Single point diamond fly cutting is widely used in the manufacture of large-aperture ultra-precision optical elements. However,some micro waviness( amplitude about 30 nm,wavelength about 15 mm) along the cutting direc...Single point diamond fly cutting is widely used in the manufacture of large-aperture ultra-precision optical elements. However,some micro waviness( amplitude about 30 nm,wavelength about 15 mm) along the cutting direction which will decrease the quality of the optical elements can always be found in the processed surface,and the axial vibration of the spindle caused by the cut-in process is speculated as the immediate cause of this waviness. In this paper,the analytical method of dynamic mesh is applied for simulating the dynamic behavior of the vertical spindle. The consequence is then exerted to the fly cutter and the processed surface profile is simulated. The wavelength of the simulation result coincides well with the experimental result which proves the importance of the cut-in process during the single point diamond fly cutting.展开更多
The diagnosis of diabetes mellitus type 2(DM2) is based either on increased plasma glucose or Glycated hemoglobin levels. Since these measures are the only means for diagnosis of DM2, they must be well adapted to each...The diagnosis of diabetes mellitus type 2(DM2) is based either on increased plasma glucose or Glycated hemoglobin levels. Since these measures are the only means for diagnosis of DM2, they must be well adapted to each population according to their metabolic characteristics, given that these may vary in each population. The World Health Organization(WHO) determined the cut-points of plasma glucose levels for the diagnosis of DM2 by associating hyperglycemia with the risk of a specific microvascular complication-retinopathy. Cardiovascular diseases are however the principal causes of mortality in patients with DM2 and we reported that in the Colombo-Ecuadorian population impaired fasting glucose and impaired glucose tolerance are both riskmarkers for myocardial infarction. We propose that the current cut-points accepted by the WHO need to be revaluated in populations such as Latin America and that there should be lower cut points for glycaemia in this population, to reduce the prevalence of cardiovascular complications associated with DM2.展开更多
The performance of engineered wood products is highly associated with proper bonding and an efficient cutting method.This paper investigates the influence of CO_(2) laser cutting on the wetting properties,the modified ch...The performance of engineered wood products is highly associated with proper bonding and an efficient cutting method.This paper investigates the influence of CO_(2) laser cutting on the wetting properties,the modified che-mical component of the laser-cut surface,and the strength and adhesive penetration near the bondline.Beech-wood is cut by the laser with varying processing parameters,cutting speeds,gas pressures,and focal point positions.The laser-cut samples were divided into two groups,sanded and non-sanded samples.Polyvinyl acetate adhesive(PVAc)was used to bond the groups of laser-cut samples.After assembly with cold pressing,the tensile shear test was carried out.Numerical modelling was carried out to determine the partial elongation and shear strain of the glue line.Based on this,the shear modulus and linear elasticity of the glue line were estimated.Scan-ning electron microscopy was used to assess the adhesive penetration into the porosity structure of the laser-cut samples,and the depth of the heat-affected zone.The laser-cut surface was analysed by Fourier transform infrared spectroscopy.The wetting properties of the laser-cut surface were investigated by using a contact angle goni-ometer.The numerical model of the strain-stress curve confirmed the experimental model.The highest modulus of the linear elasticity of the glue in the numerical calculation belongs to the joint containing laser-cut samples at a gas pressure of 21(bar).The penetration depth of PVAc adhesive into the porosity structure of the laser-cut sam-ples was similar to that of sawn samples.The deepest heat-affected zone in the laser-cut samples was 150µm.A PVAc drop disappeared immediately on the laser-cut surface without sanding,but gradually on the sanded surface.In contrast,the drop on the sawn surface remained with an angle of 32°–48°.The degradation of hemi-cellulose and lignin was proven by the lower intensity of the C=O and C-O Bonds,compared to the sawn surface.展开更多
Background: Among elderly people, rehabilitation is important for reducing the risk of falls and hospitalization and to maintain an independent life for longer. Motivation is a factor for elderly people to lead an act...Background: Among elderly people, rehabilitation is important for reducing the risk of falls and hospitalization and to maintain an independent life for longer. Motivation is a factor for elderly people to lead an active daily life and leave home more frequently. Purpose: The purposes of this study were to determine the optimal cut-off point in the Scale for Achievement Motive in Geriatrics (SAMG) that could identify individuals as inactive or active, based on the Frenchay Activities Index (FAI), and to compare characteristics between active and inactive groups classified by the cut-off point. Methods: A cross-sectional study of 285 community-dwelling elderly people measured SAMG and FAI and physical function. Receiver operating characteristic (ROC) analysis was used to calculate the area under the curve (AUC) that was the optimal cut-off point for the SAMG total score, with the associated sensitivity and 1-specificity when compared with the FAI results. Demographic parameters and physical function were compared between two groups defined by cut-off point. Results: The AUC was 0.78, the optimal cut-off for SAMG total score for indicating inactivity was ≤48, the sensitivity was 77.98% and the 1-specificity was 75.00%. The group with SAMG score >48 was characterized by a significantly higher proportion of women, fewer people sharing a house, and participation in more hobbies. Discussion: A cut-off point of 48 in the SAMG could be a predictive index of motivation toward goals for individuals with inactive daily activities. The group with score higher than the cut-off was characterized by more women, fewer people living together, and more hobbies than the group with lower scores.展开更多
