In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological a...In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.展开更多
Sijunzi Decoction,as one of the classic Chinese traditional prescriptions,has been used clinically by major physicians since the Song Dynasty.This article reviewed and sorted out the literature on the effective chemis...Sijunzi Decoction,as one of the classic Chinese traditional prescriptions,has been used clinically by major physicians since the Song Dynasty.This article reviewed and sorted out the literature on the effective chemistry of Sijunzi Decoction and the mechanism of its prevention and treatment of digestive system diseases.At present,its effective chemical components are derived from the saponins and flavonoids in ginseng and licorice,and are effective for gastrointestinal mucosal injury diseases and malignant digestive system.Digestive system diseases such as tumors,functional gastrointestinal diseases,non-alcoholic fatty liver,acute liver injury,and liver failure show a multi-path,multi-target effect mechanism.This article reviews the effective chemical components and research of Sijunzi Decoction and the related mechanisms of prevention and treatment of digestive system diseases,and provides valuable clues for the follow-up research of Sijunzi Decoction.展开更多
[Objectives]To isolate and identify chemical constituents from Phellodendron chinense.[Methods]Compounds were isolated by silica gel,Sephadex LH-20,and ODS column chromatography,and their structures were determined by...[Objectives]To isolate and identify chemical constituents from Phellodendron chinense.[Methods]Compounds were isolated by silica gel,Sephadex LH-20,and ODS column chromatography,and their structures were determined by means of the spectral analysis and physicochemical properties.[Results]Eleven compounds were isolated and identified as berberine(1),obaculactone(2),shihulimonin A(3),N-p-coumaroyltyramine(4),1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-propyl)-2-methoxyphenoxy]-propane-1,3-diol(5),phellodendrine(6),magnoflorine(7),palmatine(8),jatrorrhizine(9),columbamine(10),and obacunone(11).[Conclusions]Compounds 3 and 5 were isolated from Phellodendron for the first time,and compound 4 was isolated from this plant for the first time.展开更多
Objective:The main chemical components of galangal(Alpinia officinarum Hance)are flavonoids and diarylheptanes.In the previous work,the total heptane and total flavonoid components of galangal were isolated.In this pa...Objective:The main chemical components of galangal(Alpinia officinarum Hance)are flavonoids and diarylheptanes.In the previous work,the total heptane and total flavonoid components of galangal were isolated.In this paper,the two components were separated.The monomeric compound was purified and its cytotoxic activity was determined.Methods:Silica gel column chromatography,ODS column chromatography,preparative thin layer chromatography,preparative and semi-preparative HPLC methods were used to separate and purify the total heptane components and total flavonoid components of galangal.Structures of compounds were identified by 1H-NMR,13C-NMR modern spectroscopic techniques combined with literature.The cytotoxic activity of the isolated compounds against MDA-MB-231(breast cancer),HepG-2(liver cancer)and MKN-45(gastric cancer)cells was tested by CCK-8 method.Results:Six compounds were isolated from the total heptane fractions of galangal,and three compounds were isolated from the total flavonoids of galangal.Their structures were identified as:5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one(1),(E)-7-(4-hydr-oxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one(2),5-hydroxy-1,7-diphenylheptan-3-one(3)7-(4-hydroxyphenyl)-5-methoxy-1-phenylheptan-3-one(4),(E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(5),(E)-1,7-diphenylhept-4-en-3-one(6),pinocembrin(7),galangin(8),3-O-methylgalangin(9).Conclusion:Compounds 1-6 were isolated from the total heptane components of galangal,and compounds 7-9 were isolated from the total flavonoids of galangal.The results of CCK-8 showed that compounds 2,3,5,6,7 and 8 had weak antitumor activity.展开更多
[Objectives]This study was conducted to study the chemical constituents from Laportea bulbifera. [Methods] The 60% ethanol extract from L. bulbifera was isolated and purified by silica, Sephadex LH-20, ODS, semi-prepa...[Objectives]This study was conducted to study the chemical constituents from Laportea bulbifera. [Methods] The 60% ethanol extract from L. bulbifera was isolated and purified by silica, Sephadex LH-20, ODS, semi-preparative HPLC and recrystallization. Their chemical structures were elucidated by physicochemical properties and spectroscopic methods. [Results] These compounds were determined as kaempferol-3-O-α-L-(3-O-acetyl)-rhamnoside-7-O-α-L-rhamnoside(1), sutchuenoside A(2), kaempferol-3-O-[β-D-glucopyranosyl-(1→3)]-α-L-(4-O-acetyl)-rhamnopyranoside-7-O-α-L-rhamnopyranoside(3). Compounds 1-3 are isolated from genus Laportea for the first time. Compound 3 is a new compound. [Conclusions] This study lays a foundation for improving the quality standard of L. bulbifera and the development and utilization of its resources.展开更多
