In this editorial,we comment on the article by Lyu et al published in the recent issue of the World Journal of Gastroenterology(2023;2219-2840).Hepatocellular carcinoma(HCC)is a frequently encountered and highly aggre...In this editorial,we comment on the article by Lyu et al published in the recent issue of the World Journal of Gastroenterology(2023;2219-2840).Hepatocellular carcinoma(HCC)is a frequently encountered and highly aggressive primary liver cancer,which remains the third-commonest cause of cancer-related death despite the current therapeutic modalities.There is urgency in developing novel thera-peutic approaches,such as by manipulating extracellular vesicles,which con-stitute a highly heterogeneous nanoparticle population that contains various cargoes.These cargoes have a pivotal role in cell-to-cell communication and can modify the functional level of the recipient cells via their uptake by other recipient cells.Exosomal non-coding RNAs have particular evolving significance in HCC,such as circular RNAs,which have been found differentially expressed in normal hepatic and HCC tissues.The aberrations in their expression levels have a key role in the HCC development and progression and the overall prognosis.In this editorial,we will shed light on the emerging role of exosomal circular RNAs in HCC development and progression,focusing on the oncogenic or potentially tumor suppressive effect of mesenchymal stem cells-derived exosomal non-coding RNAs.展开更多
In this paper, a novel efficient energy absorber with free inversion of a metal foam-filled circular tube(MFFCT) is designed, and the axial compressive behavior of the MFFCT under free inversion is studied analyticall...In this paper, a novel efficient energy absorber with free inversion of a metal foam-filled circular tube(MFFCT) is designed, and the axial compressive behavior of the MFFCT under free inversion is studied analytically and numerically. The theoretical analysis reveals that the energy is mainly dissipated through the radial bending of the metal circular tube, the circumferential expansion of the metal circular tube, and the metal filled-foam compression. The principle of energy conservation is used to derive the theoretical formula for the minimum compressive force of the MFFCT over free inversion under axial loading. Furthermore, the free inversion deformation characteristics of the MFFCT are analyzed numerically. The theoretical steady values are found to be in good agreement with the results of the finite element(FE) analysis. The effects of the average diameter of the metal tube, the wall thickness of the metal tube, and the filled-foam strength on the free inversion deformation of the MFFCT are considered. It is observed that in the steady deformation stage, the load-carrying and energy-absorbing capacities of the MFFCT increase with the increase in the average diameter of the metal tube, the wall thickness of the metal tube, or the filled-foam strength. The specific energy absorption(SEA) of free inversion of the MFFCT is significantly higher than that of the metal tube alone.展开更多
Spatial covariance matrix(SCM) is essential in many multi-antenna systems such as massive multiple-input multiple-output(MIMO). For multi-antenna systems operating at millimeter-wave bands, hybrid analog-digital struc...Spatial covariance matrix(SCM) is essential in many multi-antenna systems such as massive multiple-input multiple-output(MIMO). For multi-antenna systems operating at millimeter-wave bands, hybrid analog-digital structure has been widely adopted to reduce the cost of radio frequency chains.In this situation, signals received at the antennas are unavailable to the digital receiver, and as a consequence, traditional sample average approach cannot be used for SCM reconstruction in hybrid multi-antenna systems. To address this issue, beam sweeping algorithm(BSA) which can reconstruct the SCM effectively for a hybrid uniform linear array, has been proposed in our previous works. However, direct extension of BSA to a hybrid uniform circular array(UCA)will result in a huge computational burden. To this end, a low-complexity approach is proposed in this paper. By exploiting the symmetry features of SCM for the UCA, the number of unknowns can be reduced significantly and thus the complexity of reconstruction can be saved accordingly. Furthermore, an insightful analysis is also presented in this paper, showing that the reduction of the number of unknowns can also improve the accuracy of the reconstructed SCM. Simulation results are also shown to demonstrate the proposed approach.展开更多
Seismic isolation is an effective strategy to mitigate the risk of seismic damage in tunnels.However,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under explored...Seismic isolation is an effective strategy to mitigate the risk of seismic damage in tunnels.However,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under explored.In this study,we employ the wave function expansion method to provide analytical solutions for the dynamic responses of linings in an elastic half-space and an infinite elastic space.By comparing the results of the two models,we investigate the seismic isolation effect of tunnel isolation layers induced by reflected seismic waves.Our findings reveal significant differences in the dynamic responses of the lining in the elastic half-space and the infinitely elastic space.Specifically,the dynamic stress concentration factor(DSCF)of the lining in the elastic half-space exhibits periodic fluctuations,influenced by the incident wave frequency and tunnel depth,while the DSCF in the infinitely elastic space remain stable.Overall,the seismic isolation application of the tunnel isolation layer is found to be less affected by surface-reflected seismic waves.Our results provide valuable insights for the design and assessment of the seismic isolation effect of tunnel isolation layers.展开更多
A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is pro-posed.The performance of the cavity is simulated and studied theoretically.Using thefin...A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is pro-posed.The performance of the cavity is simulated and studied theoretically.Using thefinite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance indicators.Mutual modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding performance.The optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength range.Light can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole structure.Thereby,the energy can be confined within a small mode volume to achieve an ultra-high Q/Vm ratio.展开更多
