Objective:To study the effect of Chaishao Jieyu Decoction on the improvement of mental state、immune function and diarrhea of Liver Depression and Spleen Deficiency patients with colorectal cancer after operation.Meth...Objective:To study the effect of Chaishao Jieyu Decoction on the improvement of mental state、immune function and diarrhea of Liver Depression and Spleen Deficiency patients with colorectal cancer after operation.Methods:76 cases of colorectal cancer patients after operation,according to the method of random grouping would be divided into the chinese medicine treatment(CMT)group and the western medicine control(WMC)group,each group 38 cases.The WMC group were treated with montmorillonite.The CMT group accepted oral administration of Chaishao Jieyu Decoction.The levels of anxiety and depression score,quality of life,T lymphocyte subsets and TNF-α,and improvement of diarrhea were compared.Results:With the therapy ending,the standards of SAS and SDS in CMT group were reduced signficantly than the WMC group(P<0.05),The score of QOL was obviously higher than the WMC group(P<0.05),the treatment group's CD3+、CD4+subsets levels increased obviously than the WMC group(P<0.05),the CD8+subsets and Tumor necrosis factor-alpha-levels were obviously lower than the WMC group(P<0.05),the improvement of diarrhea of the CMT group was obviously better than the WMC group(P<0.05).Conclusion:Chaishao Jieyu Decoction can effectively improve the mental state and diarrhea symptoms of postoperative patients with colorectal cancer,and significantly improve the immune function of the body,the Chaishao Jieyu Decoction's effect is excellent.展开更多
Objective:To study the improvement of Chaishao Jieyu decoction combined with Pingxiao capsule on the mental state、immune function and endometrium of patients with luminal breast cancer undergoing endocrine therapy af...Objective:To study the improvement of Chaishao Jieyu decoction combined with Pingxiao capsule on the mental state、immune function and endometrium of patients with luminal breast cancer undergoing endocrine therapy after operation.Methods:60 cases of luminal breast cancer patients after operation,according to the method of random grouping would be divided into the control group and the observation group,each group 30 cases.The control group were treated with tamoxifen.On the basis,the observation group accepted oral administration of Chaishao Jieyu Decoction and Pingxiao capsule.The levels of 5-HT、DA、T lymphocyte subsets、IGF-1 and endometrial thickness were compared.Results:At the end of treatment,the observation group's 5-HT、DA、CD3+、CD4+levels were obviously higher than the control group(P<0.05),the observation group's CD8+levels、IGF-1 levels and endometrial thickness were significantly lower than the control group(P<0.05).Conclusion:Chaishao Jieyu Decoction combined with Pingxiao capsule can significantly improve the mental state、immune function of patients with luminal breast cancer undergoing endocrine therapy after surgery,and inhibit their endometrial thickening,the effect is exact.展开更多
Objective:To explore the curative effect of Chaishao Chengqi Decoction on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type and its effect on inflammatory reaction,and to provide new id...Objective:To explore the curative effect of Chaishao Chengqi Decoction on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type and its effect on inflammatory reaction,and to provide new ideas for clinical treatment and prognosis evaluation.Methods:60 patients with moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type from June 2017 to June 2019 were randomly