Celosia L. is richly distributed in China and there are about 60 species in the world. The chemical constituents of Celosia L. include flavonoids, triterpenoid saponins, steroids, organic acids, and cyclic peptides. W...Celosia L. is richly distributed in China and there are about 60 species in the world. The chemical constituents of Celosia L. include flavonoids, triterpenoid saponins, steroids, organic acids, and cyclic peptides. Which have a variety of effects such as antimicrobial, hepatoprotective and antitumour. To provide a scientific foundation for the subsequent phase of research and development for Celosia L., 30 years of pertinent global literature is summarized, analyzed, and categorized. An overview of 75 chemical constituents, pharmacological activities, and clinical applications is provided.展开更多
Salvia miltiorrhiza Bunge(S.miltiorrhiza),a perennial plant of the genus Salvia,is widely used in traditional folklore medicine.Previous chemical research on this plant contains diterpenoid quinones,phenolic acids,pol...Salvia miltiorrhiza Bunge(S.miltiorrhiza),a perennial plant of the genus Salvia,is widely used in traditional folklore medicine.Previous chemical research on this plant contains diterpenoid quinones,phenolic acids,polysaccharides and other compounds.The pharmacological investigation of S.miltiorrhiza has shown that it has various pharmacological activities,such as cardiovascular system protection,anti-inflammatory,anti-oxidant,anti-tumor,liver protection,and neuroprotection activities.This research tends to give an overview of the main chemical constituents and pharmacological effects of S.miltiorrhiza,aiming to reveal its potential value and provide reference for its further development.展开更多
Piper amalago(P.amalago)is a traditional medicine in Brazil for the treatment of leishmanial.Owing to its rare occurrence and potent pharmacological activities,efforts have been devoted to the identification of its di...Piper amalago(P.amalago)is a traditional medicine in Brazil for the treatment of leishmanial.Owing to its rare occurrence and potent pharmacological activities,efforts have been devoted to the identification of its diverse constituents,especially terpenoids.Researchers have found that the major constituents of P.amalago were amides,monoterpenes,norisoprenoids,sesquiterpenes,aliphatic hydrocarbons and aromatic hydrocarbons.The amides show anxiolytic,anti-inflammatory,antileishmanial and antinociceptive activity.This review summarizes the research progress of the structural diversity and pharmacological activities of P.amalago.展开更多
Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate...Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate of E.ulmoides Oliv.is still very low,only bark has been used as medicine and other parts of Eucommia ulmoides Oliv.cannot be fully utilized,even the leaves have been well utilized in food products in Japan in the past decades.In order to improve the comprehensive utilization efficiency of E.ulmoides Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of E.ulmoides Oliv.The findings suggest that other parts of E.ulmoides Oliv.could replace the bark of E.ulmoides Oliv.to some extent besides of their respective applications.The unique and extensive physiological functions between different parts of E.ulmoides Oliv.indicate that the comprehensive utilization of E.ulmoides Oliv.has a wide space to develop,which is also an effective way to protect E.ulmoides Oliv.resources and improve its the utilization rate.展开更多
Two new minor constituents,musinisins A(1)and B(2),together with five known compounds(3-7),were isolated from the aerial parts of Munronia sinica.Their structures were established by means of spectroscopic methods and...Two new minor constituents,musinisins A(1)and B(2),together with five known compounds(3-7),were isolated from the aerial parts of Munronia sinica.Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment.Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.展开更多
Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,...Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and flavonoids.Pharmacological effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and anti-inflammatory.This paper summarized chemical constituents and pharmacological effects of Lilium.展开更多