Objective:Previous studies indicated that aberrant circular RNA(circRNA)expression affects gene expression regulatory networks,leading to the aberrant activation of tumor pathways and promoting tumor cell growth.Howev...Objective:Previous studies indicated that aberrant circular RNA(circRNA)expression affects gene expression regulatory networks,leading to the aberrant activation of tumor pathways and promoting tumor cell growth.However,the expression,clinical significance,and effects on cell propagation,invasion,and dissemination of circRNA_001896 in cervical cancer(CC)tissues remain unclear.Methods:The Gene Expression Omnibus(GEO)datasets(GSE113696 and GSE102686)were used to examine differential circRNA expression in CC and adjacent tissues.The expression of circRNA_001896 was detected in 72 CC patients usingfluorescence quantitative PCR.Correlation analysis with clinical pathological features was performed through COX multivariate and univariate analysis.The effect of circRNA_001896 downregulation on CC cell propagation was examined using the cell counting kit-8(CCK-8)test,clonogenic,3D sphere formation,and in vivo tumorigenesis assays.Results:Intersection of the GSE113696 and GSE102686 datasets revealed an increased expression of four circRNAs,including circRNA_001896,in CC tissues.Fluorescence quantitative PCR confirmed circRNA_001896 as a circular RNA.High expression of circRNA_001896 was considerably associated with lymph node metastasis,International Federation of Gynecologists and Obstetricians(FIGO)stage,tumor diameter,and survival period in CC patients.Proportional hazards model(COX)univariate and multivariate analyses revealed that circRNA_001896 expressions are a distinct risk factor affecting CC patients’prognosis.Cellular functional experiments showed that downregulating circRNA_001896 substantially suppressed CC cell growth,colony formation,and 3D sphere-forming ability.In vivo,tumorigenesis analysis in nude mice demonstrated that downregulating circRNA_001896 remarkably reduced the in vivo proliferation capacity of CC cells.Conclusion:CircRNA_001896 is highly expressed in CC tissues and is substantially related to lymph node metastasis,FIGO stage,tumor size,and survival period in patients.Moreover,downregulating circRNA_001896 significantly inhibits both in vivo and in vitro propagation of CC cells.Therefore,circRNA_001896 might be used as a biomarker for targeted therapy in cervical cancer.展开更多
N6-methyladenosine(m6A)is a reversible epigenetic modification, which is one of the most abundant modifiers in eukaryotic cells and has been commonly reported in messenger RNAs and non-coding RNAs. The processing modi...N6-methyladenosine(m6A)is a reversible epigenetic modification, which is one of the most abundant modifiers in eukaryotic cells and has been commonly reported in messenger RNAs and non-coding RNAs. The processing modification of m6A regulates RNA transcription, processing, splicing, degradation, and translation, and plays an important role in the biological process of tumors. Circular RNA, which lacks the 5' cap structure, has been mistakenly regarded as a "junk sequence" generated by accidental shearing during the transcription process. However, it has been found that circRNAs can be involved in tumor invasion and metastasis through microRNAs, binding proteins, translated peptides, and m6A modifications. In this paper, we reviewed the role of m6A modifications in circRNA regulation and their functions in hepatocellular carcinoma and discussed their potential clinical applications and future development in this field.展开更多
To investigate the influence of unloading effect of a circular tunnel face on rockburst process,by innovatively combining rock drilling unloading devices and triaxial systems,the strain rockburst simulation under the ...To investigate the influence of unloading effect of a circular tunnel face on rockburst process,by innovatively combining rock drilling unloading devices and triaxial systems,the strain rockburst simulation under the entire stress path of“high initial stressþinternal unloadingþstress adjustment”(HUS test)was realized for the intact cubic red sandstone samples(100 mm×100 mm×100 mm).Comparative tests were conducted on cubic red sandstone samples with prefabricated circular holes(425 mm)under the stress path of“prefabricated circular hole+þhigh initial stress+stress adjustment”(PHS test),thereby highlighting the influence of internal unloading on rockburst failure.The test results revealed that with an increase in vertical stress,the sidewalls in both the HUS and PHS tests suffered strain rockburst failure.Compared with the PHS test,the initial failure stress in the HUS test is lower,and it is easier to induce sidewall rockbursts.This indicates that the internal unloading influences the sidewall failure,causing an obvious strength-weakening effect,which becomes more significant with an increase in buried depth.The strain rockburst failure was more severe in the HUS test owing to the influence of internal unloading.V-shaped rockburst pits were formed in the HUS tests,whereas in the PHS test,arcshaped rockburst pits were produced.It was also found that strain rockburst failure may occur only when the rock has a certain degree of rockburst proneness.展开更多
Circular RNAs(circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in ...Circular RNAs(circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including acting as microRNA sponges,interacting with proteins, modulating the expression of related genes and translating into peptides or proteins.CircRNAs have also been used as biomarkers for a number of diseases, which could improve clinical practice.This review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases. We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases. Finally, we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment.展开更多
The influence of weights is usually ignored in the study of nonlinear vibrations of plates.In this paper,the effect of structure weights on the nonlinear vibration of a composite circular plate with a rigid body is pr...The influence of weights is usually ignored in the study of nonlinear vibrations of plates.In this paper,the effect of structure weights on the nonlinear vibration of a composite circular plate with a rigid body is presented.The nonlinear governing equations are derived from the generalized Hamilton's principle and the von Kármán plate theory.The equilibrium configurations due to weights are determined and validated by the finite element method(FEM).A nonlinear model for the vibration around the equilibrium configuration is established.Moreover,the natural frequencies and amplitude-frequency responses of harmonically forced vibrations are calculated.The study shows that the structure weights introduce additional linear and quadratic nonlinear terms into the dynamical model.This leads to interesting phenomena.For example,considering weights increases the natural frequency.Furthermore,when the influence of weights is considered,the vibration response of the plate becomes asymmetrical.展开更多
