Primary thrombocytopenic purpura is ahemorrhagic disease induced by rapid de-struction of blood platelets throughautoimmunity. The authors treated 10 casesof the disease with modified MinorDecoction of Bupleurum with ...Primary thrombocytopenic purpura is ahemorrhagic disease induced by rapid de-struction of blood platelets throughautoimmunity. The authors treated 10 casesof the disease with modified MinorDecoction of Bupleurum with good resultsas reported in the following:展开更多
Objective:To explore the mechanism of Bupleurum on fever by means of network pharmacology,and to provide ideas for further experimental study.Methods:The effective components and targets of Xiaochaihu Decoction and Bu...Objective:To explore the mechanism of Bupleurum on fever by means of network pharmacology,and to provide ideas for further experimental study.Methods:The effective components and targets of Xiaochaihu Decoction and Bupleurum were extracted by searching TCM systematic pharmacology database(TCMSP),and got to the effective components and targets of Xiaochaihu Decoction.By searching GeneCards database,disGeNET database,OMIM database and symmap database to extract the disease target of fever.And the"protein interaction network"was constructed with the protein interaction relationship in HINT database as the background network,and the GO enrichment analysis and KEGG pathway enrichment analysis were carried out on the targets by using R software and DAVID database.Results:726 kinds of effective components of Xiaochaihu Decoction were obtained from TCMSP database,including 215 kinds of effective components of Bupleurum,677 targets of Xiaochaihu Decoction and 516 targets of Bupleurum.A total of 7305 fever-related genes were obtained from the disease database,and 400 key targets of Bupleurum for fever treatment were obtained by mapping drug targets and disease targets GAPDH,AKT1,INS,IL-6 and VEGFA,are the targets with high node connectivity in PPI network.The results of GO enrichment of key targets by R software are cofactor binding and coenzyme binding.KEGG enrichment pathway of key targets involves infection,cancer,immune system diseases and so on.Conclusion:This study preliminarily verified the effect and mechanism of Bupleurum on fever,and provided reference for further study.展开更多
Minor bupleurum decoction is one of the classic prescriptions of traditional Chinese medicine,and it has obvious effects in the treatment of various diseases.In recent years,the application of minor bupleurum decoctio...Minor bupleurum decoction is one of the classic prescriptions of traditional Chinese medicine,and it has obvious effects in the treatment of various diseases.In recent years,the application of minor bupleurum decoction in the treatment of cancer has attracted more and more attention.This paper describes the mechanism of the role of minor bupleurum decoction in the treatment of clinical tumors and the interaction of related treatments by introducing the composition of minor bupleurum decoction and their pharmacological effects.展开更多
Minor Bupleurum Decoction is a common TCM compound and a classic prescription that can best reflect the"harmonizing method',of TCM.But there are many differences on the usage and dosage of Minor Bupleurum Dec...Minor Bupleurum Decoction is a common TCM compound and a classic prescription that can best reflect the"harmonizing method',of TCM.But there are many differences on the usage and dosage of Minor Bupleurum Decoction.Combined with the clinical treatment experience,this paper summarizes the experience of Minor Bupleurum Decoction in the clinical treatment of diseases.It is hoped that relevant suggestions can be provided for clinicians to improve the clinical therapeutic effect of Minor Bupleurum Decoction.展开更多
