Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regen...Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.展开更多
Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells ...Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological recovery.However,the mechanism of CXCR4 upregulation in induced neural stem cells remains unclear.In this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 expression.However,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial activation.In agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury mice.Notably,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head injury.In conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neural stem cells on microglial activation via upregulation of CXCR4 and Crry,thereby promoting induced neural stem cell–mediated improvement of neuronal injury,cerebral edema,and neurological disorders following closed head injury.展开更多
The neutron radiation field has vital applications in areas such as biomedicine,geology,radiation safety,and many others for neutron detection and neutron metrology.Correcting neutron fluence rate perturbation accurat...The neutron radiation field has vital applications in areas such as biomedicine,geology,radiation safety,and many others for neutron detection and neutron metrology.Correcting neutron fluence rate perturbation accurately is an important yet challenging problem.This study proposes a correction method that analyzes three physical processes.This method,which transforms the detection process from point detection to area detection,is based on a novel physical model and has been validated through theoretical analyses,experiments,and simulations.According to the average differences between the calculated and experimental results,the new method(1.67%)demonstrated better accuracy than the traditional simulation(2.17%).In a closed thermal neutron radiation field,the detector or strong neutron absorption material significantly perturbs the neutron fluence rate,whereas its impact on the energy spectrum shape and neutron directionality is relatively minor.Furthermore,based on the calculation results of the perturbation rate formula for medium materials with different compositions and sizes,the larger the volume and capture cross section of the medium,the higher the perturbation rate generated in the closed radiation field.展开更多
In the areas without terrestrial communication infrastructures,unmanned aerial vehicles(UAVs)can be utilized to serve field robots for mission-critical tasks.For this purpose,UAVs can be equipped with sensing,communic...In the areas without terrestrial communication infrastructures,unmanned aerial vehicles(UAVs)can be utilized to serve field robots for mission-critical tasks.For this purpose,UAVs can be equipped with sensing,communication,and computing modules to support various requirements of robots.In the task process,different modules assist the robots to perform tasks in a closed-loop way,which is referred to as a sensing-communication-computing-control(SC3)loop.In this work,we investigate a UAV-aided system containing multiple SC^(3)loops,which leverages non-orthogonal multiple access(NOMA)for efficient resource sharing.We describe and compare three different modelling levels for the SC^(3)loop.Based on the entropy SC^(3)loop model,a sum linear quadratic regulator(LQR)control cost minimization problem is formulated by optimizing the communication power.Further for the assure-to-be-stable case,we show that the original problem can be approximated by a modified user fairness problem,and accordingly gain more insights into the optimal solutions.Simulation results demonstrate the performance gain of using NOMA in such task-oriented systems,as well as the superiority of our proposed closed-loop-oriented design.展开更多
In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic sys...In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic system that fulfills the requisite specifications should be designed.The AMESim software model is employed to construct a closed hydraulic transmission system,and the simulation analysis is then performed according to the data of hydraulic components.According to analysis results,the prototype can be optimized and upgraded,and a verification test is further carried out.The test results demonstrate that the designed closed hydraulic transmission system meets the actual working requirements of the high-clearance wheeled sprayer and provides a stable experimental platform for intelligent control of agricultural machinery.展开更多
In recent years, there has been global interest in meeting targets relating to energy affordability and security while taking into account greenhouse gas emissions. This has heightened major interest in potential inve...In recent years, there has been global interest in meeting targets relating to energy affordability and security while taking into account greenhouse gas emissions. This has heightened major interest in potential investigations into the use of supercritical carbon dioxide (sCO2) power cycles. Climate change mitigation is the ultimate driver for this increased interest;other relevant issues include the potential for high cycle efficiency and a circular economy. In this study, a 25 MWe recompression closed Brayton cycle (RCBC) has been assessed, and sCO2 has been proposed as the working fluid for the power plant. The methodology used in this research work comprises thermodynamic and techno-economic analysis for the prospective commercialization of this sCO2 power cycle. An evaluated estimation of capital expenditure, operational expenditure, and cost of electricity has been considered in this study. The ASPEN Plus simulation results have been compared with theoretical and mathematical calculations to assess the performance of the compressors, turbine, and heat exchangers. The results thus reveal that the cycle efficiency for this prospective sCO2 recompression closed Brayton cycle increases (39% - 53.6%) as the temperature progressively increases from 550˚C to 900˚C. Data from the Aspen simulation model was used to aid the cost function calculations to estimate the total capital investment cost of the plant. Also, the techno-economic results have shown less cost for purchasing equipment due to fewer components being required for the cycle configuration as compared to the conventional steam power plant.展开更多
