The system composition, the operational principle of terminal correction mortar projectiles (TCMP) and the concept planning design of TCMP are researched in this paper. An overall design and aerodynamic configuration ...The system composition, the operational principle of terminal correction mortar projectiles (TCMP) and the concept planning design of TCMP are researched in this paper. An overall design and aerodynamic configuration layout for TCMP are made in this paper, and its aerodynamic coefficients are calculated by using computational fluid dynamics (CFD) software. Test results of TCMP simulated ballistic projectiles indicate the designed TCMP can satisfy the interior ballistic demand and has a fine flight stability. The drag coefficients identified from the radar velocity-time data are in accord with the CFD computed results. According to the exposure frequency of the ground laser designator, a four-quadrant impulse correction scheme and a high exposure frequency impulse correction scheme are brought. The latter can calculate the target azimuth angle by counting the times of the facula passing through one quadrant. Simulation results also show that the guidance precision of the velocity pursuit is higher than that of the body pursuit, and the detector axis is less circuitous. Researches on the typical trajectory indicate that the terminal impulse correction can improve the hit precision of TCMP remarkably.展开更多
BACKGROUND The prognostic value of preoperative fluorine-18-fluorodeoxyglucose positronemission tomography(18 F-FDG PET)scan for determining overall survival(OS)in breast cancer(BC)patients is controversial.AIM To eva...BACKGROUND The prognostic value of preoperative fluorine-18-fluorodeoxyglucose positronemission tomography(18 F-FDG PET)scan for determining overall survival(OS)in breast cancer(BC)patients is controversial.AIM To evaluate the OS predictive value of preoperative PET positivity after 15 years.METHODS We performed a retrospective search of the Universitair Ziekenhuis Brussel patient database for nonmetastatic patients who underwent preoperative PET between 2002-2008.PET positivity was determined by anatomical region of interest(AROI)findings for breast and axillary,sternal,and distant sites.The prognostic role of PET was examined as a qualitative binary factor(positive vs negative status)and as a continuous variable[maximum standard uptake value(SUVmax)]in multivariate survival analyses using Cox proportional hazards models.Among the 104 identified patients who received PET,36 were further analyzed for the SUVmax in the AROI.RESULTS Poor OS within the 15-year study period was predicted by PET-positive status for axillary(P=0.033),sternal(P=0.033),and combined PET-axillary/sternal(P=0.008)nodes.Poor disease-free survival was associated with PET-positive axillary status(P=0.040)and combined axillary/sternal status(P=0.023).Cox models confirmed the long-term prognostic value of combined PETaxillary/sternal status[hazard ratio(HR):3.08,95%confidence interval:1.42-6.69].SUVmax of ipsilateral breast and axilla as continuous covariates were significant predictors of long-term OS with HRs of 1.25(P=0.048)and 1.54(P=0.029),corresponding to relative increase in the risk of death of 25%and 54%per SUVmax unit,respectively.In addition,the ratio of the ipsilateral axillary SUVmax over the contralateral axillary SUVmax was the most significant OS predictor(P=0.027),with 1.94 HR,indicating a two-fold relative increase of mortality risk.CONCLUSION Preoperative PET is valuable for prediction of long-term survival.Ipsilateral axillary SUVmax ratio over the uninvolved side represents a new prognostic finding that warrants further investigation.展开更多
Taizhou is an economically-developed port city on the golden coastline of China, characterized by typical coastal and combined green cores, mountains and waters, and special plants. This paper analyzed natural conditi...Taizhou is an economically-developed port city on the golden coastline of China, characterized by typical coastal and combined green cores, mountains and waters, and special plants. This paper analyzed natural conditions and city features of Taizhou, assessed current construction of local urban forests, and proposed pertinent construction concepts in view of diversifi ed needs of urban development on forest construction. On the basis of the city development, principles of urban forest layout were put forward, and the overall structure of "one core, one belt, two rings, three corridors, four groups, fi ve windows, and multiple bases" was given for the construction of urban forest in coastal landscape cities, in addition, the effect and feasibility of the layout were analyzed.展开更多
BACKGROUND Venoarterial extracorporeal membrane oxygenation(VA-ECMO)offers hemodynamic support for patients undergoing high-risk percutaneous coronary interventions(PCIs).However,long-term outcomes associated with VA-...BACKGROUND Venoarterial extracorporeal membrane oxygenation(VA-ECMO)offers hemodynamic support for patients undergoing high-risk percutaneous coronary interventions(PCIs).However,long-term outcomes associated with VA-ECMO have not previously been studied.AIM To explore long-term outcomes in high-risk cases undergoing PCI supported by VA-ECMO.METHODS In the present observational cohort study,61 patients who received VA-ECMOsupported high-risk PCI between April 2012 and January 2020 at the Sixth Medical Center of Chinese People’s Liberation Army General Hospital were enrolled.The endpoint characteristics such as all-cause mortality,repeated cardiovascular diseases,and cardiac death were examined.RESULTS Among 61 patients,three failed stent implantation due to chronic total occlusions with severely calcified lesions.One patient showed VA-ECMO intolerance because of high left ventricular afterload.PCI was successfully performed in 57 patients(93.4%).The in-hospital mortality was 23.0%,and the overall survival was 45.9%,with a median follow-up period of 38.6(8.6-62.1)mo.CONCLUSION VA-ECMO can be used as a support in patients undergoing high-risk PCI as it is associated with favorable long-term patient survival.展开更多
基金the Ministerial Level Advanced Research Foundation (40406030101)
文摘The system composition, the operational principle of terminal correction mortar projectiles (TCMP) and the concept planning design of TCMP are researched in this paper. An overall design and aerodynamic configuration layout for TCMP are made in this paper, and its aerodynamic coefficients are calculated by using computational fluid dynamics (CFD) software. Test results of TCMP simulated ballistic projectiles indicate the designed TCMP can satisfy the interior ballistic demand and has a fine flight stability. The drag coefficients identified from the radar velocity-time data are in accord with the CFD computed results. According to the exposure frequency of the ground laser designator, a four-quadrant impulse correction scheme and a high exposure frequency impulse correction scheme are brought. The latter can calculate the target azimuth angle by counting the times of the facula passing through one quadrant. Simulation results also show that the guidance precision of the velocity pursuit is higher than that of the body pursuit, and the detector axis is less circuitous. Researches on the typical trajectory indicate that the terminal impulse correction can improve the hit precision of TCMP remarkably.
