Objective To study the relationship between traditional Chinese medicine (TCM) syndrome and serum level of IGF 1 and IGFBP 3 in patients with acute cerebral infarction (ACI).Methods 75 patients of ACI were divided int...Objective To study the relationship between traditional Chinese medicine (TCM) syndrome and serum level of IGF 1 and IGFBP 3 in patients with acute cerebral infarction (ACI).Methods 75 patients of ACI were divided into two groups by TCM`s syndrome differentiation: apolexy involving the channels (AIC) and apolexy involving the viscera (AIV).Serum level of IGF 1 and IGFBP 3 was detected by ELISA di antibody clipping technique (DACT) and was compared with that of 30 normal controls.Results Serum level of IGF 1 and IGFBP 3 in AIC group and AIV group were significantly different from control groups;and differences between AIC group and AIV group were statistically significant.Serum level of IGF 1 and IGFBP 3 in all syndromes of AIC group and AIV group were remarkably lower than control group.Among them,syndrome of Yin deficiency of liver and kidney and sthenia liver yang and syndrome of blood stasis due to Qi deficiency had lower serum level of IGF 1 and IGFBP 3 than syndrome of empty and obstruction of channel.So did collapse syndrome and syndrome of mental disorder due to phlegm fire to syndrome of wind fire evil lucid orifices and block Yin syndrome.Conclusion There are to some extent correlation with TCM’s Syndrome and serum level of IGF 1 and IGFBP 3 in patients with ACI. Serum level of IGF 1 and IGFBP 3 might be microcosmic referent markers of the damage of Qi and Yin by TCM`s syndrome differentiation.展开更多
Objective To investigate the interaction and c linical significance of changes in p lasma endothelin-1(ET-1)and prostacyclin(PGI 2 )concentrations in patients with isc hemic cerebral infarction.Methods Plasma ET-1and ...Objective To investigate the interaction and c linical significance of changes in p lasma endothelin-1(ET-1)and prostacyclin(PGI 2 )concentrations in patients with isc hemic cerebral infarction.Methods Plasma ET-1and 6-keto-PGF 1 α(resistant metabolite of PGI 2 )concentrations were measured in 37p atients(study group)with ischemic cerebral infarction a nd 34healthy volunteers(control group)by ra-dioimmunoassay.Results Plasma ET-1concentrations in patie nts of study group were markedly higher than that of control group(P <0.01)and 6-keto-PGF 1 αconcentrations in patients of study group were significantly lower than that of control subjects(P <0.01).Plasma ET-1concentrations in control subjects were positively correlated with 6-k eto-PGF 1 αconcentrations and no correlation i n the study group.Conclusion Both ET-1and PGI 2 are participated in patho-physiolo gic process of ischemic cerebral inf arction.ET-1is a virulence factor a nd may play a deleterious role in ischemic cerebral infarction,PGI 2 is a conservancy factor and endogenetic antagonist of ET-1.It may provid e useful therapy parameter to find out ectogenesis PGI 2 or analog for treating the patients with ischemic cerebral infarction wi th reason.展开更多
目的 探讨扶阳急救汤加减治疗急性脑梗死患者的疗效及对患者中医证候评分、卒中量表评分和凝血功能的影响。方法 将2020年6月—2022年6月安徽中医药大学附属太和中医院收治的120例急性脑梗死患者随机等分为观察组和对照组。对照组给予...目的 探讨扶阳急救汤加减治疗急性脑梗死患者的疗效及对患者中医证候评分、卒中量表评分和凝血功能的影响。方法 将2020年6月—2022年6月安徽中医药大学附属太和中医院收治的120例急性脑梗死患者随机等分为观察组和对照组。对照组给予抗血小板聚集等治疗措施,观察组在此基础上联合扶阳急救汤加减治疗。两组均持续治疗2周。比较两组患者的临床疗效、中医证候评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale, NIHSS)评分、凝血功能及3个月后改良RANKIN量表(Modified Rankin Scale, mRS)评分。结果 治疗后,观察组总有效率较高(P<0.05)。治疗1周、2周后,两组中医证候主证、次证、总积分和NIHSS评分逐渐明显降低(P<0.05),且观察组显著低于对照组(P<0.05)。治疗2周后,对照组凝血酶原时间(Prothrombin time, PT)、活化的部分凝血活酶时间(Activated partial thromboplastin time, APTT)、纤维蛋白原(Fibrinogen, FIB)、凝血酶时间(Thrombin time, TT)水平较治疗前差异无统计学意义(P>0.05),观察组PT、TT水平较治疗前差异无统计学意义(P>0.05),APTT及FIB水平则明显降低(P<0.05),且显著低于对照组(P<0.05)。治疗后3个月,观察组mRS评分显著低于对照组(P<0.05)。结论 扶阳急救汤加减治疗可以更好地促进痰瘀阻络证型急性脑梗死患者神经功能及中医证候的恢复,提高患者近期疗效及长期生活质量,且并未影响凝血功能,有较好的安全性,值得临床应用。展开更多