C.L. Chang’s introduction of fuzzy topology in 1981 opened up new avenues for parallel theories in topology. However, Chang’s work appears to focus more on the topology of fuzzy sets rather than fuzzy topology itsel...C.L. Chang’s introduction of fuzzy topology in 1981 opened up new avenues for parallel theories in topology. However, Chang’s work appears to focus more on the topology of fuzzy sets rather than fuzzy topology itself. In 1975, Michálek presented a functional definition of ordinary topology and later developed fuzzy topology as a distinct extension of this idea, setting it apart from Chang’s approach. While there has been significant research on Chang’s fuzzy topology, Michálek’s version has not received as much attention. This paper introduces the concept of fuzzy regularly closed filters, or FRCM filters, within Michálek’s fuzzy topological space and explores some properties of FRCM ultrafilters.展开更多
A new algorithm based on an FC-tree （frequent closed pattern tree） and a max-FCIA （maximal frequent closed itemsets algorithm） is presented, which is used to mine the frequent closed itemsets for solving memory an...A new algorithm based on an FC-tree （frequent closed pattern tree） and a max-FCIA （maximal frequent closed itemsets algorithm） is presented, which is used to mine the frequent closed itemsets for solving memory and time consuming problems. This algorithm maps the transaction database by using a Hash table,gets the support of all frequent itemsets through operating the Hash table and forms a lexicographic subset tree including the frequent itemsets.Efficient pruning methods are used to get the FC-tree including all the minimum frequent closed itemsets through processing the lexicographic subset tree.Finally,frequent closed itemsets are generated from minimum frequent closed itemsets.The experimental results show that the mapping transaction database is introduced in the algorithm to reduce time consumption and to improve the efficiency of the program.Furthermore,the effective pruning strategy restrains the number of candidates,which saves space.The results show that the algorithm is effective.展开更多
Atmospheric pressure fuctuation is one of the most important factors afecting the climate environment and gas emission in the fre area.To obtain the infuence rule of the surface atmospheric pressure change on the gas ...Atmospheric pressure fuctuation is one of the most important factors afecting the climate environment and gas emission in the fre area.To obtain the infuence rule of the surface atmospheric pressure change on the gas sampling and abnormal emission in the mine closed goaf,the No.1 coal mine in Dananhu was taken as the research object.Using Fourier transform and Fisher harmonic analysis and other statistical methods,the infuence of the periodic variation of atmospheric pressure on the gas leakage and outfow in the closed goaf was studied.The results showed that there were three atmospheric pressure periods of 15.2 d,1 d and 182.2 d,and the probability was greater than 95%.The time period with the highest number of atmospheric pressure peaks was 7:00–8:00,which accounted for 20.2%of total occurrence number in a day.And the time periods with the highest number of atmospheric pressure trough were 2:00,15:00 and 16:00,accounting for 27.4%.The peak-to-trough transition time was mainly concentrated around 6 h,and the diurnal variation curve of atmospheric pressure was mainly bimodal.The atmospheric pressure change rate was mostly concentrated in 10–50 Pa/h.It was determined that the distance that the gas sampling pipe was pre-laid into the inner side of the closed wall should be greater than 44.4 m,and the CO concentration and atmospheric pressure in the closed goaf were both periodic and negative with atmospheric pressure.The research results have important guiding signifcance for the monitoring,early warning and environmental protection of the goaf.展开更多
Two-phase closed thermosyphons(TPCTs)are widely used in infrastructure constructions in permafrost regions.Due to different climatic conditions,the effectiveness of TPCT will also be different,especially in the extrem...Two-phase closed thermosyphons(TPCTs)are widely used in infrastructure constructions in permafrost regions.Due to different climatic conditions,the effectiveness of TPCT will also be different,especially in the extremely cold region of the Da Xing'anling Mountains.In this study,a series of three-dimensional finite element TPCT embankment models were established based on the ZhanglingMohe highway TPCT test section in Da Xing'anling Mountains,and the thermal characteristics and the cooling effect of the TPCTs were analyzed.The results indicated that the TPCTs installed in the northeastern high-latitude regions is effective in cooling and stabilizing the embankment.The working cycle of the TPCTs is nearly 7 months,and the cooling range of the TPCTs can reach 3 m in this region.However,due to the extremely low temperature,the TPCT generates a large radial gradient in the permafrost layer.Meanwhile,by changing the climate conditions,the same type of TPCT embankment located in the Da Xing'anling Mountains,the Xiao Xing'anling Mountains,and the Qinghai-Tibet Plateau permafrost regions were simulated.Based on the comparison of the climate differences between the Qinghai-Tibet Plateau and Northeast China,the differences in the effectiveness of TPCTs were studied.Finally,the limitations of using existing TPCTs in high-latitude permafrost regions of China were discussed and the potential improvements of the TPCT in cold regions were presented.展开更多
