Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered ...Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic responses.The dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed herein.The simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is conducted.The effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are investigated.The results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind turbine.Considering the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid model.Moreover,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and platform.Thus,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.展开更多
1 About the Special Issue Editor Qiaoguang Li is an associate professor and master’s supervisor in the Department of College of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Engineering.He...1 About the Special Issue Editor Qiaoguang Li is an associate professor and master’s supervisor in the Department of College of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Engineering.He received his PhD from Institute of Chemical Industry of Forestry Products,Chinese Academy of Forestry in 2018.He has been focusing his research on the chemical basis and application of natural resources.He has published nearly 30 international peer reviewed papers and applied for 10 patents.展开更多
In this paper,the multi-body coupled dynamic characteristics of a semisubmersible platform and an HYSY 229 barge were investigated.First,coupled hydrodynamic analysis of the HYSY 229 barge and the semisubmersible plat...In this paper,the multi-body coupled dynamic characteristics of a semisubmersible platform and an HYSY 229 barge were investigated.First,coupled hydrodynamic analysis of the HYSY 229 barge and the semisubmersible platform was performed.Relevant hydrodynamic parameters were obtained using the retardation function method of three-dimensional frequency-domain potential flow theory.The results of the hydrodynamic analysis were highly consistent with the test findings,verifying the accuracy of the multifloating hydrodynamic coupling analysis,and key hydrodynamic parameters were solved for different water depths and the coupling effect.According to the obtained results,the hydrodynamic influence was the largest in shallow waters when the coupling effect was considered.Furthermore,the coupled motion equation combined with viscous damping,fender system,and mooring system was established,and the hydrodynamics,floating body motion,and dynamic response of the fender system were analyzed.Motion analysis revealed good agreement among the surge,sway,and yaw motions of the two floating bodies.However,when the wave period reached 10 s,the motion of the two floating bodies showed severe shock,and a relative motion was also observed.Therefore,excessive constraints should be added between the two floating bodies during construction to ensure construction safety.The numerical analysis and model test results of the semisubmersible platform and HYSY 229 barge at a water depth of 42 m and sea conditions of 0°,45°,and 90° were in good agreement,and the error was less than 5%.The maximum movement of the HYSY 229 barge reached 2.61 m in the sway direction,whereas that of the semisubmersible platform was 2.11 m.During construction,excessive constraints should be added between the two floating bodies to limit their relative movement and ensure construction safety.展开更多
In the era of the Internet,various network platforms have evolved into new hubs for information dissemination.Currently,China has established a platform-centered content regulation framework,wherein platforms proactiv...In the era of the Internet,various network platforms have evolved into new hubs for information dissemination.Currently,China has established a platform-centered content regulation framework,wherein platforms proactively enforce content regulations in accordance with legal censorship obligations.Additionally,platform policies and user agreements augment their authority in content regulation.The platforms can achieve cost-effective and highly efficient content regulation by leveraging their strategic advantages enabled by their own technical capabilities and extensive coverage.The platform self-regulation model,however,still faces challenges.First,accurately evaluating content remains a formidable task;second,ensuring effective platform publicity through self-regulation poses difficulties;third,users may potentially face disadvantages due to the platform’s right of self-regulation;and fourth,digital copyright owners face challenges when defending digital copyright disputes under the safe harbor rule.Therefore,it is imperative to establish,review,and revise the legal framework for content regulation of network platforms in order to enhance the efficiency of their governance systems.The formulation of the legal framework for content regulation of network platforms may encompass the following aspects:rationalizing obligations pertaining to platform content regulations,enhancing supervision over platform self-regulation,and establishing a dual-track responsibility system for digital copyright content regulation.This will ensure a harmonious balance among public interests,users’personal rights and interests,and commercial benefits through regulating the content on network platforms.展开更多
Visual media have dominated sensory communications for decades,and the resulting“visual hegemony”leads to the call for the“auditory return”in order to achieve a holistic balance in cultural acceptance.Romance of t...Visual media have dominated sensory communications for decades,and the resulting“visual hegemony”leads to the call for the“auditory return”in order to achieve a holistic balance in cultural acceptance.Romance of the Three Kingdoms,a classic literary work in China,has received significant attention and promotion from leading audio platforms.However,the commercialization of digital audio publishing faces unprecedented challenges due to the mismatch between the dissemination of long-form content on digital audio platforms and the current trend of short and fast information reception.Drawing on the Business Model Canvas Theory and taking Romance of the Three Kingdoms as the main focus of analysis,this paper argues that the construction of a business model for the audio publishing of classical books should start from three aspects:the user evaluation of digital audio platforms,the establishment of value propositions based on the“creative transformation and innovative development”principle,and the improvement of the audio publishing infrastructure to ensure the healthy operation and development of the digital audio platforms and consequently improve their current state of development and expand the boundaries of cultural heritage.展开更多
The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures...The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape.展开更多
Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients di...Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.展开更多