Reports manifest a continuing need for the development of rapid and on-site (point of care) assays. Current diagnostic methods commonly used for detection of antibodies and antigens have significant limitations. Scien...Reports manifest a continuing need for the development of rapid and on-site (point of care) assays. Current diagnostic methods commonly used for detection of antibodies and antigens have significant limitations. Scientists at Micro Detect, Inc. have developed an innovative diagnostic device (method) that can be utilized broadly for antibody/antigen interactions including diagnostic assays in the medical, veterinary and food industries. The developed device can be utilized for the detection of antibodies against a single antigen or vice versa. It can also be tailored for specific panels that detect antigens or antibodies for diverse infectious agents, proteins, hormones, tumor markers, autoimmune markers, and allergens. Additionally, it can also be used for detection of toxins, antitoxins, nucleic acids, enzymes, drugs, etc. in both humans and animals. Specimens used in different formats of the device can be tears, saliva, whole blood, serum, plasma, urine, stool, and other bodily discharges. The good intra and inter precisions and acceptable linearity of the device support reliable use of the device. The CV of the device is 1.9% - 2.2%. Likewise, the performance of the device using 92 confirmed negative and positive specimens via a typical assay showed 100% sensitivity, 80% specificity, 96.8% efficacy, 80% positive predictive value, and 100% negative predictive value. The results of our feasibility study suggest reliable utility of a device for rapid, easy-to-use, inexpensive, and on-site (point of care) diagnostic assays. This presents a potential breakthrough in diagnostic methodologies that can be integrated into modern medicine and food industries.展开更多
Water cut is a key evaluation parameter for reservoir development evaluation. Relative permeability curve reflects reservoir characteristics and fluid characteristics. It is important to figure out the influence law o...Water cut is a key evaluation parameter for reservoir development evaluation. Relative permeability curve reflects reservoir characteristics and fluid characteristics. It is important to figure out the influence law of oil relative permeability on water cut. Based on the 269 relative permeability curves of Bohai oilfields, the distribution of oil index of Bohai oilfields were studied. On the basis, combined with Corey expression of relative permeability and fractional flow equation, the theoretical relationship between oil index and water cut increasing rate was established. Three end points of water cut increasing rate curve were proposed and the influence law between three end points and oil index was studied. The results show that the oil index has a linear relationship with three end points. When the value of water oil mobile ratio is large than 1, with the increase of oil index, maximum value of water cut increasing rate gradually increase. When the value of water oil mobile ratio is less than 10, oil index has great effect on recovery percent when water cut increasing rate reaches to the maximum value as well as water cut when water cut increasing rate reaches to the maximum value. The application of SS field shows that the theoretical value is consistent with the field data.展开更多
In order to obtain the determining method of the installing angle and decrease the performance indices (cutting force and wearing rate) of the pick, the relationships among the installing angles (impact angle, inclina...In order to obtain the determining method of the installing angle and decrease the performance indices (cutting force and wearing rate) of the pick, the relationships among the installing angles (impact angle, inclination angle and the skew angle) were studied, and the static model of installing angles of the pick was built. The relationships among the impact angle, the tip angle of pick and the kinematics parameters of the pick were built, too. Moreover, the mechanic models of the maximum clearance angle and the wearing angle of the pick were set up. To research the relationships of the installing angles and the change law of the wearing angle along with the kinematics parameters, the simulation was done. In order to verify the correctness of the models, the cutting experiments were done by employing two picks with different pick tip angles. The results indicate that, the cutting force is the smallest when the direction of the resultant force of pick follows its axis, and the relationship derived among the installing angles should be satisfied. In addition, to decrease the cutting force and the wearing of the pick, the tip angle of pick should not be larger than the half of the difference between the minimum wearing angle and the impact angle of the pick, and the clearance angle must not be less than zero.展开更多
