Objective:To investigate the safety hazards in nursing and explore mitigation strategies for elderly patients in the endocrinology department.Methods:A total of 240 bedridden elderly patients from February 2021 to Jan...Objective:To investigate the safety hazards in nursing and explore mitigation strategies for elderly patients in the endocrinology department.Methods:A total of 240 bedridden elderly patients from February 2021 to January 2023 were recruited and divided into two groups using the random number table method.The control group(n=120)received conventional nursing care,and the observation group(n=120)received personalized nursing care.Patients’quality of life,the incidence rate of pressure sores,and patient satisfaction with nursing care were observed and analyzed.Results:The incidence of pressure ulcers in the observation group was significantly lower at 17.50%compared to 30.00%in the control group(P<0.05).Quality of life in the observation group was significantly higher than that in the control group(P<0.05).The satisfaction rate in the observation group was significantly higher at 93.33%compared to 84.17%in the control group(P<0.05).Conclusion:These findings emphasize that only through the implementation of scientific and rational nursing measures can effectively reduce nursing risks,enhance therapeutic outcomes,and improve the quality of life for elderly patients.展开更多
Triptolide was given orally to adult male Sprague-Dawley rat sat a dosage of 75 μg/kg for 35 days.After 28 days of treatment,the result of mating tests showed that all the drug treated rats were infertile.At the end ...Triptolide was given orally to adult male Sprague-Dawley rat sat a dosage of 75 μg/kg for 35 days.After 28 days of treatment,the result of mating tests showed that all the drug treated rats were infertile.At the end of drug treatment,the density of caudal spermatozoa and the weight of cpididymis were reduced significantly.All the spermatozoa were immobile.There was no detectable damage of spermatogenesis and epididymal epithelia in triptolide treated rats under microscopical examination.However,modcrate and severe damage of spermatozoa were seen in the corpus and caudal epididymis.The content of cytosolic and nuclear dihydrotestosterone (DHT) receptors in the caput and caudal epididymides was increased but insignificantly as compared with that of the controls.However, the content of DHT receptor in the cytosal of the ventral prostate was elevated very,significantly (P< 0.01).This result suggests that one of the sitcs of action of triptolide might be the epididymis.展开更多
This review provides an overview of the literature on aspects of reproductive endocrinology wherein Asian menmay differ from Caucasian, notably, prostatic nioplasm and the sensivity to pharmacological regimens of male...This review provides an overview of the literature on aspects of reproductive endocrinology wherein Asian menmay differ from Caucasian, notably, prostatic nioplasm and the sensivity to pharmacological regimens of male contra-ception. Both genetic and environmental factors, such as nutrition, might be relevant. Asian men residing in Asia seemto be relatively protected from clinical prostatic nioplasm while the prevalence of preclinical prostatic nioplasm is notdifferent. Migration to an area with a higher prevalence reduces this difference but does not undo it. With regard toprostatic nioplasm the following factors have been considered as relevant in Asian men: 1) a reduction in 5α-reductaselevel, 2) decreased levels of androgenic ketosteroid precursors of 5α-reduced androgen metabolites, 3) the decreasedpresence of a P53 mutation, 4) a higher CAG-repeat length of the androgen receptor, 5) a possible higher level ofphysical activity, 6) differences in sexual activity. Furthermore, Asian men respond to a higher degree with azoosper-mia in response to contraceptive steroids. Possible explanations offered for the more pronounced response to contracep-tive steroids are: 1) differences in testicular structure and decreased spermatogenic potential, 2) an earlier and moremarked suppression in LH secretion by exogenous androgens. The differences may be due to genetical and/or environ-mental factors influencing the peripheral testosterone metabolism. Dietary factors such as the higher intake of phytoe-strogens in Asians might exert effects on 5α-reductase activity and/or on sex hormone binding globulin (SHBG) levels,thus having an impact on the biological efficay of circulating androgens. ( Asian J Androl 2000; 2: 13 - 20)展开更多
