Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound ...Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS qualitative method was developed for the analysis of related substances in this preparation with a quick and easy extraction procedure. Besides the active pharmaceutical ingredients, two compounds named ketoconazole impurity B′ optical isomer and ketoconazole impurity E were identified. Furthermore, a new HPLC method for qualitative and quantitative assessment on related substances and degradation products, which were found in the stability test, was established and validated. The single standard to determine multi-components method was applied in the quantitative analysis, which was an effective way for reducing cost and improving accuracy. This study can provide a creative idea for routine analysis of quality control of the Compound Ketoconazole and Clobetasol Propionate Cream.展开更多
In this study, Siwi roasted date seeds (pits) as a by-product of the date factories were used in powder form for ice cream fortification to produce a new product with coffee</span></span><span><sp...In this study, Siwi roasted date seeds (pits) as a by-product of the date factories were used in powder form for ice cream fortification to produce a new product with coffee</span></span><span><span><span style="font-family:"">-</span></span></span><span><span><span style="font-family:"">like flavor. Also</span></span></span><span><span><span style="font-family:"">,</span></span></span><span><span><span style="font-family:""> this product possesses functional, nutritional and health benefits as it contains, minerals, phenolic compounds and <span>possess antioxidant activity. Six ice cream mixes were prepared</span></span></span></span><span><span><span style="font-family:"">:</span></span></span><span><span><span style="font-family:""> plain ice</span></span></span><span><span><span style="font-family:""> cream <span>without additives (control),<b> </b>five<b> </b>ice cream treatments supplemented with</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:"">powder <span>of the Nescafé (3%), Coffee (3%) and Roasted Date Seeds Powder (RDSP</span>) with ratio of 3</span></span></span><span><span><span style="font-family:"">%</span></span></span><span><span><span style="font-family:"">, 4</span></span></span><span><span><span style="font-family:"">%</span></span></span><span><span><span style="font-family:""> and 5%, respectively. The results showed that increasing the added percentage of Roasted Date Seeds Powder (RDSP) to the ice cream mixes leads to an increase in the total solids, fibers, total nitrogen and ash content of the final product. It also increases viscosity, specific gravity, weight <span>per gallon and increase the depression of</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:"">freezing point of the mixes. The</span></span></span><span><span><span style="font-family:""> overrun and melting resis</span></span></span><span><span><span style="font-family:"">tance <span>of the final ice cream also increased compared with </span></span></span></span><span><span><span style="font-family:"">the </span></span></span><span><span><span style="font-family:"">control. The sensory</span></span></span><span><span><span style="font-family:""> <span>evaluation was improved by adding RDSP comparing to control. So in this</span> <span>study</span></span></span></span><span><span><span style="font-family:"">,</span></span></span><span><span><span style="font-family:""> it is recommended </span></span></span><span><span><span style="font-family:"">to </span></span></span><span><span><span style="font-family:"">us</span></span></span><span><span><span style="font-family:"">e</span></span></span><span><span><span style="font-family:""> RDSP as </span></span></span><span><span><span style="font-family:"">the </span></span></span><span><span><span style="font-family:"">source of minerals and </span></span></span><span><span><span style="font-family:"">health-promoting for ice cream making</span></span></span><span><span><span style="font-family:"">,</span></span></span><span><span><span style="font-family:""> as it contain</span></span></span><span><span><span style="font-family:"">s</span></span></span><span><span><span style="font-family:""> bioactive</span></span></span><span><span><span style="font-family:""> compounds and also gives the ice cream desirable color and coffee-like flavor, but free of caffeine.展开更多
Objective:To investigate and analyze the anesthetic effect of compound artevacaine hydrochloride in patients undergoing oral implantation.Methods:In this study,60 patients receiving oral implant surgery in our hospita...Objective:To investigate and analyze the anesthetic effect of compound artevacaine hydrochloride in patients undergoing oral implantation.Methods:In this study,60 patients receiving oral implant surgery in our hospital were selected as the research subjects,and the operation time was from July 2019 to March 2021.Patients were randomly selected and divided into groups for the study.30 patients receiving lidocaine hydrochloride anesthesia were used as the control group,and 30 patients receiving compound artevacaine hydrochloride anesthesia were used as the research group.The anesthetic effect and safety of the two groups were compared and analyzed.Results:The anesthetic effect of the study group was significantly better than that of the control group(P<0.05).The blood pressure and heart rate in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in blood pressure and heart rate between the two groups before anesthesia(P>0.05).There was no significant difference in the incidence of ADR between the two groups(P>0.05).Conclusions:For patients undergoing oral implant surgery,choosing compound artevacaine hydrochloride as anesthetic drug has obvious anesthetic effect and can stabilize patients'life indexes.The anesthetic effect is obvious,and there is no obvious adverse reaction,and the clinical value is obvious.展开更多
文摘Related substances in pharmaceutical formulations are associated with their safety, efficacy and stability. However, there is no overall study already published on the assessment of related substances in the Compound Ketoconazole and Clobetasol Propionate Cream. In this work, a reliable HPLC-TOF-MS qualitative method was developed for the analysis of related substances in this preparation with a quick and easy extraction procedure. Besides the active pharmaceutical ingredients, two compounds named ketoconazole impurity B′ optical isomer and ketoconazole impurity E were identified. Furthermore, a new HPLC method for qualitative and quantitative assessment on related substances and degradation products, which were found in the stability test, was established and validated. The single standard to determine multi-components method was applied in the quantitative analysis, which was an effective way for reducing cost and improving accuracy. This study can provide a creative idea for routine analysis of quality control of the Compound Ketoconazole and Clobetasol Propionate Cream.