Rapeseed(Brassica napus)is an oil crop grown worldwide,making it a key plant species in molecular breeding research.However,the complexity of its polyploid genome increases sequencing costs and reduces sequencing accu...Rapeseed(Brassica napus)is an oil crop grown worldwide,making it a key plant species in molecular breeding research.However,the complexity of its polyploid genome increases sequencing costs and reduces sequencing accuracy.Target capture coupled with high-throughput sequencing is an efficient approach for detecting genetic variation at genomic regions or loci of interest.In this study,588 resequenced accessions of rapeseed were used to develop a target capture sequencing SNP genotyping platform named BnaPan50T.The platform comprised 54,765,with 54,058 resequenced markers from the pan-genome,and 855 variant trait-associated markers for 12 agronomic traits.The capture quality of BnaPan50T was demonstrated well in 12 typical accessions.Compared with a conventional genotyping array,BnaPan50T has a high SNP density and a high proportion of SNPs in unique physical positions and in annotated functional genes,promising wide application.Target capture sequencing and wholegenome resequencing in 90 doubled-haploid lines yielded 60%specificity,78%uniformity within tenfold coverage range,and 93%genotyping accuracy for the platform.BnaPan50T was used to construct a genetic map for quantitative trait loci(QTL)mapping,identify 21 unique QTL,and predict several candidate genes for yield-related traits in multiple environments.A set of 132 core SNP loci was selected from BnaPan50T to construct DNA fingerprints and germplasm identification resources.This study provides genomics resources to support target capture sequencing,genetic analysis and genomic breeding of rapeseed.展开更多
Thalassemia syndrome is a genetic blood disorder induced by the reduction of normal hemoglobin production,resulting in a drop in the size of red blood cells.In severe forms,it can lead to death.This genetic disorder h...Thalassemia syndrome is a genetic blood disorder induced by the reduction of normal hemoglobin production,resulting in a drop in the size of red blood cells.In severe forms,it can lead to death.This genetic disorder has posed a major burden on public health wherein patients with severe thalassemia need periodic therapy of iron chelation and blood transfusion for survival.Therefore,controlling thalassemia is extremely important and is made by promoting screening to the general population,particularly among thalassemia carriers.Today Twitter is one of the most influential social media platforms for sharing opinions and discussing different topics like people’s health conditions and major public health affairs.Exploring individuals’sentiments in these tweets helps the research centers to formulate strategies to promote thalassemia screening to the public.An effective Lexiconbased approach has been introduced in this study by highlighting a classifier called valence aware dictionary for sentiment reasoning(VADER).In this study applied twitter intelligence tool(TWINT),Natural Language Toolkit(NLTK),and VADER constitute the three main tools.VADER represents a gold-standard sentiment lexicon,which is basically tailored to attitudes that are communicated by using social media.The contribution of this study is to introduce an effective Lexicon-based approach by highlighting a classifier calledVADERto analyze the sentiment of the general population,particularly among thalassemia carriers on the social media platform Twitter.In this study,the results showed that the proposed approach achieved 0.829,0.816,and 0.818 regarding precision,recall,together with F-score,respectively.The tweets were crawled using the search keywords,“thalassemia screening,”thalassemia test,“and thalassemia diagnosis”.Finally,results showed that India and Pakistan ranked the highest in mentions in tweets by the public’s conversations on thalassemia screening with 181 and 164 tweets,respectively.展开更多
The high-speed railway construction involves multiple professional fields,such as railway design,construction,and supervision.This paper architects the"BIM+"project refined management platform,designs the pl...The high-speed railway construction involves multiple professional fields,such as railway design,construction,and supervision.This paper architects the"BIM+"project refined management platform,designs the platform's logical architecture,physical architecture,and solves several key technology difficulties.This"BIM+"platform has been applied on the Jingxiong Bridge Project and achieved all-round,whole-process and multi-management of high-speed railway engineering construction.It significantly improves the level of construction management,and plays a role in promoting the development of high-speed railway construction informatization.展开更多
In this paper,a typical experiment is carried out based on a high-resolution air-sea coupled model,namely,the coupled ocean-atmosphere-wave-sediment transport(COAWST)model,on both heterogeneous many-core(SW)and homoge...In this paper,a typical experiment is carried out based on a high-resolution air-sea coupled model,namely,the coupled ocean-atmosphere-wave-sediment transport(COAWST)model,on both heterogeneous many-core(SW)and homogenous multicore(Intel)supercomputing platforms.We construct a hindcast of Typhoon Lekima on both the SW and Intel platforms,compare the simulation results between these two platforms and compare the key elements of the atmospheric and ocean modules to reanalysis data.The comparative experiment in this typhoon case indicates that the domestic many-core computing platform and general cluster yield almost no differences in the simulated typhoon path and intensity,and the differences in surface pressure(PSFC)in the WRF model and sea surface temperature(SST)in the short-range forecast are very small,whereas a major difference can be identified at high latitudes after the first 10 days.Further heat budget analysis verifies that the differences in SST after 10 days are mainly caused by shortwave radiation variations,as influenced by subsequently generated typhoons in the system.These typhoons generated in the hindcast after the first 10 days attain obviously different trajectories between the two platforms.展开更多
A study of the morphological and microstructural characteristics of helcionelloids from the Nanjiang area(north Sichuan,China)at the northern Yangtze Platform was undertaken,in order to understand their phylogenetic p...A study of the morphological and microstructural characteristics of helcionelloids from the Nanjiang area(north Sichuan,China)at the northern Yangtze Platform was undertaken,in order to understand their phylogenetic position.Helcionelloids fossils from the Kuanchuanpu Formation of the Changtanhe–Maolinzi section include 7 genera and 11 species.There are distinct differences in the degree of shell bending,the apical morphology and apex position,the outline of the aperture and the height of the shell,all of which constitute important identification features.Although helcionelloid apices exhibit varying degrees of rotation towards the aperture,they do not show any signs of evident distortion.A pair of basally-symmetrical muscle scars are discovered on the shells of helcionelloids(such as Bemella simplex),showing a distinct difference when compared with those of the stem-group gastropod(e.g.,Pelagiella).The prismatic shell layer of helcionelloids has been observed,which are common components in Cambrian molluscs,but differ significantly from the dense layer microstructure found in contemporary molluscs.The microstructures,muscle scars and morphological characteristics demonstrate that helcionelloids represent a stem-group of molluscs.展开更多