Objectives:To explore the clinical value of applying diabetes health education to endocrinology care.Methods:A total of 122 patients with diabetes admitted to our department from October 2016 to October 2017 were sele...Objectives:To explore the clinical value of applying diabetes health education to endocrinology care.Methods:A total of 122 patients with diabetes admitted to our department from October 2016 to October 2017 were selected.After consulting patients,they were randomly divided into two groups,with 61 cases in each group.The control group performs routine care,and the experimental group provides patients with diabetes-specific health education.After three months,the compliance of the two groups of patients was compared.The ADL scores of the two groups of patients before and after treatment were compared.Results:Experimental group had significantly higher compliance rate than control group in all aspects.The difference was statistically significant(P<0.05).The ADL scores of both groups were significantly improved.The effects before and after the care were compared.The difference was statistically significant(P<0.05).The score of experimental group increased more significantly than that of the control group.The difference was statistically significant(P<0.05).Conclusions:In the endocrinology care,the implementation of diabetes special health education for patients can improve patient compliance and improve patients'daily living ability,which is an ideal nursing measure.It is worth promoting.展开更多
This pilot study evaluated effectiveness and acceptance of a new hospital-based reproductive endocrinology curriculum among Iranian medical students. A voluntary, anonymous questionnaire was used to compare two teachi...This pilot study evaluated effectiveness and acceptance of a new hospital-based reproductive endocrinology curriculum among Iranian medical students. A voluntary, anonymous questionnaire was used to compare two teaching methods as applied to junior medical students at Tehran University of Medical Sciences. Students were randomly assigned to one of two clinical teaching settings;no student experienced both modules. Coursework for the pilot (experimental) group (n = 19) utilized a teaching approach comprising lectures, genetics laboratory, pelvic ultrasound, small group sessions, and opportunities to observe advanced reproductive technologies such as in vitro fertilization, ICSI, and embryo transfer. A control group (n = 34) received reproductive endocrinology instruction by the ‘traditional curriculum’, consisting mainly of lectures. Students were sampled at baseline and again atthe conclusion of their reproductive endocrinology session. Pre- and post-test data were analyzed for both groups;post-test differences between groups were also compared. No significant differences in mean age or gender mix were identified between the two study groups. Overall, the ques- tionnaire did not identify any significant intergroup differences for any parameter investigated. Although student acceptance rate appeared similar for both educational modules, the ratio of students having a “favorable regard” for reproductive medicine declined only among students randomized to the control group (41.2% vs. 32.3%). This report offers the first data on teaching reproductive endocrinology to medical students in Iran. Both traditional and innovative approaches to teaching reproductive endocrinology were well-accepted by students, although negative post-test responses were more common among students in the control group. While periodic quality assessments for existing clinical teaching methods are necessary, introduction of alternative teaching approaches is also important. Additional studies are planned to evaluate the impact this initiative may have on results on standardized tests measuring reproductive endocrinology knowledge, as well as election of further specialization in training.展开更多
Introduction: Large clinical trials demonstrate that glycemic, blood pressure, and cholesterol control lead to risk reduction in cardiovascular events. We determined whether A1c, blood pressure, and cholesterol contro...Introduction: Large clinical trials demonstrate that glycemic, blood pressure, and cholesterol control lead to risk reduction in cardiovascular events. We determined whether A1c, blood pressure, and cholesterol control were associated with incident cardiovascular disease [CVD] in a community-based endocrinology practice over 10 years. Methods: 385 consecutive patients seen for diabetes management in a CBEP comprised the analysis cohort. To be included, a patient had ≥2 A1c, blood pressure, and LDLc measurements respectively without prevalent CVD. All patients were 18 years or older with a diagnosis of diabetes before or during calendar year 2000. Results: 17.6% of patients developed incident CVD over 10 years. After controlling for age, gender, and time, patients who improved their A1c展开更多
Objective:To analyze the clinical characters of 812 inpatients with infection in the Department of Endocrinology.Methods:Retrospective exhibition of these patients'clinical characters included undergoing diseases,...Objective:To analyze the clinical characters of 812 inpatients with infection in the Department of Endocrinology.Methods:Retrospective exhibition of these patients'clinical characters included undergoing diseases,infectious organs,history illness,blood glucose and glycosylated hemoglobin(HbA1C),biochemical indicators,pathogens training description and results,medical imagines,antibiotic utilization,length of stay and hospital costs,final diagnosis and situations.Results:Non-diabetic patients accounted for 176(21.67%),who were the cases of untreated well hyperthyroidism,mainly suffered with respiratory tract infection.Diabetic patients