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C-reactive protein to albumin ratio predict responses to programmed cell death-1 inhibitors in hepatocellular carcinoma patients
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作者 Bai-Bei Li Lei-Jie Chen +3 位作者 Shi-Liu Lu Biao Lei Gui-Lin Yu Shui-Ping Yu 《World Journal of Gastrointestinal Oncology》 SCIE 2024年第1期61-78,共18页
BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival outcomes.Nonetheless,significant heterogeneity surrou... BACKGROUND Over the years,programmed cell death-1(PD-1)inhibitors have been routinely used for hepatocellular carcinoma(HCC)treatment and yielded improved survival outcomes.Nonetheless,significant heterogeneity surrounds the outcomes of most studies.Therefore,it is critical to search for biomarkers that predict the efficacy of PD-1 inhibitors in patients with HCC.AIM To investigate the role of the C-reactive protein to albumin ratio(CAR)in evaluating the efficacy of PD-1 inhibitors for HCC.METHODS The clinical data of 160 patients with HCC treated with PD-1 inhibitors from January 2018 to November 2022 at the First Affiliated Hospital of Guangxi Medical University were retrospectively analyzed.RESULTS The optimal cut-off value for CAR based on progression-free survival(PFS)was determined to be 1.20 using x-tile software.Cox proportional risk model was used to determine the factors affecting prognosis.Eastern Cooperative Oncology Group performance status[hazard ratio(HR)=1.754,95%confidence interval(95%CI)=1.045-2.944,P=0.033],CAR(HR=2.118,95%CI=1.057-4.243,P=0.034)and tumor number(HR=2.932,95%CI=1.246-6.897,P=0.014)were independent prognostic factors for overall survival.CAR(HR=2.730,95%CI=1.502-4.961,P=0.001),tumor number(HR=1.584,95%CI=1.003-2.500,P=0.048)and neutrophil to lymphocyte ratio(HR=1.120,95%CI=1.022-1.228,P=0.015)were independent prognostic factors for PFS.Two nomograms were constructed based on independent prognostic factors.The C-index index and calibration plots confirmed that the nomogram is a reliable risk prediction tool.The ROC curve and decision curve analysis confirmed that the nomogram has a good predictive effect as well as a net clinical benefit.CONCLUSION Overall,we reveal that the CAR is a potential predictor of short-and long-term prognosis in patients with HCC treated with PD-1 inhibitors.If further verified,CAR-based nomogram may increase the number of markers that predict individualized prognosis. 展开更多
关键词 c-reactive protein to albumin ratio Hepatocellular carcinoma Programmed cell death-1 inhibitors Prognosis NOMOGRAM
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C-reactive Protein/Albumin Ratio as a Prognostic Indicator in Posttraumatic Shock and Outcome of Multiple Trauma Patients 被引量:1
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作者 Xin LU Wei-chen LIU +5 位作者 Yan QIN Du CHEN Peng YANG Xiong-hui CHEN Si-rong WU Feng XU 《Current Medical Science》 SCIE CAS 2023年第2期360-366,共7页
Objective C-reactive protein(CRP)/albumin ratio(CAR)is a new inflammation-based index for predicting the prognosis of various diseases.The CAR determined on admission may help to predict the prognostic value of multip... Objective C-reactive protein(CRP)/albumin ratio(CAR)is a new inflammation-based index for predicting the prognosis of various diseases.The CAR determined on admission may help to predict the prognostic value of multiple trauma patients.Methods A total of 264 adult patients with severe multiple trauma were included for the present retrospective study,together with the collection of relevant clinical and laboratory data.CAR,CRP,albumin,shock index and ISS were incorporated into the prognostic model,and the receiver operating characteristic(ROC)curve was drawn.Then,the shock index for patients with different levels of CAR was analyzed.Finally,univariate and multivariate logistic regression