Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive im...Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.展开更多
This article discusses the history of animal glue(gelatin)used in medical practice in China.In ancient times,gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 ye...This article discusses the history of animal glue(gelatin)used in medical practice in China.In ancient times,gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 years in Egypt,Greece,and China.However,it has been used medicinally almost exclusively in China and other East Asian countries influenced by Chinese medicine.Since 11th century,donkey-hide has gradually been replaced with cowhide in medicinal gelatin.Currently,donkey-hide gelatin is widely used medicinally in China.During the Edo period,medicinal gelatin was imported to Japan from China.Owing to the distaste for eating animal flesh in traditional Japanese culture,the production of gelatin and its medicinal use is not widespread in Japan.展开更多
基金supported by the National Key R&D Program of China(2018YFC1707300)the Taishan Industrial Experts Program(tscx202211148).
文摘Fufang E’jiao Jiang(FEJ)as a healthy food consisting of medicine food homology materials approved by China’s Ministry of Health has been extensively applied to replenish qi and nourish blood,and it has a positive impact on women’s health.To find out the material basis and mechanism of FEJ,a systematic“compoundeffect-target”analysis including chemical composition resolution,zebrafish,network pharmacology,molecular docking,transcriptome,and bibliometric analysis was adopted.124 chemical components including ginsenosides,and phenylethanoid glycosides in FEJ were discovered,and effects of FEJ on promoting the generation of immune cells,erythropoiesis and angiogenesis in zebrafish were exhibited.Based on network pharmacology,molecular docking and in vivo activity assay,6 compounds including jionoside A1,isoacteoside,echinacoside,acteoside,lobetyolin,and rehmannioside D were identified as active components of FEJ.Transcriptome data showed that several pathways such as complement and coagulation cascades,ECM-receptor interaction,and PI3K-Akt signaling pathway were associated with proangiogenic effect of FEJ.19 common targets were obtained through combined analysis of network pharmacology and transcriptomics,and 5 targets of them were verified by PCR.The bibliometric analysis of these common targets revealed that FEJ was related to energy metabolism,pathway in cancer,etc.,which was consistent with the results of network pharmacology and transcriptome.The studies suggested that FEJ could replenish qi and nourish blood through multi-compound and multi-targets.
基金financed by a grant from the Zhejiang Gongshang University,the Zhejiang Province"Foreign Language and Literature"Top Disciplines(A Class)Construction High-level Project(No.2020YLZS16)。
文摘This article discusses the history of animal glue(gelatin)used in medical practice in China.In ancient times,gelatin was widely made from cowhide and has been found in excavations and wall paintings older than 2000 years in Egypt,Greece,and China.However,it has been used medicinally almost exclusively in China and other East Asian countries influenced by Chinese medicine.Since 11th century,donkey-hide has gradually been replaced with cowhide in medicinal gelatin.Currently,donkey-hide gelatin is widely used medicinally in China.During the Edo period,medicinal gelatin was imported to Japan from China.Owing to the distaste for eating animal flesh in traditional Japanese culture,the production of gelatin and its medicinal use is not widespread in Japan.