The sustainable production of green hydrogen via water electrolysis necessitates cost-effective electrocatalysts.By following the circular economy principle,the utilization of waste-derived catalysts significantly pro...The sustainable production of green hydrogen via water electrolysis necessitates cost-effective electrocatalysts.By following the circular economy principle,the utilization of waste-derived catalysts significantly promotes the sustainable development of green hydrogen energy.Currently,diverse waste-derived catalysts have exhibited excellent catalytic performance toward hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and overall water electrolysis(OWE).Herein,we systematically examine recent achievements in waste-derived electrocatalysts for water electrolysis.The general principles of water electrolysis and design principles of efficient electrocatalysts are discussed,followed by the illustration of current strategies for transforming wastes into electrocatalysts.Then,applications of waste-derived catalysts(i.e.,carbon-based catalysts,transitional metal-based catalysts,and carbon-based heterostructure catalysts)in HER,OER,and OWE are reviewed successively.An emphasis is put on correlating the catalysts’structure-performance relationship.Also,challenges and research directions in this booming field are finally highlighted.This review would provide useful insights into the design,synthesis,and applications of waste-derived electrocatalysts,and thus accelerate the development of the circular economy-driven green hydrogen energy scheme.展开更多
We study embeddings of the n-dimensional hypercube into the circuit with 2nvertices.We prove that the circular wirelength attains a minimum by gray coding;that was called the CT conjecture by Chavez and Trapp(Discrete...We study embeddings of the n-dimensional hypercube into the circuit with 2nvertices.We prove that the circular wirelength attains a minimum by gray coding;that was called the CT conjecture by Chavez and Trapp(Discrete Applied Mathematics,1998).This problem had claimed to be settled by Ching-Jung Guu in her doctoral dissertation“The circular wirelength problem for hypercubes”(University of California,Riverside,1997).Many argue there are gaps in her proof.We eliminate the gaps in her dissertation.展开更多
Circular RNAs(circRNAs)are a class of regulatory non-coding RNAs characterized by the presence of covalently closed ends.A growing body of evidence suggests that circRNAs play important roles in physiology and patholo...Circular RNAs(circRNAs)are a class of regulatory non-coding RNAs characterized by the presence of covalently closed ends.A growing body of evidence suggests that circRNAs play important roles in physiology and pathology.In particular,accumulating data on circRNA functions in various central nervous system(CNS)diseases and their correlations indicate that circRNAs are critical contributors to the onset and development of brain disorders.In this review,we focus on the regulatory and functional roles of circRNAs in CNS diseases,highlighting their diagnostic and therapeutic potential,with the aim of providing new insights into CNS diseases.展开更多
A controlled transition between two different ion acceleration mechanisms would pave the way to achieving different ion energies and spectral features within the same experimental set up,depending on the region of ope...A controlled transition between two different ion acceleration mechanisms would pave the way to achieving different ion energies and spectral features within the same experimental set up,depending on the region of operation.Based on numerical simulations conducted over a wide range of experimentally achievable parameter space,reported here is a comprehensive investigation of the different facets of ion acceleration by relativistically intense circularly polarized laser pulses interacting with thin near-critical-density plasma targets.The results show that the plasma thickness,exponential density gradient,and laser frequency chirp can be controlled to switch the interaction from the transparent operating regime to the opaque one,thereby enabling the choice of a Maxwellian-like ion energy distribution with a cutoff energy in the relativistically transparent regime or a quasi-monoenergetic spectrum in the opaque regime.Next,it is established that a multispecies target configuration can be used effectively for optimal generation of quasi-monoenergetic ion bunches of a desired species.Finally,the feasibility is demonstrated for generating monoenergetic proton beams with energy peak atℰ≈20–40 MeV and a narrow energy spread ofΔℰ/ℰ≈18%–28.6%confined within a divergence angle of∼175 mrad at a reasonable laser peak intensity of I0≃5.4×10^(20)W/cm^(2).展开更多
This article addresses the circular formation control problem of a multi-agent system moving on a circle in the presence of limited communication ranges and communication delays.To minimize the number of communication...This article addresses the circular formation control problem of a multi-agent system moving on a circle in the presence of limited communication ranges and communication delays.To minimize the number of communication links,a novel distributed controller based on a cyclic pursuit strategy is developed in which each agent needs only its leading neighbour’s information.In contrast to existing works,we propose a set of new potential functions to deal with heterogeneous communication ranges and communication delays simultaneously.A new framework based on the admissible upper bound of the formation error is established so that both connectivity maintenance and order preservation can be achieved at the same time.It is shown that the multi-agent system can be driven to the desired circular formation as time goes to infinity under the proposed controller.Finally,the effectiveness of the proposed method is illustrated by some simulation examples.展开更多