An analysis of Thalassinoides ichnofabrics in the Cambrian Stage 4 Longwangmiao Formation from six sections near Chonqing in the Middle and Upper Yangtze Block of South China was conducted to promote the understanding...An analysis of Thalassinoides ichnofabrics in the Cambrian Stage 4 Longwangmiao Formation from six sections near Chonqing in the Middle and Upper Yangtze Block of South China was conducted to promote the understanding of the paleoenvironment of this period.Thalassinoides ichnofabrics are divided into three types according to their morphology,bioturbation index,abundance and related parameters:banded,mottled and grid.The completeness of the ichnofabrics gradually increases from banded to grid,the scale of the burrows expands,and the structure transitions from twodimensional to three-dimensional.Malacostracans,phyllocarids and enteropneusts are the most likely burrowers.The findings reveal that frequent changes in paleoenvironmental conditions are the dominant factors for generating the various Thalassinoides ichnofabrics.The changes in depositional rate,substrate properties and nutrient levels affect the behavior and building patterns of the burrowers,thus leading to the diversity of Thalassinoides ichnofabrics.In the lower Longwangmiao Formation beds,many incomplete Thalassinoides burrow systems were built in the substrates with terrigenous detrital minerals,revealing significant environmental pressure on the burrowers.Later,the Thalassinoides burrows went into complete three-dimensional boxworks.At the end of the stage,bioturbation almost disappeared,which indicates that burrowers were finding it difficult to survive in the harsh environment.展开更多
Offshore steel structures are a common investment in oil and gas industries operating in shallow to medium depth seas.These structures have become increasingly popular since the mid-19th century,with a typical design ...Offshore steel structures are a common investment in oil and gas industries operating in shallow to medium depth seas.These structures have become increasingly popular since the mid-19th century,with a typical design life of 30-50 years.Despite their popularity,the structural integrity of existing offshore structures remains a controversial topic.Environmental loads and material degradation have been identified as significant factors that can compromise the structural integrity of offshore structures.To address this issue,this study aims to investigate the reserved strength capacity of a selected offshore structure located in the Malaysian Seas.The study will explore the effect of oceanographic data,variations in vertical load,and corrosion on the structure’s main members.To determine the impact of each variable on the reserved strength ratio(RSR)of the structure,several pushover analyses were conducted with different variables.Previous literature has shown little or no relationship between seawater wave height,gravity loads,and corrosion allowance on submerged steel members and the RSR of offshore structures.However,this study aims tofill this gap in knowledge by examining these variables’effects on the RSR of offshore structures.The study’sfindings indicate that even a slight increase in wave height can significantly impact the structure’s RSR due to the increase in lateral loading,potentially leading to severe damage to structural components and the foundation model.Additionally,gravity loads had an adverse effect on the RSR of the structure when more than double the vertical load was added.Corrosion allowance was also found to impact the RSR,particularly when assuming significant wall thickness corrosion in primary members.Overall,thefindings of this study have important implications for the design and maintenance of offshore structures.The results suggest that engineers and operators should pay close attention to the potential impacts of environmental loads,such as wave height and gravity loads,and material degradation,such as corrosion allowance,on the structural integrity of offshore structures.This information can be used to optimize the design and maintenance of offshore structures,leading to safer and more efficient operations.展开更多
We report a design and implementation of a field-programmable-gate-arrays(FPGA)based hardware platform,which is used to realize control and signal readout of trapped-ion-based multi-level quantum systems.This platform...We report a design and implementation of a field-programmable-gate-arrays(FPGA)based hardware platform,which is used to realize control and signal readout of trapped-ion-based multi-level quantum systems.This platform integrates a four-channel 2.8 Gsps@14 bits arbitrary waveform generator,a 16-channel 1 Gsps@14 bits direct-digital-synthesisbased radio-frequency generator,a 16-channel 8 ns resolution pulse generator,a 10-channel 16 bits digital-to-analogconverter module,and a 2-channel proportion integration differentiation controller.The hardware platform can be applied in the trapped-ion-based multi-level quantum systems,enabling quantum control of multi-level quantum system and highdimensional quantum simulation.The platform is scalable and more channels for control and signal readout can be implemented by utilizing more parallel duplications of the hardware.The hardware platform also has a bright future to be applied in scaled trapped-ion-based quantum systems.展开更多
Based on the seismic, logging, drilling and other data, the distribution, structural types and mound-shoal hydrocarbon accumulation characteristics of platform margins of the Sinian Dengying Formation in the Deyang-An...Based on the seismic, logging, drilling and other data, the distribution, structural types and mound-shoal hydrocarbon accumulation characteristics of platform margins of the Sinian Dengying Formation in the Deyang-Anyue Rift and its periphery were analyzed. Four types of platform margins are developed in the Dengying Formation, i.e., single-stage fault-controlled platform margin, multi-stage fault-controlled platform margin, gentle slope platform margin, and overlapping platform margin. In the Gaoshiti West-Weiyuan East area, single-stage fault controlled platform margins are developed in the Deng 2 Member, which trend in nearly NEE direction and are shielded by faults and mudstones, forming fault-controlled–lithologic traps. In the Lezhi-Penglai area, independent and multi-stage fault controlled platform margins are developed in the Deng 2 Member, which trend in NE direction and are controlled by synsedimentary faults;the mound-shoal complexes are aggraded and built on the hanging walls of the faults, and they are shielded by tight intertidal belts and the Lower Cambrian source rocks in multiple directions, forming fault-controlled–lithologic and other composite traps. In the Weiyuan-Ziyang area, gentle slope platform margins are developed in the Deng 2 Member, which trend in NW direction;the mound-shoal complexes are mostly thin interbeds as continuous bands and shielded by tight intertidal belts in the updip direction, forming lithologic traps. In the Gaoshiti-Moxi-Yanting area, overlapping platform margins are developed in the Deng 2 and Deng 4 members;the mound-shoal complexes are aggraded and overlaid to create platform margin buildup with a huge thickness and sealed by tight intertidal belts and the Lower Cambrian mudstones in the updip direction, forming large-scale lithologic traps on the north slope of the Central Sichuan Paleouplift. To summarize, the mound-shoal complexes on the platform margins in the Dengying Formation in the Penglai-Zhongjiang area, Moxi North-Yanting area and Weiyuan-Ziyang area are large in scale, with estimated resources of 1.58×1012 m3, and they will be the key targets for the future exploration of the Dengying Formation in the Sichuan Basin.展开更多
