目的分析安罗替尼所致心血管不良反应的发生规律和临床特点,为临床安全用药提供参考。方法检索2018年8月—2022年5月万方、中国知网、维普、PubMed、Web of Science、Embase数据库中安罗替尼致心血管不良反应(ADR)的个案报道,筛选后进...目的分析安罗替尼所致心血管不良反应的发生规律和临床特点,为临床安全用药提供参考。方法检索2018年8月—2022年5月万方、中国知网、维普、PubMed、Web of Science、Embase数据库中安罗替尼致心血管不良反应(ADR)的个案报道,筛选后进行统计分析。结果共收集20篇个案报道,涉及20例患者,其中男性9例(45.0%),女性11例(55.0%)。患者年龄集中在50~69岁,ADR多发生在用药后7~90 d,以高血压最为常见,主动脉夹层、可逆性后部白质脑病综合征、高血压性视网膜病变等ADR未在说明书中提及。结论临床使用安罗替尼应加强监测,警惕其心血管ADR,尤其注重防治高血压,及时识别并发症,确保临床用药安全。展开更多
<strong>Background and Aims:</strong><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style=&...<strong>Background and Aims:</strong><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">Patients and the general public are under insur</span></span></span><span><span><span style="font-family:;" "="">mountable psychological pressure which may lead to various psychological problems, such as anxiety, fear, depression, and insomnia, causing, consequently, the impaired quality of life. Psychological crisis intervention plays a pivotal role in the overall deployment of health-related quality of life and dis<span>ease control. A novel Severe Acute Respiratory Syndrome Coronavirus-2</span> (SARS-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">CoV-2), a pathogen of the new coronavirus disease (COVID-19), has affected several sector activities, including people’s health. To enhance infection con<span>trol methods, appropriate interventions, and public health policies, the</span> present study aims to assess the fear and peri-traumatic stress during the COVID-19 inBrazil. <b>Method:</b> A cross-sectional survey has been conducted from April 12<sup>th</sup> to 18<sup>th</sup></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">from 2020</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> using the Peri-Traumatic Distress Scale (CPDI) and the Fear Scale (FCV-19S) aiming to measure the peri-traumatic stress and <span>fear as psychological reactions during the COVID-19 pandemic. For that</span> purpose, an online spreadsheet was used to send the questionnaire and scales to a sample of 1844 participants as a collecting information tool. After the data analysis, the individuals were separated into 4 groups: Group 1 (1232) population without chronic health conditions;group 2 (298) patients with previous psychological suffering, group 3 (229) patients with cardiovascular diseases, group 4 (71) patients with diabetes. For analysis, G1</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">were considered <span>control for comparison with groups 2, 3 and 4. <b>Results:</b> All the groups</span> showed the CPDI and FCV-19S increased in comparison with the G1 group. Concerning CPDI, the G 3 was increased when compared to G1, G2 and G4. The G3 had the FCV-19S higher in comparison with G1, G2 and G4. The <span>Wilcoxon-Mann-Whitney test showed a statistical difference between the </span>control group in comparison with 2 and 3 groups (Mann-Whitney p</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">< 0.05). <b>Conclusion:</b> The COVID-19 pandemic had a significant impact on the Brazilian population, with patients with heart disease and hypertension present<span>ing the highest numbers of stress and fear, with numbers comparable and</span> even higher than those who reported previous psychological distress.</span></span></span>展开更多
文摘目的分析安罗替尼所致心血管不良反应的发生规律和临床特点,为临床安全用药提供参考。方法检索2018年8月—2022年5月万方、中国知网、维普、PubMed、Web of Science、Embase数据库中安罗替尼致心血管不良反应(ADR)的个案报道,筛选后进行统计分析。结果共收集20篇个案报道,涉及20例患者,其中男性9例(45.0%),女性11例(55.0%)。患者年龄集中在50~69岁,ADR多发生在用药后7~90 d,以高血压最为常见,主动脉夹层、可逆性后部白质脑病综合征、高血压性视网膜病变等ADR未在说明书中提及。结论临床使用安罗替尼应加强监测,警惕其心血管ADR,尤其注重防治高血压,及时识别并发症,确保临床用药安全。