A major challenge facing the steady-state operation of tokamak fusion reactors is to develop a viable divertor solution with order-of-magnitude increase in power handling capability as compared with present experience...A major challenge facing the steady-state operation of tokamak fusion reactors is to develop a viable divertor solution with order-of-magnitude increase in power handling capability as compared with present experience.A recently developed divertor concept for this end has been tested recently on EAST tokamak through combining the effects of a closed divertor corner and E×B drifts.The E×B drifts in the divertor move particles towards the outer divertor corner area in the scrape-off layer for B×▽B directed away from the divertor,which can significantly enhance the particle concentration there,facilitating divertor detachment.In recent EAST experiments,the effects have been demonstrated where the lowest electron temperature at the divertor plate is obtained with strike point located close to the corner in the horizontal target and with B×▽B away from the divertor.These experimental results are in reasonable agreement with SOLPS-ITER simulations including drift effects,suggesting that the new divertor concept potentially provides a promising divertor solution for long-pulse operations of future tokamak fusion reactors with much higher power fluxes.展开更多
Objective:To compare the efficacy of open reduction and volar locking plate internal fixation with closed reduction and external fixation in the treatment of distal radius fractures by using meta analysis.Methods:The ...Objective:To compare the efficacy of open reduction and volar locking plate internal fixation with closed reduction and external fixation in the treatment of distal radius fractures by using meta analysis.Methods:The databases of CNKI,Wanfang,Weipu,Chinese biomedical literature,Pubmed,Embase,and Cochrane Library were retrieved,and the randomized controlled studies that directly compared the efficacy of plate internal fixation and closed reduction external fixation in the treatment of distal radius fractures published publicly from the establishment of the database to April 2023 were collected.The two researchers independently screened the retrieved literature according to the inclusion and exclusion criteria,extracted data,used Cochrane risk bias assessment tool for quality assessment,and used RevMan 5.4 software for meta analysis.Results:A total of 10 randomized controlled trials were included,all of which were in English.There were 1042 patients in total,and 9 of them were rated as low risk.Meta analysis results showed that one year after the treatment of distal radius fracture with volar locking plate internal fixation,DASH score[MD=-5.64,95%CI(-7.21,-4.06),P<0.00001];One year later,PRWE score[MD=-5.90,95%CI(-8.88,-2.92),P=0.001];Palm flexion[MD=5.92,95%CI(1.29,10.55),P=0.01];Pronation[MD=2.48,95%CI(0.59,4.36),P=0.01];Postrotation[MD=4.73,95%CI(2.15,7.31),P=0.0003];Grip strength[MD=0.61,95%CI(0.12,1.10),P=0.02];palmar tilt angle[MD=9.84,95%CI(5.66,14.02),P<0.00001];Radial inclination[MD=4.33,95%CI(2.97,5.69),P<0.00001]was superior to closed reduction plaster or splint external fixation.One year later,the European Five dimensional Health Scale(EQ-5D-5L)score[MD=0.02,95%CI(-0.01,0.05),P=0.27];Back extension[MD=2.22,95%CI(-4.15,8.59),P=0.49];Ulnar deviation[MD=3.49,95%CI(-0.80,7.78),P=0.11];Radial deviation[MD=2.05,95%CI(-2.39,6.50),P=0.37];Ulnar variance[MD=-1.14,95%CI(-3.16,0.88),P=0.27];There was no significant difference in complications[MD=0.77,95%CI(0.54,1.10),P=0.16](P>0.05).Conclusion:Based on the current clinical data,internal fixation with volar locking plate is more conducive to mid-term DASH score and grip strength recovery than closed reduction plaster or splint external fixation,but there is no significant difference in the quality of life and complications of patients.For adult distal radius fractures,surgical indications should be carefully grasped,and non operative treatment should be given priority.展开更多
To reduce current harmonics caused by switching frequency,T-type grid-connected inverter topology with LCL filter is adopted.In view of the disadvantages of the slow response speed of the traditional current control a...To reduce current harmonics caused by switching frequency,T-type grid-connected inverter topology with LCL filter is adopted.In view of the disadvantages of the slow response speed of the traditional current control and the failure to eliminate the influence of the LCL filter on the grid-connected current by using current PI control alone,a current double closed loop PI current tracking control is proposed.Through the theoretical analysis of the grid-connected inverter control principle,the grid-connected inverter control model is designed,and the transfer functionmodel of each control link is deduced,and the current loop PI regulator is designed at last.The simulation results show that the control strategy is feasible.展开更多
Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and ...Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and Conclusion The criteria for singular points, closed orbits and hyperbolic equilibrium points of a second order autonomous Birkhoff system are given. Moreover the stability of equilibria, stable manifolds and unstable manifolds are obtained.展开更多
