodendron(C.A.Mey)bunge 物种分布 机器学习 组合模型 荒漠物种
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Enrichment of nervonic acid in Acer truncatum Bunge oil by combination of two-stage molecular distillation,one-stage urea complexation and five-stage solvent crystallization
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作者 Yingxi Gao Jiayi Shi +4 位作者 Jie Wang Fan Zhang Shichao Tian Zhiyong Zhou Zhongqi Ren 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第7期61-71,共11页
Nervonic acid is the world’s first and only potent substance that can repair damaged nerve fibers and promote nerve cell regeneration with high nutritional value.The wide variety of fatty acids in plant oils and fats... Nervonic acid is the world’s first and only potent substance that can repair damaged nerve fibers and promote nerve cell regeneration with high nutritional value.The wide variety of fatty acids in plant oils and fats with similar structures makes the large-scale separation and purification of high-purity nervonic acid very difficult.A new combined process of molecular distillation,urea inclusion and solvent crystallization was established to prepare high-purity nervonic acid with the mixed fatty acids obtained after saponification and acidification of Acer truncatum Bunge oil as raw materials.First,according to the difference in the mean free path of fatty acids,molecular distillation was used to separate and remove C16 saturated fatty acid of palmitic acid and four C18-C20 fatty acids of stearic,oleic,linoleic,and linolenic acids.The content of C16-C20 fatty acids decreased from 72.92% to 19.22% after two-stage molecular distillation processes,in which the contents of saturated fatty acid of palmitic acid decreased to about 0.5%.Then,according to the difference in carbon chain length and saturation of fatty acid,the contents of C22-C24 saturated fatty acids of tetracosanoic and docosanoic acids decreased to 0.21% and 0.07% by urea inclusion with urea/free fatty acid preparation by saponification(SPOMFs)ratio as 0.6.In addition,all saturated fatty acids were basically separated.Finally,according to the difference in the solubility of fatty acids in solvents,the C18-C20 unsaturated fatty acids of oleic,linoleic,and linolenic acids and C22 unsaturated fatty acid of erucic acid were removed by solvent crystallization.The content of C18-C20 unsaturated fatty acids decreased to less than 5% with pentanol as the solvent after the first stage solvent crystallization.The content of erucic acid decreased to 3.47% with anhydrous ethanol as the solvent after the second to fifth stage solvent crystallization.The combined process of molecular distillation,urea inclusion and low temperature crystallization innovatively adopted an efficient,simple and easy-toindustrial solvent crystallization method to separate erucic and nervonic acids,obtaining nervonic acid with purity of 96.53% and final yield of 47.99%. 展开更多
关键词 Nervonic acid Acer truncatum bunge Molecular distillation Urea complexation Solvent crystallization
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Mechanism prediction of Astragalus mongholicus Bunge and Angelica sinensis Diels in treating interstitial lung disease based on network pharmacology and molecular docking
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作者 Jun Du Jian Hao Wei Wei 《TMR Pharmacology Research》 2023年第4期1-9,共9页
