Background The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by,and formed due to,past and current admixture events.Adaptation to diverse env...Background The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by,and formed due to,past and current admixture events.Adaptation to diverse environments,including acclimation to harsh climatic conditions,has also left selection footprints in breed genomes.Results Using the Chicken 50K_CobbCons SNP chip,we genotyped four divergently selected breeds:two aboriginal,cold tolerant Ushanka and Orloff Mille Fleur,one egg-type Russian White subjected to artificial selection for cold tolerance,and one meat-type White Cornish.Signals of selective sweeps were determined in the studied breeds using three methods:(1)assessment of runs of homozygosity islands,(2)F_(ST) based population differential analysis,and(3)haplotype differentiation analysis.Genomic regions of true selection signatures were identified by two or more methods or in two or more breeds.In these regions,we detected 540 prioritized candidate genes supplemented them with those that occurred in one breed using one statistic and were suggested in other studies.Amongst them,SOX5,ME3,ZNF536,WWP1,RIPK2,OSGIN2,DECR1,TPO,PPARGC1A,BDNF,MSTN,and beta-keratin genes can be especially mentioned as candidates for cold adaptation.Epigenetic factors may be involved in regulating some of these important genes(e.g.,TPO and BDNF).Conclusion Based on a genome-wide scan,our findings can help dissect the genetic architecture underlying various phenotypic traits in chicken breeds.These include genes representing the sine qua non for adaptation to harsh environments.Cold tolerance in acclimated chicken breeds may be developed following one of few specific gene expression mechanisms or more than one overlapping response known in cold-exposed individuals,and this warrants further investigation.展开更多
Sorghum[Sorghum bicolor(L.)Moench],a multipurpose C4 crop,is also a model species of the Poaceae family for plant research.During the process of domestication,the modification of seed dispersal mode is considered a ke...Sorghum[Sorghum bicolor(L.)Moench],a multipurpose C4 crop,is also a model species of the Poaceae family for plant research.During the process of domestication,the modification of seed dispersal mode is considered a key event,as the loss of seed shattering caused a significant increase in yield.In order to understand the seed shattering process in sorghum,we further studied eight previously identified divergent sorghum germplasm with different shattering degrees.We described their phenotypes in great detail,analyzed the histology of abscission zone,and conducted a gene co-expression analysis.We observed that the abscission layer of the most strong-shattering varieties began to differentiate before the 5-10 cm panicles development stage and was completely formed at flag leaf unfolding.The protective cells on the pedicels were also fully lignified by flowering.Through the weighted gene correlation network analysis(WGCNA),we mined for candidate genes involved in the abscission process at the heading stage.We found that these genes were mainly associated with such biological processes as hormone signal transmission(SORBI_3003G361300,SORBI_3006G216500,SORBI_3009G027800,SORBI_3007G077200),cell wall modification and degradation(SORBI_3002G205500,SORBI_3004G013800,SORBI_3010G022400,SORBI_3003G251800,SORBI_3003G254700,SORBI_3003G410800,SORBI_3009G162700,SORBI_3001G406700,SORBI_3004G042700,SORBI_3004G244600,SORBI_3001G099100),and lignin synthesis(SORBI_3004G220700,SORBI_3004G062500,SORBI_3010G214900,SORBI_3009G181800).Our study has provided candidate genes required for shedding for further study.We believe that function characterization of these genes may provide insight into our understanding of seed shattering process.展开更多
This research paper delves into the connection, between problem-solving and music. It’s a topic that has piqued the interest of scholars in fields, including science and neuroscience. The study explores how music can...This research paper delves into the connection, between problem-solving and music. It’s a topic that has piqued the interest of scholars in fields, including science and neuroscience. The study explores how music can influence our ability to think divergently which is an aspect of creative thinking. It builds upon advancements in methods to investigate the relationship between music and divergent thinking aiming to uncover potential correlations. Doing it offers insights into the interplay between artistic expression and cognitive innovation. This research combines an analysis of existing literature with data collected from a group of participants shedding light on how music impacts our capacity for creative thinking. It demonstrates that music plays a role as a catalyst, for stimulating and enhancing thinking abilities.展开更多
Based on the ERA5 reanalysis datasets during 1980-2019,a total of eleven zonal shear lines(ZSLs)that caused heavy precipitation and lasted more than 60 hours over the Tibetan Plateau in summer are selected for composi...Based on the ERA5 reanalysis datasets during 1980-2019,a total of eleven zonal shear lines(ZSLs)that caused heavy precipitation and lasted more than 60 hours over the Tibetan Plateau in summer are selected for composite analysis.By decomposing the kinetic energy(K)near the ZSL into divergent and rotational kinetic energies(K_(D)and K_(R))and the kinetic energy of interaction between the divergent wind and the rotational wind(K_(R)D),the influence of the rotational and divergent winds on the evolution of the ZSL intensity is investigated from the perspective of K_(D)and K_(R).The main results are as follows.The ZSL is a comprehensive reflection of rotation and convergence.The intensity evolution of ZSL is essentially synchronized with those of K,K_(R),and K_(RD)but lags behind K_(D)by about three hours.The enhancement of K is mainly contributed by K_(R),which is governed by the conversion from K_(D)to K_(R).Furthermore,the increase in the conversion from K_(D)to K_(R)is controlled by the geostrophic effect term Af,which is determined by the joint enhancement of the zonal rotational and meridional divergent wind components(u_(R)and v_(D)).Therefore,the joint enhancement of u_(R)and v_(D)controls the increase of the ZSL intensity,leading to increased precipitation.展开更多