analyses were performed to identify the independent risk factors for the 28-day mortality of multiple trauma patients.Results A total of 36 patients had poor survival outcomes,and the mortality rate reached 13.6%.Furthermore,after analyzing the shock index for patients with different levels of CAR,it was revealed that the shock index was significantly higher when CAR was≥4,when compared to CAR<2 and 2≤CAR<4,in multiple trauma patients.The multivariate logistic analysis helped to identify the independent association between the variables CAR(P=0.029)and shock index(P=0.019),and the 28-day mortality of multiple trauma patients.Conclusion CAR is higher in patients with severe multiple trauma.Furthermore,CAR serves as a risk factor for independently predicting the 28-day mortality of multiple trauma patients.The shock index was significantly higher when CAR was≥4 in multiple trauma patients. 展开更多
关键词 c-reactive protein/albumin ratio multiple trauma c-reactive protein albumin PROGNOSIS
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The prognostic potential of pretreatment C-reactive protein to albumin ratio in stage IE/IIE extranodal natural killer/T-cell lymphoma 被引量:1
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作者 Xiaoying Quan Chunzhi Wu +2 位作者 Lei Lei Xiaoyan Chen Bin Ye 《Oncology and Translational Medicine》 2019年第4期162-169,共8页
Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-toalbumin ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients. Metho... Objective The aim of this study was to determine the prognostic significance of the C-reactive protein-toalbumin ratio (CRP/Alb) for stage IE/IIE upper aerodigestive tract extranodal NK/T cell lymphoma patients. Methods One hundred and fourteen patients diagnosed with extranodal NK/T cell lymphoma at Sichuan Cancer Hospital from September 2011 to November 2016 were retrospectively reviewed. An optimal cutoff value of CRP/Alb for overall survival rate as an endpoint was obtained using the receiver operating curve (ROC). Results The optimal cutoff value of CRP/Alb was 0.15. For the low CRP/Alb group, the 3-year progression-free survival (PFS) was 78.6% and the 3-year overall survival (OS) was 80.7%. The 3-year PFS and OS values for the high CRP/Alb group were 41.6% and 45.2%, respectively. Differences for PFS (P < 0.001) and OS (P < 0.001) between the two groups were statistically significant. Univariate analysis showed that ECOG, IPI, CRP, GPS, and CRP/Alb were significantly associated with PFS. Similarly, all five were also significantly associated with OS. Multivariate analysis further confirmed that ECOG and CRP/ Alb were independent prognostic factors for both PFS and OS. Moreover, the cutoff value of CRP/Alb showed superior prognostic ability in discriminating between patients with different outcomes in low-risk group based on GPS, IPI, and KPI scores. Conclusion CRP/Alb is a promising prognostic marker for early-stage extranodal NK/T cell lymphoma. 展开更多
关键词 c-reactive protein to albumin ratio (crp/alb) EXTRANODAL NK/T cell LYMPHOMA prognosis introduction
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Prognostic role of C-reactive protein to albumin ratio in lung cancer:An updated systematic review and meta-analysis
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作者 Zhendong Lu Siyun Fu +2 位作者 Wei Li Xiang Gao Jinghui Wang 《Chronic Diseases and Translational Medicine》 CAS CSCD 2024年第1期31-39,共9页