This paper discusses how the positive and negative predictive values vary withcontrary variations of sensitivity and specificity at a certain disease prevalence.Let thesensitiviy be Se and the specificity be Sp at the...This paper discusses how the positive and negative predictive values vary withcontrary variations of sensitivity and specificity at a certain disease prevalence.Let thesensitiviy be Se and the specificity be Sp at the initial cutoff point,correspondingly Se’and Sp’ at a new cutoff point:A=Se’/Se:B-(1-Sp’)/(1-Sp):C=Sp’/Sp;D=(I-Se’)/(I-Se).Moving the cutoff point from the initial point to the new point,if the contrary variationsof the sensitivity and specificity satisfy the inequality A】B,then the positive predictivevalue increases,otherwise it decreases or remains unchanged.If the variations satisfy theinequality C】D,then the negative prcdictive value increases,otherwise it decreasses or re-mains unchanged.展开更多
Resonant magnetic perturbations(RMPs)with high toroidal mode number n are considered for controlling edge-localized modes(ELMs)and divertor heat flux in future ITER H-mode operations.In this paper,characteristics of d...Resonant magnetic perturbations(RMPs)with high toroidal mode number n are considered for controlling edge-localized modes(ELMs)and divertor heat flux in future ITER H-mode operations.In this paper,characteristics of divertor heat flux under high-nRMPs(n=3 and 4)in H-mode plasma are investigated using newly upgraded infrared thermography diagnostic in EAST.Additional splitting strike point(SSP)accompanying with ELM suppression is observed under both RMPs with n=3 and n=4,the SSP in heat flux profile agrees qualitatively with the modeled magnetic footprint.Although RMPs suppress ELMs,they increase the stationary heat flux during ELM suppression.The dependence of heat flux on q_(95)during ELM suppression is preliminarily investigated,and further splitting in the original strike point is observed at q 495=during ELM suppression.In terms of ELM pulses,the presence of RMPs shows little influence on transient heat flux distribution.展开更多
The Jing-well point temperatures test method is a method to diagnose and guide the treatment of diseases by measuring the subjects' symmetrical well point temperature. it is improved from the method of knowing hea...The Jing-well point temperatures test method is a method to diagnose and guide the treatment of diseases by measuring the subjects' symmetrical well point temperature. it is improved from the method of knowing heat sensitivity. The application of Jing-well point temperatures test method is wide, and it can be used in internal and external gynecology and pediatrics and facial features department. at the same time, it has the advantage of objective and accurate diagnosis. The old law has some shortcomings, such as poor intuition, unavoidable omission of information, incomplete interpretation of information and so on. In this paper, Excel software is used to transform the data into line chart form, which improves the intuition and comprehensiveness of this method, so that the data can be better interpreted and used. It is newly proposed in this article that in addition to observing the longitudinal di fference of well point temperature, more attention should be paid to the horizontal contrast difference of well point temperature in different meridians. The article also summarizes a number of treatment methods, including acupuncture, moxa moxibustion, cupping and scraping, and the selection of acupoints, including mother acupoints, tenderness points and heat-sensitive moxibustion, so that doctors can combine traditional Chinese medicine professional knowledge in clinic.展开更多
This article deals with the use of an interdisciplinary approach to modelling and creation of a complex technical system of different physical nature in relation to the kinematics of cutting and shaping. The professor...This article deals with the use of an interdisciplinary approach to modelling and creation of a complex technical system of different physical nature in relation to the kinematics of cutting and shaping. The professor of the National Technical University of Ukraine, Kuznetcov Iu. N., proposed the approach based on generalization of knowledge, methodological basis of which is the theory of evolution of the systems and methods of genetic analysis and synthesis. For generalization of the knowledge in the fundamental sciences is based on the principles of a limited number of elementary generic structures with the introduction of the gene concept. The modelling and synthesis of kinematic cutting schemes are providing the efficiency and viability of genetic and morphological approach. The material point, which can interact with other ma-terial points in space and time, simulating anthropogenic system of different origin, is introduced as a material object.展开更多
基金Sponsored by the National Science and Technology Special Program(Grant No.2011ZX04004-041)the National Natural Science Foundation of China(Grant No.90923023 and No.51275115)
文摘Single point diamond fly cutting is widely used in the manufacture of large-aperture ultra-precision optical elements. However,some micro waviness( amplitude about 30 nm,wavelength about 15 mm) along the cutting direction which will decrease the quality of the optical elements can always be found in the processed surface,and the axial vibration of the spindle caused by the cut-in process is speculated as the immediate cause of this waviness. In this paper,the analytical method of dynamic mesh is applied for simulating the dynamic behavior of the vertical spindle. The consequence is then exerted to the fly cutter and the processed surface profile is simulated. The wavelength of the simulation result coincides well with the experimental result which proves the importance of the cut-in process during the single point diamond fly cutting.