Age-related macular degeneration(AMD)causes irreversible blindness in people aged over 50 worldwide.The dysfunction of the retinal pigment epithelium is the primary cause of atrophic AMD.In the current study,we used t...Age-related macular degeneration(AMD)causes irreversible blindness in people aged over 50 worldwide.The dysfunction of the retinal pigment epithelium is the primary cause of atrophic AMD.In the current study,we used the ComBat and Training Distribution Matching method to integrate data obtained from the Gene Expression Omnibus database.We analyzed the integrated sequencing data by the Gene Set Enrichment Analysis.Peroxisome and tumor necrosis factor-α(TNF-α)signaling and nuclear factor kappa B(NF-κB)were among the top 10 pathways,and thus we selected them to construct AMD cell models to identify differentially expressed circular RNAs(circRNAs).We then constructed a competing endogenous RNA network,which is related to differentially expressed circRNAs.This network included seven circRNAs,15 microRNAs,and 82 mRNAs.The Kyoto Encyclopedia of Genes and Genomes analysis of mRNAs in this network showed that the hypoxia-inducible factor-1(HIF-1)signaling pathway was a common downstream event.The results of the current study may provide insights into the pathological processes of atrophic AMD.展开更多
A dimension decomposition(DIDE)method for multiple incoherent source localization using uniform circular array(UCA)is proposed.Due to the fact that the far-field signal can be considered as the state where the range p...A dimension decomposition(DIDE)method for multiple incoherent source localization using uniform circular array(UCA)is proposed.Due to the fact that the far-field signal can be considered as the state where the range parameter of the nearfield signal is infinite,the algorithm for the near-field source localization is also suitable for estimating the direction of arrival(DOA)of far-field signals.By decomposing the first and second exponent term of the steering vector,the three-dimensional(3-D)parameter is transformed into two-dimensional(2-D)and onedimensional(1-D)parameter estimation.First,by partitioning the received data,we exploit propagator to acquire the noise subspace.Next,the objective function is established and partial derivative is applied to acquire the spatial spectrum of 2-D DOA.At last,the estimated 2-D DOA is utilized to calculate the phase of the decomposed vector,and the least squares(LS)is performed to acquire the range parameters.In comparison to the existing algorithms,the proposed DIDE algorithm requires neither the eigendecomposition of covariance matrix nor the search process of range spatial spectrum,which can achieve satisfactory localization and reduce computational complexity.Simulations are implemented to illustrate the advantages of the proposed DIDE method.Moreover,simulations demonstrate that the proposed DIDE method can also classify the mixed far-field and near-field signals.展开更多
In this paper,we study the circular formation problem for the second-order multi-agent systems in a plane,in which the agents maintain a circular formation based on a probabilistic position.A distributed hybrid contro...In this paper,we study the circular formation problem for the second-order multi-agent systems in a plane,in which the agents maintain a circular formation based on a probabilistic position.A distributed hybrid control protocol based on a probabilistic position is designed to achieve circular formation stabilization and consensus.In the current framework,the mobile agents follow the following rules:1)the agent must follow a circular trajectory;2)all the agents in the same circular trajectory must have the same direction.The formation control objective includes two parts:1)drive all the agents to the circular formation;2)avoid a collision.Based on Lyapunov methods,convergence and stability of the proposed circular formation protocol are provided.Due to limitations in collision avoidance,we extend the results to LaSalle’s invariance principle.Some theoretical examples and numerical simulations show the effectiveness of the proposed scheme.展开更多
The influence of the width of the circular ring of a car cooling fan on the aerodynamic noise is investigated numerically through the determination of the overall sound pressure level(OASPL).The results demonstrate th...The influence of the width of the circular ring of a car cooling fan on the aerodynamic noise is investigated numerically through the determination of the overall sound pressure level(OASPL).The results demonstrate that when the circular rings cover near 2/3 of the width of the blade tips of the rotor in the axis direction,the rotor has the lowest OASPL and the related total pressure efficiency and flow mass rate are better than the corresponding values obtained for a reference rotor without a circular ring.With increasing the width of the circular ring in the axis direction,the tip vortex around the trailing edge of the blade tip becomes smaller and finally disappears.Meanwhile,a separated flow field arises gradually and then grows in size around the middle of the junction of the blade tips with the ring.When the circular rings cover nearly 2/3 s of the width of the blade tips of the fan in the axis direction,the extension of the separated flow around the blade’s tip attains a minimum.展开更多
文摘In this editorial,we comment on the article by Lyu et al published in the recent issue of the World Journal of Gastroenterology(2023;2219-2840).Hepatocellular carcinoma(HCC)is a frequently encountered and highly aggressive primary liver cancer,which remains the third-commonest cause of cancer-related death despite the current therapeutic modalities.There is urgency in developing novel thera-peutic approaches,such as by manipulating extracellular vesicles,which con-stitute a highly heterogeneous nanoparticle population that contains various cargoes.These cargoes have a pivotal role in cell-to-cell communication and can modify the functional level of the recipient cells via their uptake by other recipient cells.Exosomal non-coding RNAs have particular evolving significance in HCC,such as circular RNAs,which have been found differentially expressed in normal hepatic and HCC tissues.The aberrations in their expression levels have a key role in the HCC development and progression and the overall prognosis.In this editorial,we will shed light on the emerging role of exosomal circular RNAs in HCC development and progression,focusing on the oncogenic or potentially tumor suppressive effect of mesenchymal stem cells-derived exosomal non-coding RNAs.