目的:观察柴胡桂枝干姜汤治疗上热下寒型失眠的临床疗效。方法:选择2023年4—10月安阳市中医院脑病三科门诊诊治的100例上热下寒型失眠患者,按照随机数字表法分为对照组和试验组,每组各50例。对照组给予艾司唑仑片治疗,试验组给予柴胡...目的:观察柴胡桂枝干姜汤治疗上热下寒型失眠的临床疗效。方法:选择2023年4—10月安阳市中医院脑病三科门诊诊治的100例上热下寒型失眠患者,按照随机数字表法分为对照组和试验组,每组各50例。对照组给予艾司唑仑片治疗,试验组给予柴胡桂枝干姜汤加减治疗。比较两组患者的临床疗效、不良反应积分及治疗前后中医证候积分、匹兹堡睡眠治疗指数、世界卫生组织生存质量测定量表简表(the world health organization quality of life scale,WHOQOL-BREF)积分变化情况。结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后试验组低于对照组(P<0.05)。试验组有效率为92.0%,高于对照组的86.0%,差异有统计学意义(P<0.05)。两组患者治疗后匹兹堡睡眠指数低于本组治疗前,且治疗后试验组低于对照组(P<0.05)。两组患者治疗后WHOQOL-BREF评分高于本组治疗前,且治疗后试验组高于对照组(P<0.05)。对照组不良反应积分为(2.72±0.73)分,试验组不良反应积分为(0.60±0.67)分,差异具有统计学意义(P<0.05)。结论:柴胡桂枝干姜汤加减治疗上热下寒型失眠临床疗效确切,可改善患者的临床症状,提高睡眠质量及生活质量。展开更多
文摘Primary thrombocytopenic purpura is ahemorrhagic disease induced by rapid de-struction of blood platelets throughautoimmunity. The authors treated 10 casesof the disease with modified MinorDecoction of Bupleurum with good resultsas reported in the following:
基金National Natural Science Foundation of China(No.81603518)Department of Science and Technology of Shaanxi Province(No.2018ZDXM-SF-008)Xi'an Science and Technology Bureau(No.201805103YX11SF37)。
文摘Objective:To explore the mechanism of Bupleurum on fever by means of network pharmacology,and to provide ideas for further experimental study.Methods:The effective components and targets of Xiaochaihu Decoction and Bupleurum were extracted by searching TCM systematic pharmacology database(TCMSP),and got to the effective components and targets of Xiaochaihu Decoction.By searching GeneCards database,disGeNET database,OMIM database and symmap database to extract the disease target of fever.And the"protein interaction network"was constructed with the protein interaction relationship in HINT database as the background network,and the GO enrichment analysis and KEGG pathway enrichment analysis were carried out on the targets by using R software and DAVID database.Results:726 kinds of effective components of Xiaochaihu Decoction were obtained from TCMSP database,including 215 kinds of effective components of Bupleurum,677 targets of Xiaochaihu Decoction and 516 targets of Bupleurum.A total of 7305 fever-related genes were obtained from the disease database,and 400 key targets of Bupleurum for fever treatment were obtained by mapping drug targets and disease targets GAPDH,AKT1,INS,IL-6 and VEGFA,are the targets with high node connectivity in PPI network.The results of GO enrichment of key targets by R software are cofactor binding and coenzyme binding.KEGG enrichment pathway of key targets involves infection,cancer,immune system diseases and so on.Conclusion:This study preliminarily verified the effect and mechanism of Bupleurum on fever,and provided reference for further study.
文摘Minor bupleurum decoction is one of the classic prescriptions of traditional Chinese medicine,and it has obvious effects in the treatment of various diseases.In recent years,the application of minor bupleurum decoction in the treatment of cancer has attracted more and more attention.This paper describes the mechanism of the role of minor bupleurum decoction in the treatment of clinical tumors and the interaction of related treatments by introducing the composition of minor bupleurum decoction and their pharmacological effects.
文摘Minor Bupleurum Decoction is a common TCM compound and a classic prescription that can best reflect the"harmonizing method',of TCM.But there are many differences on the usage and dosage of Minor Bupleurum Decoction.Combined with the clinical treatment experience,this paper summarizes the experience of Minor Bupleurum Decoction in the clinical treatment of diseases.It is hoped that relevant suggestions can be provided for clinicians to improve the clinical therapeutic effect of Minor Bupleurum Decoction.
文摘目的:观察柴胡桂枝干姜汤治疗上热下寒型失眠的临床疗效。方法:选择2023年4—10月安阳市中医院脑病三科门诊诊治的100例上热下寒型失眠患者,按照随机数字表法分为对照组和试验组,每组各50例。对照组给予艾司唑仑片治疗,试验组给予柴胡桂枝干姜汤加减治疗。比较两组患者的临床疗效、不良反应积分及治疗前后中医证候积分、匹兹堡睡眠治疗指数、世界卫生组织生存质量测定量表简表(the world health organization quality of life scale,WHOQOL-BREF)积分变化情况。结果:两组患者治疗后中医证候积分低于本组治疗前,且治疗后试验组低于对照组(P<0.05)。试验组有效率为92.0%,高于对照组的86.0%,差异有统计学意义(P<0.05)。两组患者治疗后匹兹堡睡眠指数低于本组治疗前,且治疗后试验组低于对照组(P<0.05)。两组患者治疗后WHOQOL-BREF评分高于本组治疗前,且治疗后试验组高于对照组(P<0.05)。对照组不良反应积分为(2.72±0.73)分,试验组不良反应积分为(0.60±0.67)分,差异具有统计学意义(P<0.05)。结论:柴胡桂枝干姜汤加减治疗上热下寒型失眠临床疗效确切,可改善患者的临床症状,提高睡眠质量及生活质量。