Background: C-reactive protein to albumin ratio(CRP/Alb ratio,CAR)has been suggested as a potential prognostic biomarker in lung cancer.This updated systematic review and meta-analysis aimed to assess the association ... Background: C-reactive protein to albumin ratio(CRP/Alb ratio,CAR)has been suggested as a potential prognostic biomarker in lung cancer.This updated systematic review and meta-analysis aimed to assess the association between CAR and lung cancer prognosis in current literature.Methods: A systematic search of databases was conducted to identify relevant studies published up to April 2023.Pooled hazard ratios(HRs)and 95%confidence intervals(CIs)were calculated to assess the association between CAR and overall survival(OS)and progression-free survival(PFS)and recurrence-free survival(RF)in lung cancer patients.Results: This meta-analysis includes 16 studies with a total of 5337 patients,indicating a significant association between higher CAR and poorer OS,PFS,and RFS in lung cancer patients,with a pooled HR of 1.78(95%CI=1.60-1.99),1.57(95%CI=1.36-1.80),and 1.97(95%CI=1.40-2.77),respectively.Conclusions: This updated meta-analysis provides evidence for the potential prognostic role of CAR in lung cancer,suggesting its utility as an effective and noninvasive biomarker for identifying high-risk patients and informing treatment decisions in a cost-effective manner.However,further large-scale studies will be necessary to establish the optimal cut-off value for CAR in lung cancer and confirm the present findings. 展开更多
关键词 c-reactive protein to albumin ratio inflammation:biomarker lung cancer prognosis
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CHF患者CRP/Alb、PDGF、BUN/Cr水平变化及对预后的评估价值
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作者 宋鑫 先本婧 刘峥嵘 《河北医药》 CAS 2024年第1期34-38,共5页
目的 探讨慢性心力衰竭(CHF)患者C-反应蛋白与白蛋白比值(CRP/Alb)、血小板源性生长因子(PDGF)联合血尿素氮与肌酐比值(BUN/Cr)水平变化,并分析各指标预测心血管死亡和全因死亡的效能。方法 选取2020年1月至2022年3月收治的109例CHF患者... 目的 探讨慢性心力衰竭(CHF)患者C-反应蛋白与白蛋白比值(CRP/Alb)、血小板源性生长因子(PDGF)联合血尿素氮与肌酐比值(BUN/Cr)水平变化,并分析各指标预测心血管死亡和全因死亡的效能。方法 选取2020年1月至2022年3月收治的109例CHF患者,根据1年内心血管死亡和全因死亡情况分为死亡组(26例)和存活组(83例)。比较2组社会人口学资料和临床特征[美国纽约心脏病学会心功能分级(NYHA)、左心室射血分数、左心室舒张末期内径、左心室收缩末期内径、N-末端脑钠肽前体(NT-proBNP)、临床用药]、CRP/Alb、PDGF、BUN/Cr水平,分析CRP/Alb、PDGF、BUN/Cr水平的相关性,采用Cox回归分析CHF患者心血管死亡和全因死亡的相关影响因素,采用受试者工作特征曲线(ROC)分析预测价值,采用卡普兰-迈耶曲线(K-M)生存曲线分析不同CRP/Alb、PDGF、BUN/Cr水平患者的生存率。结果 死亡组NYHA心功能分级、左心室舒张末期内径、左心室收缩末期内径、NT-proBNP高于存活组,左心室射血分数低于存活组(P<0.05);死亡组CRP/Alb、PDGF、BUN/Cr高于存活组(P<0.05);CHF患者CRP/Alb与PDGF、BUN/Cr呈正相关,PDGF与BUN/Cr呈正相关(P<0.05);在校正了NYHA心功能分级等混杂因素后,CRP/Alb、PDGF、BUN/Cr仍是CHF患者心血管死亡和全因死亡的相关影响因素(P<0.05);CRP/Alb、PDGF、BUN/Cr预测心血管死亡和全因死亡的ROC下面积(AUC)分别为0.712、0.801、0.738,三者联合时的AUC为0.911(P<0.05);CRP/Alb、PDGF、BUN/Cr高水平患者生存率低于低水平患者(P<0.05)。结论 CRP/Alb、PDGF、BUN/Cr与CHF患者心血管死亡和全因死亡有关,联合检测可作为预测患者病情转归的一个方案,为临床评估预后、治疗等提供参考依据。 展开更多
关键词 crp/alb PDGF BUN/Cr 慢性心力衰竭 心血管死亡 全因死亡
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脓毒症患者hs-CRP/ALB和hs-CRP/PA与膈肌功能障碍的相关性 被引量:1
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作者 马金兰 丁欢 +4 位作者 杨晓军 丁永安 杨红晓 杨光飞 王晓红 《中国急救医学》 CAS CSCD 2023年第9期704-710,共7页
目的探讨超敏C反应蛋白与血清白蛋白比值(hs-CRP/ALB)和超敏C反应蛋白与前白蛋白比值(hs-CRP/PA)与脓毒症膈肌功能障碍的相关性。方法采用前瞻性观察性研究方法,选择2020年1月至2021年5月入住宁夏医科大学总医院重症医学科(ICU)的80例... 目的探讨超敏C反应蛋白与血清白蛋白比值(hs-CRP/ALB)和超敏C反应蛋白与前白蛋白比值(hs-CRP/PA)与脓毒症膈肌功能障碍的相关性。方法采用前瞻性观察性研究方法,选择2020年1月至2021年5月入住宁夏医科大学总医院重症医学科(ICU)的80例脓毒症患者为研究对象,以入ICU第1天床旁超声测量膈肌位移(diaphragmatic excursion,DE)<10 mm诊断为膈肌功能障碍,将其分为脓毒症膈肌功能障碍组(n=29)和脓毒症非膈肌功能障碍组(n=51),并选择年龄、性别与研究对象相匹配的30例普通术后非脓毒症患者和15例健康志愿者为术后对照组和正常对照组。收集临床资料,动态观察脓毒症患者超敏C反应蛋白(hyper-sensitive C-reactive protein,hs-CRP)、血清白蛋白(albumin,ALB)、前白蛋白(prealbumin,PA)等指标,计算hs-CRP/ALB和hs-CRP/PA。并用间接测热法测量脓毒症患者静息能量消耗水平,计算静息能量消耗水平与实际给予能量的差值,即能量缺失值。结果①入ICU第1天,脓毒症膈肌功能障碍组、脓毒症非膈肌功能障碍组和术后对照组DE均低于正常对照组(均P<0.05),且脓毒症膈肌功能障碍组DE低于脓毒症非膈肌功能障碍组和术后对照组[mm:8.8(6.7,9.3)vs.13.3(12.3,17.8)和12.9(10.5,15.7),P<0.05];脓毒症膈肌功能障碍组能量缺失值高于脓毒症非膈肌功能障碍组(P<0.05)。②入ICU第1、3、7天,脓毒症膈肌功能障碍组hs-CRP/ALB高于脓毒症非膈肌功能障碍组[第1天:7.73(3.95,9.15)vs.5.44(2.76,8.14);第3天:4.63(3.12,6.17)vs.2.60(1.04,5.09);第7天:2.21(0.84,5.84)vs.0.81(0.52,2.36),均P<0.05]。脓毒症膈肌功能障碍组hs-CRP和hs-CRP/PA仅入ICU第3天高于脓毒症非膈肌功能障碍组[hs-CRP(mg/L):150.0(92.4,169.0)vs.62.5(30.3,152.0);hs-CRP/PA:1.74(1.12,2.73)vs.0.78(0.21,1.97),均P<0.05]。两组间各时相点ALB、PA比较差异均无统计学意义(均P>0.05)。脓毒症膈肌功能障碍组入ICU第1天hs-CRP/ALB、hs-CRP/PA均高于第7天(P<0.05)。③脓毒症患者DE与各指标相关分析:入ICU第1、3、7天,DE均与hs-CRP/ALB呈负相关(r分别为-0.241、-0.373、-0.465,均P<0.05);入ICU第3、7天,DE均与hs-CRP/PA呈负相关(r分别为-0.325、-0.468,均P<0.05)。结论脓毒症患者血清hs-CRP/ALB、hs-CRP/PA与膈肌功能障碍呈负相关。 展开更多