基金Project supported by the National Natural Science Foundation of China (Nos. 12272290 and11872291)the State Key Laboratory of Automotive Safety and Energy of China (No. KFY2202)。
文摘In this paper, a novel efficient energy absorber with free inversion of a metal foam-filled circular tube(MFFCT) is designed, and the axial compressive behavior of the MFFCT under free inversion is studied analytically and numerically. The theoretical analysis reveals that the energy is mainly dissipated through the radial bending of the metal circular tube, the circumferential expansion of the metal circular tube, and the metal filled-foam compression. The principle of energy conservation is used to derive the theoretical formula for the minimum compressive force of the MFFCT over free inversion under axial loading. Furthermore, the free inversion deformation characteristics of the MFFCT are analyzed numerically. The theoretical steady values are found to be in good agreement with the results of the finite element(FE) analysis. The effects of the average diameter of the metal tube, the wall thickness of the metal tube, and the filled-foam strength on the free inversion deformation of the MFFCT are considered. It is observed that in the steady deformation stage, the load-carrying and energy-absorbing capacities of the MFFCT increase with the increase in the average diameter of the metal tube, the wall thickness of the metal tube, or the filled-foam strength. The specific energy absorption(SEA) of free inversion of the MFFCT is significantly higher than that of the metal tube alone.
基金supported by National Key Research and Development Program of China under Grant 2020YFB1804901State Key Laboratory of Rail Traffic Control and Safety(Contract:No.RCS2022ZT 015)Special Key Project of Technological Innovation and Application Development of Chongqing Science and Technology Bureau(cstc2019jscx-fxydX0053).
文摘Spatial covariance matrix(SCM) is essential in many multi-antenna systems such as massive multiple-input multiple-output(MIMO). For multi-antenna systems operating at millimeter-wave bands, hybrid analog-digital structure has been widely adopted to reduce the cost of radio frequency chains.In this situation, signals received at the antennas are unavailable to the digital receiver, and as a consequence, traditional sample average approach cannot be used for SCM reconstruction in hybrid multi-antenna systems. To address this issue, beam sweeping algorithm(BSA) which can reconstruct the SCM effectively for a hybrid uniform linear array, has been proposed in our previous works. However, direct extension of BSA to a hybrid uniform circular array(UCA)will result in a huge computational burden. To this end, a low-complexity approach is proposed in this paper. By exploiting the symmetry features of SCM for the UCA, the number of unknowns can be reduced significantly and thus the complexity of reconstruction can be saved accordingly. Furthermore, an insightful analysis is also presented in this paper, showing that the reduction of the number of unknowns can also improve the accuracy of the reconstructed SCM. Simulation results are also shown to demonstrate the proposed approach.
基金supported by the National Natural Science Foundation of China[grant number 51991393]support from the Guangdong Provincial Key Laboratory of Earthquake Engineering and Applied Technology and Key Laboratory of Earthquake Resistance,Earthquake Mitigation,and Structural Safety funded by the Ministry of Education。
文摘Seismic isolation is an effective strategy to mitigate the risk of seismic damage in tunnels.However,the impact of surface-reflected seismic waves on the effectiveness of tunnel isolation layers remains under explored.In this study,we employ the wave function expansion method to provide analytical solutions for the dynamic responses of linings in an elastic half-space and an infinite elastic space.By comparing the results of the two models,we investigate the seismic isolation effect of tunnel isolation layers induced by reflected seismic waves.Our findings reveal significant differences in the dynamic responses of the lining in the elastic half-space and the infinitely elastic space.Specifically,the dynamic stress concentration factor(DSCF)of the lining in the elastic half-space exhibits periodic fluctuations,influenced by the incident wave frequency and tunnel depth,while the DSCF in the infinitely elastic space remain stable.Overall,the seismic isolation application of the tunnel isolation layer is found to be less affected by surface-reflected seismic waves.Our results provide valuable insights for the design and assessment of the seismic isolation effect of tunnel isolation layers.
基金supported by the Open Fund of the State Key Laboratory of Advanced Optical Communication Systems and Networks (SJTU)(Grant No. 2023GZKF018)the Open Fund of IPOC (BUPT)(Grant No. IPOC2021B03)+4 种基金the National Natural Science Foundation of China (NSFC)(Grant No. 11974188)the China Postdoctoral Science Foundation (Grant Nos. 2021T140339 and 2018M632345)the Jiangsu Province Postdoctoral Science Foundation (Grant No. 2021K617C)the Postgraduate Research and Practice Innovation Program of Jiangsu Province (Grant No.KYCX22_0945)the Qing Lan Project of Jiangsu Province
文摘A photonic crystal nanobeam cavity(M-PCNC)with a structure incorporating a mixture of diamond-shaped and circular air holes is pro-posed.The performance of the cavity is simulated and studied theoretically.Using thefinite-difference time-domain method,the parameters of the M-PCNC,including cavity thickness and width,lattice constant,and radii and numbers of holes,are optimized,with the quality factor Q and mode volume Vm as performance indicators.Mutual modulation of the lattice constant and hole radius enable the proposed M-PCNC to realize outstanding performance.The optimized cavity possesses a high quality factor Q 1.45105 and an ultra-small mode=×volume Vm 0.01(λ/n)[Zeng et al.,Opt Lett 2023:48;3981–3984]in the telecommunications wavelength range.Light can be progres-=sively squeezed in both the propagation direction and the perpendicular in-plane direction by a series of interlocked anti-slots and slots in the diamond-shaped hole structure.Thereby,the energy can be confined within a small mode volume to achieve an ultra-high Q/Vm ratio.