Maca(Lepidium meyenii Walp.),a famous food supplement,has drawn an unprecedented international interest over the last two decades.It was assumed that glucosinolates,macamides,macaenes,and alkaloids are the main bioact...Maca(Lepidium meyenii Walp.),a famous food supplement,has drawn an unprecedented international interest over the last two decades.It was assumed that glucosinolates,macamides,macaenes,and alkaloids are the main bioactive components of Maca before.Recently,a series of novel thiohydantoins which generally exhibit a variety of activities have been isolated from Maca.This review focuses on the progress on the main bioactive components of Maca and their biosynthetic pathway,which indicates that macamides,thiohydantoins,and some alkaloids may originate from glucosinolates.Interestingly,thiohydantoins from Maca are the first type of thiohydantoin derivatives to be found from a natural source and may contribute to some significant effects of Maca.展开更多
Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps sinensis.Its main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and polysaccharides....Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps sinensis.Its main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and polysaccharides.Due to the huge development potential of P.hepiali in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the public.In this paper,the chemical constituents and their pharmacological effects of P.hepiali are reviewed,which can provide reference for the development and application of P.hepiali.展开更多
Rhizome atractylodes macrocephalae is the dry roots of Atractylodes macrocephala Koidz.It is one of commonly used Chinese medicine.In the "Shennong′s Herbal",it was listed as the top grade.It mainly contain...Rhizome atractylodes macrocephalae is the dry roots of Atractylodes macrocephala Koidz.It is one of commonly used Chinese medicine.In the "Shennong′s Herbal",it was listed as the top grade.It mainly contains volatile oil,atractylenolides,atractylodes polysaccharides,glycosides and amino acids.And it has the medical functions of good for spleen and intestine,diuretic and dehumidification,hidroschesis,miscarriage prevention and soon.In order to provide references for further development and utilization,this paper systematic arranged the Chinese medicine atractylodes chemical composition,pharmacological effects,processing technology and effect of processing technology on chemical composition and pharmacological action.展开更多
Two new compounds,maniesculentins A(1)and B(6),together with four known ones were isolated from the stems of Manihot esculenta Crantz.The structures of the new compounds were elucidated by extensive spectroscopic meth...Two new compounds,maniesculentins A(1)and B(6),together with four known ones were isolated from the stems of Manihot esculenta Crantz.The structures of the new compounds were elucidated by extensive spectroscopic methods including NMR spectroscopy and mass spectrometry.The two new compounds(1,6)were assayed for antibacterial activity against four tested bacteria lines.展开更多
Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Act...Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Actinidia species.A large number of secondary metabolites including triterpenoids,flavonoids,phenols,etc.have been identified from differents parts of Actinidia plants,which exhibited significant in vitro and in vivo pharmacological activities including anticancer,anti-inflammatory,neuroprotective,anti-oxidative,anti-bacterial,and anti-diabetic activities.In order to fully understand the chemical compo-nents and biological activities of Actinidia plants,and to improve their further research,development and utilization,this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020,classifies the types of constituents,reports on the pharmacological activities of relative compounds and medicinal potentials.展开更多
Sauropus spatulifolius Beille is a small evergreen shrub in Sauropus of the Euphorbiaceae family.It mainly contains chemical components such as amino acids,proteins,carbohydrates,polypeptides,glycosides,saponins,tanni...Sauropus spatulifolius Beille is a small evergreen shrub in Sauropus of the Euphorbiaceae family.It mainly contains chemical components such as amino acids,proteins,carbohydrates,polypeptides,glycosides,saponins,tannins,organic acids,alkaloids,coumarin and lactones,volatile oils and oils.In addition,the chemical components obtained by different extraction processes are also different.S.spatulifolius Beille mainly has antitussive and expectorant,anti-inflammatory and analgesic,bacteriostatic,antioxidant,and anti-allergic effects.The rich biological activity of S.spatulifolius Beille makes it have clinical applications such as adjuvant treatment of pulmonary edema,recovery of lung function,and treatment of chronic laryngitis or chronic pharyngitis.In this paper,the main chemical components,extraction and identification methods and biological activity of S.spatulifolius Beille were described in depth,in order to further lay a solid foundation for the in-depth research,development and utilization of S.spatulifolius Beille.展开更多