To dampen periodic off-levelling motions within an inertial platform while undergoing horizontal accelerations of the same period and to achieve a levelling accuracy of a few tens of arcseconds with that system,an int...To dampen periodic off-levelling motions within an inertial platform while undergoing horizontal accelerations of the same period and to achieve a levelling accuracy of a few tens of arcseconds with that system,an internally damped inertial platform for a marine scalar gravity system was the developed.Methods for attenuating horizontal acceleration and reducing off-levelling error by a satisfactory gyro-levelling loop,which are fundamental to the internally damped inertial platform,were designed and implemented.In addition,phase delays are introduced by the levelling loop.The resulting off-levelling gravity errors were analyzed and modeled.A series of tests on a motion simulator were performed in laboratory for a variety of simulated sea conditions.We found that the motion of the platform is a function of the amplitude and period of the simulated ship motions and ranges between 10 and 40 arcseconds.In addition,the phase lag between platform motion and ship motion is not constant but ranges 180°-270°,depending on the period and amplitude of the motion.Then,the platform,on which a gravimeter was mounted,was installed on the R/V Shiyan 2 to conduct a gravity survey in the South China Sea.Despite rough sea conditions,it was shown that in short periods of 2-30 s,the off-levelling angle was less than 30 arcseconds,and the phase lagged the horizontal acceleration by 230°-260°.From a repeated survey line and intersecting survey points,the estimated errors of gravity measurements were between 1.3 and 1.7 mGal.The marine measurements results were compared with those of satellite altimetry data and show a mean value of 0.5 mGal in a standard deviation of 1.5 mGal.展开更多
With the development of medical level, specialized, refined and multidisciplinary collaborative therapy is the requirement and main development direction of neurosurgery. With the improvement of people’s medical awar...With the development of medical level, specialized, refined and multidisciplinary collaborative therapy is the requirement and main development direction of neurosurgery. With the improvement of people’s medical awareness, people cannot meet the simple surgical treatment, and there is a great demand for nursing treatment. At the same time, the demand for efficiency and convenience of medical nursing practice teaching continues to improve, and the multi-functional medical nursing training innovation platform has been paid more and more attention. The rapid development of material technology as well as digitalization has brought about a huge change, and we have created a multifunctional, spatially efficient and easy-to-transfer information platform for medical care training. A base box, placement drawer, platform board and display are used as the base module and the base module is filled with specific functional components. Lifting and lowering using motors and spiral base, moving using universal wheels. These devices together constitute the training platform. A survey of students and teachers was conducted through a questionnaire, and they all gave very good feedback that the multi-functional platform was very practical and useful. This platform effectively solves the drawbacks of the original training platform which is time-consuming, laborious and inconvenient, and is worthy of further promotion and research.展开更多
In the inflammatory microenvironment,there are numerous exosomes secreted by immune cells(Macrophages,neutrophils,dendritic cells),mesenchymal stem cells(MSCs)and platelets as intercellular communicators,which partici...In the inflammatory microenvironment,there are numerous exosomes secreted by immune cells(Macrophages,neutrophils,dendritic cells),mesenchymal stem cells(MSCs)and platelets as intercellular communicators,which participate in the regulation of inflammation by modulating gene expression and releasing anti-inflammatory factors.Due to their good biocompatibility,accurate targeting,low toxicity and immunogenicity,these exosomes are able to selectively deliver therapeutic drugs to the site of inflammation through interactions between their surface-antibody or modified ligand with cell surface receptors.Therefore,the role of exosome-based biomimetic delivery strategies in inflammatory diseases has attracted increasing attention.Here we review current knowledge and techniques for exosome identification,isolation,modification and drug loading.More importantly,we highlight progress in using exosomes to treat chronic inflammatory diseases such as rheumatoid arthritis(RA),osteoarthritis(OA),atherosclerosis(AS),and inflammatory bowel disease(IBD).Finally,we also discuss their potential and challenges as anti-inflammatory drug carriers.展开更多
As the sustainable exploitation of marine resources develops,dual-platform joint operation has caught increasing attention.Dual-platform joint operation requires smaller relative motion between the two sub-platforms,w...As the sustainable exploitation of marine resources develops,dual-platform joint operation has caught increasing attention.Dual-platform joint operation requires smaller relative motion between the two sub-platforms,which is normally difficult to be satisfied by the traditional mooring system.Therefore,a new hybrid mooring system is developed and studied in this article.To ensure safety during platform movements,both the number of anchor chains and the relative motion between the two sub-platforms are reduced in the new hybrid mooring system.By performing numerical simulations based on three-dimensional potential flow theory in AQWA and physical experiments,the performances of both the new hybrid and traditional mooring systems under two different wave conditions(i.e.,working wave and freak wave conditions) are systematically investigated.Regarding the new hybrid mooring system,the relative stability between the two sub-platforms of the new system is better,and the platforms can restore stability faster when affected by freak waves.展开更多
基金funded by the Key Technology Research and Development Program(Nos.2022YFB4201301,and 2022YFB4201304)the National Natural Science Foundation of China(Nos.52101333,52071058,51939002,and 52071301)+2 种基金the Zhejiang Provincial Natural Science Foundation of China(No.LQ21E090009)supported by the Natural Science Foundation of Liaoning Province(No.2022-KF-18-01)the special funds for Promoting High-Quality Development from the Department of Natural Resources of Guangdong Province(No.GDNRC[2020]016).
文摘Recently,semisubmersible floating offshore wind turbine technologies have received considerable attention.For the coupled simulation of semisubmersible floating offshore wind energy,the platform is usually considered a rigid model,which could affect the calculation accuracy of the dynamic responses.The dynamic responses of a TripleSpar floating offshore wind turbine equipped with a 10 MW offshore wind turbine are discussed herein.The simulation of a floating offshore wind turbine under regular waves,white noise waves,and combined wind-wave conditions is conducted.The effects of the tower and platform flexibility on the motion and force responses of the TripleSpar semisubmersible floating offshore wind turbine are investigated.The results show that the flexibility of the tower and platform can influence the dynamic responses of a TripleSpar semisubmersible floating offshore wind turbine.Considering the flexibility of the tower and platform,the tower and platform pitch motions markedly increased compared with the fully rigid model.Moreover,the force responses,particularly for tower base loads,are considerably influenced by the flexibility of the tower and platform.Thus,the flexibility of the tower and platform for the coupled simulation of floating offshore wind turbines must be appropriately examined.
基金supported by the National Natural Science Foundation of China (Grant No.32101475)Scarce and Quality Economic Forest Engineering Technology Research Center (Grant No.2022GCZX002)the Key Lab.of Biomass Energy and Material,Jiangsu Province (Grant No.JSBEM-S-202305).