关键词 脓毒症 膈肌功能 超敏C反应蛋白与血清白蛋白比值(hs-crp/alb) 超敏C反应蛋白与前白蛋白比值(hs-crp/PA) 相关性
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CRP/ALB、FC和FIB联合检测对克罗恩病肠黏膜愈合和复发预测的价值 被引量:1
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作者 姚潇 马田田 +1 位作者 李小洁 高金波 《现代消化及介入诊疗》 2023年第7期823-827,共5页
目的探讨C反应蛋白/白蛋白比值(CRP/Alb)、粪钙卫蛋白(FC)和纤维蛋白原(FIB)联合检测的克罗恩病肠黏膜愈合和复发预测价值。方法对2021年1月~2022年12月收治且达临床愈合(克罗恩病疾病活动指数<150分)的克罗恩病患者106例进行回顾性... 目的探讨C反应蛋白/白蛋白比值(CRP/Alb)、粪钙卫蛋白(FC)和纤维蛋白原(FIB)联合检测的克罗恩病肠黏膜愈合和复发预测价值。方法对2021年1月~2022年12月收治且达临床愈合(克罗恩病疾病活动指数<150分)的克罗恩病患者106例进行回顾性分析。患者均进行肠镜SES-CD评分评价并分为肠黏膜愈合组(n=47)和非肠黏膜愈合组(n=59)。比较两组患者复发率,并通过诊断性试验四格表分析克罗恩病肠黏膜愈合状况对其复发的预测价值。根据患者复发状况分为复发组(n=31)和非复发组(n=75)。收集比较不同组别患者治疗前后的CRP/ALB、FC、FIB水平,并通过绘制ROC曲线分析CRP/ALB、FC、FIB水平单独和联合预测克罗恩病肠黏膜愈合和复发的效能。结果非肠黏膜愈合组的复发率和治疗前后的CRP/ALB、FC、FIB水平均高于肠黏膜愈合组(P<0.05)。诊断性试验四格表分析结果显示,克罗恩病临床愈合后未肠黏膜愈合预测其复发的敏感度、特异度及准确性分别为80.65%、54.67%和62.26%。复发组治疗前后的CRP/ALB、FC、FIB水平均高于非复发患者(P<0.05)。ROC曲线分析结果显示,治疗前CRP/ALB、FC和FIB联合检测的克罗恩病肠黏膜愈合和复发预测效能均更佳,其曲线下面积分别为0.741和0.839。结论CRP/ALB、FC和FIB均能在一定程度上预测克罗恩病肠黏膜愈合和复发状况,且联合检测的预测效能最佳。 展开更多
关键词 C反应蛋白/白蛋白比值(crp/alb) 粪钙卫蛋白(FC) 纤维蛋白原(FIB) 联合 克罗恩病 肠黏膜愈合 复发 预测
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AGI评分、甘油三酯联合hs-CRP/Alb比值评估高甘油三酯血症性急性胰腺炎患者疾病严重程度及复发情况的临床应用研究 被引量:3
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作者 刘翠华 刘纪宁 +2 位作者 盛洁 喻洪 朱伦刚 《中国临床新医学》 2023年第5期491-496,共6页
目的探讨采用急性胃肠损伤(AGI)评分、甘油三酯(TG)联合高敏C反应蛋白/白蛋白(hs-CRP/Alb)比值评估高甘油三酯血症性急性胰腺炎(HTG-AP)患者疾病严重程度及复发情况的应用效能。方法招募2019年6月至2022年6月电子科技大学医学院附属绵... 目的探讨采用急性胃肠损伤(AGI)评分、甘油三酯(TG)联合高敏C反应蛋白/白蛋白(hs-CRP/Alb)比值评估高甘油三酯血症性急性胰腺炎(HTG-AP)患者疾病严重程度及复发情况的应用效能。方法招募2019年6月至2022年6月电子科技大学医学院附属绵阳医院收治的HTG-AP患者89例,其中轻度急性胰腺炎(MAP)32例(MAP组),中重度急性胰腺炎(MSAP)38例(MSAP组)和严重急性胰腺炎(SAP)19例(SAP组)。随访观察患者出院3个月内病情复发情况,采用多因素Cox回归分析探讨影响疾病复发的因素,采用受试者工作特征(ROC)曲线评估AGI、TG联合hs-CRP/Alb比值预测疾病复发的效能。结果SAP组AGI评分、hs-CRP、hs-CRP/Alb比值水平显著高于MSAP组和MAP组(P<0.05),Alb水平显著低于MSAP组和MAP组(P<0.05)。MSAP组AGI评分、hs-CRP、hs-CRP/Alb比值水平显著高于MAP组(P<0.05),Alb水平显著低于MAP组(P<0.05)。89例患者失访5例,在随访期间复发29例,未复发55例。多因素Cox回归分析结果显示,较高水平的AGI评分、TG、hs-CRP/Alb比值是HTG-AP患者病情复发的独立危险因素(P<0.05)。ROC曲线分析结果显示,TG、AGI评分、hs-CRP/Alb比值均具有预测HTG-AP患者病情复发的应用价值(P<0.05),且三者联合可进一步提高预测效能[AUC(95%CI)=0.965(0.916~1.000),P<0.05]。结论AGI评分、hs-CRP/Alb比值增高与HTG-AP严重程度具有关联性,TG、AGI评分联合hs-CRP/Alb比值可用于评估HTG-AP病情复发的风险。 展开更多
关键词 急性胃肠损伤评分 高敏C反应蛋白/血清白蛋白比值 甘油三酯 高甘油三酯血症性急性胰腺炎 复发
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The Clinical Value of NLR, D-D and CRP/ALB Ratio in the Diagnosis of Pulmonary Thromboembolism
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作者 Tiantian Shan Zhen Cheng +1 位作者 Min Yan Xiangtao Pan 《Journal of Biosciences and Medicines》 2021年第10期65-73,共9页
<strong>Objective:</strong> To evaluate the clinical diagnostic value of C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR) and D-dimer (D-D) in patients with pulmonary thromboemboli... <strong>Objective:</strong> To evaluate the clinical diagnostic value of C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR) and D-dimer (D-D) in patients with pulmonary thromboembolism (PTE). <strong>Methods:</strong> We conducted a retrospective analysis comparing hematology and coagulation in 362 PTCA-confirmed PTE patients with the control group and analyzing their relationships with CAR, NLR, and D-D. Receiver operating characteristic curve (ROC) was used to analyze the diagnostic threshold, area under the curve (AUC), diagnostic sensitivity and specificity of CAR, NLR and D-D for PTE. <strong>Results:</strong> 1) CAR, NLR and D-D levels in PTE patients were 2.13 ± 2.08, 8.96 ± 1.94 and 9.69 ± 8.61 respectively, significantly higher than those in control group (CAR = 0.03 ± 0.01, t = 20.7736, P < 0.01;NLR = 1.76 ± 0.53, t = 2.4281, P < 0.05 and PTE = 0.20 ± 0.11, t = 3.0066, P < 0.01 respectively). 