divided into control group treated with conventional therapy and treatment group treated with Chaishao Chengqi Decoction for 2 weeks.The differences of clinical efficacy and TCM syndromes between the two groups were compared.Ranson score,Balthazar CTSI score,SIRS score and modified Marshall score were recorded before and after treatment.The levels of inflammatory factors and oxidative stress-related molecules were compared before and after treatment.Result:After treatment,the total effective rates of the control group and the treatment group were 80.0%and 93.3%,respectively,with statistical difference(χ2=8.845,P=0.027);after treatment,the total effective rates of TCM syndromes evaluation of the control group and the treatment group were 76.7%and 93.3%,respectively,with statistical difference(χ2=10.024,P=0.012);after treatment,the Ranson score,Balthazar CTSI score,SIRS score and improved Marshall score were all significantly decreased(P<0.05),and the decrease was more significant in the treatment group(P<0.05);after treatment,the serum levels of TNF-α,IL-6 and MDA were significantly decreased in both groups,and superoxide dismutase(SOD)was significantly increased(P<0.05),and the treatment group improved more(P<0.05).Conclusion:Chaishao Chengqi Decoction has a good curative effect on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type,and can effectively improve inflammatory response and oxidative stress,which has a high clinical significance.展开更多
目的:探究糖尿病应用柴芍六君子汤合半夏泻心汤加减治疗对血糖水平及临床症状的影响,评估该治疗方式的应用价值,为临床推广提供参考。方法:根据治疗方式将符合条件的63例糖尿病患者分为两组,试验组32例行柴芍六君子汤与半夏泻心汤加减...目的:探究糖尿病应用柴芍六君子汤合半夏泻心汤加减治疗对血糖水平及临床症状的影响,评估该治疗方式的应用价值,为临床推广提供参考。方法:根据治疗方式将符合条件的63例糖尿病患者分为两组,试验组32例行柴芍六君子汤与半夏泻心汤加减合用治疗方式,对照组31例行二甲双胍药物治疗方式,对比两组干预治疗效果及远期疗效。结果:干预前,两组血糖水平(Hb A1c、2 h PG及FPG)和胰岛β细胞功能(FINS和HOMA-β)差异无统计学意义(P>0.05);干预后,与对照组比,试验组血糖水平均显著偏低(P<0.05),胰岛β细胞功能显著偏高(P<0.05)。与对照组比,试验组中医症状评分(水谷不消、肠鸣下利、倦怠乏力、呕恶纳呆、便溏)显著偏低(P<0.05),各方面生活质量评分(身体健康、心理应对、生活障碍、生活满意度和积极影响)显著偏高(P<0.05)。试验组临床总有效28例,占比87.5%,明显高于对照组(χ^(2)=5.709,P=0.017<0.05)。试验组不良反应发生2例,占比6.3%,明显低于对照组(χ^(2)=4.510,P=0.034<0.05)。结论:柴芍六君子汤与半夏泻心汤加减两药合用可减轻糖尿病临床症状,降低血糖水平,提高胰岛β细胞功能,提升生活质量,降低不良反应,适合临床推广。展开更多
基金Youth project of national natural science foundation(No.81803711)
文摘Objective:To study the effect of Chaishao Jieyu Decoction on the improvement of mental state、immune function and diarrhea of Liver Depression and Spleen Deficiency patients with colorectal cancer after operation.Methods:76 cases of colorectal cancer patients after operation,according to the method of random grouping would be divided into the chinese medicine treatment(CMT)group and the western medicine control(WMC)group,each group 38 cases.The WMC group were treated with montmorillonite.The CMT group accepted oral administration of Chaishao Jieyu Decoction.The levels of anxiety and depression score,quality of life,T lymphocyte subsets and TNF-α,and improvement of diarrhea were compared.Results:With the therapy ending,the standards of SAS and SDS in CMT group were reduced signficantly than the WMC group(P<0.05),The score of QOL was obviously higher than the WMC group(P<0.05),the treatment group's CD3+、CD4+subsets levels increased obviously than the WMC group(P<0.05),the CD8+subsets and Tumor necrosis factor-alpha-levels were obviously lower than the WMC group(P<0.05),the improvement of diarrhea of the CMT group was obviously better than the WMC group(P<0.05).Conclusion:Chaishao Jieyu Decoction can effectively improve the mental state and diarrhea symptoms of postoperative patients with colorectal cancer,and significantly improve the immune function of the body,the Chaishao Jieyu Decoction's effect is excellent.