文摘1 About the Special Issue Editor Qiaoguang Li is an associate professor and master’s supervisor in the Department of College of Chemistry and Chemical Engineering,Zhongkai University of Agriculture and Engineering.He received his PhD from Institute of Chemical Industry of Forestry Products,Chinese Academy of Forestry in 2018.He has been focusing his research on the chemical basis and application of natural resources.He has published nearly 30 international peer reviewed papers and applied for 10 patents.
基金the National Natural Science Foundation of China(No.U20A20328).
文摘In this paper,the multi-body coupled dynamic characteristics of a semisubmersible platform and an HYSY 229 barge were investigated.First,coupled hydrodynamic analysis of the HYSY 229 barge and the semisubmersible platform was performed.Relevant hydrodynamic parameters were obtained using the retardation function method of three-dimensional frequency-domain potential flow theory.The results of the hydrodynamic analysis were highly consistent with the test findings,verifying the accuracy of the multifloating hydrodynamic coupling analysis,and key hydrodynamic parameters were solved for different water depths and the coupling effect.According to the obtained results,the hydrodynamic influence was the largest in shallow waters when the coupling effect was considered.Furthermore,the coupled motion equation combined with viscous damping,fender system,and mooring system was established,and the hydrodynamics,floating body motion,and dynamic response of the fender system were analyzed.Motion analysis revealed good agreement among the surge,sway,and yaw motions of the two floating bodies.However,when the wave period reached 10 s,the motion of the two floating bodies showed severe shock,and a relative motion was also observed.Therefore,excessive constraints should be added between the two floating bodies during construction to ensure construction safety.The numerical analysis and model test results of the semisubmersible platform and HYSY 229 barge at a water depth of 42 m and sea conditions of 0°,45°,and 90° were in good agreement,and the error was less than 5%.The maximum movement of the HYSY 229 barge reached 2.61 m in the sway direction,whereas that of the semisubmersible platform was 2.11 m.During construction,excessive constraints should be added between the two floating bodies to limit their relative movement and ensure construction safety.
基金This paper is a phased achievement of the key project of the Chongqing Municipal Education Commission entitled“Research on Establishment of Regional Legal Framework for Rural Revitalization”(Project No.23SKJD033)the university-level project of Southwest University of Political Science&Law entitled“A Comparative Study on Legislation for Agricultural and Rural Modernization”(Project No.DFLF2020Y12).
文摘In the era of the Internet,various network platforms have evolved into new hubs for information dissemination.Currently,China has established a platform-centered content regulation framework,wherein platforms proactively enforce content regulations in accordance with legal censorship obligations.Additionally,platform policies and user agreements augment their authority in content regulation.The platforms can achieve cost-effective and highly efficient content regulation by leveraging their strategic advantages enabled by their own technical capabilities and extensive coverage.The platform self-regulation model,however,still faces challenges.First,accurately evaluating content remains a formidable task;second,ensuring effective platform publicity through self-regulation poses difficulties;third,users may potentially face disadvantages due to the platform’s right of self-regulation;and fourth,digital copyright owners face challenges when defending digital copyright disputes under the safe harbor rule.Therefore,it is imperative to establish,review,and revise the legal framework for content regulation of network platforms in order to enhance the efficiency of their governance systems.The formulation of the legal framework for content regulation of network platforms may encompass the following aspects:rationalizing obligations pertaining to platform content regulations,enhancing supervision over platform self-regulation,and establishing a dual-track responsibility system for digital copyright content regulation.This will ensure a harmonious balance among public interests,users’personal rights and interests,and commercial benefits through regulating the content on network platforms.
基金This study is a phased achievement of the“Research on Innovative Communication of Romance of the Three Kingdoms under Audio Empowerment”project(No.23ZGL16)funded by Zhuge Liang Research Center,a key research base of social sciences in Sichuan Province.
文摘Visual media have dominated sensory communications for decades,and the resulting“visual hegemony”leads to the call for the“auditory return”in order to achieve a holistic balance in cultural acceptance.Romance of the Three Kingdoms,a classic literary work in China,has received significant attention and promotion from leading audio platforms.However,the commercialization of digital audio publishing faces unprecedented challenges due to the mismatch between the dissemination of long-form content on digital audio platforms and the current trend of short and fast information reception.Drawing on the Business Model Canvas Theory and taking Romance of the Three Kingdoms as the main focus of analysis,this paper argues that the construction of a business model for the audio publishing of classical books should start from three aspects:the user evaluation of digital audio platforms,the establishment of value propositions based on the“creative transformation and innovative development”principle,and the improvement of the audio publishing infrastructure to ensure the healthy operation and development of the digital audio platforms and consequently improve their current state of development and expand the boundaries of cultural heritage.
文摘The research aims to explore the transition from monolithic Digital Experience Platforms (DXPs) to Microservices-based DXPs, addressing scalability challenges. The study systematically decomposes monolithic structures into Microservices, emphasizing business capability and subdomain decomposition. Concrete insights, challenges, and solutions encountered during this transformation process are presented. The research contributes valuable insights into the challenges and benefits of adopting Microservices in DXPs. Results highlight the importance of architectural patterns and strategic scaling dimensions for improved performance and scalability. The case study on Backbase’s Engagement Banking Platform showcases successful implementation, providing flexibility, integration, and efficient development in the evolving DXP landscape.
文摘Objective:To explore the application effect of the blended education strategy based on the Learning Pass platform in the phase III cardiac rehabilitation of patients with coronary artery disease.Methods:90 patients diagnosed with coronary artery disease in the Department of Cardiology of our hospital from January 2019 to January 2021 were selected and divided into the control group and the experimental group according to the method of randomized numerical table,with 45 cases in each group.Both the experimental group and the control group received pre-discharge cardiac rehabilitation education by conventional means.The control group received education and supervision information via WeChat after discharge,while the experimental group joined the Learning Pass platform to receive online and offline hybrid education and supervision,with online as the mainstay and offline as a supplement.The disease cognitive level,self-management skills,quality of life,medication adherence,and emotional status of the two groups were compared.Results:The disease cognitive levels in the experimental group were significantly higher than those of the control group(P<0.05);the scores of the experimental group in terms of quality of life,self-management skills,and medication adherence were significantly higher than those of the control group(P<0.05);and the scores of anxiety and depression in the experimental group were significantly lower than those of the control group(P<0.05).Conclusion:The blended education strategy based on the Learning Pass platform has a significant application effect in phase III cardiac rehabilitation of patients with coronary artery disease.It can improve patients’disease cognitive level,self-management skills,and quality of life,and provide a basis for improving patients’prognosis.