2) NLR was positively correlated with CAR (r = 0.2111, t = 4.0971, P < 0.01) and D-D (r = 0.1065, t = 2.0481, P < 0.05), but CAR was not correlated with D-D (r = 0.0975, P > 0.05). 3) The levels of HB, LY, PLT and AT in PTE patients were significantly lower than those in control group, while WBC, NE and FB were significantly higher than those in control group. 4) CAR was negatively correlated with Hb and AT (P all < 0.01), but positively correlated with WBC, NE, MO and FB (P all < 0.01). NLR was negatively correlated with LY and AT (P all < 0.01), but positively correlated with WBC, NE and FB (P all < 0.01). DD was negatively correlated with Hb and PLT (P all < 0.05), but positively correlated with WBC, NE and MO (P all < 0.01). <strong>Conclusion:</strong> The levels of Hb, LY, PLT and AT were significantly decreased in PTE patients, while WBC, NE and FB were significantly increased. CAR, NLR and D-D were highly expressed in PTE patients, and were closely correlated with Hb, AT and FB. Combined detection of CAR, NLR and D-D can improve the diagnostic value of PTE. 展开更多
关键词 Pulmonary Thromboembolism CAR c-reactive protein/albumin ratio Neutrophil to Lymphocyte ratio Plasma D-Dimer Clinical Diagnosis
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急性ST段抬高型心肌梗死患者的hs-CRP/ALB变化对预后的预测价值 被引量:30
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作者 郭红玲 欧阳艳红 +2 位作者 王圣 苏健玲 吴曾繁 《中国急救医学》 CAS CSCD 北大核心 2020年第2期102-107,共6页
目的探讨急性ST段抬高型心肌梗死(STEMI)患者的高敏C-反应蛋白(hs-CRP)/白蛋白(ALB)变化对预后的预测价值.方法选取2014年7月至2018年7月收治的80例急性STEMI患者,收集患者一般资料、高危因素、相关检查结果和实验室指标.所有患者均予... 目的探讨急性ST段抬高型心肌梗死(STEMI)患者的高敏C-反应蛋白(hs-CRP)/白蛋白(ALB)变化对预后的预测价值.方法选取2014年7月至2018年7月收治的80例急性STEMI患者,收集患者一般资料、高危因素、相关检查结果和实验室指标.所有患者均予以介入治疗并术后随访,截至2019年7月,记录主要心血管不良事件(MACE)发生情况.根据患者随访结果,将患者分为MACE组(16例)与非MACE组(64例),比较两组一般资料、高危因素和实验室指标.采用多因素Logistic回归分析明确MACE的危险因素.绘制hs-CRP/ALB预测MACE的受试者工作特征(ROC)曲线,分析hs-CRP/ALB对MACE的预测价值.并以最佳截断值将患者分为两组,绘制Kaplan-Meier生存曲线,比较两组生存情况.结果80例患者随访结束后,MACE发生率20%(16/80).MACE组与非MACE组性别、体质量指数、心率、收缩压、舒张压、高血压史、冠心病史、吸烟史、甘油三脂(TG)、总胆固醇(TC)、血白细胞计数(WBC)、B型利钠肽(BNP)、D-二聚体(DD)及ALB比较差异无统计学意义(P>0.05).MACE组年龄、糖尿病史占比、血清BNP、hs-CRP及hs-CRP/ALB高于非MACE组,左室射血分数(LVEF)低于非MACE组,差异有统计学意义(P<0.05).经Logistic多元回归分析,年龄、糖尿病、BNP、hs-CRP及hs-CRP/ALB是MACE的危险因素,LVEF是MACE的保护因素(P<0.05).hs-CRP/ALB预测急性STEMI患者介入术后MACE的ROC曲线下面积(AUC)0.918(95%CI0.855~0.978),hs-CRP的AUC 0.741(95%CI0.697~0.845),hs-CRP/ALB对MACE的预测价值更高.当hs-CRP/ALB=0.58时的预测价值最高,此时敏感度为87.5%,特异度为79.7%.根据ROC曲线分析结果,将患者分为hs-CRP/ALB≥0.58组(31例)与hs-CRP/ALB<0.58组(49例).截至2019年7月,hs-CRP/ALB<0.58组的生存率为95.92%(47/49),较hs-CRP/ALB≥0.58组的80.65%(25/31)相对更高,且生存时间更长,Kaplan-Meier生存曲线的差异有统计学意义(Log-rank P=0.039).结论年龄、糖尿病史、BNP、hs-CRP/ALB是急性SIEMI患者介入术后MACE的危险因素,LVEF是MACE的保护因素,且hs-CRP/ALB对急性STEMI患者介入术后的MACE有较大预测价值,不同hs-CRP/ALB值的患者生存情况也不同,hs-CRP/ALB<0.58的患者生存率更高,生存时间更长. 展开更多
关键词 急性ST段抬高型心肌梗死(STEMI) 高敏C-反应蛋白(hs-crp) 白蛋白(alb) 主要心血管不良事件(MACE) 预后 预测价值
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感染性休克患者CRP/ALB比值对预测急性呼吸窘迫综合征的临床价值 被引量:10
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作者 段莉莉 《标记免疫分析与临床》 CAS 2016年第6期630-632,647,共4页
目的 探讨感染性休克患者血清C反应蛋白(C reactive protein,CRP)、白蛋白(albumin,ALB)比值(CRP/ALB)对预测急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)的临床价值。方法 回顾性分析2013年1月至2015年5月我... 目的 探讨感染性休克患者血清C反应蛋白(C reactive protein,CRP)、白蛋白(albumin,ALB)比值(CRP/ALB)对预测急性呼吸窘迫综合征(acute respiratory distress syndrome,ARDS)的临床价值。方法 回顾性分析2013年1月至2015年5月我院ICU感染性休克患者65例。患者于入ICU后采外周静脉血,检测CRP、ALB,前7 d每天进行急性生理功能和慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluation-Ⅱ,APACHE-Ⅱ),根据7 d内是否合并ARDS分成感染性休克组和ARDS组。比较两组CRP、ALB和CRP/ALB,APACHE II评分,Spearman相关分析入选时CRP/ALB、APACHE-Ⅱ评分的关系,受试者工作特征(ROC)曲线下面积法检验CRP/ALB的预测效力。结果 感染性休克组与ARDS组患者CRP、ALB含量差异无统计学意义(P〉0.05),而CRP/ALB比值差异具有统计学意义(t=5.93,P〈0.05)。CRP/ALB和APACHE-Ⅱ预测脓毒症的ROC曲线下面积分别为0.904(95%,CI:0.821~0.998),0.748(95%,CI:0.625~0.903)。CRP/ALB与APACHEII评分呈正相关(r=0.74,P〈0.05)。结论 CRP/ALB可预测感染性休克即将发生的ARDS,可能是一个有价值的临床指标,值得进一步研究。 展开更多