Special cooling methods are needed for normal growth of crops in closed greenhouses which permit no ventilation, especially during warm seasons. Experi- ments were designed to evaluate two cooling methods （Watergy ch...Special cooling methods are needed for normal growth of crops in closed greenhouses which permit no ventilation, especially during warm seasons. Experi- ments were designed to evaluate two cooling methods （Watergy chimney method and pool method） in a closed greenhouse in Beijing during warm seasons. Prelimi- nary results showed that average temperature at daytime （from 8：00 to 18：00） at 100 cm above ground surface in the closed greenhouse could be reduced by 8 with the Watergy chimney method. Average relative humidity fluctuated between 45% and 75% during daytime at 100 cm above ground surface within the closed greenhouse. With the pool method, average temperature was about 10 ℃ lower than that of the control greenhouse without pool at 50 cm above the ground surface. The peak temperature at 50 cm height was about 32℃ between 11：30 and 15：00 and, close to outside temperature. Temperature in this system satisfied normal growth of most crops, but relative humidity at 50 cm height were above 90% at daytime.展开更多
A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K∩N<<M. Any direct summand of closed weak supplemented module is also closed wea...A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K∩N<<M. Any direct summand of closed weak supplemented module is also closed weak supplemented. Any nonsingular image of closed weak supplemented module is closed weak supplemented. Nonsingular V-rings in which all nonsingular modules are closed weak supplemented are characterized in Section 4.展开更多
This essay aims at an analysis of Murphy's failure of his quest for freedom from the aspect of narrative temporality whichwill focus on order, duration and frequency. From the perspective of temporal order, the es...This essay aims at an analysis of Murphy's failure of his quest for freedom from the aspect of narrative temporality whichwill focus on order, duration and frequency. From the perspective of temporal order, the essay will endeavor to probe into the pro-lepsis in the novel to analyse predetermined narrative and its function. Considering with temporal duration, this essay will penetratethe deceleration of narrative—scene and pause in Murphy to explore its thematic meaning. To investigate the temporal frequency,iterative narrative within text will be exemplified to discuss closed systems in the novel. Based on the analysis of the narrativity tem-porality in Murphy, the essay will focuses on that how its narrative strategy well embodies its theme—the predetermined failure ofMurphy's quest for freedom in closed systems.展开更多
Multiresolution modeling is becoming a powerful tool for fast display, and geometric data compression and transmission of complex shapes. Most of the existing literatures investigating the multiresolution for B-spline...Multiresolution modeling is becoming a powerful tool for fast display, and geometric data compression and transmission of complex shapes. Most of the existing literatures investigating the multiresolution for B-spline curves and surfaces are concentrated on open ones. In this paper, we focus on the multiresolution representations and editing of closed B-spline curves and surfaces using wavelets. A repetition approach is adopted for the multiresolution analysis of closed B-spline curves and surfaces. Since the closed curve or surface itself is periodic, it can overcome the drawback brought by the repetition method, i.e. introducing the discontinuities at the boundaries. Based on the models at different multiresolution levels, the multiresolution editing methods of closed curves and surfaces are introduced. Users can edit the overall shape of a closed one while preserving its details, or change its details without affecting its overall shape.展开更多
Hepatitis B virus(HBV) infection is a major global health problem. Although current therapies, such as the use of nucleos(t)ide analogs, inhibit HBV replication efficiently, they do not eliminate covalently closed cir...Hepatitis B virus(HBV) infection is a major global health problem. Although current therapies, such as the use of nucleos(t)ide analogs, inhibit HBV replication efficiently, they do not eliminate covalently closed circular DNA(ccc DNA), which persists in hepatocyte nuclei. As HBV ccc DNA is a viral transcription template, novel therapeutic approaches to directly target HBV ccc DNA are necessary to completely eradicate persistent HBV infections. HBV ccc DNA levels in HBV-infected human liver cells are extremely low; thus, more reliable and simple measurement methods are needed to correctly monitor their levels during therapeutic treatment. Although reverse transcription-polymerase chain reaction or Southern blot procedures are currently used in research studies, these methods are not completely reliable and are also time-consuming and labor-intensive. Genome editing technologies, such as zinc finger nucleases, transcription activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeats/Cas9(CRISPR/Cas9) system, which are designed to target specific DNA sequences, represent highly promising potential therapeutic tools. In particular, the CRISPR/Cas9 system is an easily customizable sequencespecific nuclease with high flexibility and may be the most feasible approach to target HBV ccc DNA. Further research to develop easier, safer, and more effective protocols should be pursued.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82271397(to MG),82001293(to MG),82171355(to RX),81971295(to RX)and 81671189(to RX)。
文摘Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.