Dendrobium nobile Lindl (D. nobile), a well-known precious herb, has a long history of use as a medicine and health food in China. Phytochemically, D. nobile has been found to contain various bioactive compounds, such...Dendrobium nobile Lindl (D. nobile), a well-known precious herb, has a long history of use as a medicine and health food in China. Phytochemically, D. nobile has been found to contain various bioactive compounds, such as alkaloids, bibenzyl, phenanthrene, phenylpropanoids, and polysaccharides. Its medicinal applications are closely correlated to its diverse pharmacological activities, including antitumor, anti-inflammatory, nervous system protective, antifatigue, hypoglycemic, and hypolipidemic actions. In this review, we provide a comprehensive summary of the main chemical constituents and pharmacological activities of D. nobile, as well as the underlying molecular mechanisms for its bioactivities. It is expected that this review will provide a helpful scientific reference for the development and use of D. nobile.展开更多
[Objectives]To make a preliminary study on the chemical constituents of Clerodendrum japonicum,a Zhuang medicine,so as to provide theoretical support and scientific basis for exploring its medicinal value and comprehe...[Objectives]To make a preliminary study on the chemical constituents of Clerodendrum japonicum,a Zhuang medicine,so as to provide theoretical support and scientific basis for exploring its medicinal value and comprehensive development and utilization.[Methods]The compounds were separated by macroporous adsorption resin,silica gel,Sephadex LH-20,ODS chromatographic column and preparative high performance liquid chromatography,and their structures were identified by NMR and MS data.[Results]8 compounds were isolated and identified from Clerodendrum japonicum extract with 80%ethanol solution:(1)fumaric acid,(2)trans-p-hydroxycinnamic acid,(3)cis-p-hydroxycinnamic acid,(4)ethyl caffeate,(5)acteoside,(6)kaempferol,(7)apigenin-7-O-β-D-glucopyranoside,(8)caffeic acid.[Conclusions]8 compounds were isolated and purified from the ethanol extract of Clerodendrum japonicum.展开更多
Sigesbeckiae Herba,a dry whole plant of Sigesbeckia glabrescens Makino,Sigesbeckia pubescens Makino and Sigesbeckia orientalis L.,is a traditional Chinese medicine used to dispel dampness,dredge meridians and collater...Sigesbeckiae Herba,a dry whole plant of Sigesbeckia glabrescens Makino,Sigesbeckia pubescens Makino and Sigesbeckia orientalis L.,is a traditional Chinese medicine used to dispel dampness,dredge meridians and collaterals,clear heat and detoxicate.Its chemical components are complex and abundant,including mainly diterpenoids,sesquiterpenoids and flavonoids.Among them,diterpenoids are the main active components.Modern pharmacological studies have found that the compounds isolated from Sigesbeckiae Herba have anti-inflammatory,anti-tumor,antithrombus and other pharmacological activities.This review systematically summarized the chemical components identified from Sigesbeckiae Herba and their pharmacological activities by searching Chinese and English databases,in order to provide references for the further development of Sigesbeckiae Herba and the improvement of its quality standards.展开更多
基金supported by the National Natural Science Foundation of China(81660649),and Innovative Scientific Research Project for Postgraduates of Hainan Medical University(HYYS2020-05)。
文摘In order to develop and utilize the tropical medicinal resource Amomum(A.)longiligulare T.L.Wu more reasonably and effectively,this paper summarizes the research progress in chemical constituents and pharmacological activities of A.longiligulare by consulting the literatures,so as to provide a certain theoretical basis for exploring its material basis.The chemical constituents of A.longiligulare mainly include volatile oil,diphenylheptane and flavonoids,which have good efficacy in anti-peptic ulcer,as well as antioxidant,analgesic and other pharmacological activities.This paper briefly discusses the reasons for the differences in the composition of volatile oil studied by different scholars.By summarizing its pharmacological activities,it is found that its various pharmacological activities may be the basis of its anti-peptic ulcer.