关键词 C反应蛋白(crp) 白蛋白 感染性休克 急性呼吸窘迫综合征
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CRP和Alb与初诊断的非小细胞肺癌临床病理特征联系及预后价值分析 被引量:10
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作者 周小林 《东南国防医药》 2016年第5期489-492,共4页
目的分析初诊非小细胞肺癌(NSCLC)患者血清C-反应蛋白(CRP)、血清白蛋白(Alb)水平与临床病理特征及患者总生存期的联系,探讨其在NSCLC患者预后转归的临床意义。方法回顾性分析2011年1月-2013年1月医院收治的105例NSCLC患者的临床资料,... 目的分析初诊非小细胞肺癌(NSCLC)患者血清C-反应蛋白(CRP)、血清白蛋白(Alb)水平与临床病理特征及患者总生存期的联系,探讨其在NSCLC患者预后转归的临床意义。方法回顾性分析2011年1月-2013年1月医院收治的105例NSCLC患者的临床资料,根据患者术前外周血CRP和Alb中位值,分别分为高值组和低值组,分析CRP、Alb水平高低与临床病理特征的关系,根据随访生存情况,采用Kaplan-Meier法单因素、Cox比例风险回归模型多因素分析术前CRP、Alb等因素对NSCLC患者总生存期的影响。结果治疗前NSCLC患者血清CRP的水平为(18.14±10.75)mg/L,Alb值为(35.32±12.83)g/L。Alb低值组与高龄、淋巴结转移、较晚的临床分期相关,而CRP高值组与淋巴结转移、较晚的临床分期相关,具有统计学意义(P<0.05)。单因素分析显示高CRP和低Alb水平与较差的总生存期有关,多因素生存分析显示淋巴结转移,较晚的临床分期和高CRP值是影响NSCLC患者生存预后的独立危险因素。结论 CRP和Alb两项指标对肺癌的诊断、预后判断和疗效监测具有重要应用价值,是NSCLC预后潜在的生物标志物。 展开更多
关键词 非小细胞肺癌 C反应蛋白 血清白蛋白 生存分析 预后
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Correlation analysis of CRP/ALB and P-CRP in the prognosis of non-small cell lung cancer 被引量:1
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作者 Qi Fu Zhi-Biao Zhao +1 位作者 Shan-Shan Zhang Ming-Hong Bi 《Journal of Hainan Medical University》 2021年第24期37-41,共5页
Objective:The purpose of this study was to investigate the relationship between preoperative C-reactive protein/albumin ratio(CRP/ALB),platelet count and C-reactive protein product(P-CRP)and clinical prognosis in pati... Objective:The purpose of this study was to investigate the relationship between preoperative C-reactive protein/albumin ratio(CRP/ALB),platelet count and C-reactive protein product(P-CRP)and clinical prognosis in patients with non-small cell lung cancer.Methods:From January 2015 to December 2015,284 patients who underwent surgery for lung cancer in the First Affiliated Hospital of Bengbu Medical College were selected.According to their 3-year and 5-year survival conditions,ROC curves were drawn and the best cut-off value was determined.According to the cut-off value,the patients were divided into high CRP/ALB group,low CRP/ALB group,high P-CRP group and low P-CRP group.Survival curves were described by Kaplan-Meier method and compared by Log-rank test.The univariate and multivariate analyses were performed with the Cox proportional hazard model to evaluate the prognostic factors.Results:Survival analysis showed that there was no significant difference in 3-year survival rate between high CRP/ALB and P-CRP groups and low CRP/ALB and P-CRP groups,while the 5-year survival rate in high CRP/ALB and P-CRP groups was significantly lower than that in low CRP/ALB and P-CRP groups.Cox proportional hazard model showed that CRP/ALB,age,smoking history,lymph node metastasis and TNM stage were risk factors for 5-year survival rate.Conclusion:as a prognostic index based on inflammation,preoperative CRP/ALB level can better reflect the prognosis of patients than P-CRP. 展开更多
关键词 c-reactive protein/albumin ratio Platelet and c-reactive protein product Non-small cell lung cancer PROGNOSIS
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初始治疗前CRP/Alb比值与小细胞肺癌患者临床病理特征及预后的关系 被引量:3
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作者 嵇桂娟 刘平莉 +2 位作者 罗涛 朱述阳 陈碧 《徐州医科大学学报》 CAS 2019年第7期481-486,共6页
目的探讨初始治疗前CRP/Alb比值(CAR)与小细胞肺癌(small cell lung cancer,SCLC)临床病理特征相关性及其在预后中的价值。方法回顾性分析本中心80例健康对照人群及SCLC患者的治疗前CRP、Alb值,计算CAR值,卡方检验分析CAR值与SCLC患者... 目的探讨初始治疗前CRP/Alb比值(CAR)与小细胞肺癌(small cell lung cancer,SCLC)临床病理特征相关性及其在预后中的价值。方法回顾性分析本中心80例健康对照人群及SCLC患者的治疗前CRP、Alb值,计算CAR值,卡方检验分析CAR值与SCLC患者临床病理特征的相关性,Kaplan-Meier法及COX回归模型分析CAR与SCLC预后的关系。结果治疗前SCLC患者血清CRP(6.95±3.21)mg/L,显著高于健康对照组(3.13±1.69)mg/L,具有统计学差异(P<0.05)。Alb水平(35.71±6.68)g/L低于健康对照组(45.63±5.78),差异具有统计学意义(P<0.05)。CAR水平(0.20±0.10)高于健康对照组(0.07±0.04),具有统计学差异(P<0.05)。进一步分析CAR值与淋巴结转移和临床分期呈正相关(P<0.05),与年龄、性别、吸烟史以及肿瘤大小无关。生存分析证实:相比较于CAR值低表达患者,CAR值高表达患者预后更差,具有统计学差异(P<0.05)。COX多因素回归分析证实,CAR高低可作为判定预后的独立因素(P<0.05)。结论CAR检测具有高效灵敏便捷经济及创伤小等优点,通过联合检测CRP和Alb对SCLC的临床分期及预后判断具有重要应用价值。 展开更多