基金This study was supported by the Nantong Science and Technology Plan Project(No.JC22022107).
文摘Objective:Previous studies indicated that aberrant circular RNA(circRNA)expression affects gene expression regulatory networks,leading to the aberrant activation of tumor pathways and promoting tumor cell growth.However,the expression,clinical significance,and effects on cell propagation,invasion,and dissemination of circRNA_001896 in cervical cancer(CC)tissues remain unclear.Methods:The Gene Expression Omnibus(GEO)datasets(GSE113696 and GSE102686)were used to examine differential circRNA expression in CC and adjacent tissues.The expression of circRNA_001896 was detected in 72 CC patients usingfluorescence quantitative PCR.Correlation analysis with clinical pathological features was performed through COX multivariate and univariate analysis.The effect of circRNA_001896 downregulation on CC cell propagation was examined using the cell counting kit-8(CCK-8)test,clonogenic,3D sphere formation,and in vivo tumorigenesis assays.Results:Intersection of the GSE113696 and GSE102686 datasets revealed an increased expression of four circRNAs,including circRNA_001896,in CC tissues.Fluorescence quantitative PCR confirmed circRNA_001896 as a circular RNA.High expression of circRNA_001896 was considerably associated with lymph node metastasis,International Federation of Gynecologists and Obstetricians(FIGO)stage,tumor diameter,and survival period in CC patients.Proportional hazards model(COX)univariate and multivariate analyses revealed that circRNA_001896 expressions are a distinct risk factor affecting CC patients’prognosis.Cellular functional experiments showed that downregulating circRNA_001896 substantially suppressed CC cell growth,colony formation,and 3D sphere-forming ability.In vivo,tumorigenesis analysis in nude mice demonstrated that downregulating circRNA_001896 remarkably reduced the in vivo proliferation capacity of CC cells.Conclusion:CircRNA_001896 is highly expressed in CC tissues and is substantially related to lymph node metastasis,FIGO stage,tumor size,and survival period in patients.Moreover,downregulating circRNA_001896 significantly inhibits both in vivo and in vitro propagation of CC cells.Therefore,circRNA_001896 might be used as a biomarker for targeted therapy in cervical cancer.
基金Key Project Research and Development Plan of Hainan Province(No.ZDYF2020134,ZDYF2022SHFZ283)Natural Science Foundation of Hainan Province(No.821QN391)。
文摘N6-methyladenosine(m6A)is a reversible epigenetic modification, which is one of the most abundant modifiers in eukaryotic cells and has been commonly reported in messenger RNAs and non-coding RNAs. The processing modification of m6A regulates RNA transcription, processing, splicing, degradation, and translation, and plays an important role in the biological process of tumors. Circular RNA, which lacks the 5' cap structure, has been mistakenly regarded as a "junk sequence" generated by accidental shearing during the transcription process. However, it has been found that circRNAs can be involved in tumor invasion and metastasis through microRNAs, binding proteins, translated peptides, and m6A modifications. In this paper, we reviewed the role of m6A modifications in circRNA regulation and their functions in hepatocellular carcinoma and discussed their potential clinical applications and future development in this field.
基金This work was supported by the National Natural Science Foundation of China(Grant No.42077244)the Open Research Fund of State Key Laboratory of Deep Earth Science and Engineering(Sichuan University)(Grant No.DESE 202201)the Fundamental Research Funds for the Central Universities(Grant No.2242022k30054).
文摘To investigate the influence of unloading effect of a circular tunnel face on rockburst process,by innovatively combining rock drilling unloading devices and triaxial systems,the strain rockburst simulation under the entire stress path of“high initial stressþinternal unloadingþstress adjustment”(HUS test)was realized for the intact cubic red sandstone samples(100 mm×100 mm×100 mm).Comparative tests were conducted on cubic red sandstone samples with prefabricated circular holes(425 mm)under the stress path of“prefabricated circular hole+þhigh initial stress+stress adjustment”(PHS test),thereby highlighting the influence of internal unloading on rockburst failure.The test results revealed that with an increase in vertical stress,the sidewalls in both the HUS and PHS tests suffered strain rockburst failure.Compared with the PHS test,the initial failure stress in the HUS test is lower,and it is easier to induce sidewall rockbursts.This indicates that the internal unloading influences the sidewall failure,causing an obvious strength-weakening effect,which becomes more significant with an increase in buried depth.The strain rockburst failure was more severe in the HUS test owing to the influence of internal unloading.V-shaped rockburst pits were formed in the HUS tests,whereas in the PHS test,arcshaped rockburst pits were produced.It was also found that strain rockburst failure may occur only when the rock has a certain degree of rockburst proneness.
基金supported in part by the National Natural Science Foundation of China(Grant No.82130096)the Priority Academic Program Development of Jiangsu Higher Education Institutions(Public Health and Preventive Medicine)。
文摘Circular RNAs(circRNAs) are characterized by a covalent closed-loop structure with an absence of both 5′ cap structure and 3′ polyadenylated tail. Numerous studies have found that circRNAs play an important role in various diseases and have a variety of biological regulatory mechanisms, including acting as microRNA sponges,interacting with proteins, modulating the expression of related genes and translating into peptides or proteins.CircRNAs have also been used as biomarkers for a number of diseases, which could improve clinical practice.This review summarizes the most recent advances in biogenesis and knowledge of the biological functions of circRNAs as well as the related bioinformatics databases. We specifically describe developments in understanding of circRNA functions in the field of environmental exposure-induced diseases. Finally, we focus on potential clinical implications of circRNAs to facilitate their clinical transformation into disease treatment.