文摘Sijunzi Decoction,as one of the classic Chinese traditional prescriptions,has been used clinically by major physicians since the Song Dynasty.This article reviewed and sorted out the literature on the effective chemistry of Sijunzi Decoction and the mechanism of its prevention and treatment of digestive system diseases.At present,its effective chemical components are derived from the saponins and flavonoids in ginseng and licorice,and are effective for gastrointestinal mucosal injury diseases and malignant digestive system.Digestive system diseases such as tumors,functional gastrointestinal diseases,non-alcoholic fatty liver,acute liver injury,and liver failure show a multi-path,multi-target effect mechanism.This article reviews the effective chemical components and research of Sijunzi Decoction and the related mechanisms of prevention and treatment of digestive system diseases,and provides valuable clues for the follow-up research of Sijunzi Decoction.
文摘[Objectives]To isolate and identify chemical constituents from Phellodendron chinense.[Methods]Compounds were isolated by silica gel,Sephadex LH-20,and ODS column chromatography,and their structures were determined by means of the spectral analysis and physicochemical properties.[Results]Eleven compounds were isolated and identified as berberine(1),obaculactone(2),shihulimonin A(3),N-p-coumaroyltyramine(4),1-(4-hydroxy-3-methoxyphenyl)-2-[4-(3-hydroxy-propyl)-2-methoxyphenoxy]-propane-1,3-diol(5),phellodendrine(6),magnoflorine(7),palmatine(8),jatrorrhizine(9),columbamine(10),and obacunone(11).[Conclusions]Compounds 3 and 5 were isolated from Phellodendron for the first time,and compound 4 was isolated from this plant for the first time.
基金Key R&D Projects in Hainan Province(ZDYF2022SHFZ127)National Natural Science Foundation of China(No.81660649)。
文摘Objective:The main chemical components of galangal(Alpinia officinarum Hance)are flavonoids and diarylheptanes.In the previous work,the total heptane and total flavonoid components of galangal were isolated.In this paper,the two components were separated.The monomeric compound was purified and its cytotoxic activity was determined.Methods:Silica gel column chromatography,ODS column chromatography,preparative thin layer chromatography,preparative and semi-preparative HPLC methods were used to separate and purify the total heptane components and total flavonoid components of galangal.Structures of compounds were identified by 1H-NMR,13C-NMR modern spectroscopic techniques combined with literature.The cytotoxic activity of the isolated compounds against MDA-MB-231(breast cancer),HepG-2(liver cancer)and MKN-45(gastric cancer)cells was tested by CCK-8 method.Results:Six compounds were isolated from the total heptane fractions of galangal,and three compounds were isolated from the total flavonoids of galangal.Their structures were identified as:5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-phenylheptan-3-one(1),(E)-7-(4-hydr-oxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one(2),5-hydroxy-1,7-diphenylheptan-3-one(3)7-(4-hydroxyphenyl)-5-methoxy-1-phenylheptan-3-one(4),(E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one(5),(E)-1,7-diphenylhept-4-en-3-one(6),pinocembrin(7),galangin(8),3-O-methylgalangin(9).Conclusion:Compounds 1-6 were isolated from the total heptane components of galangal,and compounds 7-9 were isolated from the total flavonoids of galangal.The results of CCK-8 showed that compounds 2,3,5,6,7 and 8 had weak antitumor activity.
基金Supported by Guangxi University Scientific Research Project of Colleges and Universities in Guangxi (NO. YB2014192)Key R&D Program of Guangxi (GK AB19110027)High-level Innovation Team and Outstanding Scholar Program of Colleges and Universities in Guangxi:Basic and Clinical Innovation Team of Zhuang Medicine (GJR[2014]07)。
文摘[Objectives]This study was conducted to study the chemical constituents from Laportea bulbifera. [Methods] The 60% ethanol extract from L. bulbifera was isolated and purified by silica, Sephadex LH-20, ODS, semi-preparative HPLC and recrystallization. Their chemical structures were elucidated by physicochemical properties and spectroscopic methods. [Results] These compounds were determined as kaempferol-3-O-α-L-(3-O-acetyl)-rhamnoside-7-O-α-L-rhamnoside(1), sutchuenoside A(2), kaempferol-3-O-[β-D-glucopyranosyl-(1→3)]-α-L-(4-O-acetyl)-rhamnopyranoside-7-O-α-L-rhamnopyranoside(3). Compounds 1-3 are isolated from genus Laportea for the first time. Compound 3 is a new compound. [Conclusions] This study lays a foundation for improving the quality standard of L. bulbifera and the development and utilization of its resources.