关键词 小细胞肺癌 C反应蛋白 血清白蛋白 crp/alb比值
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异基因造血干细胞移植输血不良反应风险预警模型的构建及验证
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作者 张燕 季玲 顾伟英 《护理研究》 北大核心 2024年第14期2484-2489,共6页
目的:探讨异基因造血干细胞移植(allo-HSCT)输血不良反应的危险因素,建立风险预警模型。方法:选取2018年1月—2023年2月我院收治的115例allo-HSCT病人作为研究对象,将其分为建模组(73例)和验证组(42例)。对病人一般资料进行调查,对病人... 目的:探讨异基因造血干细胞移植(allo-HSCT)输血不良反应的危险因素,建立风险预警模型。方法:选取2018年1月—2023年2月我院收治的115例allo-HSCT病人作为研究对象,将其分为建模组(73例)和验证组(42例)。对病人一般资料进行调查,对病人血清中C反应蛋白(CRP)、白蛋白(ALB)、中性粒细胞、淋巴细胞进行检验,计算CRP/ALB和中性粒细胞与淋巴细胞比值(NLR),采用单因素分析和Logistic回归分析筛选allo-HSCT输血不良反应的危险因素,构建风险预警模型并转化为风险评分系统;采用受试者工作特征(ROC)曲线和Hosmer-Lemeshow(H-L)检验评价模型的区分度与校准度;对预警模型进行验证。结果:发生输血不良反应组CRP/ALB和NLR高于未发生输血不良反应组,差异有统计学意义(均P<0.05)。Logistic回归分析结果显示,输血次数≥3次、有原发性血液病史、有输血史、有过敏史、病人基础体温≥38℃、发血至输血时间≥30 min、输注红细胞滴速每分钟≥50滴、输注血小板滴速每分钟≥90滴以及CRP/ALB≥0.90和NLR≥1.37是allo-HSCT发生输血不良反应的危险因素(均P<0.05)。建模组ROC曲线下面积为0.841,H-L检验结果显示P=0.856,模型的灵敏度为0.909,特异度为0.775,Youden指数为0.684。验证组ROC曲线下面积为0.798,H-L检验结果显示P=0.813,灵敏度为0.818,特异度为0.775,Youden指数为0.593。结论:构建的allo-HSCT输血不良反应风险预警模型预测效能较好,可为allo-HSCT输血不良反应的护理提供针对性的指导。 展开更多
关键词 异基因造血干细胞移植(allo-HSCT) C反应蛋白/白蛋白(crp/alb) 中性粒细胞/淋巴细胞比值(NLR) 输血 不良反应 预警模型 护理
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Cross-sectional association of serum C-reactive protein and uric acid with albuminuria in Chinese type 2 diabetic patients 被引量:6
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作者 Ling Yan Li Xiao-mu Gao Xin 《Chinese Medical Journal》 SCIE CAS CSCD 2013年第21期4023-4029,共7页
Background Evidences show that subclinical chronic inflammation is involved in the pathogenesis of diabetic nephropathy. The aim of this study was to examine the relationship between serum C-reactive protein (CRP), ... Background Evidences show that subclinical chronic inflammation is involved in the pathogenesis of diabetic nephropathy. The aim of this study was to examine the relationship between serum C-reactive protein (CRP), serum uric acid, and albuminuria in Chinese type 2 diabetic patients. 展开更多
关键词 c-reactive protein inflammation uric acid albumin to creatinine ratio type 2 diabetes
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UMA、BNP、hsCRP及UACR联合检测对慢性心衰患者的诊治及预后评估的价值 被引量:9
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作者 王淑婵 冯书锐 《海南医学》 CAS 2016年第15期2432-2434,共3页
目的探讨联合检测尿微量白蛋白(UMA)、脑钠肽(BNP)、超敏C-反应蛋白(hs-CRP)及尿白蛋白比肌酐比率(UACR)在慢性心衰患者的诊治及预后评估中的应用价值。方法选取本院2014年5月至2015年5月住院慢性心衰(CHF)患者共80例为观察组,40例健康... 目的探讨联合检测尿微量白蛋白(UMA)、脑钠肽(BNP)、超敏C-反应蛋白(hs-CRP)及尿白蛋白比肌酐比率(UACR)在慢性心衰患者的诊治及预后评估中的应用价值。方法选取本院2014年5月至2015年5月住院慢性心衰(CHF)患者共80例为观察组,40例健康体检者为对照组,联合检测UMA、BNP、hs-CRP及UACR水平,比较两组及观察组治疗前后的各指标的差异。结果观察组治疗过程中死亡8例、3例中途退出。观察组患者治疗前的UMA、BNP和hs-CRP水平分别为(32.1±16.5)mg/L、(399.8±187.6)pg/m L和(31.5±18.9)mg/L,均明显高于健康对照组的(11.3±5.4)mg/L、(59.3±16.7)pg/m L和(5.0±2.4)mg/L,差异均有显著统计学意义(P<0.01);观察组患者治疗后的UMA、BNP及hs-CRP水平分别为(15.1±3.0)mg/L、(258.7±122.0)pg/m L、(14.5±5.4)mg/L,与治疗前比较均明显降低,差异均有显著统计学意义(P<0.01);不同NYHA分级的UACR水平比较差异有统计学意义(F=128.71,P<0.05),且UACR水平与不同心功能分级呈正相关(r=0.71,P<0.01)。结论 UMA、BNP、hs-CRP及UACR联合检测对CHF的诊治及预后评估具有重要的临床价值。 展开更多
关键词 尿微量白蛋白 脑钠肽 高敏C反应蛋白 尿白蛋白比肌酐比率 慢性心衰
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Prognostic value of a nomogram model for postoperative liver metastasis of colon cancer
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作者 De-Xin Cheng Kang-Di Xu +1 位作者 Han-Bo Liu Yi Liu 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第4期1055-1065,共11页