Based on basic equations in isobaric coordinates and the quasi-geostrophic balance,an eddy-flux form budget equation of the divergent wind has been derived. This newly derived budget equation has evident physical sign...Based on basic equations in isobaric coordinates and the quasi-geostrophic balance,an eddy-flux form budget equation of the divergent wind has been derived. This newly derived budget equation has evident physical significance. It can show the intensity of a weather system,the variation of its flow pattern,and the feedback effects from smaller-scale systems(eddy flows). The usefulness of this new budget equation is examined by calculating budgets for the strong divergent-wind centers associated with the South Asian high,and the strong divergence centers over the Tibetan Plateau,during summer(June–August) 2010. The results indicate that the South Asian high significantly interacts with eddy flows. Compared with effects from the mean flow(background circulation),the eddy flows' feedback influences are of greater importance in determining the flow pattern of the South Asian high. Although the positive divergence centers over the Tibetan Plateau intensify through different mechanisms,certain similarities are also obvious. First,the effects from mean flow are dominant in the rapid intensification process of the positive divergence center. Second,an intense offsetting mechanism exists between the effects associated with the eddy flows' horizontal component and the effects related to the eddy flows' convection activities,which weakens the total effects of the eddy flows significantly. Finally,compared with the effects associated with the convection activities of the mean flow,the accumulated effects of the eddy flows' convection activities may be more favorable for the enhancement of the positive-divergence centers.展开更多
Our research studied the physiological response of participants during a creative task to investigate if a person’s psychophysiological state was correlated with divergent thinking performance. We used heart rate var...Our research studied the physiological response of participants during a creative task to investigate if a person’s psychophysiological state was correlated with divergent thinking performance. We used heart rate variability as our physiological measure. We asked 50 participants to perform a cognitive task that assessed their divergent thinking skills and recorded their heart rate and heart rate variability (HRV) before and during the task. Frequency domain analysis was performed on the HRV. The results showed that there was a significant negative correlation between log-transformed low frequency HRV power and the number of “divergent thinking” words generated. Our results suggest that a person’s psychophysiological state is correlated with their divergent thinking performance, and that attention and motivation may be important factors, however this needs further research. Our findings also suggest that being in a relaxed state before the start of a creative task is not a predictor of creative performance.展开更多
This article mainly studied Humulus scandens’ ITS sequence, its system position and its divergent time. ITS is 624 bp with a GC percentage content of 57.21%. It only has the variation in 585 (C changes T), systematic...This article mainly studied Humulus scandens’ ITS sequence, its system position and its divergent time. ITS is 624 bp with a GC percentage content of 57.21%. It only has the variation in 585 (C changes T), systematic position in Humulus lupulus (GenBank: EF136401) and Humulus scandens (GenBank: FJ980285), Humulus lupulus (GenBank: DQ005990), with Humulus scandens (GenBank: FJ980285), Humulus lupulus (GenBank: DQ005990) has the near sibship. Humulus in Moraceae family system position between Cudrania tricuspidata and Artocarpeae, support the Cannabiodeae promotion for Cannabinaceae. The divergent time of Humulus is 70.88 mya in Moraceae, Humulus scandens and Humulus lupulus (GenBank: EF136401) is 12.78 mya, with Humulus scandens (GenBank: FJ980285), Humulus lupulus (GenBank: DQ005990) is 1.10 mya. In the Moraceae branch’s molecular systematics research, the suitable choice is to choose Humulus scandens as Moraceae’s outgroup.展开更多
The TCM philosophy of a meridian and associated channels pertains to the specific function of one or more organs. We define the <span style="font-family:Verdana;">Lung Primary Meridian (LUM) together w...The TCM philosophy of a meridian and associated channels pertains to the specific function of one or more organs. We define the <span style="font-family:Verdana;">Lung Primary Meridian (LUM) together with the </span><span style="font-family:Verdana;">Lung Sinew (LUSC), Divergent (LUDC), Luo-connecting (LULCC) Channels as a system of routes plus some parts of the body (such as muscles) to fulfil respiration, as a main function under different situations. There is very limited information about the Lung associated channels in classical literature of TCM. With a clear focus on the function of respiration, we have carried out a detailed analysis of the biomedical consequence of stimulating the LUM, analysed the roles played by LUSC, LUDC, and LULCC. The updated LUM and LUDC include acupoints of other meridians, serving the same purpose of performing satisfactory respiration starting from checking the quality of the inflow through the nose. The LUSC includes the respiratory muscles (plus the associated connective tissues) extending to various parts of the body. The muscles of the limb (as part of the LUSC) embrace the nerves that provide routes for somatosensory reflexes and play the role of locomotion, providing voluntary respiration via the pectoralis muscles. The muscles of LUSC are bounded by stiff connective tissue layers, forming compartments, and are part of the pulley system for various body locomotions. Within a compartment, the interstitial fluid, blood, lymph flows must be potent to protect the associated nerves related to LUM;the healthy state of the LUSC also provides freedom of various types of locomotion. The LULCC exists because the vagus nerve has a part of it passing through the spinal cords all the way down to the sacrum domain, with exiting nerve innervating two-third of the large intestine. The crucial steps of our deductions </span><span style="font-family:Verdana;">are supported by experimental evidence based on modern neurophysiology and kinesiology. We discover that all the four channels stated above work as a unit system to allow respiration to be possible under various postures/conditions. </span><span style="font-family:Verdana;">The complexity of structures and processes is eased off by providing 29 figures and 13 tables for the relevant muscles and nerves. In addition to respiration, the Lung system in TCM context includes interaction of this system with the sweat gland and neuroendocrine system;such aspects will be left to another study.</span>展开更多