文摘Celosia L. is richly distributed in China and there are about 60 species in the world. The chemical constituents of Celosia L. include flavonoids, triterpenoid saponins, steroids, organic acids, and cyclic peptides. Which have a variety of effects such as antimicrobial, hepatoprotective and antitumour. To provide a scientific foundation for the subsequent phase of research and development for Celosia L., 30 years of pertinent global literature is summarized, analyzed, and categorized. An overview of 75 chemical constituents, pharmacological activities, and clinical applications is provided.
文摘Salvia miltiorrhiza Bunge(S.miltiorrhiza),a perennial plant of the genus Salvia,is widely used in traditional folklore medicine.Previous chemical research on this plant contains diterpenoid quinones,phenolic acids,polysaccharides and other compounds.The pharmacological investigation of S.miltiorrhiza has shown that it has various pharmacological activities,such as cardiovascular system protection,anti-inflammatory,anti-oxidant,anti-tumor,liver protection,and neuroprotection activities.This research tends to give an overview of the main chemical constituents and pharmacological effects of S.miltiorrhiza,aiming to reveal its potential value and provide reference for its further development.
文摘Piper amalago(P.amalago)is a traditional medicine in Brazil for the treatment of leishmanial.Owing to its rare occurrence and potent pharmacological activities,efforts have been devoted to the identification of its diverse constituents,especially terpenoids.Researchers have found that the major constituents of P.amalago were amides,monoterpenes,norisoprenoids,sesquiterpenes,aliphatic hydrocarbons and aromatic hydrocarbons.The amides show anxiolytic,anti-inflammatory,antileishmanial and antinociceptive activity.This review summarizes the research progress of the structural diversity and pharmacological activities of P.amalago.
基金the National Key Research and Development Plan,China(2016YFD0400203-4).
文摘Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate of E.ulmoides Oliv.is still very low,only bark has been used as medicine and other parts of Eucommia ulmoides Oliv.cannot be fully utilized,even the leaves have been well utilized in food products in Japan in the past decades.In order to improve the comprehensive utilization efficiency of E.ulmoides Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of E.ulmoides Oliv.The findings suggest that other parts of E.ulmoides Oliv.could replace the bark of E.ulmoides Oliv.to some extent besides of their respective applications.The unique and extensive physiological functions between different parts of E.ulmoides Oliv.indicate that the comprehensive utilization of E.ulmoides Oliv.has a wide space to develop,which is also an effective way to protect E.ulmoides Oliv.resources and improve its the utilization rate.
基金supported financially by the Bureau of Science and Technology of Kunming City.
文摘Two new minor constituents,musinisins A(1)and B(2),together with five known compounds(3-7),were isolated from the aerial parts of Munronia sinica.Their structures were established by means of spectroscopic methods and the absolute stereochemistry of 1 was determined by single crystal X-ray experiment.Compound 4 showed antiangiogenic activity evaluated by a zebrafish model and apoptosis-inducing effect on A549 lung cancer cells.
基金Science and Technology Development Program of Henan Province(192102110112)Science and Technology Project of Kaifeng(1908005).
文摘Genus Lilium is famous for edible and medicinal function which is related to its chemical constituents and pharmacological effects.Chemical researches showed that genus Lilium genus mainly contains steroidal saponins,polysaccharides,alkaloids and flavonoids.Pharmacological effects of Lilium include anti-tumor,hypoglycemic,antibacterial,anti-oxidation,anti-depression and anti-inflammatory.This paper summarized chemical constituents and pharmacological effects of Lilium.