Objective:To investigate the mechanism by which Astragalus mongholicus Bunge(AM),and Angelica sinensis Diels(AS)act in interstitial lung disease(ILD)based on computational prediction.Methods:We screened the ingredient... Objective:To investigate the mechanism by which Astragalus mongholicus Bunge(AM),and Angelica sinensis Diels(AS)act in interstitial lung disease(ILD)based on computational prediction.Methods:We screened the ingredients of AM and AS in PubMed,the Web of Science,China National Knowledge Infrastructure(CNKI)Databases,etc.Then obtained the potential effective components.By sharing the same molecular with ILD,we got the possible target genes for ILD treatment and constructed components–targets–disease network with Cytoscape software.The CTD(Comparative Toxicogenomics Database)database was used for GO and KEGG enrichment analysis of these target genes.Results:59 active ingredients that can be druggable were chosen from AM,67 active ingredients were chosen from AS.77 overlapping target genes for AM and ILD and 36 overlapping target genes for AS and ILD were acquired.The hub targets of AM were PTGS2,PTGS1,CDK2,MAOA,ESR1,TOP2A,GSK3B,ESR2,PPARG,NOS2,The hub targets of AS were PTGS2,GABRA1,PTGS1,CHRM1,SLC6A2,ADRA1B,ADRAIA,ADRB2,CHRM3,GABRA2,CHRM2.Quercetin,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,and 5-Hydroxycoumarin were the main active ingredients which have more effective targets.Prediction of the protein-protein interaction network showed PTGS2,GSK3B,PPARG,etc.,were the important predicted targets.The enriched KEGG pathways,including the Immune System,Metabolism of lipids and lipoproteins,Cytokine Signaling in the Immune system,Generic Transcription Pathway,The interleukin pathway,Metabolism of proteins,PI3K-Akt signaling pathway,Metabolic pathways,Innate Immune System,Neuroactive ligand-receptor interaction,Metabolism,GPCR downstream signaling,Amine ligand-binding receptors,Class A/1,Calcium signaling pathway.Molecular docking showed that quercetin,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,5-Hydroxycoumarin had good binding activities with PTGS2 and GSK3B,which mainly mediated PI3K/Akt and other important signaling pathways in the pathogenesis of ILD.Conclusion:The components in AS and AM share some common targets,such as PTGS2.AM and AS may ameliorate ILD through the PI3K-Akt signaling pathway which is mediated by GSK3B.PTGS2,PPARG may also be vital target genes in the treatment of ILD with AM and AS. 展开更多
关键词 Astragalus mongholicus bunge Angelica sinensis Diels computational prediction interstitial lung disease PI3K-Akt signaling pathways
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Study on Pollinating Insects of Astragalus membranaceus (Ficsh) Bunge 被引量:4
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作者 张建 杨发君 +2 位作者 刘顺 郭爽 任跃英 《Agricultural Science & Technology》 CAS 2010年第2期27-30,共4页
[Objective The aim was to study species and pollinating characters of Astragalus membranaceus(Ficsh)Bunge pollinating insects and lay a theory foundation for the breeding of Astragalus membranaceus(Ficsh)Bunge.[Method... [Objective The aim was to study species and pollinating characters of Astragalus membranaceus(Ficsh)Bunge pollinating insects and lay a theory foundation for the breeding of Astragalus membranaceus(Ficsh)Bunge.[Method] With Astragalus membranaceus(Ficsh)Bunge as research object,the species of pollinating insect and pollination behavior were investigated.[Result] There were 16 pollinating insect species,among which,Bombus ignitus,Bombus lucoru,Apis sp.,Betasyrphus serarius(wiedemann)and Colias erate(Esper)we... 展开更多
关键词 Astragalus membranaceus(Ficsh)bunge Pollinating insects Flower-visiting behavior Flower-visiting frequency
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Study on Tissue Culture and Effective Clone Establishment of Hemistepta lyrata Bunge 被引量:3
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作者 张文 郭晓丹 +2 位作者 王艳 徐娜 姜长阳 《Agricultural Science & Technology》 CAS 2009年第1期47-50,104,共5页
