A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer＇s disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decocti...A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer＇s disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction （main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarinowii, radix polygalae, fructus alpiniae oxyphyllae, and radix glycyrrhizae preparata） and a piracetam suspension. Following treatment with traditional Chinese medicine or western medicine, β-amyloid expression decreased and neuronal morphology was normal in the rat hippocampal CA1 region, in addition to significantly shortened average latency in the Morris water navigation task. These findings suggested that compound prescription of Buyuan Congnao decoction, similar to the curative effects of piracetam, decreased hippocampal β-amyloid expression in a rat model of Alzheimer＇s disease, as well as improved learning and memory.展开更多
目的:观察聪脑通络法联合补中益气汤药浴对痉挛型脑瘫患儿的影响。方法:将84例痉挛型脑瘫患儿按随机数字表法分为对照组和观察组各42例。对照组予补中益气汤药浴,观察组在对照组基础予聪脑通络法针刺。4周为1个疗程,治疗3个疗程后比较...目的:观察聪脑通络法联合补中益气汤药浴对痉挛型脑瘫患儿的影响。方法:将84例痉挛型脑瘫患儿按随机数字表法分为对照组和观察组各42例。对照组予补中益气汤药浴,观察组在对照组基础予聪脑通络法针刺。4周为1个疗程,治疗3个疗程后比较两组患儿治疗前后粗大运动功能(gross motor function measure,GMFM)量表、精细运动功能(fine motor function measure,FMFM)量表、临床痉挛指数(clinical spasticity index,CSI)量表、Ashwonh肌张力评定量表评分及大脑前、中、后动脉的平均血流速度与临床疗效。结果:观察组总有效率为92.86%(39/42),高于对照组的76.19%(32/42)(P<0.05)。观察组治疗后GMFM、FMFM评分升高程度较对照组明显,CSI、Ashworth评分降低程度较对照组明显,大脑前、中、后动脉血流速度加快程度较对照组明显,差异均有统计学意义(P<0.05)。结论:聪脑通络法联合补中益气汤药浴可改善痉挛性脑瘫患儿粗大运动功能、精细运动功能及肌力,缓解肌肉痉挛,增加脑血流速度,联合治疗效果优于单纯补中益气汤药浴。展开更多
基金supported by Liaoning Provincial Education Department,No.20060551
文摘A mixture of ibotenic acid and β-amyloid 1-42 was injected into the hippocampus of a rat model of Alzheimer＇s disease, followed by intragastric administration of a traditional Chinese medicine Buyuan Congnao decoction （main components included radix astragali, radix polygoni multiflori preparata, rhizoma acori talarinowii, radix polygalae, fructus alpiniae oxyphyllae, and radix glycyrrhizae preparata） and a piracetam suspension. Following treatment with traditional Chinese medicine or western medicine, β-amyloid expression decreased and neuronal morphology was normal in the rat hippocampal CA1 region, in addition to significantly shortened average latency in the Morris water navigation task. These findings suggested that compound prescription of Buyuan Congnao decoction, similar to the curative effects of piracetam, decreased hippocampal β-amyloid expression in a rat model of Alzheimer＇s disease, as well as improved learning and memory.
文摘目的:观察聪脑通络法联合补中益气汤药浴对痉挛型脑瘫患儿的影响。方法:将84例痉挛型脑瘫患儿按随机数字表法分为对照组和观察组各42例。对照组予补中益气汤药浴,观察组在对照组基础予聪脑通络法针刺。4周为1个疗程,治疗3个疗程后比较两组患儿治疗前后粗大运动功能(gross motor function measure,GMFM)量表、精细运动功能(fine motor function measure,FMFM)量表、临床痉挛指数(clinical spasticity index,CSI)量表、Ashwonh肌张力评定量表评分及大脑前、中、后动脉的平均血流速度与临床疗效。结果:观察组总有效率为92.86%(39/42),高于对照组的76.19%(32/42)(P<0.05)。观察组治疗后GMFM、FMFM评分升高程度较对照组明显,CSI、Ashworth评分降低程度较对照组明显,大脑前、中、后动脉血流速度加快程度较对照组明显,差异均有统计学意义(P<0.05)。结论:聪脑通络法联合补中益气汤药浴可改善痉挛性脑瘫患儿粗大运动功能、精细运动功能及肌力,缓解肌肉痉挛,增加脑血流速度,联合治疗效果优于单纯补中益气汤药浴。
