BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of life.Current treatment options like metformin(MET)effectively counteract hyperglycemia...BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of life.Current treatment options like metformin(MET)effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy,neuropathy,nephropathy,hepatopathy,and cardiovascular diseases.AIM To propose the supplementation of cholecalciferol(CHO)and taurine(TAU)to enhance MET efficacy in controlling diabetes while minimizing the risk of associated complications.METHODS The study involved sixty rats,including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by streptozotocin.The experimental rats were further subdivided into positive control and treatment subgroups.The four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO,TAU,or both.RESULTS Diabetic rats exhibited elevated levels of glucose,insulin,Homeostasis Model Assessment of Insulin Resistance(HOMA-IR),glycated hemoglobin percentage,lipid markers,aspartate aminotransferase,and malondialdehyde,along with reduced levels of antioxidant enzymes(catalase and superoxide dismutase).The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet mass.The antioxidative,anti-inflammatory,and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned abnormalities.CONCLUSION The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative,anti-inflammatory,and antiapoptotic effects.展开更多
Postmenopausal osteoporosis and osteopenia are chronic and uncurable conditions that invariably lead to an increased risk of vertebral, hip, and femoral neck fracture if left untreated. Clinical guidelines establish, ...Postmenopausal osteoporosis and osteopenia are chronic and uncurable conditions that invariably lead to an increased risk of vertebral, hip, and femoral neck fracture if left untreated. Clinical guidelines establish, in general, pharmacological combinations allied to lifestyle changes as the mainstay of their management, and also increasing bone marrow density, lowering fracture risk, and improving quality of life are their main therapeutic goals. The objective of this systematic review was to analyze the available data in the scientific medical literature regarding the role of the ibandronate and cholecalciferol combination in postmenopausal osteoporosis and osteopenia management. Based on our results, we concluded that the above combination is safe and feasible for the clinical control of both conditions.展开更多
Prostate cancer poses a significant health challenge globally,demanding proactive prevention strategies.This editorial explores the emerging role of vitamin D in prostate cancer prevention.While traditionally associat...Prostate cancer poses a significant health challenge globally,demanding proactive prevention strategies.This editorial explores the emerging role of vitamin D in prostate cancer prevention.While traditionally associated with bone health,vitamin D is increasingly recognized for its broader impact on immune function,cellular signaling,and cancer prevention.Epidemiological studies suggest an intriguing link between vitamin D deficiency and elevated prostate cancer risk,particularly in regions with limited sunlight exposure.Mechanistically,vitamin D regulates cellular processes,inhibiting unchecked cancer cell growth and bols-tering immune surveillance.Personalized prevention strategies,considering individual factors,are deemed essential for harnessing the full potential of vitamin D.To unlock this potential,the future calls for robust research,public awareness campaigns,dietary improvements,and vigilant medical guidance.Collaborative efforts are poised to pave the way toward a future where vitamin D stands as a sentinel in prostate cancer prevention,ushering in hope and improved health for men worldwide.展开更多
This experiment was conducted to determine whether dietary cholecalciferol will alleviate a calcium and phosphorous(Ca-P) deficiency when one-alpha-hydroxy-cholecalciferol,1 a(OH)D_3,is supplemented,and to determine t...This experiment was conducted to determine whether dietary cholecalciferol will alleviate a calcium and phosphorous(Ca-P) deficiency when one-alpha-hydroxy-cholecalciferol,1 a(OH)D_3,is supplemented,and to determine the effects of adequate and inadequate Ca-P when 1 a(OH)D_3 is supplemented and vitamin D_3 is adequate.A total of 144 one-d-old broiler chicks(Ross 308) were allocated to 3 treatments.The dietary treatments were as follows: treatment A,adequate Ca-P + cholecalciferol + 5 mg/kg 1 a(OH)D_3;treatment B,inadequate Ca-P + cholecalciferol + 5 mg/kg 1 a(OH)D_3; treatment C,inadequate Ca-P + 5 mg/kg 1 a(OH)D_3.All diets were mixed with 500 FTU/kg of phytase,and cholecalciferol was provided in 5,000 IU/kg except for treatment C that fed diets without vitamin D_3.The Ca-P levels in the adequate diets were 0.90% Ca,0.66% total phosphorus(t P); 0.75% Ca,0.59% t P; 0.69% Ca,0.54% t P for the starter,grower and finisher periods.At d 42 of age,broilers were inspected for incidence and severity of tibial dyschondroplasia(TD).The results showed that inadequate Ca-P supplementation with cholecalciferol significantly decreased the incidence of TD,score and tibia ash compared with broilers fed the same diet in the absence of cholecalciferol(P < 0.05).The broilers fed inadequate Ca-P diets with cholecalciferol were unable to achieve the same tibia ash and incidence of TD as those fed Ca-P adequate diets(P < 0.05).In conclusion,this trial suggests that broilers fed an inadequate Ca-P diet with 1 a(OH)D_3 and adequate level of cholecalciferol are unable to sufficient bone formation.There was no indication that 1 a(OH)D_3 in the absence of cholecalciferol was effective in reducing TD whereas it could improve tibia ash.展开更多
文摘BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of life.Current treatment options like metformin(MET)effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy,neuropathy,nephropathy,hepatopathy,and cardiovascular diseases.AIM To propose the supplementation of cholecalciferol(CHO)and taurine(TAU)to enhance MET efficacy in controlling diabetes while minimizing the risk of associated complications.METHODS The study involved sixty rats,including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by streptozotocin.The experimental rats were further subdivided into positive control and treatment subgroups.The four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO,TAU,or both.RESULTS Diabetic rats exhibited elevated levels of glucose,insulin,Homeostasis Model Assessment of Insulin Resistance(HOMA-IR),glycated hemoglobin percentage,lipid markers,aspartate aminotransferase,and malondialdehyde,along with reduced levels of antioxidant enzymes(catalase and superoxide dismutase).The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet mass.The antioxidative,anti-inflammatory,and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned abnormalities.CONCLUSION The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative,anti-inflammatory,and antiapoptotic effects.