The issue of bilingualism has been widely explored in the past decades,showing that there are multiple positive effects of"additive bilingualism".Such positive factors are closely linked with children’s cog...The issue of bilingualism has been widely explored in the past decades,showing that there are multiple positive effects of"additive bilingualism".Such positive factors are closely linked with children’s cognitive development and intelligence.This paper gives a detailed review on how bilingualism plays a role in children’s divergent thinking ability.Fully taking advantage of such positive effects in language education should be a significant part for bilingual education and foreign language programs.Thus,this paper further discusses the educational implications of these theoretic findings,suggesting that an additive bilingual environment should be cultivated through multiple ways of curriculum and program planning.展开更多
Scaffold diversity is a key feature of a compound library and plays a pivotal role in its success in biological screening.Therefore,it is highly desirable to develop efficient strategies to rapidly construct structura...Scaffold diversity is a key feature of a compound library and plays a pivotal role in its success in biological screening.Therefore,it is highly desirable to develop efficient strategies to rapidly construct structurally distinct and diverse“privileged”molecular scaffolds,thereby giving rise to compound libraries with selective and differing biological activities.This review covers recent efforts in this emerging field of Ni-catalyzed divergent and selective synthesis,and will focus on reactions using the same substrate to generate structurally diverse molecular scaffolds by varying the ligand backbone under otherwise almost identical reaction conditions.We hope that the field will be encouraged by the progress achieved,drawing attention to the design and development of new selective catalytic systems,and revealing new modes of catalytic transformation for broader synthetic applications.展开更多
Comprehensive Summary Alcohols as among the most widely occurring organic compounds known,deoxygenative transformations of free alcohols as partners in radical addition reactions remain formidable challenges with grea...Comprehensive Summary Alcohols as among the most widely occurring organic compounds known,deoxygenative transformations of free alcohols as partners in radical addition reactions remain formidable challenges with great opportunities to achieve new and useful transformations.Herein,we report a protocol via C—O bond cleavage and C—C bond-forming reaction of trifluoromethyl alkenes with free alcohols assisted by titanium reagents via a deoxygenative radical strategy,enabling the divergent synthesis for functional-group-rich organofluorinated compounds in high efficiencies.In this transformation,tertiary alcohols by Ti-catalysis could be converted to trifluoromethyl alkanes without defluorination in acidic conditions,while benzyl alcohols are employed by Ti-mediated activation to supply the gem-difluoroalkenes with defluorination in the presence of a base.This protocol is applicable for a broad range of trifluoromethyl alkenes with good functional group tolerance and a variety of tertiary alcohols and benzyl alcohols(including primary。展开更多
Electrochemistry-enabled rhodium-catalyzed C–H amination and amination cyclization of arene assisted by a weakly coordinating amide have been reported. Additionally, aryl amines and dihydroquinazolinones could be obt...Electrochemistry-enabled rhodium-catalyzed C–H amination and amination cyclization of arene assisted by a weakly coordinating amide have been reported. Additionally, aryl amines and dihydroquinazolinones could be obtained selectively by controlling the electric current. Mechanistic studies suggested that the amination reaction likely involves an electrochemical oxidation-induced reductive elimination of a high valent rhodium intermediate, which led to the amination reaction even proceeding smoothly at room temperature.展开更多
Purpose The Filed of View(FOV)of eXTP/LAD is limited by lead-glass capillary plate collimators placed in front of the Silicon Drift Detectors(SDDs)for reducing the background contamination caused by the photons of Cos...Purpose The Filed of View(FOV)of eXTP/LAD is limited by lead-glass capillary plate collimators placed in front of the Silicon Drift Detectors(SDDs)for reducing the background contamination caused by the photons of Cosmic X-ray Background(CXB)leaking from outside the FOV.The core quality parameters of lead-glass capillary plate collimators are Open Area Ratio(OAR)and FOV.The performance of lead-glass capillary plate collimators is determined by its design specification such as pore-to-pore misalignment,pore perpendicularity with collimator surface and pore diameter.Since the design specification is the result of a large number of micropores,we use the full width at half maximum(FWHM)and peak value of point spread function(PSF)to characterize the capillary plate collimator performance.In order to quickly evaluate the performances of collimators,we developed a direct PSF measurement method using divergent beams.Methods In this paper,the simulation package of the divergent beamsmeasurement setup is developed based on Geant4.The simulation parameters of scintillator absorption length are corrected by experimental data.We simulate the PSF of collimators with different distribution of pore diameter and misalignment by parallel beams and divergent beams.By comparing the peak value and FWHM of collimators PSF,the feasibility in replacing parallel beams measurement with divergent beams measurement is studied.Results It is verified that the influence of the geometric size of 33μm radius of the micro-focus of X-ray tube can be ignored.The results show that the FWHM of collimators is increased with error root mean square error(RMS)of the distribution of collimators pore diameter and pore inclination angle.The peak value of PSF is mainly influenced by pore non-parallelism of the pores,and it decreases with an increase in pore inclination angle.Comparison of parallel beams PSF and divergent beams PSF shows well consistency of peak value and FWHM of collimator.But,the peak value of the divergent beams PSF is mainly affected by the defects of the pores close to the optical axis and result in difference from the parallel beams results consequently.We have developed capillary plate collimators response function based on the projected area function of a cylindrical pore and the fluorescence broadening of the scintillator and fitted PSF by response function.The capillary plate collimator open area ratio is calculated by using the micropores radius and collimator frame thickness obtained by fitting parameter,and the result is close to the parallel beams PSF.Conclusion The feasibility divergent beams measurement is verified.展开更多