[Objective] The research aimed to study the rapid propagation technology and establish effective clone of Hemistepta lyrata Bunge. [Method] With tender stem of Hemistepta lyrata Bunge as material, the conditions neede... [Objective] The research aimed to study the rapid propagation technology and establish effective clone of Hemistepta lyrata Bunge. [Method] With tender stem of Hemistepta lyrata Bunge as material, the conditions needed in calluses induction and differentiation, adventitious bud differentiation and radication, test tube seedling cutting and transplantation were studied. [ Result] The results showed that the optimum medium for granulated calluses induction from tender stem was MS + BA 0.3 mg/L +2,4-D 1 -1.5 mg/L, for granulated calluses and adventitious bud differentiation was MS + AgNO31.5 mg/L + BA 0.4 mg/L + NAA 0.1 mg/L. 1/2 MS + IAA 0.6 mg/L was suitable for test tube seedling rooting and regeneration, and cinder was used as transplantation and cutting substrate. [ Conclusion]This study will provide the scientific reference for choosing the feasible medium in tissue culture of Hemistepta lyrata Bunge. 展开更多
关键词 Hemistepta lyrata bunge Calluses CLONE Rapid propagation
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Studies on Triterpenoid Saponins of Seeds of Aesculus chinensis Bunge var. chekiangensis (Hu et Fang) Fang 被引量:2
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作者 郭杰 杨秀伟 《Journal of Chinese Pharmaceutical Sciences》 CAS 2004年第2期87-91,共5页
Aim To study the saponin constituents of the seeds of Aesculus chinensis Bunge var. chekiangensis (Hu et Fang) Fang. Methods Compounds were separated and purified by macroreticular resin column chromatography and high... Aim To study the saponin constituents of the seeds of Aesculus chinensis Bunge var. chekiangensis (Hu et Fang) Fang. Methods Compounds were separated and purified by macroreticular resin column chromatography and high-performance liquid chromatography. Their structures were elucidated by spectroscopic and hydrolysis analysis. Results Six compounds were isolated from the 70% ethanolic extracts. They were identified as escins IVc, IVd, Ia, Ib, isoescins Ia and Ib, respectively. Conclusion The above compounds were obtained from the seeds of Aesculus chinensis Bunge var.chekiangensis (Hu et Fang) Fang for the first time. 展开更多
关键词 Aesculus chinensis bunge var. chekiangensis TRITERPENOIDS ESCIN isoescin
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Effects of Salt Stress on Root Vitality of Limonium bicolor (Bunge) Kuntze 被引量:2
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作者 林莺 范海 《Agricultural Science & Technology》 CAS 2013年第6期832-834,910,共4页
[Objective] This study aimed to investigate the effects of different salt concentrations on the root vitality of Limonium bicolor (Bunge) Kuntze. [Method] Limonium bicolor (Bunge) Kuntze was treated with 0, 100, 2... [Objective] This study aimed to investigate the effects of different salt concentrations on the root vitality of Limonium bicolor (Bunge) Kuntze. [Method] Limonium bicolor (Bunge) Kuntze was treated with 0, 100, 200 and 400 mmol/L NaCl, respectively. After two weeks, root vitality, biomass and other physiological indicators were measured. [Result] Salt stress had significant influences on the growth of roots. Root vitality of Limonium bicolor increased firstly and reduced gradually with the increase of salt concentration. [Conclusion] The results indicate that Limonium bicolor has certain salt tolerance ability at low salt concentrations; under relatively high salt concentrations, Limonium bicolor roots can maintain high vitality; however, with the continuous increase of salt concentration, Limonium bicolor roots are damaged, with decreasing vitality. 展开更多
关键词 Limonium bicolor bunge) Kuntze Salt stress Root vitality
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Acute Toxicity of Oxytropis Kansuensis Bunge on Rats