基金This research work was financially supported by NSFC project and YiKe R&D Project(KIB-20140708Q)as well as Foundation of Key Laboratory of Tobacco Chemistry of Yunnan Province(KCFZ-2017-1096)Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China(P2010-ZZ14).
文摘Maca(Lepidium meyenii Walp.),a famous food supplement,has drawn an unprecedented international interest over the last two decades.It was assumed that glucosinolates,macamides,macaenes,and alkaloids are the main bioactive components of Maca before.Recently,a series of novel thiohydantoins which generally exhibit a variety of activities have been isolated from Maca.This review focuses on the progress on the main bioactive components of Maca and their biosynthetic pathway,which indicates that macamides,thiohydantoins,and some alkaloids may originate from glucosinolates.Interestingly,thiohydantoins from Maca are the first type of thiohydantoin derivatives to be found from a natural source and may contribute to some significant effects of Maca.
基金This work was financially supported by the Natural Science Foundation of Fujian Province of China(Grant No:2019J05032).
文摘Paecilomyces hepiali is a fungus with edible and pharmaceutic value,isolated from Ophiocordyceps sinensis.Its main bioactive constituents contain alkaloids,cyclic dipeptides,steroids,organic acids,and polysaccharides.Due to the huge development potential of P.hepiali in the field of food and medicine,it has been developed into a variety of products that cater to the needs of the public.In this paper,the chemical constituents and their pharmacological effects of P.hepiali are reviewed,which can provide reference for the development and application of P.hepiali.
基金supported by National Natural Science Foundation of China(81473549)National Natural Science Foundation of China Youth Fund Project(31402237)+1 种基金National "Major New Drug Creation" Major Science and Technology Projects(2014ZX09304-306-04)Ministry of Education of the Central University Basic Scientific Research Business Fee(XDJK2015D016)
文摘Rhizome atractylodes macrocephalae is the dry roots of Atractylodes macrocephala Koidz.It is one of commonly used Chinese medicine.In the "Shennong′s Herbal",it was listed as the top grade.It mainly contains volatile oil,atractylenolides,atractylodes polysaccharides,glycosides and amino acids.And it has the medical functions of good for spleen and intestine,diuretic and dehumidification,hidroschesis,miscarriage prevention and soon.In order to provide references for further development and utilization,this paper systematic arranged the Chinese medicine atractylodes chemical composition,pharmacological effects,processing technology and effect of processing technology on chemical composition and pharmacological action.
基金National Natural Science Foundation of China(31170332)the Candidates of the Young Academic and Technical Leaders of Yunnan Province(2010CI047)。
文摘Two new compounds,maniesculentins A(1)and B(6),together with four known ones were isolated from the stems of Manihot esculenta Crantz.The structures of the new compounds were elucidated by extensive spectroscopic methods including NMR spectroscopy and mass spectrometry.The two new compounds(1,6)were assayed for antibacterial activity against four tested bacteria lines.
基金the National Natural Science Foundation of China(22177139)the Scientific Research Program of Hubei Provincial Department of Education,China(D20183001).
文摘Kiwi,a fruit from plants of the genus Actinidia,is one of the famous fruits with thousand years of edible history.In the past twenty years,a great deal of research has been done on the chemical constituents of the Actinidia species.A large number of secondary metabolites including triterpenoids,flavonoids,phenols,etc.have been identified from differents parts of Actinidia plants,which exhibited significant in vitro and in vivo pharmacological activities including anticancer,anti-inflammatory,neuroprotective,anti-oxidative,anti-bacterial,and anti-diabetic activities.In order to fully understand the chemical compo-nents and biological activities of Actinidia plants,and to improve their further research,development and utilization,this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020,classifies the types of constituents,reports on the pharmacological activities of relative compounds and medicinal potentials.