We propose a novel polynomial network autoregressive model by incorporating higher-order connected relationships to simultaneously model the effects of both direct and indirect connections. A quasimaximum likelihood e...We propose a novel polynomial network autoregressive model by incorporating higher-order connected relationships to simultaneously model the effects of both direct and indirect connections. A quasimaximum likelihood estimation method is proposed to estimate the unknown influence parameters, and we demonstrate its consistency and asymptotic normality without imposing any distribution assumption. Moreover,an extended Bayesian information criterion is set for order selection with a divergent upper order. The application of the proposed polynomial network autoregressive model is demonstrated through both the simulation and the real data analysis.展开更多
This paper is the Part Ⅱ of studying the budget of kinetic energy of the typhoon No. 7507, with the emphasis on the conversion between the kinetic energy of the divergent winds and that of the non-divergent winds, an...This paper is the Part Ⅱ of studying the budget of kinetic energy of the typhoon No. 7507, with the emphasis on the conversion between the kinetic energy of the divergent winds and that of the non-divergent winds, and its relationship to the heating field. The main findings have been brought out as follows.展开更多
The longitudinal dispersion of the projectile in shooting tests of two-dimensional trajectory corrections fused with fixed canards is extremely large that it sometimes exceeds the correction ability of the correction ...The longitudinal dispersion of the projectile in shooting tests of two-dimensional trajectory corrections fused with fixed canards is extremely large that it sometimes exceeds the correction ability of the correction fuse actuator.The impact point easily deviates from the target,and thus the correction result cannot be readily evaluated.However,the cost of shooting tests is considerably high to conduct many tests for data collection.To address this issue,this study proposes an aiming method for shooting tests based on small sample size.The proposed method uses the Bootstrap method to expand the test data;repeatedly iterates and corrects the position of the simulated theoretical impact points through an improved compatibility test method;and dynamically adjusts the weight of the prior distribution of simulation results based on Kullback-Leibler divergence,which to some extent avoids the real data being"submerged"by the simulation data and achieves the fusion Bayesian estimation of the dispersion center.The experimental results show that when the simulation accuracy is sufficiently high,the proposed method yields a smaller mean-square deviation in estimating the dispersion center and higher shooting accuracy than those of the three comparison methods,which is more conducive to reflecting the effect of the control algorithm and facilitating test personnel to iterate their proposed structures and algorithms.;in addition,this study provides a knowledge base for further comprehensive studies in the future.展开更多
The forcing of anomalous divergent wind and transient vorticity fluxes to the anomaly ofstationary waves of DJF (December—January—February) 1982/1983 is studied.The results showthat the anomaly of the transient vort...The forcing of anomalous divergent wind and transient vorticity fluxes to the anomaly ofstationary waves of DJF (December—January—February) 1982/1983 is studied.The results showthat the anomaly of the transient vorticity flux convergence tends to cancel or dissipate the anomalyof the vorticity sources generated by divergent wind.The stationary wave anomalies are maintainedby both of these forcings.It is also found that,for the DJF 1982/1983 case,both of the vorticitysource anomaly over the tropical and equatorial eastern Pacific and that over the midlatitude NorthPacific are important to maintain the atmospheric circulation anomaly over the Pacific/NorthAmerica region.展开更多
A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible ...A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed.The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole,benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.展开更多
O-Mannosylation plays a vital role in the regulation of a variety range of biological processes,for instance,brain and muscle development.However,the precise function remains largely unknown due to its innate heteroge...O-Mannosylation plays a vital role in the regulation of a variety range of biological processes,for instance,brain and muscle development.However,the precise function remains largely unknown due to its innate heterogeneity.In this regard,it is still welcome to develop efficient methods to access diverse structurally-defined glycopeptides.In this study,a diversity-oriented assembly of O-mannosylα-dystroglycan(α-DG)glycopeptides has been achieved via a chemoenzymatic strategy.This strategy features(i)gram scale divergent synthesis of core m1,core m2 and core m3 mannosylated amino acids from judiciously designed protecting group strategies and chemical glycosidation;(i)efficient glycopeptide assembly via the optimized microwave-assisted solid phase peptide synthesis(SPpS);and(ii)enzymatic elaboration of the core glycan structures to install galactosyl and sialyl-galactosyl moieties.The efficiency and flexibility of this chemoenzymatic approach was demonstrated with the construction of 12 glycopeptides with different core m1,core m2 and core m3 mannosyl glycans,including a core m2 glycopeptide bearing a heptasaccharide for the first time.展开更多