文摘The diagnosis of diabetes mellitus type 2(DM2) is based either on increased plasma glucose or Glycated hemoglobin levels. Since these measures are the only means for diagnosis of DM2, they must be well adapted to each population according to their metabolic characteristics, given that these may vary in each population. The World Health Organization(WHO) determined the cut-points of plasma glucose levels for the diagnosis of DM2 by associating hyperglycemia with the risk of a specific microvascular complication-retinopathy. Cardiovascular diseases are however the principal causes of mortality in patients with DM2 and we reported that in the Colombo-Ecuadorian population impaired fasting glucose and impaired glucose tolerance are both riskmarkers for myocardial infarction. We propose that the current cut-points accepted by the WHO need to be revaluated in populations such as Latin America and that there should be lower cut points for glycaemia in this population, to reduce the prevalence of cardiovascular complications associated with DM2.
文摘The performance of engineered wood products is highly associated with proper bonding and an efficient cutting method.This paper investigates the influence of CO_(2) laser cutting on the wetting properties,the modified che-mical component of the laser-cut surface,and the strength and adhesive penetration near the bondline.Beech-wood is cut by the laser with varying processing parameters,cutting speeds,gas pressures,and focal point positions.The laser-cut samples were divided into two groups,sanded and non-sanded samples.Polyvinyl acetate adhesive(PVAc)was used to bond the groups of laser-cut samples.After assembly with cold pressing,the tensile shear test was carried out.Numerical modelling was carried out to determine the partial elongation and shear strain of the glue line.Based on this,the shear modulus and linear elasticity of the glue line were estimated.Scan-ning electron microscopy was used to assess the adhesive penetration into the porosity structure of the laser-cut samples,and the depth of the heat-affected zone.The laser-cut surface was analysed by Fourier transform infrared spectroscopy.The wetting properties of the laser-cut surface were investigated by using a contact angle goni-ometer.The numerical model of the strain-stress curve confirmed the experimental model.The highest modulus of the linear elasticity of the glue in the numerical calculation belongs to the joint containing laser-cut samples at a gas pressure of 21(bar).The penetration depth of PVAc adhesive into the porosity structure of the laser-cut sam-ples was similar to that of sawn samples.The deepest heat-affected zone in the laser-cut samples was 150µm.A PVAc drop disappeared immediately on the laser-cut surface without sanding,but gradually on the sanded surface.In contrast,the drop on the sawn surface remained with an angle of 32°–48°.The degradation of hemi-cellulose and lignin was proven by the lower intensity of the C=O and C-O Bonds,compared to the sawn surface.