accounted for 636(78.33%).In the type2 diabetes patients 376(59.12)suffered with urinary tract infection.192(30.19%)suffered with respiratory system infection,124(19.50%)were accompanied with diabetic foot infection,which had 74(59.67%)patients with HbA1C>9.0%.Statistical comparisons showed that the days of antibiotic use and average length of stay in hospital per capita in patients with HbA1C≥8%were more than ones with HbA1C<8%in those with diabetic infections(P<0.01).The days of antibiotic use per capita in patients with HbA1C>9%were more than ones with HbA1C<7%in those with diabetic foot infections(P<0.01).Conclusion:Endocrine diseases lack rigid and effective long-term control,which may result in the complications involved with urinary tract,respiratory tract and infections in other organs.The time of hospitalization per capita and the duration of antibiotic use rise are longer in diabetic patients with poor blood sugar control and diabetic foot infection.展开更多
Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus common second-line choice after metformin for treating T2...Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus common second-line choice after metformin for treating T2DM.Various considerations can make selecting and switching between different GLP-1 RAs challenging.Our study aims to provide a comprehensive guide for the usage of GLP-1 RAs and dual GIP and GLP-1 RAs for the management of T2DM.展开更多
Objective:To investigate the influence of season on live birth and clinical pregnancy rates,as well as assisted reproductive technology(ART)outcomes,in the Hainan region.Methods:Patients were categorized into four gro...Objective:To investigate the influence of season on live birth and clinical pregnancy rates,as well as assisted reproductive technology(ART)outcomes,in the Hainan region.Methods:Patients were categorized into four groups based on the dates of artificial insemination and transplantation:spring,summer,autumn,or winter.The main outcome measures were clinical pregnancy rates and live birth rates.Secondary outcomes included body mass index(BMI),oocyte number,two pronuclei(2PN)cleavage rate,total gonadotropin(Gn)dosage and days,age,2PN fertilization rate,sperm concentration,sperm PR rate,anti-Müllerian hormone(AMH),and endometrial thickness.Outpatient semen quality indicators included sperm PR rate,total sperm count,sperm concentration,and total sperm motility.Results:This retrospective cohort study analyzed 2,016 artificial insemination cycles and 1,783 ovarian retrieval cycles from January 2017 to October 2022,and assessed the semen quality of 6,651 outpatients from May 2017 to October 2022.In artificial insemination cycles,sperm PR rate and clinical pregnancy rate were highest in winter,with a statistically significant difference between groups(P<0.05).Clinical pregnancy rate was influenced by both age and sperm PR rate(P<0.05).In ovarian retrieval cycles,the winter group had significantly higher clinical pregnancy,2PN fertilization,and 2PN cleavage rates than the other groups.The autumn group had higher live birth rates,though not significantly different.Additionally,winter months showed higher total sperm concentration and total sperm number compared to other seasons.Conclusion:Seasonality affected clinical pregnancy and live birth rates in artificial insemination cycles but not in ovarian retrieval cycles in the Hainan region.These findings suggest that while there is no need to choose a specific season for ovarian retrieval cycles,artificial insemination in winter may be preferable for patients.展开更多
The human endocrine system normally functions in abalanced physiological state. Any excess or deficiencywill cause an endocrine imbalance and result in hyper-orhypo-function, requiring readjustment by hormonesuppressi...The human endocrine system normally functions in abalanced physiological state. Any excess or deficiencywill cause an endocrine imbalance and result in hyper-orhypo-function, requiring readjustment by hormonesuppression or supplementation in order to reestablish anormal physiological balance.展开更多
Female reproductive endocrinology plays an important role in obstetrics and gynecology, and is a component part of perinatology, family planning and geriatrics. It is closely linked with the physiological changes, dis...Female reproductive endocrinology plays an important role in obstetrics and gynecology, and is a component part of perinatology, family planning and geriatrics. It is closely linked with the physiological changes, disease conditions and health care in different reproductive stages of a woman’s life. Ovarian function consists of ovulation and hormonal secretion, which acts upon the uterine endometrium and other target organs and feeds back to the hypothalamus-pituitary unit. Thus, it is connected with other endocrine systems, cerebral cortex and the external environment. Whether the ovrian function is normal or not reflects itself clinically in the changes of menstrual cycle and reproductive status and may be evaluated by laboratory assays.展开更多