基金supported by the National Natural Science Foundation of China,Nos.82271397(to MG),82001293(to MG),82171355(to RX),81971295(to RX),and 81671189(to RX)。
文摘Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and repair.We previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological recovery.However,the mechanism of CXCR4 upregulation in induced neural stem cells remains unclear.In this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 expression.However,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial activation.In agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury mice.Notably,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head injury.In conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neural stem cells on microglial activation via upregulation of CXCR4 and Crry,thereby promoting induced neural stem cell–mediated improvement of neuronal injury,cerebral edema,and neurological disorders following closed head injury.
基金supported by the Fundamental Research Funds of the National Institute of MetrologyChina(No.AKYZZ2113)+1 种基金National Key Research and Development Program of China(No.2017YFF0206205)the Team Building Program of Nanjing University(No.1480604114)。
文摘The neutron radiation field has vital applications in areas such as biomedicine,geology,radiation safety,and many others for neutron detection and neutron metrology.Correcting neutron fluence rate perturbation accurately is an important yet challenging problem.This study proposes a correction method that analyzes three physical processes.This method,which transforms the detection process from point detection to area detection,is based on a novel physical model and has been validated through theoretical analyses,experiments,and simulations.According to the average differences between the calculated and experimental results,the new method(1.67%)demonstrated better accuracy than the traditional simulation(2.17%).In a closed thermal neutron radiation field,the detector or strong neutron absorption material significantly perturbs the neutron fluence rate,whereas its impact on the energy spectrum shape and neutron directionality is relatively minor.Furthermore,based on the calculation results of the perturbation rate formula for medium materials with different compositions and sizes,the larger the volume and capture cross section of the medium,the higher the perturbation rate generated in the closed radiation field.
基金supported in part by the National Key Research and Development Program of China under Grant 2020YFA0711301in part by the National Natural Science Foundation of China under Grant 62341110, Grant U22A2002, and Grant 62025110in part by the Suzhou Science and Technology Project
文摘In the areas without terrestrial communication infrastructures,unmanned aerial vehicles(UAVs)can be utilized to serve field robots for mission-critical tasks.For this purpose,UAVs can be equipped with sensing,communication,and computing modules to support various requirements of robots.In the task process,different modules assist the robots to perform tasks in a closed-loop way,which is referred to as a sensing-communication-computing-control(SC3)loop.In this work,we investigate a UAV-aided system containing multiple SC^(3)loops,which leverages non-orthogonal multiple access(NOMA)for efficient resource sharing.We describe and compare three different modelling levels for the SC^(3)loop.Based on the entropy SC^(3)loop model,a sum linear quadratic regulator(LQR)control cost minimization problem is formulated by optimizing the communication power.Further for the assure-to-be-stable case,we show that the original problem can be approximated by a modified user fairness problem,and accordingly gain more insights into the optimal solutions.Simulation results demonstrate the performance gain of using NOMA in such task-oriented systems,as well as the superiority of our proposed closed-loop-oriented design.
基金Supported by 2023 Xinjiang Uygur Autonomous Region R&D and Promotion and Application of Key Technologies of CNC Sprayer for Seed Corn(2023NC010).
文摘In conjunction with the working characteristics of the high-clearance wheeled sprayer and the benefits of the closed hydraulic system,a series of reasonable working parameters should be established,and a hydraulic system that fulfills the requisite specifications should be designed.The AMESim software model is employed to construct a closed hydraulic transmission system,and the simulation analysis is then performed according to the data of hydraulic components.According to analysis results,the prototype can be optimized and upgraded,and a verification test is further carried out.The test results demonstrate that the designed closed hydraulic transmission system meets the actual working requirements of the high-clearance wheeled sprayer and provides a stable experimental platform for intelligent control of agricultural machinery.
文摘In recent years, there has been global interest in meeting targets relating to energy affordability and security while taking into account greenhouse gas emissions. This has heightened major interest in potential investigations into the use of supercritical carbon dioxide (sCO2) power cycles. Climate change mitigation is the ultimate driver for this increased interest;other relevant issues include the potential for high cycle efficiency and a circular economy. In this study, a 25 MWe recompression closed Brayton cycle (RCBC) has been assessed, and sCO2 has been proposed as the working fluid for the power plant. The methodology used in this research work comprises thermodynamic and techno-economic analysis for the prospective commercialization of this sCO2 power cycle. An evaluated estimation of capital expenditure, operational expenditure, and cost of electricity has been considered in this study. The ASPEN Plus simulation results have been compared with theoretical and mathematical calculations to assess the performance of the compressors, turbine, and heat exchangers. The results thus reveal that the cycle efficiency for this prospective sCO2 recompression closed Brayton cycle increases (39% - 53.6%) as the temperature progressively increases from 550˚C to 900˚C. Data from the Aspen simulation model was used to aid the cost function calculations to estimate the total capital investment cost of the plant. Also, the techno-economic results have shown less cost for purchasing equipment due to fewer components being required for the cycle configuration as compared to the conventional steam power plant.