文摘Background: Among elderly people, rehabilitation is important for reducing the risk of falls and hospitalization and to maintain an independent life for longer. Motivation is a factor for elderly people to lead an active daily life and leave home more frequently. Purpose: The purposes of this study were to determine the optimal cut-off point in the Scale for Achievement Motive in Geriatrics (SAMG) that could identify individuals as inactive or active, based on the Frenchay Activities Index (FAI), and to compare characteristics between active and inactive groups classified by the cut-off point. Methods: A cross-sectional study of 285 community-dwelling elderly people measured SAMG and FAI and physical function. Receiver operating characteristic (ROC) analysis was used to calculate the area under the curve (AUC) that was the optimal cut-off point for the SAMG total score, with the associated sensitivity and 1-specificity when compared with the FAI results. Demographic parameters and physical function were compared between two groups defined by cut-off point. Results: The AUC was 0.78, the optimal cut-off for SAMG total score for indicating inactivity was ≤48, the sensitivity was 77.98% and the 1-specificity was 75.00%. The group with SAMG score >48 was characterized by a significantly higher proportion of women, fewer people sharing a house, and participation in more hobbies. Discussion: A cut-off point of 48 in the SAMG could be a predictive index of motivation toward goals for individuals with inactive daily activities. The group with score higher than the cut-off was characterized by more women, fewer people living together, and more hobbies than the group with lower scores.
文摘Reports manifest a continuing need for the development of rapid and on-site (point of care) assays. Current diagnostic methods commonly used for detection of antibodies and antigens have significant limitations. Scientists at Micro Detect, Inc. have developed an innovative diagnostic device (method) that can be utilized broadly for antibody/antigen interactions including diagnostic assays in the medical, veterinary and food industries. The developed device can be utilized for the detection of antibodies against a single antigen or vice versa. It can also be tailored for specific panels that detect antigens or antibodies for diverse infectious agents, proteins, hormones, tumor markers, autoimmune markers, and allergens. Additionally, it can also be used for detection of toxins, antitoxins, nucleic acids, enzymes, drugs, etc. in both humans and animals. Specimens used in different formats of the device can be tears, saliva, whole blood, serum, plasma, urine, stool, and other bodily discharges. The good intra and inter precisions and acceptable linearity of the device support reliable use of the device. The CV of the device is 1.9% - 2.2%. Likewise, the performance of the device using 92 confirmed negative and positive specimens via a typical assay showed 100% sensitivity, 80% specificity, 96.8% efficacy, 80% positive predictive value, and 100% negative predictive value. The results of our feasibility study suggest reliable utility of a device for rapid, easy-to-use, inexpensive, and on-site (point of care) diagnostic assays. This presents a potential breakthrough in diagnostic methodologies that can be integrated into modern medicine and food industries.
文摘Water cut is a key evaluation parameter for reservoir development evaluation. Relative permeability curve reflects reservoir characteristics and fluid characteristics. It is important to figure out the influence law of oil relative permeability on water cut. Based on the 269 relative permeability curves of Bohai oilfields, the distribution of oil index of Bohai oilfields were studied. On the basis, combined with Corey expression of relative permeability and fractional flow equation, the theoretical relationship between oil index and water cut increasing rate was established. Three end points of water cut increasing rate curve were proposed and the influence law between three end points and oil index was studied. The results show that the oil index has a linear relationship with three end points. When the value of water oil mobile ratio is large than 1, with the increase of oil index, maximum value of water cut increasing rate gradually increase. When the value of water oil mobile ratio is less than 10, oil index has great effect on recovery percent when water cut increasing rate reaches to the maximum value as well as water cut when water cut increasing rate reaches to the maximum value. The application of SS field shows that the theoretical value is consistent with the field data.
基金Project(51005232) supported by the National Natural Science Foundation of ChinaProject(20100481176) supported by the China Postdoctoral Science Foundation+1 种基金Project(201104583) supported by the China Postdoctoral Special FundProject(1101106c) supported by Jiangsu Postdoctoral Foundation, China
文摘In order to obtain the determining method of the installing angle and decrease the performance indices (cutting force and wearing rate) of the pick, the relationships among the installing angles (impact angle, inclination angle and the skew angle) were studied, and the static model of installing angles of the pick was built. The relationships among the impact angle, the tip angle of pick and the kinematics parameters of the pick were built, too. Moreover, the mechanic models of the maximum clearance angle and the wearing angle of the pick were set up. To research the relationships of the installing angles and the change law of the wearing angle along with the kinematics parameters, the simulation was done. In order to verify the correctness of the models, the cutting experiments were done by employing two picks with different pick tip angles. The results indicate that, the cutting force is the smallest when the direction of the resultant force of pick follows its axis, and the relationship derived among the installing angles should be satisfied. In addition, to decrease the cutting force and the wearing of the pick, the tip angle of pick should not be larger than the half of the difference between the minimum wearing angle and the impact angle of the pick, and the clearance angle must not be less than zero.