Sargassum species is a group of big marine algae.It can be seen around the world and the coastal people have used it as food for years.The use of Sargassum spp.in medicine is very interesting.In this short article,the...Sargassum species is a group of big marine algae.It can be seen around the world and the coastal people have used it as food for years.The use of Sargassum spp.in medicine is very interesting.In this short article,the authors summarize and discuss on Sargassum spp.and its usefulness in endocrinology.展开更多
6.1 Diabetes mellitus 2007165 Evaluation of the first-phase insulin release and insulin sensitivity in patients with newly-diagnosed type 2 diabetes. JIA Weiping(贾伟平), et al. Dept Endocrinol & Metab, 6th Peo...6.1 Diabetes mellitus 2007165 Evaluation of the first-phase insulin release and insulin sensitivity in patients with newly-diagnosed type 2 diabetes. JIA Weiping(贾伟平), et al. Dept Endocrinol & Metab, 6th People′s Hosp, Shanghai Jiaotong Univ, Shanghai 200233. Chin J Endocrinol Metab 2007;23(2):100-103. Objective To evaluate the first-phase insulin release and insulin sensitivity in patients with newly-diagnosed type 2 diabetes. Methods A total of 332 patients with newly-diagnosed type 2 diabetes were classified into two groups of normal or abnormal islet function according to arginine stimulation test, and their results were evaluated. Results(1)Body weight, body mass index (BMI), waist circumference, hip circumference, femoral circumference, fasting serum true insulin and triglyceride in normal islet function group were significantly higher than those in abnormal group (all P【0.01). (2) After adjusting gender, age, BMI and waist to hip ratio, increment of true insulin (△TI) and insulin resistant index (HOMA-IR) in normal group were significantly higher than those in abnormal group (both P【0.01). (3)The proportion of patients of normal insulin releasing function with insulin resistance, patients of normal insulin releasing function without insulin resistance, patients of impaired insulin releasing function with insulin resistance and patients of impaired insulin releasing function without insulin resistance were 35.11%, 5.02%, 29.78% and 30.09%, respectively. Conclusion The patients with type 2 diabetes could be divided into three categories being simple islet function abnormality, simple insulin resistance and islet function abnormality combined with insulin resistance. Both diagnosis and therapy project should be based on such pathophysiological assessment.展开更多
5.1 Diabetes Mellitus2007025 Phenotype-based glomerular gene expression profiling of patients with diabetic nephropathy. CHEN Shan(陈姗),et al, Res Instit Nephrol, Jinling Hosp, Nanjing Univ Sch Med, Nanjing 210002. C...5.1 Diabetes Mellitus2007025 Phenotype-based glomerular gene expression profiling of patients with diabetic nephropathy. CHEN Shan(陈姗),et al, Res Instit Nephrol, Jinling Hosp, Nanjing Univ Sch Med, Nanjing 210002. Chin J Nephrol 2006;22(9):528-533. Objective To get more insight into progression of diabetic nephropathy (DN) and select individual genes associated with the progression of the disease.展开更多
文摘Objective:To investigate the safety hazards in nursing and explore mitigation strategies for elderly patients in the endocrinology department.Methods:A total of 240 bedridden elderly patients from February 2021 to January 2023 were recruited and divided into two groups using the random number table method.The control group(n=120)received conventional nursing care,and the observation group(n=120)received personalized nursing care.Patients’quality of life,the incidence rate of pressure sores,and patient satisfaction with nursing care were observed and analyzed.Results:The incidence of pressure ulcers in the observation group was significantly lower at 17.50%compared to 30.00%in the control group(P<0.05).Quality of life in the observation group was significantly higher than that in the control group(P<0.05).The satisfaction rate in the observation group was significantly higher at 93.33%compared to 84.17%in the control group(P<0.05).Conclusion:These findings emphasize that only through the implementation of scientific and rational nursing measures can effectively reduce nursing risks,enhance therapeutic outcomes,and improve the quality of life for elderly patients.
文摘Triptolide was given orally to adult male Sprague-Dawley rat sat a dosage of 75 μg/kg for 35 days.After 28 days of treatment,the result of mating tests showed that all the drug treated rats were infertile.At the end of drug treatment,the density of caudal spermatozoa and the weight of cpididymis were reduced significantly.All the spermatozoa were immobile.There was no detectable damage of spermatogenesis and epididymal epithelia in triptolide treated rats under microscopical examination.However,modcrate and severe damage of spermatozoa were seen in the corpus and caudal epididymis.The content of cytosolic and nuclear dihydrotestosterone (DHT) receptors in the caput and caudal epididymides was increased but insignificantly as compared with that of the controls.However, the content of DHT receptor in the cytosal of the ventral prostate was elevated very,significantly (P< 0.01).This result suggests that one of the sitcs of action of triptolide might be the epididymis.