基金supported by the National Natural Science Foundation of China(31871653 to K.L.,31830067 to J.L.)the Talent Project of Chongqing Natural Science Foundation(cstc2021ycjhbgzxm0033 to K.L.)Germplasm Creation Special Program of Southwest University.
文摘Rapeseed(Brassica napus)is an oil crop grown worldwide,making it a key plant species in molecular breeding research.However,the complexity of its polyploid genome increases sequencing costs and reduces sequencing accuracy.Target capture coupled with high-throughput sequencing is an efficient approach for detecting genetic variation at genomic regions or loci of interest.In this study,588 resequenced accessions of rapeseed were used to develop a target capture sequencing SNP genotyping platform named BnaPan50T.The platform comprised 54,765,with 54,058 resequenced markers from the pan-genome,and 855 variant trait-associated markers for 12 agronomic traits.The capture quality of BnaPan50T was demonstrated well in 12 typical accessions.Compared with a conventional genotyping array,BnaPan50T has a high SNP density and a high proportion of SNPs in unique physical positions and in annotated functional genes,promising wide application.Target capture sequencing and wholegenome resequencing in 90 doubled-haploid lines yielded 60%specificity,78%uniformity within tenfold coverage range,and 93%genotyping accuracy for the platform.BnaPan50T was used to construct a genetic map for quantitative trait loci(QTL)mapping,identify 21 unique QTL,and predict several candidate genes for yield-related traits in multiple environments.A set of 132 core SNP loci was selected from BnaPan50T to construct DNA fingerprints and germplasm identification resources.This study provides genomics resources to support target capture sequencing,genetic analysis and genomic breeding of rapeseed.
基金The authors are thankful to the Deanship of Scientific Research at Najran University for funding this work under the Research Collaboration Funding program grant coder NU/RC/SERC/11/5.
文摘Thalassemia syndrome is a genetic blood disorder induced by the reduction of normal hemoglobin production,resulting in a drop in the size of red blood cells.In severe forms,it can lead to death.This genetic disorder has posed a major burden on public health wherein patients with severe thalassemia need periodic therapy of iron chelation and blood transfusion for survival.Therefore,controlling thalassemia is extremely important and is made by promoting screening to the general population,particularly among thalassemia carriers.Today Twitter is one of the most influential social media platforms for sharing opinions and discussing different topics like people’s health conditions and major public health affairs.Exploring individuals’sentiments in these tweets helps the research centers to formulate strategies to promote thalassemia screening to the public.An effective Lexiconbased approach has been introduced in this study by highlighting a classifier called valence aware dictionary for sentiment reasoning(VADER).In this study applied twitter intelligence tool(TWINT),Natural Language Toolkit(NLTK),and VADER constitute the three main tools.VADER represents a gold-standard sentiment lexicon,which is basically tailored to attitudes that are communicated by using social media.The contribution of this study is to introduce an effective Lexicon-based approach by highlighting a classifier calledVADERto analyze the sentiment of the general population,particularly among thalassemia carriers on the social media platform Twitter.In this study,the results showed that the proposed approach achieved 0.829,0.816,and 0.818 regarding precision,recall,together with F-score,respectively.The tweets were crawled using the search keywords,“thalassemia screening,”thalassemia test,“and thalassemia diagnosis”.Finally,results showed that India and Pakistan ranked the highest in mentions in tweets by the public’s conversations on thalassemia screening with 181 and 164 tweets,respectively.
基金supported by China State Railway Group Co.,Ltd.Science and Technology Research and Development Plan(K2021G025).
文摘The high-speed railway construction involves multiple professional fields,such as railway design,construction,and supervision.This paper architects the"BIM+"project refined management platform,designs the platform's logical architecture,physical architecture,and solves several key technology difficulties.This"BIM+"platform has been applied on the Jingxiong Bridge Project and achieved all-round,whole-process and multi-management of high-speed railway engineering construction.It significantly improves the level of construction management,and plays a role in promoting the development of high-speed railway construction informatization.
基金This work is supported by the National Key Research and Development Plan program of the Ministry of Science and Technology of China(No.2016YFB0201100)Additionally,this work is supported by the National Laboratory for Marine Science and Technology(Qingdao)Major Project of the Aoshan Science and Technology Innovation Program(No.2018ASKJ01-04)the Open Fundation of Key Laboratory of Marine Science and Numerical Simulation,Ministry of Natural Resources(No.2021-YB-02).
文摘In this paper,a typical experiment is carried out based on a high-resolution air-sea coupled model,namely,the coupled ocean-atmosphere-wave-sediment transport(COAWST)model,on both heterogeneous many-core(SW)and homogenous multicore(Intel)supercomputing platforms.We construct a hindcast of Typhoon Lekima on both the SW and Intel platforms,compare the simulation results between these two platforms and compare the key elements of the atmospheric and ocean modules to reanalysis data.The comparative experiment in this typhoon case indicates that the domestic many-core computing platform and general cluster yield almost no differences in the simulated typhoon path and intensity,and the differences in surface pressure(PSFC)in the WRF model and sea surface temperature(SST)in the short-range forecast are very small,whereas a major difference can be identified at high latitudes after the first 10 days.Further heat budget analysis verifies that the differences in SST after 10 days are mainly caused by shortwave radiation variations,as influenced by subsequently generated typhoons in the system.These typhoons generated in the hindcast after the first 10 days attain obviously different trajectories between the two platforms.