文摘Postmenopausal osteoporosis and osteopenia are chronic and uncurable conditions that invariably lead to an increased risk of vertebral, hip, and femoral neck fracture if left untreated. Clinical guidelines establish, in general, pharmacological combinations allied to lifestyle changes as the mainstay of their management, and also increasing bone marrow density, lowering fracture risk, and improving quality of life are their main therapeutic goals. The objective of this systematic review was to analyze the available data in the scientific medical literature regarding the role of the ibandronate and cholecalciferol combination in postmenopausal osteoporosis and osteopenia management. Based on our results, we concluded that the above combination is safe and feasible for the clinical control of both conditions.
文摘Prostate cancer poses a significant health challenge globally,demanding proactive prevention strategies.This editorial explores the emerging role of vitamin D in prostate cancer prevention.While traditionally associated with bone health,vitamin D is increasingly recognized for its broader impact on immune function,cellular signaling,and cancer prevention.Epidemiological studies suggest an intriguing link between vitamin D deficiency and elevated prostate cancer risk,particularly in regions with limited sunlight exposure.Mechanistically,vitamin D regulates cellular processes,inhibiting unchecked cancer cell growth and bols-tering immune surveillance.Personalized prevention strategies,considering individual factors,are deemed essential for harnessing the full potential of vitamin D.To unlock this potential,the future calls for robust research,public awareness campaigns,dietary improvements,and vigilant medical guidance.Collaborative efforts are poised to pave the way toward a future where vitamin D stands as a sentinel in prostate cancer prevention,ushering in hope and improved health for men worldwide.
基金support from the Young Researchers and Elite Club,Isfahan Branch (Grant No.2016/ 003)
文摘This experiment was conducted to determine whether dietary cholecalciferol will alleviate a calcium and phosphorous(Ca-P) deficiency when one-alpha-hydroxy-cholecalciferol,1 a(OH)D_3,is supplemented,and to determine the effects of adequate and inadequate Ca-P when 1 a(OH)D_3 is supplemented and vitamin D_3 is adequate.A total of 144 one-d-old broiler chicks(Ross 308) were allocated to 3 treatments.The dietary treatments were as follows: treatment A,adequate Ca-P + cholecalciferol + 5 mg/kg 1 a(OH)D_3;treatment B,inadequate Ca-P + cholecalciferol + 5 mg/kg 1 a(OH)D_3; treatment C,inadequate Ca-P + 5 mg/kg 1 a(OH)D_3.All diets were mixed with 500 FTU/kg of phytase,and cholecalciferol was provided in 5,000 IU/kg except for treatment C that fed diets without vitamin D_3.The Ca-P levels in the adequate diets were 0.90% Ca,0.66% total phosphorus(t P); 0.75% Ca,0.59% t P; 0.69% Ca,0.54% t P for the starter,grower and finisher periods.At d 42 of age,broilers were inspected for incidence and severity of tibial dyschondroplasia(TD).The results showed that inadequate Ca-P supplementation with cholecalciferol significantly decreased the incidence of TD,score and tibia ash compared with broilers fed the same diet in the absence of cholecalciferol(P < 0.05).The broilers fed inadequate Ca-P diets with cholecalciferol were unable to achieve the same tibia ash and incidence of TD as those fed Ca-P adequate diets(P < 0.05).In conclusion,this trial suggests that broilers fed an inadequate Ca-P diet with 1 a(OH)D_3 and adequate level of cholecalciferol are unable to sufficient bone formation.There was no indication that 1 a(OH)D_3 in the absence of cholecalciferol was effective in reducing TD whereas it could improve tibia ash.