目的:观察中医辨证护理结合思维导图对急性脑梗死伴吞咽障碍患者康复效果的影响。方法:将60例急性脑梗死伴吞咽障碍患者随机分为A组(常规护理)和B组(常规护理加中医辨证护理及思维导图干预)各30例,干预1个月后比较两组患者美国国立卫生...目的:观察中医辨证护理结合思维导图对急性脑梗死伴吞咽障碍患者康复效果的影响。方法:将60例急性脑梗死伴吞咽障碍患者随机分为A组(常规护理)和B组(常规护理加中医辨证护理及思维导图干预)各30例,干预1个月后比较两组患者美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、Barthel指数及并发症发生情况。结果:B组患者干预后NIHSS评分低于干预前及A组干预后(P<0.05),B组Barthel指数优于干预前及A组干预后(P<0.05);B组误吸及吸入性肺炎发生率低于A组(P<0.05)。结论:中医辨证护理结合思维导图干预有助于改善急性脑梗死伴吞咽障碍患者的神经功能,提高患者生活运动能力,降低相关并发症发生率。展开更多
文摘Objective To study the relationship between traditional Chinese medicine (TCM) syndrome and serum level of IGF 1 and IGFBP 3 in patients with acute cerebral infarction (ACI).Methods 75 patients of ACI were divided into two groups by TCM`s syndrome differentiation: apolexy involving the channels (AIC) and apolexy involving the viscera (AIV).Serum level of IGF 1 and IGFBP 3 was detected by ELISA di antibody clipping technique (DACT) and was compared with that of 30 normal controls.Results Serum level of IGF 1 and IGFBP 3 in AIC group and AIV group were significantly different from control groups;and differences between AIC group and AIV group were statistically significant.Serum level of IGF 1 and IGFBP 3 in all syndromes of AIC group and AIV group were remarkably lower than control group.Among them,syndrome of Yin deficiency of liver and kidney and sthenia liver yang and syndrome of blood stasis due to Qi deficiency had lower serum level of IGF 1 and IGFBP 3 than syndrome of empty and obstruction of channel.So did collapse syndrome and syndrome of mental disorder due to phlegm fire to syndrome of wind fire evil lucid orifices and block Yin syndrome.Conclusion There are to some extent correlation with TCM’s Syndrome and serum level of IGF 1 and IGFBP 3 in patients with ACI. Serum level of IGF 1 and IGFBP 3 might be microcosmic referent markers of the damage of Qi and Yin by TCM`s syndrome differentiation.
文摘Objective To investigate the interaction and c linical significance of changes in p lasma endothelin-1(ET-1)and prostacyclin(PGI 2 )concentrations in patients with isc hemic cerebral infarction.Methods Plasma ET-1and 6-keto-PGF 1 α(resistant metabolite of PGI 2 )concentrations were measured in 37p atients(study group)with ischemic cerebral infarction a nd 34healthy volunteers(control group)by ra-dioimmunoassay.Results Plasma ET-1concentrations in patie nts of study group were markedly higher than that of control group(P <0.01)and 6-keto-PGF 1 αconcentrations in patients of study group were significantly lower than that of control subjects(P <0.01).Plasma ET-1concentrations in control subjects were positively correlated with 6-k eto-PGF 1 αconcentrations and no correlation i n the study group.Conclusion Both ET-1and PGI 2 are participated in patho-physiolo gic process of ischemic cerebral inf arction.ET-1is a virulence factor a nd may play a deleterious role in ischemic cerebral infarction,PGI 2 is a conservancy factor and endogenetic antagonist of ET-1.It may provid e useful therapy parameter to find out ectogenesis PGI 2 or analog for treating the patients with ischemic cerebral infarction wi th reason.
文摘目的 探讨扶阳急救汤加减治疗急性脑梗死患者的疗效及对患者中医证候评分、卒中量表评分和凝血功能的影响。方法 将2020年6月—2022年6月安徽中医药大学附属太和中医院收治的120例急性脑梗死患者随机等分为观察组和对照组。对照组给予抗血小板聚集等治疗措施,观察组在此基础上联合扶阳急救汤加减治疗。两组均持续治疗2周。比较两组患者的临床疗效、中医证候评分、美国国立卫生研究院卒中量表(National Institute of Health stroke scale, NIHSS)评分、凝血功能及3个月后改良RANKIN量表(Modified Rankin Scale, mRS)评分。结果 治疗后,观察组总有效率较高(P<0.05)。治疗1周、2周后,两组中医证候主证、次证、总积分和NIHSS评分逐渐明显降低(P<0.05),且观察组显著低于对照组(P<0.05)。治疗2周后,对照组凝血酶原时间(Prothrombin time, PT)、活化的部分凝血活酶时间(Activated partial thromboplastin time, APTT)、纤维蛋白原(Fibrinogen, FIB)、凝血酶时间(Thrombin time, TT)水平较治疗前差异无统计学意义(P>0.05),观察组PT、TT水平较治疗前差异无统计学意义(P>0.05),APTT及FIB水平则明显降低(P<0.05),且显著低于对照组(P<0.05)。治疗后3个月,观察组mRS评分显著低于对照组(P<0.05)。结论 扶阳急救汤加减治疗可以更好地促进痰瘀阻络证型急性脑梗死患者神经功能及中医证候的恢复,提高患者近期疗效及长期生活质量,且并未影响凝血功能,有较好的安全性,值得临床应用。
文摘目的:观察中医辨证护理结合思维导图对急性脑梗死伴吞咽障碍患者康复效果的影响。方法:将60例急性脑梗死伴吞咽障碍患者随机分为A组(常规护理)和B组(常规护理加中医辨证护理及思维导图干预)各30例,干预1个月后比较两组患者美国国立卫生研究院卒中量表(national institute of health stroke scale,NIHSS)、Barthel指数及并发症发生情况。结果:B组患者干预后NIHSS评分低于干预前及A组干预后(P<0.05),B组Barthel指数优于干预前及A组干预后(P<0.05);B组误吸及吸入性肺炎发生率低于A组(P<0.05)。结论:中医辨证护理结合思维导图干预有助于改善急性脑梗死伴吞咽障碍患者的神经功能,提高患者生活运动能力,降低相关并发症发生率。