基金funded by the National Natural Science Foundation of China(Grant Nos.41872007,41972026)the Sichuan Science and Technology Program(2018JY0491)。
文摘A study of the morphological and microstructural characteristics of helcionelloids from the Nanjiang area(north Sichuan,China)at the northern Yangtze Platform was undertaken,in order to understand their phylogenetic position.Helcionelloids fossils from the Kuanchuanpu Formation of the Changtanhe–Maolinzi section include 7 genera and 11 species.There are distinct differences in the degree of shell bending,the apical morphology and apex position,the outline of the aperture and the height of the shell,all of which constitute important identification features.Although helcionelloid apices exhibit varying degrees of rotation towards the aperture,they do not show any signs of evident distortion.A pair of basally-symmetrical muscle scars are discovered on the shells of helcionelloids(such as Bemella simplex),showing a distinct difference when compared with those of the stem-group gastropod(e.g.,Pelagiella).The prismatic shell layer of helcionelloids has been observed,which are common components in Cambrian molluscs,but differ significantly from the dense layer microstructure found in contemporary molluscs.The microstructures,muscle scars and morphological characteristics demonstrate that helcionelloids represent a stem-group of molluscs.
基金financially supported by the National Key Science and Technology Planning Project(2016ZX05007–004 and 2017ZX05001001–002)。
文摘An analysis of Thalassinoides ichnofabrics in the Cambrian Stage 4 Longwangmiao Formation from six sections near Chonqing in the Middle and Upper Yangtze Block of South China was conducted to promote the understanding of the paleoenvironment of this period.Thalassinoides ichnofabrics are divided into three types according to their morphology,bioturbation index,abundance and related parameters:banded,mottled and grid.The completeness of the ichnofabrics gradually increases from banded to grid,the scale of the burrows expands,and the structure transitions from twodimensional to three-dimensional.Malacostracans,phyllocarids and enteropneusts are the most likely burrowers.The findings reveal that frequent changes in paleoenvironmental conditions are the dominant factors for generating the various Thalassinoides ichnofabrics.The changes in depositional rate,substrate properties and nutrient levels affect the behavior and building patterns of the burrowers,thus leading to the diversity of Thalassinoides ichnofabrics.In the lower Longwangmiao Formation beds,many incomplete Thalassinoides burrow systems were built in the substrates with terrigenous detrital minerals,revealing significant environmental pressure on the burrowers.Later,the Thalassinoides burrows went into complete three-dimensional boxworks.At the end of the stage,bioturbation almost disappeared,which indicates that burrowers were finding it difficult to survive in the harsh environment.
文摘Offshore steel structures are a common investment in oil and gas industries operating in shallow to medium depth seas.These structures have become increasingly popular since the mid-19th century,with a typical design life of 30-50 years.Despite their popularity,the structural integrity of existing offshore structures remains a controversial topic.Environmental loads and material degradation have been identified as significant factors that can compromise the structural integrity of offshore structures.To address this issue,this study aims to investigate the reserved strength capacity of a selected offshore structure located in the Malaysian Seas.The study will explore the effect of oceanographic data,variations in vertical load,and corrosion on the structure’s main members.To determine the impact of each variable on the reserved strength ratio(RSR)of the structure,several pushover analyses were conducted with different variables.Previous literature has shown little or no relationship between seawater wave height,gravity loads,and corrosion allowance on submerged steel members and the RSR of offshore structures.However,this study aims tofill this gap in knowledge by examining these variables’effects on the RSR of offshore structures.The study’sfindings indicate that even a slight increase in wave height can significantly impact the structure’s RSR due to the increase in lateral loading,potentially leading to severe damage to structural components and the foundation model.Additionally,gravity loads had an adverse effect on the RSR of the structure when more than double the vertical load was added.Corrosion allowance was also found to impact the RSR,particularly when assuming significant wall thickness corrosion in primary members.Overall,thefindings of this study have important implications for the design and maintenance of offshore structures.The results suggest that engineers and operators should pay close attention to the potential impacts of environmental loads,such as wave height and gravity loads,and material degradation,such as corrosion allowance,on the structural integrity of offshore structures.This information can be used to optimize the design and maintenance of offshore structures,leading to safer and more efficient operations.
基金the Strategic Priority Research Program of CAS(Grant No.XDC07020200)the National Key R&D Program of China(Grants No.2018YFA0306600)+5 种基金the National Natural Science Foundation of China(Grant Nos.11974330 and 92165206)the Chinese Academy of Sciences(Grant No.QYZDY-SSW-SLH004)the Innovation Program for Quantum Science and Technology(Grant Nos.2021ZD0302200 and 2021ZD0301603)the Anhui Initiative in Quantum Information Technologies(Grant No.AHY050000)the Hefei Comprehensive National Science Centerthe Fundamental Research Funds for the Central Universities。
文摘We report a design and implementation of a field-programmable-gate-arrays(FPGA)based hardware platform,which is used to realize control and signal readout of trapped-ion-based multi-level quantum systems.This platform integrates a four-channel 2.8 Gsps@14 bits arbitrary waveform generator,a 16-channel 1 Gsps@14 bits direct-digital-synthesisbased radio-frequency generator,a 16-channel 8 ns resolution pulse generator,a 10-channel 16 bits digital-to-analogconverter module,and a 2-channel proportion integration differentiation controller.The hardware platform can be applied in the trapped-ion-based multi-level quantum systems,enabling quantum control of multi-level quantum system and highdimensional quantum simulation.The platform is scalable and more channels for control and signal readout can be implemented by utilizing more parallel duplications of the hardware.The hardware platform also has a bright future to be applied in scaled trapped-ion-based quantum systems.