基金National Innovation and Entrepreneurship Training Program for College Students(202210599038X)Guangxi Key R&D Project(GK AB18221095)+1 种基金Famous Teacher Training Program of Youjiang Medical College for Nationalities—National Famous Teacher Training Program(YYYZ[2018]98)High-level Talent Scientific Research Project of Youjiang Medical College for Nationalities(01002018079)。
文摘Sauropus spatulifolius Beille is a small evergreen shrub in Sauropus of the Euphorbiaceae family.It mainly contains chemical components such as amino acids,proteins,carbohydrates,polypeptides,glycosides,saponins,tannins,organic acids,alkaloids,coumarin and lactones,volatile oils and oils.In addition,the chemical components obtained by different extraction processes are also different.S.spatulifolius Beille mainly has antitussive and expectorant,anti-inflammatory and analgesic,bacteriostatic,antioxidant,and anti-allergic effects.The rich biological activity of S.spatulifolius Beille makes it have clinical applications such as adjuvant treatment of pulmonary edema,recovery of lung function,and treatment of chronic laryngitis or chronic pharyngitis.In this paper,the main chemical components,extraction and identification methods and biological activity of S.spatulifolius Beille were described in depth,in order to further lay a solid foundation for the in-depth research,development and utilization of S.spatulifolius Beille.
文摘Dendrobium nobile Lindl (D. nobile), a well-known precious herb, has a long history of use as a medicine and health food in China. Phytochemically, D. nobile has been found to contain various bioactive compounds, such as alkaloids, bibenzyl, phenanthrene, phenylpropanoids, and polysaccharides. Its medicinal applications are closely correlated to its diverse pharmacological activities, including antitumor, anti-inflammatory, nervous system protective, antifatigue, hypoglycemic, and hypolipidemic actions. In this review, we provide a comprehensive summary of the main chemical constituents and pharmacological activities of D. nobile, as well as the underlying molecular mechanisms for its bioactivities. It is expected that this review will provide a helpful scientific reference for the development and use of D. nobile.
基金Guangxi Natural Science Foundation(2019GXNSFAA245090,2018GXNSFAA050141)the Project of Improving the Scientific Research Basic Ability of Young and Middle-aged Teachers in Guangxi Colleges and Universities in 2020(2020KY13034)+1 种基金Opening Project of Guangxi Zhuang and Yao Medicine Key Laboratory(GXZYKF2020A-08)the First Batch of High-level Talent Research Project of the Affiliated Hospital of Youjiang Medical University for Nationalities in 2019(Y20196311).
文摘[Objectives]To make a preliminary study on the chemical constituents of Clerodendrum japonicum,a Zhuang medicine,so as to provide theoretical support and scientific basis for exploring its medicinal value and comprehensive development and utilization.[Methods]The compounds were separated by macroporous adsorption resin,silica gel,Sephadex LH-20,ODS chromatographic column and preparative high performance liquid chromatography,and their structures were identified by NMR and MS data.[Results]8 compounds were isolated and identified from Clerodendrum japonicum extract with 80%ethanol solution:(1)fumaric acid,(2)trans-p-hydroxycinnamic acid,(3)cis-p-hydroxycinnamic acid,(4)ethyl caffeate,(5)acteoside,(6)kaempferol,(7)apigenin-7-O-β-D-glucopyranoside,(8)caffeic acid.[Conclusions]8 compounds were isolated and purified from the ethanol extract of Clerodendrum japonicum.
基金This work was supported by the National Natural Science Foundation of China(No.81903789)the China Postdoctoral Science Foundation(No.2020M670675&No.2020M680988)College Student Innovation and Entrepreneurship Training Program(No.S202010163009).
文摘Sigesbeckiae Herba,a dry whole plant of Sigesbeckia glabrescens Makino,Sigesbeckia pubescens Makino and Sigesbeckia orientalis L.,is a traditional Chinese medicine used to dispel dampness,dredge meridians and collaterals,clear heat and detoxicate.Its chemical components are complex and abundant,including mainly diterpenoids,sesquiterpenoids and flavonoids.Among them,diterpenoids are the main active components.Modern pharmacological studies have found that the compounds isolated from Sigesbeckiae Herba have anti-inflammatory,anti-tumor,antithrombus and other pharmacological activities.This review systematically summarized the chemical components identified from Sigesbeckiae Herba and their pharmacological activities by searching Chinese and English databases,in order to provide references for the further development of Sigesbeckiae Herba and the improvement of its quality standards.