文摘C.L. Chang’s introduction of fuzzy topology in 1981 opened up new avenues for parallel theories in topology. However, Chang’s work appears to focus more on the topology of fuzzy sets rather than fuzzy topology itself. In 1975, Michálek presented a functional definition of ordinary topology and later developed fuzzy topology as a distinct extension of this idea, setting it apart from Chang’s approach. While there has been significant research on Chang’s fuzzy topology, Michálek’s version has not received as much attention. This paper introduces the concept of fuzzy regularly closed filters, or FRCM filters, within Michálek’s fuzzy topological space and explores some properties of FRCM ultrafilters.
基金The National Natural Science Foundation of China(No.60603047)the Natural Science Foundation of Liaoning ProvinceLiaoning Higher Education Research Foundation(No.2008341)
文摘A new algorithm based on an FC-tree （frequent closed pattern tree） and a max-FCIA （maximal frequent closed itemsets algorithm） is presented, which is used to mine the frequent closed itemsets for solving memory and time consuming problems. This algorithm maps the transaction database by using a Hash table,gets the support of all frequent itemsets through operating the Hash table and forms a lexicographic subset tree including the frequent itemsets.Efficient pruning methods are used to get the FC-tree including all the minimum frequent closed itemsets through processing the lexicographic subset tree.Finally,frequent closed itemsets are generated from minimum frequent closed itemsets.The experimental results show that the mapping transaction database is introduced in the algorithm to reduce time consumption and to improve the efficiency of the program.Furthermore,the effective pruning strategy restrains the number of candidates,which saves space.The results show that the algorithm is effective.
基金This work was financially sponsored by the National Natural Science Foundation of China(51864045,51804161,52074156 and 51804355)And Central University Basic Scientifc Research Business Expenses Special Funds(2023ZKPYAQ03).
文摘Atmospheric pressure fuctuation is one of the most important factors afecting the climate environment and gas emission in the fre area.To obtain the infuence rule of the surface atmospheric pressure change on the gas sampling and abnormal emission in the mine closed goaf,the No.1 coal mine in Dananhu was taken as the research object.Using Fourier transform and Fisher harmonic analysis and other statistical methods,the infuence of the periodic variation of atmospheric pressure on the gas leakage and outfow in the closed goaf was studied.The results showed that there were three atmospheric pressure periods of 15.2 d,1 d and 182.2 d,and the probability was greater than 95%.The time period with the highest number of atmospheric pressure peaks was 7:00–8:00,which accounted for 20.2%of total occurrence number in a day.And the time periods with the highest number of atmospheric pressure trough were 2:00,15:00 and 16:00,accounting for 27.4%.The peak-to-trough transition time was mainly concentrated around 6 h,and the diurnal variation curve of atmospheric pressure was mainly bimodal.The atmospheric pressure change rate was mostly concentrated in 10–50 Pa/h.It was determined that the distance that the gas sampling pipe was pre-laid into the inner side of the closed wall should be greater than 44.4 m,and the CO concentration and atmospheric pressure in the closed goaf were both periodic and negative with atmospheric pressure.The research results have important guiding signifcance for the monitoring,early warning and environmental protection of the goaf.
基金the National Natural Science Foundation of China(No.41971076No.42171128)the Heilongjiang Provincial Department of Science and Technology(GA21A501)。
文摘Two-phase closed thermosyphons(TPCTs)are widely used in infrastructure constructions in permafrost regions.Due to different climatic conditions,the effectiveness of TPCT will also be different,especially in the extremely cold region of the Da Xing'anling Mountains.In this study,a series of three-dimensional finite element TPCT embankment models were established based on the ZhanglingMohe highway TPCT test section in Da Xing'anling Mountains,and the thermal characteristics and the cooling effect of the TPCTs were analyzed.The results indicated that the TPCTs installed in the northeastern high-latitude regions is effective in cooling and stabilizing the embankment.The working cycle of the TPCTs is nearly 7 months,and the cooling range of the TPCTs can reach 3 m in this region.However,due to the extremely low temperature,the TPCT generates a large radial gradient in the permafrost layer.Meanwhile,by changing the climate conditions,the same type of TPCT embankment located in the Da Xing'anling Mountains,the Xiao Xing'anling Mountains,and the Qinghai-Tibet Plateau permafrost regions were simulated.Based on the comparison of the climate differences between the Qinghai-Tibet Plateau and Northeast China,the differences in the effectiveness of TPCTs were studied.Finally,the limitations of using existing TPCTs in high-latitude permafrost regions of China were discussed and the potential improvements of the TPCT in cold regions were presented.