基金supported by the Russian Science Foundation within the Project No.21-66-00007support of the Russian Ministry of Science and Higher Education。
文摘Background The genomes of worldwide poultry breeds divergently selected for performance and other phenotypic traits may also be affected by,and formed due to,past and current admixture events.Adaptation to diverse environments,including acclimation to harsh climatic conditions,has also left selection footprints in breed genomes.Results Using the Chicken 50K_CobbCons SNP chip,we genotyped four divergently selected breeds:two aboriginal,cold tolerant Ushanka and Orloff Mille Fleur,one egg-type Russian White subjected to artificial selection for cold tolerance,and one meat-type White Cornish.Signals of selective sweeps were determined in the studied breeds using three methods:(1)assessment of runs of homozygosity islands,(2)F_(ST) based population differential analysis,and(3)haplotype differentiation analysis.Genomic regions of true selection signatures were identified by two or more methods or in two or more breeds.In these regions,we detected 540 prioritized candidate genes supplemented them with those that occurred in one breed using one statistic and were suggested in other studies.Amongst them,SOX5,ME3,ZNF536,WWP1,RIPK2,OSGIN2,DECR1,TPO,PPARGC1A,BDNF,MSTN,and beta-keratin genes can be especially mentioned as candidates for cold adaptation.Epigenetic factors may be involved in regulating some of these important genes(e.g.,TPO and BDNF).Conclusion Based on a genome-wide scan,our findings can help dissect the genetic architecture underlying various phenotypic traits in chicken breeds.These include genes representing the sine qua non for adaptation to harsh environments.Cold tolerance in acclimated chicken breeds may be developed following one of few specific gene expression mechanisms or more than one overlapping response known in cold-exposed individuals,and this warrants further investigation.
基金supported by the National Key Research and Development Program of China(2018YFD1000706,2018YFD1000700).
文摘Sorghum[Sorghum bicolor(L.)Moench],a multipurpose C4 crop,is also a model species of the Poaceae family for plant research.During the process of domestication,the modification of seed dispersal mode is considered a key event,as the loss of seed shattering caused a significant increase in yield.In order to understand the seed shattering process in sorghum,we further studied eight previously identified divergent sorghum germplasm with different shattering degrees.We described their phenotypes in great detail,analyzed the histology of abscission zone,and conducted a gene co-expression analysis.We observed that the abscission layer of the most strong-shattering varieties began to differentiate before the 5-10 cm panicles development stage and was completely formed at flag leaf unfolding.The protective cells on the pedicels were also fully lignified by flowering.Through the weighted gene correlation network analysis(WGCNA),we mined for candidate genes involved in the abscission process at the heading stage.We found that these genes were mainly associated with such biological processes as hormone signal transmission(SORBI_3003G361300,SORBI_3006G216500,SORBI_3009G027800,SORBI_3007G077200),cell wall modification and degradation(SORBI_3002G205500,SORBI_3004G013800,SORBI_3010G022400,SORBI_3003G251800,SORBI_3003G254700,SORBI_3003G410800,SORBI_3009G162700,SORBI_3001G406700,SORBI_3004G042700,SORBI_3004G244600,SORBI_3001G099100),and lignin synthesis(SORBI_3004G220700,SORBI_3004G062500,SORBI_3010G214900,SORBI_3009G181800).Our study has provided candidate genes required for shedding for further study.We believe that function characterization of these genes may provide insight into our understanding of seed shattering process.
文摘This research paper delves into the connection, between problem-solving and music. It’s a topic that has piqued the interest of scholars in fields, including science and neuroscience. The study explores how music can influence our ability to think divergently which is an aspect of creative thinking. It builds upon advancements in methods to investigate the relationship between music and divergent thinking aiming to uncover potential correlations. Doing it offers insights into the interplay between artistic expression and cognitive innovation. This research combines an analysis of existing literature with data collected from a group of participants shedding light on how music impacts our capacity for creative thinking. It demonstrates that music plays a role as a catalyst, for stimulating and enhancing thinking abilities.
基金the Key Program of the National Science Foundation of China(Grant No.42030611)the Second Tibetan Plateau Scientific Expedition and Research(STEP)program(Grant No.2019QZKK0105)+1 种基金the Integration Project of Major Research Program of the National Natural Science Foundation of China(Grant No.91937301)the General Program of the National Science Foundation of China(Grant No.42175008).
文摘Based on the ERA5 reanalysis datasets during 1980-2019,a total of eleven zonal shear lines(ZSLs)that caused heavy precipitation and lasted more than 60 hours over the Tibetan Plateau in summer are selected for composite analysis.By decomposing the kinetic energy(K)near the ZSL into divergent and rotational kinetic energies(K_(D)and K_(R))and the kinetic energy of interaction between the divergent wind and the rotational wind(K_(R)D),the influence of the rotational and divergent winds on the evolution of the ZSL intensity is investigated from the perspective of K_(D)and K_(R).The main results are as follows.The ZSL is a comprehensive reflection of rotation and convergence.The intensity evolution of ZSL is essentially synchronized with those of K,K_(R),and K_(RD)but lags behind K_(D)by about three hours.The enhancement of K is mainly contributed by K_(R),which is governed by the conversion from K_(D)to K_(R).Furthermore,the increase in the conversion from K_(D)to K_(R)is controlled by the geostrophic effect term Af,which is determined by the joint enhancement of the zonal rotational and meridional divergent wind components(u_(R)and v_(D)).Therefore,the joint enhancement of u_(R)and v_(D)controls the increase of the ZSL intensity,leading to increased precipitation.
