Primary thrombocytopenic purpura is ahemorrhagic disease induced by rapid de-struction of blood platelets throughautoimmunity. The authors treated 10 casesof the disease with modified MinorDecoction of Bupleurum with ...Primary thrombocytopenic purpura is ahemorrhagic disease induced by rapid de-struction of blood platelets throughautoimmunity. The authors treated 10 casesof the disease with modified MinorDecoction of Bupleurum with good resultsas reported in the following:展开更多
Objective:To explore the mechanism of Bupleurum on fever by means of network pharmacology,and to provide ideas for further experimental study.Methods:The effective components and targets of Xiaochaihu Decoction and Bu...Objective:To explore the mechanism of Bupleurum on fever by means of network pharmacology,and to provide ideas for further experimental study.Methods:The effective components and targets of Xiaochaihu Decoction and Bupleurum were extracted by searching TCM systematic pharmacology database(TCMSP),and got to the effective components and targets of Xiaochaihu Decoction.By searching GeneCards database,disGeNET database,OMIM database and symmap database to extract the disease target of fever.And the"protein interaction network"was constructed with the protein interaction relationship in HINT database as the background network,and the GO enrichment analysis and KEGG pathway enrichment analysis were carried out on the targets by using R software and DAVID database.Results:726 kinds of effective components of Xiaochaihu Decoction were obtained from TCMSP database,including 215 kinds of effective components of Bupleurum,677 targets of Xiaochaihu Decoction and 516 targets of Bupleurum.A total of 7305 fever-related genes were obtained from the disease database,and 400 key targets of Bupleurum for fever treatment were obtained by mapping drug targets and disease targets GAPDH,AKT1,INS,IL-6 and VEGFA,are the targets with high node connectivity in PPI network.The results of GO enrichment of key targets by R software are cofactor binding and coenzyme binding.KEGG enrichment pathway of key targets involves infection,cancer,immune system diseases and so on.Conclusion:This study preliminarily verified the effect and mechanism of Bupleurum on fever,and provided reference for further study.展开更多
Minor bupleurum decoction is one of the classic prescriptions of traditional Chinese medicine,and it has obvious effects in the treatment of various diseases.In recent years,the application of minor bupleurum decoctio...Minor bupleurum decoction is one of the classic prescriptions of traditional Chinese medicine,and it has obvious effects in the treatment of various diseases.In recent years,the application of minor bupleurum decoction in the treatment of cancer has attracted more and more attention.This paper describes the mechanism of the role of minor bupleurum decoction in the treatment of clinical tumors and the interaction of related treatments by introducing the composition of minor bupleurum decoction and their pharmacological effects.展开更多
Minor Bupleurum Decoction is a common TCM compound and a classic prescription that can best reflect the"harmonizing method',of TCM.But there are many differences on the usage and dosage of Minor Bupleurum Dec...Minor Bupleurum Decoction is a common TCM compound and a classic prescription that can best reflect the"harmonizing method',of TCM.But there are many differences on the usage and dosage of Minor Bupleurum Decoction.Combined with the clinical treatment experience,this paper summarizes the experience of Minor Bupleurum Decoction in the clinical treatment of diseases.It is hoped that relevant suggestions can be provided for clinicians to improve the clinical therapeutic effect of Minor Bupleurum Decoction.展开更多
文摘Primary thrombocytopenic purpura is ahemorrhagic disease induced by rapid de-struction of blood platelets throughautoimmunity. The authors treated 10 casesof the disease with modified MinorDecoction of Bupleurum with good resultsas reported in the following:
基金National Natural Science Foundation of China(No.81603518)Department of Science and Technology of Shaanxi Province(No.2018ZDXM-SF-008)Xi'an Science and Technology Bureau(No.201805103YX11SF37)。
文摘Objective:To explore the mechanism of Bupleurum on fever by means of network pharmacology,and to provide ideas for further experimental study.Methods:The effective components and targets of Xiaochaihu Decoction and Bupleurum were extracted by searching TCM systematic pharmacology database(TCMSP),and got to the effective components and targets of Xiaochaihu Decoction.By searching GeneCards database,disGeNET database,OMIM database and symmap database to extract the disease target of fever.And the"protein interaction network"was constructed with the protein interaction relationship in HINT database as the background network,and the GO enrichment analysis and KEGG pathway enrichment analysis were carried out on the targets by using R software and DAVID database.Results:726 kinds of effective components of Xiaochaihu Decoction were obtained from TCMSP database,including 215 kinds of effective components of Bupleurum,677 targets of Xiaochaihu Decoction and 516 targets of Bupleurum.A total of 7305 fever-related genes were obtained from the disease database,and 400 key targets of Bupleurum for fever treatment were obtained by mapping drug targets and disease targets GAPDH,AKT1,INS,IL-6 and VEGFA,are the targets with high node connectivity in PPI network.The results of GO enrichment of key targets by R software are cofactor binding and coenzyme binding.KEGG enrichment pathway of key targets involves infection,cancer,immune system diseases and so on.Conclusion:This study preliminarily verified the effect and mechanism of Bupleurum on fever,and provided reference for further study.
文摘Minor bupleurum decoction is one of the classic prescriptions of traditional Chinese medicine,and it has obvious effects in the treatment of various diseases.In recent years,the application of minor bupleurum decoction in the treatment of cancer has attracted more and more attention.This paper describes the mechanism of the role of minor bupleurum decoction in the treatment of clinical tumors and the interaction of related treatments by introducing the composition of minor bupleurum decoction and their pharmacological effects.
文摘Minor Bupleurum Decoction is a common TCM compound and a classic prescription that can best reflect the"harmonizing method',of TCM.But there are many differences on the usage and dosage of Minor Bupleurum Decoction.Combined with the clinical treatment experience,this paper summarizes the experience of Minor Bupleurum Decoction in the clinical treatment of diseases.It is hoped that relevant suggestions can be provided for clinicians to improve the clinical therapeutic effect of Minor Bupleurum Decoction.
文摘目的:观察柴胡加龙骨牡蛎汤联合功能性电刺激(functional electrical stimulation,FES)治疗中风后患者下肢痉挛性偏瘫的临床疗效。方法:选择2021年4月至2022年4月南京中医药大学沭阳附属医院治疗的中风后痉挛性偏瘫患者108例,随机分为观察组、对照组A、对照组B,每组36例。对照A组给予FES治疗,对照B组给予柴胡加龙骨牡蛎汤加减治疗,观察组给予柴胡加龙骨牡蛎汤联合FES治疗。运用美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、临床痉挛指数(clinical spasm index,CSI)、简化Fugl-Meyer量表(Fugl-Meyer assessment scale,FMA)、改良Barthel指数(modified barthel index,MBI)对三组患者治疗前后神经功能缺损程度、临床痉挛程度、肢体运动功能及日常生活活动能力进行评价,同时记录不良反应发生情况。结果:三组患者治疗后NIHSS评分、CSI评分低于本组治疗前,且观察组NIHSS评分、CSI评分低于对照组A、对照组B,差异具有统计学意义(P<0.05);三组患者治疗后FMA评分、MBI评分高于本组治疗前,且观察组FMA评分、MBI评分高于对照组A、对照组B,差异具有统计学意义(P<0.05);三组治疗过程中均无不良反应发生。结论:柴胡加龙骨牡蛎汤联合FES治疗中风后下肢痉挛性偏瘫,可改善患者神经功能缺损,缓解下肢痉挛程度,提高肢体活动功能及日常生活能力。