文摘In this study, Siwi roasted date seeds (pits) as a by-product of the date factories were used in powder form for ice cream fortification to produce a new product with coffee</span></span><span><span><span style="font-family:"">-</span></span></span><span><span><span style="font-family:"">like flavor. Also</span></span></span><span><span><span style="font-family:"">,</span></span></span><span><span><span style="font-family:""> this product possesses functional, nutritional and health benefits as it contains, minerals, phenolic compounds and <span>possess antioxidant activity. Six ice cream mixes were prepared</span></span></span></span><span><span><span style="font-family:"">:</span></span></span><span><span><span style="font-family:""> plain ice</span></span></span><span><span><span style="font-family:""> cream <span>without additives (control),<b> </b>five<b> </b>ice cream treatments supplemented with</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:"">powder <span>of the Nescafé (3%), Coffee (3%) and Roasted Date Seeds Powder (RDSP</span>) with ratio of 3</span></span></span><span><span><span style="font-family:"">%</span></span></span><span><span><span style="font-family:"">, 4</span></span></span><span><span><span style="font-family:"">%</span></span></span><span><span><span style="font-family:""> and 5%, respectively. The results showed that increasing the added percentage of Roasted Date Seeds Powder (RDSP) to the ice cream mixes leads to an increase in the total solids, fibers, total nitrogen and ash content of the final product. It also increases viscosity, specific gravity, weight <span>per gallon and increase the depression of</span></span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:"">freezing point of the mixes. The</span></span></span><span><span><span style="font-family:""> overrun and melting resis</span></span></span><span><span><span style="font-family:"">tance <span>of the final ice cream also increased compared with </span></span></span></span><span><span><span style="font-family:"">the </span></span></span><span><span><span style="font-family:"">control. The sensory</span></span></span><span><span><span style="font-family:""> <span>evaluation was improved by adding RDSP comparing to control. So in this</span> <span>study</span></span></span></span><span><span><span style="font-family:"">,</span></span></span><span><span><span style="font-family:""> it is recommended </span></span></span><span><span><span style="font-family:"">to </span></span></span><span><span><span style="font-family:"">us</span></span></span><span><span><span style="font-family:"">e</span></span></span><span><span><span style="font-family:""> RDSP as </span></span></span><span><span><span style="font-family:"">the </span></span></span><span><span><span style="font-family:"">source of minerals and </span></span></span><span><span><span style="font-family:"">health-promoting for ice cream making</span></span></span><span><span><span style="font-family:"">,</span></span></span><span><span><span style="font-family:""> as it contain</span></span></span><span><span><span style="font-family:"">s</span></span></span><span><span><span style="font-family:""> bioactive</span></span></span><span><span><span style="font-family:""> compounds and also gives the ice cream desirable color and coffee-like flavor, but free of caffeine.
文摘Objective:To investigate and analyze the anesthetic effect of compound artevacaine hydrochloride in patients undergoing oral implantation.Methods:In this study,60 patients receiving oral implant surgery in our hospital were selected as the research subjects,and the operation time was from July 2019 to March 2021.Patients were randomly selected and divided into groups for the study.30 patients receiving lidocaine hydrochloride anesthesia were used as the control group,and 30 patients receiving compound artevacaine hydrochloride anesthesia were used as the research group.The anesthetic effect and safety of the two groups were compared and analyzed.Results:The anesthetic effect of the study group was significantly better than that of the control group(P<0.05).The blood pressure and heart rate in the study group were significantly lower than those in the control group(P<0.05).There was no significant difference in blood pressure and heart rate between the two groups before anesthesia(P>0.05).There was no significant difference in the incidence of ADR between the two groups(P>0.05).Conclusions:For patients undergoing oral implant surgery,choosing compound artevacaine hydrochloride as anesthetic drug has obvious anesthetic effect and can stabilize patients'life indexes.The anesthetic effect is obvious,and there is no obvious adverse reaction,and the clinical value is obvious.