基金Project supported by the National Natural Science Foundation of China(No.12002195)the National Science Fund for Distinguished Young Scholars of China(No.12025204)the Program of Shanghai Municipal Education Commission of China(No.2019-01-07-00-09-E00018)。
文摘The influence of weights is usually ignored in the study of nonlinear vibrations of plates.In this paper,the effect of structure weights on the nonlinear vibration of a composite circular plate with a rigid body is presented.The nonlinear governing equations are derived from the generalized Hamilton's principle and the von Kármán plate theory.The equilibrium configurations due to weights are determined and validated by the finite element method(FEM).A nonlinear model for the vibration around the equilibrium configuration is established.Moreover,the natural frequencies and amplitude-frequency responses of harmonically forced vibrations are calculated.The study shows that the structure weights introduce additional linear and quadratic nonlinear terms into the dynamical model.This leads to interesting phenomena.For example,considering weights increases the natural frequency.Furthermore,when the influence of weights is considered,the vibration response of the plate becomes asymmetrical.
基金supported by the Australian Research Council (ARC) Discovery Project (DP220101139)support of the Australian Research Council (ARC) through Project DE220100530support of the Australian Research Council (ARC) through Project DE200100970
文摘The sustainable production of green hydrogen via water electrolysis necessitates cost-effective electrocatalysts.By following the circular economy principle,the utilization of waste-derived catalysts significantly promotes the sustainable development of green hydrogen energy.Currently,diverse waste-derived catalysts have exhibited excellent catalytic performance toward hydrogen evolution reaction(HER),oxygen evolution reaction(OER),and overall water electrolysis(OWE).Herein,we systematically examine recent achievements in waste-derived electrocatalysts for water electrolysis.The general principles of water electrolysis and design principles of efficient electrocatalysts are discussed,followed by the illustration of current strategies for transforming wastes into electrocatalysts.Then,applications of waste-derived catalysts(i.e.,carbon-based catalysts,transitional metal-based catalysts,and carbon-based heterostructure catalysts)in HER,OER,and OWE are reviewed successively.An emphasis is put on correlating the catalysts’structure-performance relationship.Also,challenges and research directions in this booming field are finally highlighted.This review would provide useful insights into the design,synthesis,and applications of waste-derived electrocatalysts,and thus accelerate the development of the circular economy-driven green hydrogen energy scheme.
文摘We study embeddings of the n-dimensional hypercube into the circuit with 2nvertices.We prove that the circular wirelength attains a minimum by gray coding;that was called the CT conjecture by Chavez and Trapp(Discrete Applied Mathematics,1998).This problem had claimed to be settled by Ching-Jung Guu in her doctoral dissertation“The circular wirelength problem for hypercubes”(University of California,Riverside,1997).Many argue there are gaps in her proof.We eliminate the gaps in her dissertation.
基金supported by grants from the Science and Technology Innovation 2030-Major Project of the Ministry of Science and Technology of China(No.2021ZD0202904 and No.2021ZD0202900)the National Natural Science Foundation of China(No.82230115 and No.82273914)+1 种基金the National Science Fund for Distinguished Young Scholars(No.82025033)the Jiangsu Provincial Key Laboratory of Critical Care Medicine(No.JSKLCCM-2022-02-008).
文摘Circular RNAs(circRNAs)are a class of regulatory non-coding RNAs characterized by the presence of covalently closed ends.A growing body of evidence suggests that circRNAs play important roles in physiology and pathology.In particular,accumulating data on circRNA functions in various central nervous system(CNS)diseases and their correlations indicate that circRNAs are critical contributors to the onset and development of brain disorders.In this review,we focus on the regulatory and functional roles of circRNAs in CNS diseases,highlighting their diagnostic and therapeutic potential,with the aim of providing new insights into CNS diseases.
基金supported by the IMPULSE project,which receives funding from the European Union Framework Programme for Research and Innovation Horizon 2020 under Grant Agreement No.871161.ELI-ALPSsupported by the European Union and co-financed by the European Regional Development Fund(ERDF)(Grant No.GINOP-2.3.6-15-2015-00001)+2 种基金S.K.and S.M.acknowledge Project No.2020-1.2.4-TÉT-IPARI-2021-00018has been implemented with support provided by the National Research,Development and Innovation Office of Hungary and financed under the Grant No.2020-1.2.4-TET-IPARI-CN funding scheme.S.C.D.M.S.K.acknowledge the High Performance Computation(HPC)facility/service at ELI-ALPS.
文摘A controlled transition between two different ion acceleration mechanisms would pave the way to achieving different ion energies and spectral features within the same experimental set up,depending on the region of operation.Based on numerical simulations conducted over a wide range of experimentally achievable parameter space,reported here is a comprehensive investigation of the different facets of ion acceleration by relativistically intense circularly polarized laser pulses interacting with thin near-critical-density plasma targets.The results show that the plasma thickness,exponential density gradient,and laser frequency chirp can be controlled to switch the interaction from the transparent operating regime to the opaque one,thereby enabling the choice of a Maxwellian-like ion energy distribution with a cutoff energy in the relativistically transparent regime or a quasi-monoenergetic spectrum in the opaque regime.Next,it is established that a multispecies target configuration can be used effectively for optimal generation of quasi-monoenergetic ion bunches of a desired species.Finally,the feasibility is demonstrated for generating monoenergetic proton beams with energy peak atℰ≈20–40 MeV and a narrow energy spread ofΔℰ/ℰ≈18%–28.6%confined within a divergence angle of∼175 mrad at a reasonable laser peak intensity of I0≃5.4×10^(20)W/cm^(2).