基金supported by the National Natural Science Foundation of China (Grant Nos.91637211,41205027 and 41375053)the National Key Basic Research and Development Project of China (Grant No.2012CB417201)
文摘Based on basic equations in isobaric coordinates and the quasi-geostrophic balance,an eddy-flux form budget equation of the divergent wind has been derived. This newly derived budget equation has evident physical significance. It can show the intensity of a weather system,the variation of its flow pattern,and the feedback effects from smaller-scale systems(eddy flows). The usefulness of this new budget equation is examined by calculating budgets for the strong divergent-wind centers associated with the South Asian high,and the strong divergence centers over the Tibetan Plateau,during summer(June–August) 2010. The results indicate that the South Asian high significantly interacts with eddy flows. Compared with effects from the mean flow(background circulation),the eddy flows' feedback influences are of greater importance in determining the flow pattern of the South Asian high. Although the positive divergence centers over the Tibetan Plateau intensify through different mechanisms,certain similarities are also obvious. First,the effects from mean flow are dominant in the rapid intensification process of the positive divergence center. Second,an intense offsetting mechanism exists between the effects associated with the eddy flows' horizontal component and the effects related to the eddy flows' convection activities,which weakens the total effects of the eddy flows significantly. Finally,compared with the effects associated with the convection activities of the mean flow,the accumulated effects of the eddy flows' convection activities may be more favorable for the enhancement of the positive-divergence centers.
文摘Our research studied the physiological response of participants during a creative task to investigate if a person’s psychophysiological state was correlated with divergent thinking performance. We used heart rate variability as our physiological measure. We asked 50 participants to perform a cognitive task that assessed their divergent thinking skills and recorded their heart rate and heart rate variability (HRV) before and during the task. Frequency domain analysis was performed on the HRV. The results showed that there was a significant negative correlation between log-transformed low frequency HRV power and the number of “divergent thinking” words generated. Our results suggest that a person’s psychophysiological state is correlated with their divergent thinking performance, and that attention and motivation may be important factors, however this needs further research. Our findings also suggest that being in a relaxed state before the start of a creative task is not a predictor of creative performance.
文摘This article mainly studied Humulus scandens’ ITS sequence, its system position and its divergent time. ITS is 624 bp with a GC percentage content of 57.21%. It only has the variation in 585 (C changes T), systematic position in Humulus lupulus (GenBank: EF136401) and Humulus scandens (GenBank: FJ980285), Humulus lupulus (GenBank: DQ005990), with Humulus scandens (GenBank: FJ980285), Humulus lupulus (GenBank: DQ005990) has the near sibship. Humulus in Moraceae family system position between Cudrania tricuspidata and Artocarpeae, support the Cannabiodeae promotion for Cannabinaceae. The divergent time of Humulus is 70.88 mya in Moraceae, Humulus scandens and Humulus lupulus (GenBank: EF136401) is 12.78 mya, with Humulus scandens (GenBank: FJ980285), Humulus lupulus (GenBank: DQ005990) is 1.10 mya. In the Moraceae branch’s molecular systematics research, the suitable choice is to choose Humulus scandens as Moraceae’s outgroup.
文摘The TCM philosophy of a meridian and associated channels pertains to the specific function of one or more organs. We define the <span style="font-family:Verdana;">Lung Primary Meridian (LUM) together with the </span><span style="font-family:Verdana;">Lung Sinew (LUSC), Divergent (LUDC), Luo-connecting (LULCC) Channels as a system of routes plus some parts of the body (such as muscles) to fulfil respiration, as a main function under different situations. There is very limited information about the Lung associated channels in classical literature of TCM. With a clear focus on the function of respiration, we have carried out a detailed analysis of the biomedical consequence of stimulating the LUM, analysed the roles played by LUSC, LUDC, and LULCC. The updated LUM and LUDC include acupoints of other meridians, serving the same purpose of performing satisfactory respiration starting from checking the quality of the inflow through the nose. The LUSC includes the respiratory muscles (plus the associated connective tissues) extending to various parts of the body. The muscles of the limb (as part of the LUSC) embrace the nerves that provide routes for somatosensory reflexes and play the role of locomotion, providing voluntary respiration via the pectoralis muscles. The muscles of LUSC are bounded by stiff connective tissue layers, forming compartments, and are part of the pulley system for various body locomotions. Within a compartment, the interstitial fluid, blood, lymph flows must be potent to protect the associated nerves related to LUM;the healthy state of the LUSC also provides freedom of various types of locomotion. The LULCC exists because the vagus nerve has a part of it passing through the spinal cords all the way down to the sacrum domain, with exiting nerve innervating two-third of the large intestine. The crucial steps of our deductions </span><span style="font-family:Verdana;">are supported by experimental evidence based on modern neurophysiology and kinesiology. We discover that all the four channels stated above work as a unit system to allow respiration to be possible under various postures/conditions. </span><span style="font-family:Verdana;">The complexity of structures and processes is eased off by providing 29 figures and 13 tables for the relevant muscles and nerves. In addition to respiration, the Lung system in TCM context includes interaction of this system with the sweat gland and neuroendocrine system;such aspects will be left to another study.</span>
文摘The issue of bilingualism has been widely explored in the past decades,showing that there are multiple positive effects of"additive bilingualism".Such positive factors are closely linked with children’s cognitive development and intelligence.This paper gives a detailed review on how bilingualism plays a role in children’s divergent thinking ability.Fully taking advantage of such positive effects in language education should be a significant part for bilingual education and foreign language programs.Thus,this paper further discusses the educational implications of these theoretic findings,suggesting that an additive bilingual environment should be cultivated through multiple ways of curriculum and program planning.