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作者 赵剑喜 刘晔玮 +3 位作者 李丽 黄新异 柳军玺 邸多隆 《Plant Diseases and Pests》 CAS 2011年第5期59-60,64,共3页
[ Objective] The paper was to study the acute toxicity of Oxytropis Kansuensis Bunge on rats. [ Method ] Forty rats were randomly divided into two gToups: control group (distilled water) and trial group (water ext... [ Objective] The paper was to study the acute toxicity of Oxytropis Kansuensis Bunge on rats. [ Method ] Forty rats were randomly divided into two gToups: control group (distilled water) and trial group (water extract of 0. Kansuens/s) to carry out the acute toxicity experiment. The trial group was supplied with the maximum dose (6.0 g/ml,0.8 ml/20 g) twice per day for continuous 7 d. [Result] The maximal tolerance dose of rats to water extract of O. Kansuens/s was more than 480 g/kg. Feeding rats with O. Kansuens/s would not lead to the death of rats within short time (7 d) and no obvious macroscopic pathological changes in the viscera of rats could be seen in naked eyes. [Condusion] The study provided theoretical basis for full use of O. Kansuens/s resources. 展开更多
关键词 Oxytropis Kansuensis bunge Acute toxicity Maximum tolerated dose China
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Discovery of Triploid Allium macrostemon Bunge in Laizhou City of Shandong Province
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作者 王爱云 王艳化 +1 位作者 任晓莉 张琳丰 《Agricultural Science & Technology》 CAS 2009年第1期124-126,共3页
[Objective]The study was to analyze the karyotype of Allium macrostemon Bunge in Laizhou City of Shandong Province.[ Method] The root tip of A. macrostemon was pretreated with 8-hydroxyquinoline solution, fixed, disso... [Objective]The study was to analyze the karyotype of Allium macrostemon Bunge in Laizhou City of Shandong Province.[ Method] The root tip of A. macrostemon was pretreated with 8-hydroxyquinoline solution, fixed, dissociated and stained for preparing the glass slide to reveal the chromosome number via the microscopic examination; the sparse cells with good chromosome morphology were photographed under microscope. [ Result ]Allium macrostemon Bunge in Laizhou City introduced in this study was tdploid; its somatic chromosome number was 24 and karyotype formula was K(2n) =3x=24m(2SAT) + 1Bs, thus the karyotype belongs to 1A type. One of the chromosome No. 3 contained satellite, and chromosome deletion may be existed in one of the chromosome No. 5. In addition, B chromosome was observed in some cells.[ Conclusion] This introduction of triploid A. macrostemon found in China was the first time. 展开更多
关键词 Allium macrostemon bunge Karyotype analysis TRIPLOID
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Dynamic of Root Dry Weight of Salvia miltiorrhiza Bunge
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作者 刘红云 韩卫省 +1 位作者 梁宗锁 朱庆松 《Agricultural Science & Technology》 CAS 2013年第7期979-981,1004,共4页
ObjectiveThis study was to investigate the dynamic of root dry weight of Salvia miltiorrhiza to provide a basis for optimal management in field cultivation. MethodThe Salvia miltiorrhiza Bunge seedlings were transplan... ObjectiveThis study was to investigate the dynamic of root dry weight of Salvia miltiorrhiza to provide a basis for optimal management in field cultivation. MethodThe Salvia miltiorrhiza Bunge seedlings were transplanted at three different dates November 26, 2009 (T 1 ), March 9, 2010(T 2 ) and March 27, 2010(T 3 ), and at three different densities 20 cm × 25 cm (D 1 ), 25 cm × 25 cm (D 2 ), 25 cm × 30 cm (D 3 ). So a total of nine treatments were finally set. The samples were collected regularly for measuring the root dry weight and plotting the dynamic curves. Normalized root weight was fitted with CURVE EXPERT 1.3. ResultLogistic equation was the most superior equation, and estimated respectively two inflection points and length of fast growing time of S. miltiorrhiza. ConclusionThe fast-growing time of S. miltiorrhiza root was in 1 900 ℃·d to 2 200 ℃·d GDD. 展开更多