文摘BACKGROUND The prognostic value of preoperative fluorine-18-fluorodeoxyglucose positronemission tomography(18 F-FDG PET)scan for determining overall survival(OS)in breast cancer(BC)patients is controversial.AIM To evaluate the OS predictive value of preoperative PET positivity after 15 years.METHODS We performed a retrospective search of the Universitair Ziekenhuis Brussel patient database for nonmetastatic patients who underwent preoperative PET between 2002-2008.PET positivity was determined by anatomical region of interest(AROI)findings for breast and axillary,sternal,and distant sites.The prognostic role of PET was examined as a qualitative binary factor(positive vs negative status)and as a continuous variable[maximum standard uptake value(SUVmax)]in multivariate survival analyses using Cox proportional hazards models.Among the 104 identified patients who received PET,36 were further analyzed for the SUVmax in the AROI.RESULTS Poor OS within the 15-year study period was predicted by PET-positive status for axillary(P=0.033),sternal(P=0.033),and combined PET-axillary/sternal(P=0.008)nodes.Poor disease-free survival was associated with PET-positive axillary status(P=0.040)and combined axillary/sternal status(P=0.023).Cox models confirmed the long-term prognostic value of combined PETaxillary/sternal status[hazard ratio(HR):3.08,95%confidence interval:1.42-6.69].SUVmax of ipsilateral breast and axilla as continuous covariates were significant predictors of long-term OS with HRs of 1.25(P=0.048)and 1.54(P=0.029),corresponding to relative increase in the risk of death of 25%and 54%per SUVmax unit,respectively.In addition,the ratio of the ipsilateral axillary SUVmax over the contralateral axillary SUVmax was the most significant OS predictor(P=0.027),with 1.94 HR,indicating a two-fold relative increase of mortality risk.CONCLUSION Preoperative PET is valuable for prediction of long-term survival.Ipsilateral axillary SUVmax ratio over the uninvolved side represents a new prognostic finding that warrants further investigation.
文摘Taizhou is an economically-developed port city on the golden coastline of China, characterized by typical coastal and combined green cores, mountains and waters, and special plants. This paper analyzed natural conditions and city features of Taizhou, assessed current construction of local urban forests, and proposed pertinent construction concepts in view of diversifi ed needs of urban development on forest construction. On the basis of the city development, principles of urban forest layout were put forward, and the overall structure of "one core, one belt, two rings, three corridors, four groups, fi ve windows, and multiple bases" was given for the construction of urban forest in coastal landscape cities, in addition, the effect and feasibility of the layout were analyzed.
文摘BACKGROUND Venoarterial extracorporeal membrane oxygenation(VA-ECMO)offers hemodynamic support for patients undergoing high-risk percutaneous coronary interventions(PCIs).However,long-term outcomes associated with VA-ECMO have not previously been studied.AIM To explore long-term outcomes in high-risk cases undergoing PCI supported by VA-ECMO.METHODS In the present observational cohort study,61 patients who received VA-ECMOsupported high-risk PCI between April 2012 and January 2020 at the Sixth Medical Center of Chinese People’s Liberation Army General Hospital were enrolled.The endpoint characteristics such as all-cause mortality,repeated cardiovascular diseases,and cardiac death were examined.RESULTS Among 61 patients,three failed stent implantation due to chronic total occlusions with severely calcified lesions.One patient showed VA-ECMO intolerance because of high left ventricular afterload.PCI was successfully performed in 57 patients(93.4%).The in-hospital mortality was 23.0%,and the overall survival was 45.9%,with a median follow-up period of 38.6(8.6-62.1)mo.CONCLUSION VA-ECMO can be used as a support in patients undergoing high-risk PCI as it is associated with favorable long-term patient survival.