文摘This paper discusses how the positive and negative predictive values vary withcontrary variations of sensitivity and specificity at a certain disease prevalence.Let thesensitiviy be Se and the specificity be Sp at the initial cutoff point,correspondingly Se’and Sp’ at a new cutoff point:A=Se’/Se:B-(1-Sp’)/(1-Sp):C=Sp’/Sp;D=(I-Se’)/(I-Se).Moving the cutoff point from the initial point to the new point,if the contrary variationsof the sensitivity and specificity satisfy the inequality A】B,then the positive predictivevalue increases,otherwise it decreases or remains unchanged.If the variations satisfy theinequality C】D,then the negative prcdictive value increases,otherwise it decreasses or re-mains unchanged.
基金supported by the National Key Research and Development Program of China (No. 2017YFA0402500)the National MCF Energy R&D Program of China (No. 2019YFE03040000)+5 种基金National Natural Science Foundation of China (Nos. 12005262 and 11975274)the Foundation of President of Hefei Institutes of Physical Science, CAS (No. YZJJ2018QN8)the Anhui Provincial Natural Science Foundation (No. 2108085J06)the Users with Excellence Program of Hefei Science Center CAS (Nos. 2021HSC-UE018 and 2020HSC-UE011)External Cooperation Program of Chinese Academy of Sciences (No. 116134KYSB20180035)Science Foundation of Institute of Plasma Physics, Chinese Academy of Sciences (No. DSJJ-2021-04)
文摘Resonant magnetic perturbations(RMPs)with high toroidal mode number n are considered for controlling edge-localized modes(ELMs)and divertor heat flux in future ITER H-mode operations.In this paper,characteristics of divertor heat flux under high-nRMPs(n=3 and 4)in H-mode plasma are investigated using newly upgraded infrared thermography diagnostic in EAST.Additional splitting strike point(SSP)accompanying with ELM suppression is observed under both RMPs with n=3 and n=4,the SSP in heat flux profile agrees qualitatively with the modeled magnetic footprint.Although RMPs suppress ELMs,they increase the stationary heat flux during ELM suppression.The dependence of heat flux on q_(95)during ELM suppression is preliminarily investigated,and further splitting in the original strike point is observed at q 495=during ELM suppression.In terms of ELM pulses,the presence of RMPs shows little influence on transient heat flux distribution.
文摘The Jing-well point temperatures test method is a method to diagnose and guide the treatment of diseases by measuring the subjects' symmetrical well point temperature. it is improved from the method of knowing heat sensitivity. The application of Jing-well point temperatures test method is wide, and it can be used in internal and external gynecology and pediatrics and facial features department. at the same time, it has the advantage of objective and accurate diagnosis. The old law has some shortcomings, such as poor intuition, unavoidable omission of information, incomplete interpretation of information and so on. In this paper, Excel software is used to transform the data into line chart form, which improves the intuition and comprehensiveness of this method, so that the data can be better interpreted and used. It is newly proposed in this article that in addition to observing the longitudinal di fference of well point temperature, more attention should be paid to the horizontal contrast difference of well point temperature in different meridians. The article also summarizes a number of treatment methods, including acupuncture, moxa moxibustion, cupping and scraping, and the selection of acupoints, including mother acupoints, tenderness points and heat-sensitive moxibustion, so that doctors can combine traditional Chinese medicine professional knowledge in clinic.
文摘This article deals with the use of an interdisciplinary approach to modelling and creation of a complex technical system of different physical nature in relation to the kinematics of cutting and shaping. The professor of the National Technical University of Ukraine, Kuznetcov Iu. N., proposed the approach based on generalization of knowledge, methodological basis of which is the theory of evolution of the systems and methods of genetic analysis and synthesis. For generalization of the knowledge in the fundamental sciences is based on the principles of a limited number of elementary generic structures with the introduction of the gene concept. The modelling and synthesis of kinematic cutting schemes are providing the efficiency and viability of genetic and morphological approach. The material point, which can interact with other ma-terial points in space and time, simulating anthropogenic system of different origin, is introduced as a material object.