关键词 Salvia miltiorrhiza bunge Root dry weight GDD Curve fitting
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Pesticidal character of phytoecdysteroids from Ajuga multiflora Bunge (Labiatae) on larvae of Cryptorrhynchus lapathi L. (Coleoptera: Curculionidae)
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作者 迟德富 孙明学 夏文富 《Journal of Forestry Research》 SCIE CAS CSCD 2002年第3期177-182,250,共6页
Eight kinds of phytoecdysteroids extracted from different parts of Ajuga multiflora Bunge (Labiatae) that were collected from different places at different time were tested for killing effects on the 2-instar larvae o... Eight kinds of phytoecdysteroids extracted from different parts of Ajuga multiflora Bunge (Labiatae) that were collected from different places at different time were tested for killing effects on the 2-instar larvae of Cryptorrhynchus lapathi L by adding them to the artificial diet of larvae. The experimental results indicated that adding 1-3-mL phytoecdysteroids to the artificial diet could lead 58%-100% of 2-instar larvae of C. lapathi to death within 24 days. The phytoecdysteroids extracted from the whole plant of A. multiflora which was collected before flowering time were much more effective than those extracted from the plants collected at flowering and after flowering periods, and the modified mortality rate of larvae reached 65.22%, 85.07%, and 98.11% at the dosage level of 1-mL, 2-mL, and 3-mL extracts, respectively. The extract made from root of A. multiflora plant was more effective in killing efficiency than those from stem and leaves, and the average death rates of larvae were up to 100%, 98.20% and 98.32% at dosage levels of 1-mL, 2-mL, and 3-mL extracts, respectively. The killing speed of the extracted phytoecdysteroids was slower than that of triflumuron, hexaflumuron or deltamethrin emulsifiable concentrate. The mortality rate of larvae is closely related to the feeding duration on the diets containing phytoecdysteroids. Feeding on the diets with addition of phytoecdysteroids for 16 days, more than 80% of treated 2-instar larvae of C. lapathi were led to death. The killing effect of the extracts was little affected by the growth areas of A. multiflora plant and the adding way to artificial diet. 展开更多
关键词 Ajuga multifora bunge Cryptorrhynchus lapathi L. Larva Phytoecdysteroid
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Cardioprotective effects of Salvia miltiorrhiza Bunge and Lignum dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury
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《中国药理学通报》 CAS CSCD 北大核心 2015年第B11期168-169,共2页
Aim Salvia miltiorrhiza Bunge (SM) and lignum dalbergiae odoriferae (DO) are both traditional Chi- nese medicine that have cardioprotective effects. Here, we further examined the combined effects of SM and DO on r... Aim Salvia miltiorrhiza Bunge (SM) and lignum dalbergiae odoriferae (DO) are both traditional Chi- nese medicine that have cardioprotective effects. Here, we further examined the combined effects of SM and DO on rat myocardial ischemia/reperfusion injury. The possible mechanism of SM and DO also were elucidated. Methods DO was divided into aqueous extract of lignum dalbergiae odoriferae (DOW) and lignum dalbergiae odoriferae oil (DOO). Sprague-Dawley rats were randomized to seven groups: sham group, model group, treatment groups inclu- ding SM (10 g · kg^-1), DOW (5 g · kg^-1), DOO (0.5 ml · kg^-1), SM + DOW (10 g · kg^-1 + 5 g · kg^-1), SM + DOO ( 10 g · kg^-1 + 0. 