BACKGROUND Colon cancer is one of the most common malignant tumors of the digestive system.Liver metastasis after colon cancer surgery is the primary cause of death in patients with colon cancer.AIM To construct a nov... BACKGROUND Colon cancer is one of the most common malignant tumors of the digestive system.Liver metastasis after colon cancer surgery is the primary cause of death in patients with colon cancer.AIM To construct a novel nomogram model including various factors to predict liver metastasis after colon cancer surgery.METHODS We retrospectively analyzed 242 patients with colon cancer who were admitted and underwent radical resection for colon cancer in Zhejiang Provincial People’s Hospital from December 2019 to December 2022.Patients were divided into liver metastasis and non-liver metastasis groups.Sex,age,and other general and clinicopathological data(preoperative blood routine and biochemical test indexes)were compared.The risk factors for liver metastasis were analyzed using singlefactor and multifactorial logistic regression.A predictive model was then constructed and evaluated for efficacy.RESULTS Systemic inflammatory index(SII),C-reactive protein/albumin ratio(CAR),red blood cell distribution width(RDW),alanine aminotransferase,preoperative carcinoembryonic antigen level,and lymphatic metastasis were different between groups(P<0.05).SII,CAR,and RDW were risk factors for liver metastasis after colon cancer surgery(P<0.05).The area under the curve was 0.93 for the column-line diagram prediction model constructed based on these risk factors to distinguish whether liver metastasis occurred postoperatively.The actual curve of the column-line diagram predicting the risk of postoperative liver metastasis was close to the ideal curve,with good agreement.The prediction model curves in the decision curve analysis showed higher net benefits for a larger threshold range than those in extreme cases,indicating that the model is safer.CONCLUSION Liver metastases after colorectal cancer surgery could be well predicted by a nomogram based on the SII,CAR,and RDW. 展开更多
关键词 Systemic immunoinflammatory index c-reactive protein/albumin ratio Erythrocyte distribution width Colon cancer Liver metastasis Novel nomogram model
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老年人小腿围、HCAR与认知障碍的因果中介分析--基于CLHLS2014数据
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作者 徐吟文 胡填 +1 位作者 田晴晴 刘洲 《广东医科大学学报》 2024年第2期162-168,共7页
目的探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/albumin ratio,HCAR)的中介作用。方法筛选2014年CLHLS数据库中的1784例老年人数据。通过中文版简易精神状态量表(Chinese version of th... 目的探究小腿围与认知障碍的关系及超敏C反应蛋白/白蛋白比值(hypersensitive C-reactive protein/albumin ratio,HCAR)的中介作用。方法筛选2014年CLHLS数据库中的1784例老年人数据。通过中文版简易精神状态量表(Chinese version of the brief mental state examination,cMMSE)评估认知功能。使用R软件进行数据处理和分析,Bootstrap抽样法验证中介效应。结果校正多种协变量后,小腿围与认知障碍呈显著负相关(OR=0.951,95%CI:0.933~0.970),HCAR在其中起到中介作用(中介效应比例为0.022,95%CI:0.002~0.060)。结论小腿围与认知障碍之间存在负关联,HCAR起中介作用。该发现对预防和干预认知障碍有重要意义。 展开更多
关键词 超敏C反应蛋白/白蛋白比值 小腿围 认知障碍 中介分析 CLHLS数据库
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血PCT、SAA及AFR对老年重症肺炎预后的评估价值分析 被引量:5
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作者 王璐璐 《罕少疾病杂志》 2023年第5期32-34,共3页
目的探讨血降钙素原(PCT)、淀粉样蛋白A(SAA)及白蛋白(ALB)/纤维蛋白原(FIB)比值(AFR)对老年重症肺炎预后的评估价值分析。方法选取河南中医药大学人民医院/郑州人民医院收治的112例老年重症肺炎患者,患者入院后均参照指南要求,接受液... 目的探讨血降钙素原(PCT)、淀粉样蛋白A(SAA)及白蛋白(ALB)/纤维蛋白原(FIB)比值(AFR)对老年重症肺炎预后的评估价值分析。方法选取河南中医药大学人民医院/郑州人民医院收治的112例老年重症肺炎患者,患者入院后均参照指南要求,接受液体复苏、抗感染、机械通气等治疗。采集患者入院次日及治疗后4、7d的静脉血3 mL,检测血PCT、SAA及ALB、FIB,计算AFR。根据存活情况分为死亡组(35例)和生存组(77例)。对比分析死亡组和存活组患者基线临床资料的差异,以及血清学指标的动态变化情况。Logistic回归模型分析老年重症肺炎死亡的危险因素。分析血PCT、SAA及AFR与老年重症肺炎预后的关系。结果老年重症肺炎患者中,死亡组年龄≥70岁的患者占比高于生存组,ICU居住时间长于生存组,APACHEⅡ评分高于生存组(均P<0.05)。从入院时到治疗后4、7天,死亡组血PCT、SAA逐渐升高,生存组逐渐降低,死亡组AFR逐渐降低,生存组逐渐升高;死亡组患者各个观察时间点血清血PCT、SAA高于生存组,血AFR低于生存组(均P<0.05)。多因素分析结果显示,APACHEⅡ评分(OR=2.102,95%CI=1.094~3.212)、血PCT(OR=1.984,95%CI=1.103~2.094)、SAA高(OR=1.594,95%CI=1.231~2.186),血AFR低(OR=1.294,95%CI=1.092~1.985)均为影响老年重症肺炎患者死亡的危险因素(P<0.05)。经Pearson相关系数分析,血PCT、SAA与老年重症肺炎预后呈正相关(r=0.432,0.543),血AFR呈负相关(r=-0.321)(均P<0.05)。结论老年重症肺炎患者的血清PCT、SAA水平越高,血AFR水平越低,其预后越差,死亡风险越高;对以上指标进行监测分析有利于对疾病的病情进行判断,以改善患者预后。 展开更多
关键词 老年重症肺炎 降钙素原 淀粉样蛋白A 白蛋白(alb)/纤维蛋白原(FIB)比值 评估价值 预后
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