基金Supported by the Science and Technology Project of PetroChina (2021DJ0605)。
文摘Based on the seismic, logging, drilling and other data, the distribution, structural types and mound-shoal hydrocarbon accumulation characteristics of platform margins of the Sinian Dengying Formation in the Deyang-Anyue Rift and its periphery were analyzed. Four types of platform margins are developed in the Dengying Formation, i.e., single-stage fault-controlled platform margin, multi-stage fault-controlled platform margin, gentle slope platform margin, and overlapping platform margin. In the Gaoshiti West-Weiyuan East area, single-stage fault controlled platform margins are developed in the Deng 2 Member, which trend in nearly NEE direction and are shielded by faults and mudstones, forming fault-controlled–lithologic traps. In the Lezhi-Penglai area, independent and multi-stage fault controlled platform margins are developed in the Deng 2 Member, which trend in NE direction and are controlled by synsedimentary faults;the mound-shoal complexes are aggraded and built on the hanging walls of the faults, and they are shielded by tight intertidal belts and the Lower Cambrian source rocks in multiple directions, forming fault-controlled–lithologic and other composite traps. In the Weiyuan-Ziyang area, gentle slope platform margins are developed in the Deng 2 Member, which trend in NW direction;the mound-shoal complexes are mostly thin interbeds as continuous bands and shielded by tight intertidal belts in the updip direction, forming lithologic traps. In the Gaoshiti-Moxi-Yanting area, overlapping platform margins are developed in the Deng 2 and Deng 4 members;the mound-shoal complexes are aggraded and overlaid to create platform margin buildup with a huge thickness and sealed by tight intertidal belts and the Lower Cambrian mudstones in the updip direction, forming large-scale lithologic traps on the north slope of the Central Sichuan Paleouplift. To summarize, the mound-shoal complexes on the platform margins in the Dengying Formation in the Penglai-Zhongjiang area, Moxi North-Yanting area and Weiyuan-Ziyang area are large in scale, with estimated resources of 1.58×1012 m3, and they will be the key targets for the future exploration of the Dengying Formation in the Sichuan Basin.
基金Supported by the National Natural Science Foundation of China(Nos.42192535,41876136)the Guangdong Special Support Program(No.2019BT02H594)supported by the Key Special Projects of the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(for Introduced Talents Team)(Nos.GML2021GD0810,GML2019ZD0602)。
文摘To dampen periodic off-levelling motions within an inertial platform while undergoing horizontal accelerations of the same period and to achieve a levelling accuracy of a few tens of arcseconds with that system,an internally damped inertial platform for a marine scalar gravity system was the developed.Methods for attenuating horizontal acceleration and reducing off-levelling error by a satisfactory gyro-levelling loop,which are fundamental to the internally damped inertial platform,were designed and implemented.In addition,phase delays are introduced by the levelling loop.The resulting off-levelling gravity errors were analyzed and modeled.A series of tests on a motion simulator were performed in laboratory for a variety of simulated sea conditions.We found that the motion of the platform is a function of the amplitude and period of the simulated ship motions and ranges between 10 and 40 arcseconds.In addition,the phase lag between platform motion and ship motion is not constant but ranges 180°-270°,depending on the period and amplitude of the motion.Then,the platform,on which a gravimeter was mounted,was installed on the R/V Shiyan 2 to conduct a gravity survey in the South China Sea.Despite rough sea conditions,it was shown that in short periods of 2-30 s,the off-levelling angle was less than 30 arcseconds,and the phase lagged the horizontal acceleration by 230°-260°.From a repeated survey line and intersecting survey points,the estimated errors of gravity measurements were between 1.3 and 1.7 mGal.The marine measurements results were compared with those of satellite altimetry data and show a mean value of 0.5 mGal in a standard deviation of 1.5 mGal.
文摘With the development of medical level, specialized, refined and multidisciplinary collaborative therapy is the requirement and main development direction of neurosurgery. With the improvement of people’s medical awareness, people cannot meet the simple surgical treatment, and there is a great demand for nursing treatment. At the same time, the demand for efficiency and convenience of medical nursing practice teaching continues to improve, and the multi-functional medical nursing training innovation platform has been paid more and more attention. The rapid development of material technology as well as digitalization has brought about a huge change, and we have created a multifunctional, spatially efficient and easy-to-transfer information platform for medical care training. A base box, placement drawer, platform board and display are used as the base module and the base module is filled with specific functional components. Lifting and lowering using motors and spiral base, moving using universal wheels. These devices together constitute the training platform. A survey of students and teachers was conducted through a questionnaire, and they all gave very good feedback that the multi-functional platform was very practical and useful. This platform effectively solves the drawbacks of the original training platform which is time-consuming, laborious and inconvenient, and is worthy of further promotion and research.
基金by the National Natural Science Foundation of China[grant numbers 82170459,2021]Sichuan Science and Technology Program[grant numbers 2022YFH0007,2022]+2 种基金Sichuan Science and Technology Program[grant numbers 23NSFSC1345,2022]the Key Project of Application and Basic Research of Southwest Medical University[grant numbers 2021ZKZD016,2021]the Special Support Project for Young Talents of Southwest Medical University[grant numbers 2020-2022].
文摘In the inflammatory microenvironment,there are numerous exosomes secreted by immune cells(Macrophages,neutrophils,dendritic cells),mesenchymal stem cells(MSCs)and platelets as intercellular communicators,which participate in the regulation of inflammation by modulating gene expression and releasing anti-inflammatory factors.Due to their good biocompatibility,accurate targeting,low toxicity and immunogenicity,these exosomes are able to selectively deliver therapeutic drugs to the site of inflammation through interactions between their surface-antibody or modified ligand with cell surface receptors.Therefore,the role of exosome-based biomimetic delivery strategies in inflammatory diseases has attracted increasing attention.Here we review current knowledge and techniques for exosome identification,isolation,modification and drug loading.More importantly,we highlight progress in using exosomes to treat chronic inflammatory diseases such as rheumatoid arthritis(RA),osteoarthritis(OA),atherosclerosis(AS),and inflammatory bowel disease(IBD).Finally,we also discuss their potential and challenges as anti-inflammatory drug carriers.
基金financially supported by the National Natural Science Foundation of China (Grant No. 52071161)。
文摘As the sustainable exploitation of marine resources develops,dual-platform joint operation has caught increasing attention.Dual-platform joint operation requires smaller relative motion between the two sub-platforms,which is normally difficult to be satisfied by the traditional mooring system.Therefore,a new hybrid mooring system is developed and studied in this article.To ensure safety during platform movements,both the number of anchor chains and the relative motion between the two sub-platforms are reduced in the new hybrid mooring system.By performing numerical simulations based on three-dimensional potential flow theory in AQWA and physical experiments,the performances of both the new hybrid and traditional mooring systems under two different wave conditions(i.e.,working wave and freak wave conditions) are systematically investigated.Regarding the new hybrid mooring system,the relative stability between the two sub-platforms of the new system is better,and the platforms can restore stability faster when affected by freak waves.