5 ml · kg^-1). Rats were pretreated with homologous drug for 7 days and then subjec- ted to 30 rain of ischemia followed by 180 rain of reperfusion. Electrocardiogram (ECG) and heart rate were moni- tored and recorded continuously. At the end of reperfusion, blood samples were collected to determine the serum levels of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH). Hearts were harvested to assess heart- body rate, infarct size and histopathological changes as well. Maximum and minimum effective points were deter- mined by measuring indicators associate with myocardial injury at different time-points of reperfusion (Smin, 15min, 30min, 45rain, 60min, 120min, 180min). The potential therapeutic mechanism of SM and SM + DOO were carried out by detecting superoxide dismutase (SOD), malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6). Results The results showed SM and DO can ameliorate cardiac function respectively, and this cardioprotective effect was further strengthened by their combinations. Among all the combi- nations, SM + DOO showed predominant potential to improve ECG and heart rate, reduce heart-body rate (28.5% + 1.4% , P 〈 0.01 vs model) and myocardial infarct size ( 20.96% + 1.61% , P 〈 0.01 vs model, P 〈 0.05 vs SM) , attenuate histopathological damage, decrease the levels of CK-MB and LDH (P 〈 0.01 vs model, P 〈 0.05 vs SM). The maximum effective points of SM and SM + DOO were 15min and 30rain respectively, and the minimum effective points of them were 180rain. In reducing serum level of MDA, TNF-alpha, IL-6 and increasing SOD activ- ity, SM + DOO was similar to SM. Conclusion The results of this study indicated that SM + DOO have combined effects that are highly effective than single pretreatment against myocardial ischemie reperfusion injury in rats. The possible mechanism of SM and DO were likely through its anti-oxidant and anti-inflammatory properties, and thus may be an effective and promising medicine for both prophylaxis and treatment of ischemic heart disease. 展开更多
关键词 Keywords:myocardialischemia/reperfusioninjury Salviamiltiorrhizabunge Lignumdalbergiaeodoriferae the MYOCARDIAL ISCHEMIA/REPERFUSION INJURY SALVIA miltiorrhiza bungE Lignum dalbergiae odoriferae themaximum and minimum effective points ANTI-OXIDANT anti-inflammatory
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梭梭(Haloxylon ammodendron(C.A.Mey.)Bunge)物候期的观察 被引量:22
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作者 盛晋华 刘宏义 +3 位作者 潘多智 杨晓军 翟志席 郭玉海 《中国农业科技导报》 CAS CSCD 2003年第3期60-63,共4页
梭梭是我国西北荒漠半荒漠地区的珍稀植物。通过对生长在内蒙古自治区阿拉善盟的天然梭梭林连续三年的观察测定 ,将其物候期划分为萌动期、营养枝扩展期、开花期、果实成熟期和营养枝脱落期五个主要物候期。对各个时期梭梭的形态特征进... 梭梭是我国西北荒漠半荒漠地区的珍稀植物。通过对生长在内蒙古自治区阿拉善盟的天然梭梭林连续三年的观察测定 ,将其物候期划分为萌动期、营养枝扩展期、开花期、果实成熟期和营养枝脱落期五个主要物候期。对各个时期梭梭的形态特征进行了较为详尽的描述 。 展开更多
关键词 梭梭 西北地区 荒漠半荒漠地区 物侯期 萌动期 营养枝扩展期 开花期 果实成熟期 脱落期 生物学特性 生态适应性
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梭梭(Haloxylon ammodend rom(C.A.Mey)Bunge)光合枝细胞组织学观察及其抗逆性特征 被引量:23
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作者 董占元 姚云峰 +1 位作者 赵金仁 贾志成 《干旱区资源与环境》 CSSCI CSCD 2000年第S1期78-83,共6页
通过细胞组织学解剖方法 ,观察研究梭梭幼嫩光合枝显微结构的抗逆性特征 ,并结合 H2 O2 酶活性的测定 ,得出梭梭光合枝显微结构中有 3点与相关文献报道不同。 1是具有一层海棉组织 ,富含叶绿体 ,细胞体积相对较小 ,为不规则圆球状细胞层... 通过细胞组织学解剖方法 ,观察研究梭梭幼嫩光合枝显微结构的抗逆性特征 ,并结合 H2 O2 酶活性的测定 ,得出梭梭光合枝显微结构中有 3点与相关文献报道不同。 1是具有一层海棉组织 ,富含叶绿体 ,细胞体积相对较小 ,为不规则圆球状细胞层 ;2是退化的鳞片状叶表皮层下仍有一层细胞体积小 ,圆形 ,具有明显的细胞核 ,无叶绿体 ,排列紧密的细胞层 ;3是栅栏组织细胞具泌盐的功能 ,并有发育较好的盐结晶存在于细胞之间 ,显示出较强的抗逆特征。 展开更多
关键词 梭梭 光合枝 显微结构
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Studies of Chemical Constituents and Their Antioxidant Activities From Astragalus mongholicus Bunge 被引量:23
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作者 DE-HONG YU YONG-MING BAO CHAO-LIANG WEI, LI-JIA AN 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2005年第5期297-301,共5页
