间变型弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一种罕见的非特指型DLBCL,组织形态学常为窦性或者弥漫生长。该文报道1例,其左侧腋窝淋巴结具有大量多形性的中心母细胞样伴间变特征的细胞和HRS样细胞呈结节状或滤泡...间变型弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一种罕见的非特指型DLBCL,组织形态学常为窦性或者弥漫生长。该文报道1例,其左侧腋窝淋巴结具有大量多形性的中心母细胞样伴间变特征的细胞和HRS样细胞呈结节状或滤泡生发中心样生长,符合DLBCL,非特殊类型,间变型。结合相关文献探讨其临床病理学及分子遗传学特征,以提高临床和病理医师对该肿瘤的认识。展开更多
原发性睾丸淋巴瘤(PTL)是一种罕见且具有侵袭性的结外淋巴瘤,可分为原发和继发两类。1) 原发性:以睾丸肿块为原发症状或主要症状,无其他结外器官受累,经病理确诊为DLBCL。2) 继发性:系统性累及睾丸的DLBCL为继发睾丸DLBCL,以原发性常见...原发性睾丸淋巴瘤(PTL)是一种罕见且具有侵袭性的结外淋巴瘤,可分为原发和继发两类。1) 原发性:以睾丸肿块为原发症状或主要症状,无其他结外器官受累,经病理确诊为DLBCL。2) 继发性:系统性累及睾丸的DLBCL为继发睾丸DLBCL,以原发性常见。目前PTl-DLBCL的相关文献报道较少且发病机制未明,推荐的综合治疗方案仍存在较高的结外复发风险。Primary Testicular Lymphoma (PTL) is a rare and invasive extranodal lymphoma, which can be divided into primary and secondary types. 1) Primary: Testicular mass is the primary symptom or the main symptom without other extranodal organ involvement, which is pathologically diagnosed as DLBCL. 2) Secondary: DLBCL with systemic involvement of the testis is secondary testicular DLBCL, which is common in primary. At present, there are few reports on PTl-DLBCL and the pathogenesis is unknown. The recommended comprehensive treatment still has a high risk of extranodal recurrence.展开更多
脂质代谢异常是恶性肿瘤发生发展中重要的代谢改变。脂质代谢相关基因变化引发的脂质重编程及后续脂质代谢产物异常对于肿瘤细胞的增殖、侵袭和转移具有重要影响。临床与基础研究显示,弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,...脂质代谢异常是恶性肿瘤发生发展中重要的代谢改变。脂质代谢相关基因变化引发的脂质重编程及后续脂质代谢产物异常对于肿瘤细胞的增殖、侵袭和转移具有重要影响。临床与基础研究显示,弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者中存在着脂质代谢相关基因及代谢产物的异常表达,且该变化与预后有关;靶向脂质代谢异常的干预可以改变DLBCL细胞生物学行为。因此,本文对DLBCL中存在的脂质代谢异常及其发生机制和靶向脂质代谢的干预进行综述,为挖掘DLBCL的潜在诊治靶点提供有益总结。展开更多
文摘间变型弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)是一种罕见的非特指型DLBCL,组织形态学常为窦性或者弥漫生长。该文报道1例,其左侧腋窝淋巴结具有大量多形性的中心母细胞样伴间变特征的细胞和HRS样细胞呈结节状或滤泡生发中心样生长,符合DLBCL,非特殊类型,间变型。结合相关文献探讨其临床病理学及分子遗传学特征,以提高临床和病理医师对该肿瘤的认识。
文摘原发性睾丸淋巴瘤(PTL)是一种罕见且具有侵袭性的结外淋巴瘤,可分为原发和继发两类。1) 原发性:以睾丸肿块为原发症状或主要症状,无其他结外器官受累,经病理确诊为DLBCL。2) 继发性:系统性累及睾丸的DLBCL为继发睾丸DLBCL,以原发性常见。目前PTl-DLBCL的相关文献报道较少且发病机制未明,推荐的综合治疗方案仍存在较高的结外复发风险。Primary Testicular Lymphoma (PTL) is a rare and invasive extranodal lymphoma, which can be divided into primary and secondary types. 1) Primary: Testicular mass is the primary symptom or the main symptom without other extranodal organ involvement, which is pathologically diagnosed as DLBCL. 2) Secondary: DLBCL with systemic involvement of the testis is secondary testicular DLBCL, which is common in primary. At present, there are few reports on PTl-DLBCL and the pathogenesis is unknown. The recommended comprehensive treatment still has a high risk of extranodal recurrence.
文摘脂质代谢异常是恶性肿瘤发生发展中重要的代谢改变。脂质代谢相关基因变化引发的脂质重编程及后续脂质代谢产物异常对于肿瘤细胞的增殖、侵袭和转移具有重要影响。临床与基础研究显示,弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者中存在着脂质代谢相关基因及代谢产物的异常表达,且该变化与预后有关;靶向脂质代谢异常的干预可以改变DLBCL细胞生物学行为。因此,本文对DLBCL中存在的脂质代谢异常及其发生机制和靶向脂质代谢的干预进行综述,为挖掘DLBCL的潜在诊治靶点提供有益总结。