基金supported by the National Natural Science Foundation of China(22171215)Hubei Provincial Outstanding Youth Fund(2022CFA092)Guangdong Basic and Applied Basic Research Foundation(2022A1515010246)。
文摘Scaffold diversity is a key feature of a compound library and plays a pivotal role in its success in biological screening.Therefore,it is highly desirable to develop efficient strategies to rapidly construct structurally distinct and diverse“privileged”molecular scaffolds,thereby giving rise to compound libraries with selective and differing biological activities.This review covers recent efforts in this emerging field of Ni-catalyzed divergent and selective synthesis,and will focus on reactions using the same substrate to generate structurally diverse molecular scaffolds by varying the ligand backbone under otherwise almost identical reaction conditions.We hope that the field will be encouraged by the progress achieved,drawing attention to the design and development of new selective catalytic systems,and revealing new modes of catalytic transformation for broader synthetic applications.
基金the 71th China Postdoctoral Science Foundation(2022M7132)the National Natural Science Foundation of China(21821002).
文摘Comprehensive Summary Alcohols as among the most widely occurring organic compounds known,deoxygenative transformations of free alcohols as partners in radical addition reactions remain formidable challenges with great opportunities to achieve new and useful transformations.Herein,we report a protocol via C—O bond cleavage and C—C bond-forming reaction of trifluoromethyl alkenes with free alcohols assisted by titanium reagents via a deoxygenative radical strategy,enabling the divergent synthesis for functional-group-rich organofluorinated compounds in high efficiencies.In this transformation,tertiary alcohols by Ti-catalysis could be converted to trifluoromethyl alkanes without defluorination in acidic conditions,while benzyl alcohols are employed by Ti-mediated activation to supply the gem-difluoroalkenes with defluorination in the presence of a base.This protocol is applicable for a broad range of trifluoromethyl alkenes with good functional group tolerance and a variety of tertiary alcohols and benzyl alcohols(including primary。
基金supported by the National Key Research and Development Program of China (2021YFA1500100)the National Natural Science Foundation of China (21821002, 21772222, 91956112)+1 种基金the Science and Technology Commission of Shanghai Municipality (S&TCSM) of Shanghai (18JC1415600, 20JC1417100)Bayer AG (Germany)。
文摘Electrochemistry-enabled rhodium-catalyzed C–H amination and amination cyclization of arene assisted by a weakly coordinating amide have been reported. Additionally, aryl amines and dihydroquinazolinones could be obtained selectively by controlling the electric current. Mechanistic studies suggested that the amination reaction likely involves an electrochemical oxidation-induced reductive elimination of a high valent rhodium intermediate, which led to the amination reaction even proceeding smoothly at room temperature.
基金We would like to acknowledge support from the Strategic Priority Program on Space Science,China,the Chinese Academy of Sciences,Grant No.XDA15020500.
文摘Purpose The Filed of View(FOV)of eXTP/LAD is limited by lead-glass capillary plate collimators placed in front of the Silicon Drift Detectors(SDDs)for reducing the background contamination caused by the photons of Cosmic X-ray Background(CXB)leaking from outside the FOV.The core quality parameters of lead-glass capillary plate collimators are Open Area Ratio(OAR)and FOV.The performance of lead-glass capillary plate collimators is determined by its design specification such as pore-to-pore misalignment,pore perpendicularity with collimator surface and pore diameter.Since the design specification is the result of a large number of micropores,we use the full width at half maximum(FWHM)and peak value of point spread function(PSF)to characterize the capillary plate collimator performance.In order to quickly evaluate the performances of collimators,we developed a direct PSF measurement method using divergent beams.Methods In this paper,the simulation package of the divergent beamsmeasurement setup is developed based on Geant4.The simulation parameters of scintillator absorption length are corrected by experimental data.We simulate the PSF of collimators with different distribution of pore diameter and misalignment by parallel beams and divergent beams.By comparing the peak value and FWHM of collimators PSF,the feasibility in replacing parallel beams measurement with divergent beams measurement is studied.Results It is verified that the influence of the geometric size of 33μm radius of the micro-focus of X-ray tube can be ignored.The results show that the FWHM of collimators is increased with error root mean square error(RMS)of the distribution of collimators pore diameter and pore inclination angle.The peak value of PSF is mainly influenced by pore non-parallelism of the pores,and it decreases with an increase in pore inclination angle.Comparison of parallel beams PSF and divergent beams PSF shows well consistency of peak value and FWHM of collimator.But,the peak value of the divergent beams PSF is mainly affected by the defects of the pores close to the optical axis and result in difference from the parallel beams results consequently.We have developed capillary plate collimators response function based on the projected area function of a cylindrical pore and the fluorescence broadening of the scintillator and fitted PSF by response function.The capillary plate collimator open area ratio is calculated by using the micropores radius and collimator frame thickness obtained by fitting parameter,and the result is close to the parallel beams PSF.Conclusion The feasibility divergent beams measurement is verified.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.JBK2207075)The second author was supported by National Natural Science Foundation of China(Grant Nos.71991472,12171395,11931014 and 71532001)+1 种基金the Joint Lab of Data Science and Business Intelligence at Southwestern University of Finance and Economics and the Fundamental Research Funds for the Central Universities(Grant No.JBK1806002)The fourth author was supported by the Humanity and Social Science Youth Foundation of Ministry of Education of China(Grant No.19YJC790204)。
文摘We propose a novel polynomial network autoregressive model by incorporating higher-order connected relationships to simultaneously model the effects of both direct and indirect connections. A quasimaximum likelihood estimation method is proposed to estimate the unknown influence parameters, and we demonstrate its consistency and asymptotic normality without imposing any distribution assumption. Moreover,an extended Bayesian information criterion is set for order selection with a divergent upper order. The application of the proposed polynomial network autoregressive model is demonstrated through both the simulation and the real data analysis.