To evaluate the antioxidant activities of different chemical constituents from Astragalus mongholicus Bunge and their protection against xanthine (XA)/xanthine oxidase (XO)-induced toxicity in PC12 cells. Methods ... To evaluate the antioxidant activities of different chemical constituents from Astragalus mongholicus Bunge and their protection against xanthine (XA)/xanthine oxidase (XO)-induced toxicity in PC12 cells. Methods The compounds of Astragalus mongholicus Bunge were isolated by chromatography and the structures were elucidated on the basis of spectral data interpretation. Their antioxidant activities were detected by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities in a cell-free system. Meanwhile, the effects against XA/XO-induced toxicity were assessed using MTT assay in PC12 cells. Results Ten principal constituents were isolated and identified as formononetin (Ⅰ), ononin (Ⅱ), calycosin (Ⅲ), calycosin-7-O-β-D-glucoside (Ⅳ), 9,10-dimethoxypterocarpan-3-O-β-D-glucoside (Ⅴ), adenosine (Ⅵ), pinitol (Ⅶ), daucosterol (Ⅷ), β-sitoster (Ⅸ) and saccharose (Ⅹ) from Astragalus mongholicus Bunge. The compounds Ⅰ, Ⅲ, and Ⅳ scavenged DPPH free radicals in vitro. Formononetin and calycosin were found to inhibit XA/XO-induced cell injury significantly, with an estimated EC50 of 50 ng/mL. Conclusion Compound Ⅲ, Ⅵ, and Ⅶ are first reported in this plant. Calycosin exhibits the most potent antioxidant activity both in the cell-free system and in the cell system. 展开更多
关键词 Astragalus mongholicus bunge Constituents ANTIOXIDANT PC12 TOXICITY
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Evaluation of biodiesel from Xanthoceras sorbifolia Bunge seed kernel oil from 13 areas in China 被引量:7
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作者 Zhan Shen Kaiquan Zhang +2 位作者 Yan Ao Luyi Ma Jie Duan 《Journal of Forestry Research》 SCIE CAS CSCD 2019年第3期869-877,共9页
Oil content from seed kernels of Xanthoceras sorbifolia from 13 areas in China was analyzed by gas chromatography–mass spectrometry to determine oil characteristics and biodiesel properties. The seeds had a high kern... Oil content from seed kernels of Xanthoceras sorbifolia from 13 areas in China was analyzed by gas chromatography–mass spectrometry to determine oil characteristics and biodiesel properties. The seeds had a high kernel percentage (53.67%± 7.51), oil content (52.21%± 4.01), and biodiesel yield (99.77%± 0.21). Among the fatty acids in the oil were high percentages of linoleic acid (41.66 ± 2.26)% and oleic acid (28.44%± 2.03). Most of the fuel properties complied well with the ASTM D6751-10, EN 14214-08, and GB/T 20828-2014 standards. The 13 sampling areas were grouped into four clusters based on different kernel percentage, oil content, biodiesel yield, and fatty acid composition. The results showed that the quality of kernel oils from seeds from Ar Horqin Banner was the best, although kernel oils from seeds in all 13 areas were suitable for biodiesel production. This study provides a basis for selecting optimal sites to harvest seeds from X. sorbifolia. 展开更多
关键词 Xanthoceras sorbifolia bungE BIODIESEL FATTY ACID COMPOSITION FUEL properties
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采用BSLB(Brine Shrimp Letality Bioassay)法对元宝枫 (Acer truncatum Bunge .)及同属植物活性部位的筛选(英文) 被引量:3
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作者 魏希颖 吕居娴 +1 位作者 李映丽 贺浪冲 《天然产物研究与开发》 CAS CSCD 2004年第4期317-319,共3页
本文通过BSLB法对元宝枫及同属植物不同部位的水提物进行了活性试验 ,得知 :元宝枫的幼技、种皮的水提物具一定的生物致死活性 ;同属植物青榨槭叶和种子 ,秦岭槭、杈叶槭果翅的水提物也具一定的生物致死活性。
关键词 元宝枫 生物致死活性 肿瘤细胞 水提物
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葱属植物挥发油研究——1 中药薤白(Allium macrostemon Bunge)挥发油成分的研究 被引量:19
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作者 吴雁 彭军鹏 +1 位作者 姚利强 姚新生 《沈阳药学院学报》 CSCD 1993年第1期45-46,62,共3页
首次用GC-MS-联用方法对薤白挥发油成分进行了分析,鉴定了21种化合物,其中19种为含硫化合物。主要成分为二甲基三硫,甲基丙基三硫,甲基丙基二硫和丙基异丙基二硫;并含有对血小板聚集有强烈抑制作用的甲基烯丙基三硫。
关键词 薤白 挥发油 含硫化合物
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