基金supported in part by the National Natural Science Foundation of China(61773327,62273182)the Research Grants Council of the Hong Kong Special Administrative Region of China(CityU/11217619)the Fundamental Research Funds for the Central Universities(30921011213)。
文摘This article addresses the circular formation control problem of a multi-agent system moving on a circle in the presence of limited communication ranges and communication delays.To minimize the number of communication links,a novel distributed controller based on a cyclic pursuit strategy is developed in which each agent needs only its leading neighbour’s information.In contrast to existing works,we propose a set of new potential functions to deal with heterogeneous communication ranges and communication delays simultaneously.A new framework based on the admissible upper bound of the formation error is established so that both connectivity maintenance and order preservation can be achieved at the same time.It is shown that the multi-agent system can be driven to the desired circular formation as time goes to infinity under the proposed controller.Finally,the effectiveness of the proposed method is illustrated by some simulation examples.
基金funded by the National Natural Science Foundation of China(Grant No.81970821)the Postgraduate Research Innovation Program of Jiangsu Provinc(Grant No.SJCX21_0624).
文摘Age-related macular degeneration(AMD)causes irreversible blindness in people aged over 50 worldwide.The dysfunction of the retinal pigment epithelium is the primary cause of atrophic AMD.In the current study,we used the ComBat and Training Distribution Matching method to integrate data obtained from the Gene Expression Omnibus database.We analyzed the integrated sequencing data by the Gene Set Enrichment Analysis.Peroxisome and tumor necrosis factor-α(TNF-α)signaling and nuclear factor kappa B(NF-κB)were among the top 10 pathways,and thus we selected them to construct AMD cell models to identify differentially expressed circular RNAs(circRNAs).We then constructed a competing endogenous RNA network,which is related to differentially expressed circRNAs.This network included seven circRNAs,15 microRNAs,and 82 mRNAs.The Kyoto Encyclopedia of Genes and Genomes analysis of mRNAs in this network showed that the hypoxia-inducible factor-1(HIF-1)signaling pathway was a common downstream event.The results of the current study may provide insights into the pathological processes of atrophic AMD.
基金supported by the National Natural Science Foundation of China(62022091,61921001).
文摘A dimension decomposition(DIDE)method for multiple incoherent source localization using uniform circular array(UCA)is proposed.Due to the fact that the far-field signal can be considered as the state where the range parameter of the nearfield signal is infinite,the algorithm for the near-field source localization is also suitable for estimating the direction of arrival(DOA)of far-field signals.By decomposing the first and second exponent term of the steering vector,the three-dimensional(3-D)parameter is transformed into two-dimensional(2-D)and onedimensional(1-D)parameter estimation.First,by partitioning the received data,we exploit propagator to acquire the noise subspace.Next,the objective function is established and partial derivative is applied to acquire the spatial spectrum of 2-D DOA.At last,the estimated 2-D DOA is utilized to calculate the phase of the decomposed vector,and the least squares(LS)is performed to acquire the range parameters.In comparison to the existing algorithms,the proposed DIDE algorithm requires neither the eigendecomposition of covariance matrix nor the search process of range spatial spectrum,which can achieve satisfactory localization and reduce computational complexity.Simulations are implemented to illustrate the advantages of the proposed DIDE method.Moreover,simulations demonstrate that the proposed DIDE method can also classify the mixed far-field and near-field signals.
文摘In this paper,we study the circular formation problem for the second-order multi-agent systems in a plane,in which the agents maintain a circular formation based on a probabilistic position.A distributed hybrid control protocol based on a probabilistic position is designed to achieve circular formation stabilization and consensus.In the current framework,the mobile agents follow the following rules:1)the agent must follow a circular trajectory;2)all the agents in the same circular trajectory must have the same direction.The formation control objective includes two parts:1)drive all the agents to the circular formation;2)avoid a collision.Based on Lyapunov methods,convergence and stability of the proposed circular formation protocol are provided.Due to limitations in collision avoidance,we extend the results to LaSalle’s invariance principle.Some theoretical examples and numerical simulations show the effectiveness of the proposed scheme.
基金supported by the Guiding Project of Scientific Research Plan of Hubei Education Department of China[Grant No.B2020227].
文摘The influence of the width of the circular ring of a car cooling fan on the aerodynamic noise is investigated numerically through the determination of the overall sound pressure level(OASPL).The results demonstrate that when the circular rings cover near 2/3 of the width of the blade tips of the rotor in the axis direction,the rotor has the lowest OASPL and the related total pressure efficiency and flow mass rate are better than the corresponding values obtained for a reference rotor without a circular ring.With increasing the width of the circular ring in the axis direction,the tip vortex around the trailing edge of the blade tip becomes smaller and finally disappears.Meanwhile,a separated flow field arises gradually and then grows in size around the middle of the junction of the blade tips with the ring.When the circular rings cover nearly 2/3 s of the width of the blade tips of the fan in the axis direction,the extension of the separated flow around the blade’s tip attains a minimum.