文摘This paper is the Part Ⅱ of studying the budget of kinetic energy of the typhoon No. 7507, with the emphasis on the conversion between the kinetic energy of the divergent winds and that of the non-divergent winds, and its relationship to the heating field. The main findings have been brought out as follows.
基金the National Natural Science Foundation of China(Grant No.61973033)Preliminary Research of Equipment(Grant No.9090102010305)for funding the experiments。
文摘The longitudinal dispersion of the projectile in shooting tests of two-dimensional trajectory corrections fused with fixed canards is extremely large that it sometimes exceeds the correction ability of the correction fuse actuator.The impact point easily deviates from the target,and thus the correction result cannot be readily evaluated.However,the cost of shooting tests is considerably high to conduct many tests for data collection.To address this issue,this study proposes an aiming method for shooting tests based on small sample size.The proposed method uses the Bootstrap method to expand the test data;repeatedly iterates and corrects the position of the simulated theoretical impact points through an improved compatibility test method;and dynamically adjusts the weight of the prior distribution of simulation results based on Kullback-Leibler divergence,which to some extent avoids the real data being"submerged"by the simulation data and achieves the fusion Bayesian estimation of the dispersion center.The experimental results show that when the simulation accuracy is sufficiently high,the proposed method yields a smaller mean-square deviation in estimating the dispersion center and higher shooting accuracy than those of the three comparison methods,which is more conducive to reflecting the effect of the control algorithm and facilitating test personnel to iterate their proposed structures and algorithms.;in addition,this study provides a knowledge base for further comprehensive studies in the future.
文摘The forcing of anomalous divergent wind and transient vorticity fluxes to the anomaly ofstationary waves of DJF (December—January—February) 1982/1983 is studied.The results showthat the anomaly of the transient vorticity flux convergence tends to cancel or dissipate the anomalyof the vorticity sources generated by divergent wind.The stationary wave anomalies are maintainedby both of these forcings.It is also found that,for the DJF 1982/1983 case,both of the vorticitysource anomaly over the tropical and equatorial eastern Pacific and that over the midlatitude NorthPacific are important to maintain the atmospheric circulation anomaly over the Pacific/NorthAmerica region.
基金the financial support of the National Natural Science Foundation of China(Grants 21977073)the Liao-ning BaiQianWan Talents Program+2 种基金Liaoning Revitalization Tale nts Programthe program for the innoyative research team of the Ministry of Educationthe program for the Liaoning innovative research team in university.
文摘A gold(Ⅰ)-catalyzed 6-endo-dig cyclization of aromatic 1,5-enynes was developed to synthesize 2-(naphthalen-2-yl)anilines.The functional group tolerance of this cyclization was examined systematically and a possible mechanism was proposed.The derivatization of 2-(naphthalen-2-yl)aniline was carried out to facile access to benzo[α]carbazole,benzo[c,h]cinnoline and dibenzo[i]phenanthridine derivatives in a divergent way.
基金This work is financially supported by the National Natural Science Foundation of China(Grant Nos.22177061,92053110,21977063,21907056)the China Postdoctoral Science Foundation(2020M680090)+2 种基金the Shenzhen Science and Technology Program(RCBS20200714114957255)the Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology(2021CCG01&02)the Central Government Guide Local Science and Technology Development Funds(YDZX20203700002579).
文摘O-Mannosylation plays a vital role in the regulation of a variety range of biological processes,for instance,brain and muscle development.However,the precise function remains largely unknown due to its innate heterogeneity.In this regard,it is still welcome to develop efficient methods to access diverse structurally-defined glycopeptides.In this study,a diversity-oriented assembly of O-mannosylα-dystroglycan(α-DG)glycopeptides has been achieved via a chemoenzymatic strategy.This strategy features(i)gram scale divergent synthesis of core m1,core m2 and core m3 mannosylated amino acids from judiciously designed protecting group strategies and chemical glycosidation;(i)efficient glycopeptide assembly via the optimized microwave-assisted solid phase peptide synthesis(SPpS);and(ii)enzymatic elaboration of the core glycan structures to install galactosyl and sialyl-galactosyl moieties.The efficiency and flexibility of this chemoenzymatic approach was demonstrated with the construction of 12 glycopeptides with different core m1,core m2 and core m3 mannosyl glycans,including a core m2 glycopeptide bearing a heptasaccharide for the first time.