文摘动脉粥样硬化(atherosclerosis, AS)是脂质沉积于血管壁导致的慢性炎症性疾病,是冠心病、高血压病、心力衰竭等心脑血管疾病的病理基础,动脉粥样硬化斑块的稳定或破裂是心血管事件发生与否的重要影响因素。细胞焦亡是一种促炎性质的程序性细胞死亡,过度的细胞焦亡可引起细胞裂解死亡并发级联炎症反应。越来越多的研究表明细胞焦亡在AS的病理进程中扮演重要角色,NOD样受体蛋白3 (nod-like receptor protein 3,NLRP3)、半胱氨酸天冬氨酸蛋白酶-1(cysteinyl aspartate specific proteinase-1,Caspase-1)、细胞焦亡执行蛋白(gasdermin D,GSDMD)等细胞焦亡的关键蛋白参与AS血管内皮细胞损伤、内皮功能障碍、平滑肌细胞表型转换、巨噬细胞死亡、泡沫细胞形成等过程,已成为AS新的治疗靶点。中医药是历史悠久的医药学体系,随着研究的深入,中药复方及中药单体活性成分通过调控细胞焦亡干预AS的作用逐步被阐明,且具有多途径,多靶点,不良反应小等独特优势。基于上述研究,阐述细胞焦亡的概念及发生机制,归纳细胞焦亡在AS病程中的作用,并总结中药复方和单味中药有效成分基于细胞焦亡干预AS的研究进展,以期为AS的防治及中药新药的开发提供新的思路。
文摘<strong>Background and Aims:</strong><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">Patients and the general public are under insur</span></span></span><span><span><span style="font-family:;" "="">mountable psychological pressure which may lead to various psychological problems, such as anxiety, fear, depression, and insomnia, causing, consequently, the impaired quality of life. Psychological crisis intervention plays a pivotal role in the overall deployment of health-related quality of life and dis<span>ease control. A novel Severe Acute Respiratory Syndrome Coronavirus-2</span> (SARS-</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">CoV-2), a pathogen of the new coronavirus disease (COVID-19), has affected several sector activities, including people’s health. To enhance infection con<span>trol methods, appropriate interventions, and public health policies, the</span> present study aims to assess the fear and peri-traumatic stress during the COVID-19 inBrazil. <b>Method:</b> A cross-sectional survey has been conducted from April 12<sup>th</sup> to 18<sup>th</sup></span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">from 2020</span></span></span><span><span><span style="font-family:;" "="">,</span></span></span><span><span><span style="font-family:;" "=""> using the Peri-Traumatic Distress Scale (CPDI) and the Fear Scale (FCV-19S) aiming to measure the peri-traumatic stress and <span>fear as psychological reactions during the COVID-19 pandemic. For that</span> purpose, an online spreadsheet was used to send the questionnaire and scales to a sample of 1844 participants as a collecting information tool. After the data analysis, the individuals were separated into 4 groups: Group 1 (1232) population without chronic health conditions;group 2 (298) patients with previous psychological suffering, group 3 (229) patients with cardiovascular diseases, group 4 (71) patients with diabetes. For analysis, G1</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">were considered <span>control for comparison with groups 2, 3 and 4. <b>Results:</b> All the groups</span> showed the CPDI and FCV-19S increased in comparison with the G1 group. Concerning CPDI, the G 3 was increased when compared to G1, G2 and G4. The G3 had the FCV-19S higher in comparison with G1, G2 and G4. The <span>Wilcoxon-Mann-Whitney test showed a statistical difference between the </span>control group in comparison with 2 and 3 groups (Mann-Whitney p</span></span></span><span><span><span style="font-family:;" "=""> </span></span></span><span><span><span style="font-family:;" "="">< 0.05). <b>Conclusion:</b> The COVID-19 pandemic had a significant impact on the Brazilian population, with patients with heart disease and hypertension present<span>ing the highest numbers of stress and fear, with numbers comparable and</span> even higher than those who reported previous psychological distress.</span></span></span>