基金funded by the National Magnetic Confinement Fusion Program of China(Nos.2019YFE03030000,2019YFE03080500 and 2022YFE03060004)National Natural Science Foundation of China(No.U19A20113)。
文摘A major challenge facing the steady-state operation of tokamak fusion reactors is to develop a viable divertor solution with order-of-magnitude increase in power handling capability as compared with present experience.A recently developed divertor concept for this end has been tested recently on EAST tokamak through combining the effects of a closed divertor corner and E×B drifts.The E×B drifts in the divertor move particles towards the outer divertor corner area in the scrape-off layer for B×▽B directed away from the divertor,which can significantly enhance the particle concentration there,facilitating divertor detachment.In recent EAST experiments,the effects have been demonstrated where the lowest electron temperature at the divertor plate is obtained with strike point located close to the corner in the horizontal target and with B×▽B away from the divertor.These experimental results are in reasonable agreement with SOLPS-ITER simulations including drift effects,suggesting that the new divertor concept potentially provides a promising divertor solution for long-pulse operations of future tokamak fusion reactors with much higher power fluxes.
基金2022 Key Specialty Construction Project of Traditional Chinese Medicine:Traditional Chinese Orthopedics and Traumatology Department (No.962042)2020 Regional Traditional Chinese Medicine (Orthopedics and Traumatology)Diagnosis and Treatment Center (Jin Wei Zhong[2020]No.5)。
文摘Objective:To compare the efficacy of open reduction and volar locking plate internal fixation with closed reduction and external fixation in the treatment of distal radius fractures by using meta analysis.Methods:The databases of CNKI,Wanfang,Weipu,Chinese biomedical literature,Pubmed,Embase,and Cochrane Library were retrieved,and the randomized controlled studies that directly compared the efficacy of plate internal fixation and closed reduction external fixation in the treatment of distal radius fractures published publicly from the establishment of the database to April 2023 were collected.The two researchers independently screened the retrieved literature according to the inclusion and exclusion criteria,extracted data,used Cochrane risk bias assessment tool for quality assessment,and used RevMan 5.4 software for meta analysis.Results:A total of 10 randomized controlled trials were included,all of which were in English.There were 1042 patients in total,and 9 of them were rated as low risk.Meta analysis results showed that one year after the treatment of distal radius fracture with volar locking plate internal fixation,DASH score[MD=-5.64,95%CI(-7.21,-4.06),P<0.00001];One year later,PRWE score[MD=-5.90,95%CI(-8.88,-2.92),P=0.001];Palm flexion[MD=5.92,95%CI(1.29,10.55),P=0.01];Pronation[MD=2.48,95%CI(0.59,4.36),P=0.01];Postrotation[MD=4.73,95%CI(2.15,7.31),P=0.0003];Grip strength[MD=0.61,95%CI(0.12,1.10),P=0.02];palmar tilt angle[MD=9.84,95%CI(5.66,14.02),P<0.00001];Radial inclination[MD=4.33,95%CI(2.97,5.69),P<0.00001]was superior to closed reduction plaster or splint external fixation.One year later,the European Five dimensional Health Scale(EQ-5D-5L)score[MD=0.02,95%CI(-0.01,0.05),P=0.27];Back extension[MD=2.22,95%CI(-4.15,8.59),P=0.49];Ulnar deviation[MD=3.49,95%CI(-0.80,7.78),P=0.11];Radial deviation[MD=2.05,95%CI(-2.39,6.50),P=0.37];Ulnar variance[MD=-1.14,95%CI(-3.16,0.88),P=0.27];There was no significant difference in complications[MD=0.77,95%CI(0.54,1.10),P=0.16](P>0.05).Conclusion:Based on the current clinical data,internal fixation with volar locking plate is more conducive to mid-term DASH score and grip strength recovery than closed reduction plaster or splint external fixation,but there is no significant difference in the quality of life and complications of patients.For adult distal radius fractures,surgical indications should be carefully grasped,and non operative treatment should be given priority.
基金Supported by Science and Technology Projects of State Grid Corporation ofChina(J2022019).
文摘To reduce current harmonics caused by switching frequency,T-type grid-connected inverter topology with LCL filter is adopted.In view of the disadvantages of the slow response speed of the traditional current control and the failure to eliminate the influence of the LCL filter on the grid-connected current by using current PI control alone,a current double closed loop PI current tracking control is proposed.Through the theoretical analysis of the grid-connected inverter control principle,the grid-connected inverter control model is designed,and the transfer functionmodel of each control link is deduced,and the current loop PI regulator is designed at last.The simulation results show that the control strategy is feasible.