基金Special project of national traditional Chinese medicine clinical research base of state administration of traditional Chinese medicine(No.JDZX2015057)
文摘Objective:To study the improvement of Chaishao Jieyu decoction combined with Pingxiao capsule on the mental state、immune function and endometrium of patients with luminal breast cancer undergoing endocrine therapy after operation.Methods:60 cases of luminal breast cancer patients after operation,according to the method of random grouping would be divided into the control group and the observation group,each group 30 cases.The control group were treated with tamoxifen.On the basis,the observation group accepted oral administration of Chaishao Jieyu Decoction and Pingxiao capsule.The levels of 5-HT、DA、T lymphocyte subsets、IGF-1 and endometrial thickness were compared.Results:At the end of treatment,the observation group's 5-HT、DA、CD3+、CD4+levels were obviously higher than the control group(P<0.05),the observation group's CD8+levels、IGF-1 levels and endometrial thickness were significantly lower than the control group(P<0.05).Conclusion:Chaishao Jieyu Decoction combined with Pingxiao capsule can significantly improve the mental state、immune function of patients with luminal breast cancer undergoing endocrine therapy after surgery,and inhibit their endometrial thickening,the effect is exact.
基金Zhangjiagang municipal commission of health and family planning system youth science and technology project in 2018(ZJGQNLKJ201813).
文摘Objective:To explore the curative effect of Chaishao Chengqi Decoction on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type and its effect on inflammatory reaction,and to provide new ideas for clinical treatment and prognosis evaluation.Methods:60 patients with moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type from June 2017 to June 2019 were randomly divided into control group treated with conventional therapy and treatment group treated with Chaishao Chengqi Decoction for 2 weeks.The differences of clinical efficacy and TCM syndromes between the two groups were compared.Ranson score,Balthazar CTSI score,SIRS score and modified Marshall score were recorded before and after treatment.The levels of inflammatory factors and oxidative stress-related molecules were compared before and after treatment.Result:After treatment,the total effective rates of the control group and the treatment group were 80.0%and 93.3%,respectively,with statistical difference(χ2=8.845,P=0.027);after treatment,the total effective rates of TCM syndromes evaluation of the control group and the treatment group were 76.7%and 93.3%,respectively,with statistical difference(χ2=10.024,P=0.012);after treatment,the Ranson score,Balthazar CTSI score,SIRS score and improved Marshall score were all significantly decreased(P<0.05),and the decrease was more significant in the treatment group(P<0.05);after treatment,the serum levels of TNF-α,IL-6 and MDA were significantly decreased in both groups,and superoxide dismutase(SOD)was significantly increased(P<0.05),and the treatment group improved more(P<0.05).Conclusion:Chaishao Chengqi Decoction has a good curative effect on moderate to severe acute pancreatitis of heat stagnation and Fu-organ excess type,and can effectively improve inflammatory response and oxidative stress,which has a high clinical significance.
文摘目的:探究糖尿病应用柴芍六君子汤合半夏泻心汤加减治疗对血糖水平及临床症状的影响,评估该治疗方式的应用价值,为临床推广提供参考。方法:根据治疗方式将符合条件的63例糖尿病患者分为两组,试验组32例行柴芍六君子汤与半夏泻心汤加减合用治疗方式,对照组31例行二甲双胍药物治疗方式,对比两组干预治疗效果及远期疗效。结果:干预前,两组血糖水平(Hb A1c、2 h PG及FPG)和胰岛β细胞功能(FINS和HOMA-β)差异无统计学意义(P>0.05);干预后,与对照组比,试验组血糖水平均显著偏低(P<0.05),胰岛β细胞功能显著偏高(P<0.05)。与对照组比,试验组中医症状评分(水谷不消、肠鸣下利、倦怠乏力、呕恶纳呆、便溏)显著偏低(P<0.05),各方面生活质量评分(身体健康、心理应对、生活障碍、生活满意度和积极影响)显著偏高(P<0.05)。试验组临床总有效28例,占比87.5%,明显高于对照组(χ^(2)=5.709,P=0.017<0.05)。试验组不良反应发生2例,占比6.3%,明显低于对照组(χ^(2)=4.510,P=0.034<0.05)。结论:柴芍六君子汤与半夏泻心汤加减两药合用可减轻糖尿病临床症状,降低血糖水平,提高胰岛β细胞功能,提升生活质量,降低不良反应,适合临床推广。