文摘Aim To study singular points, closed orbits, stable manifolds and unstable manifolds of a second order autonomous Birkhoff system. Methods Qualitative methods of ordinary differential equation were used. Results and Conclusion The criteria for singular points, closed orbits and hyperbolic equilibrium points of a second order autonomous Birkhoff system are given. Moreover the stability of equilibria, stable manifolds and unstable manifolds are obtained.
基金Supported by National High Technology Research and Development Program of China(2012AA101903,2011AA100504)Natural Science Foundation of Shaanxi Province(K3320215199)Research Fund for the Doctoral Program of Northwest A&F University(2452015291)~~
文摘Special cooling methods are needed for normal growth of crops in closed greenhouses which permit no ventilation, especially during warm seasons. Experi- ments were designed to evaluate two cooling methods （Watergy chimney method and pool method） in a closed greenhouse in Beijing during warm seasons. Prelimi- nary results showed that average temperature at daytime （from 8：00 to 18：00） at 100 cm above ground surface in the closed greenhouse could be reduced by 8 with the Watergy chimney method. Average relative humidity fluctuated between 45% and 75% during daytime at 100 cm above ground surface within the closed greenhouse. With the pool method, average temperature was about 10 ℃ lower than that of the control greenhouse without pool at 50 cm above the ground surface. The peak temperature at 50 cm height was about 32℃ between 11：30 and 15：00 and, close to outside temperature. Temperature in this system satisfied normal growth of most crops, but relative humidity at 50 cm height were above 90% at daytime.
基金Project (No. 102028) supported by the Natural Science Foundation of Zhejiang Province, China
文摘A module M is called closed weak supplemented if for any closed submodule N of M, there is a submodule K of M such that M=K+N and K∩N<<M. Any direct summand of closed weak supplemented module is also closed weak supplemented. Any nonsingular image of closed weak supplemented module is closed weak supplemented. Nonsingular V-rings in which all nonsingular modules are closed weak supplemented are characterized in Section 4.
文摘This essay aims at an analysis of Murphy's failure of his quest for freedom from the aspect of narrative temporality whichwill focus on order, duration and frequency. From the perspective of temporal order, the essay will endeavor to probe into the pro-lepsis in the novel to analyse predetermined narrative and its function. Considering with temporal duration, this essay will penetratethe deceleration of narrative—scene and pause in Murphy to explore its thematic meaning. To investigate the temporal frequency,iterative narrative within text will be exemplified to discuss closed systems in the novel. Based on the analysis of the narrativity tem-porality in Murphy, the essay will focuses on that how its narrative strategy well embodies its theme—the predetermined failure ofMurphy's quest for freedom in closed systems.
文摘Multiresolution modeling is becoming a powerful tool for fast display, and geometric data compression and transmission of complex shapes. Most of the existing literatures investigating the multiresolution for B-spline curves and surfaces are concentrated on open ones. In this paper, we focus on the multiresolution representations and editing of closed B-spline curves and surfaces using wavelets. A repetition approach is adopted for the multiresolution analysis of closed B-spline curves and surfaces. Since the closed curve or surface itself is periodic, it can overcome the drawback brought by the repetition method, i.e. introducing the discontinuities at the boundaries. Based on the models at different multiresolution levels, the multiresolution editing methods of closed curves and surfaces are introduced. Users can edit the overall shape of a closed one while preserving its details, or change its details without affecting its overall shape.
文摘Hepatitis B virus(HBV) infection is a major global health problem. Although current therapies, such as the use of nucleos(t)ide analogs, inhibit HBV replication efficiently, they do not eliminate covalently closed circular DNA(ccc DNA), which persists in hepatocyte nuclei. As HBV ccc DNA is a viral transcription template, novel therapeutic approaches to directly target HBV ccc DNA are necessary to completely eradicate persistent HBV infections. HBV ccc DNA levels in HBV-infected human liver cells are extremely low; thus, more reliable and simple measurement methods are needed to correctly monitor their levels during therapeutic treatment. Although reverse transcription-polymerase chain reaction or Southern blot procedures are currently used in research studies, these methods are not completely reliable and are also time-consuming and labor-intensive. Genome editing technologies, such as zinc finger nucleases, transcription activator-like effector nucleases, and the clustered regularly interspaced short palindromic repeats/Cas9(CRISPR/Cas9) system, which are designed to target specific DNA sequences, represent highly promising potential therapeutic tools. In particular, the CRISPR/Cas9 system is an easily customizable sequencespecific nuclease with high flexibility and may be the most feasible approach to target HBV ccc DNA. Further research to develop easier, safer, and more effective protocols should be pursued.