文摘This review provides an overview of the literature on aspects of reproductive endocrinology wherein Asian menmay differ from Caucasian, notably, prostatic nioplasm and the sensivity to pharmacological regimens of male contra-ception. Both genetic and environmental factors, such as nutrition, might be relevant. Asian men residing in Asia seemto be relatively protected from clinical prostatic nioplasm while the prevalence of preclinical prostatic nioplasm is notdifferent. Migration to an area with a higher prevalence reduces this difference but does not undo it. With regard toprostatic nioplasm the following factors have been considered as relevant in Asian men: 1) a reduction in 5α-reductaselevel, 2) decreased levels of androgenic ketosteroid precursors of 5α-reduced androgen metabolites, 3) the decreasedpresence of a P53 mutation, 4) a higher CAG-repeat length of the androgen receptor, 5) a possible higher level ofphysical activity, 6) differences in sexual activity. Furthermore, Asian men respond to a higher degree with azoosper-mia in response to contraceptive steroids. Possible explanations offered for the more pronounced response to contracep-tive steroids are: 1) differences in testicular structure and decreased spermatogenic potential, 2) an earlier and moremarked suppression in LH secretion by exogenous androgens. The differences may be due to genetical and/or environ-mental factors influencing the peripheral testosterone metabolism. Dietary factors such as the higher intake of phytoe-strogens in Asians might exert effects on 5α-reductase activity and/or on sex hormone binding globulin (SHBG) levels,thus having an impact on the biological efficay of circulating androgens. ( Asian J Androl 2000; 2: 13 - 20)
文摘Objectives:To explore the clinical value of applying diabetes health education to endocrinology care.Methods:A total of 122 patients with diabetes admitted to our department from October 2016 to October 2017 were selected.After consulting patients,they were randomly divided into two groups,with 61 cases in each group.The control group performs routine care,and the experimental group provides patients with diabetes-specific health education.After three months,the compliance of the two groups of patients was compared.The ADL scores of the two groups of patients before and after treatment were compared.Results:Experimental group had significantly higher compliance rate than control group in all aspects.The difference was statistically significant(P<0.05).The ADL scores of both groups were significantly improved.The effects before and after the care were compared.The difference was statistically significant(P<0.05).The score of experimental group increased more significantly than that of the control group.The difference was statistically significant(P<0.05).Conclusions:In the endocrinology care,the implementation of diabetes special health education for patients can improve patient compliance and improve patients'daily living ability,which is an ideal nursing measure.It is worth promoting.
文摘This pilot study evaluated effectiveness and acceptance of a new hospital-based reproductive endocrinology curriculum among Iranian medical students. A voluntary, anonymous questionnaire was used to compare two teaching methods as applied to junior medical students at Tehran University of Medical Sciences. Students were randomly assigned to one of two clinical teaching settings;no student experienced both modules. Coursework for the pilot (experimental) group (n = 19) utilized a teaching approach comprising lectures, genetics laboratory, pelvic ultrasound, small group sessions, and opportunities to observe advanced reproductive technologies such as in vitro fertilization, ICSI, and embryo transfer. A control group (n = 34) received reproductive endocrinology instruction by the ‘traditional curriculum’, consisting mainly of lectures. Students were sampled at baseline and again atthe conclusion of their reproductive endocrinology session. Pre- and post-test data were analyzed for both groups;post-test differences between groups were also compared. No significant differences in mean age or gender mix were identified between the two study groups. Overall, the ques- tionnaire did not identify any significant intergroup differences for any parameter investigated. Although student acceptance rate appeared similar for both educational modules, the ratio of students having a “favorable regard” for reproductive medicine declined only among students randomized to the control group (41.2% vs. 32.3%). This report offers the first data on teaching reproductive endocrinology to medical students in Iran. Both traditional and innovative approaches to teaching reproductive endocrinology were well-accepted by students, although negative post-test responses were more common among students in the control group. While periodic quality assessments for existing clinical teaching methods are necessary, introduction of alternative teaching approaches is also important. Additional studies are planned to evaluate the impact this initiative may have on results on standardized tests measuring reproductive endocrinology knowledge, as well as election of further specialization in training.
文摘Introduction: Large clinical trials demonstrate that glycemic, blood pressure, and cholesterol control lead to risk reduction in cardiovascular events. We determined whether A1c, blood pressure, and cholesterol control were associated with incident cardiovascular disease [CVD] in a community-based endocrinology practice over 10 years. Methods: 385 consecutive patients seen for diabetes management in a CBEP comprised the analysis cohort. To be included, a patient had ≥2 A1c, blood pressure, and LDLc measurements respectively without prevalent CVD. All patients were 18 years or older with a diagnosis of diabetes before or during calendar year 2000. Results: 17.6% of patients developed incident CVD over 10 years. After controlling for age, gender, and time, patients who improved their A1c
文摘Objective:To analyze the clinical characters of 812 inpatients with infection in the Department of Endocrinology.Methods:Retrospective exhibition of these patients'clinical characters included undergoing diseases,infectious organs,history illness,blood glucose and glycosylated hemoglobin(HbA1C),biochemical indicators,pathogens training description and results,medical imagines,antibiotic utilization,length of stay and hospital costs,final diagnosis and situations.Results:Non-diabetic patients accounted for 176(21.67%),who were the cases of untreated well hyperthyroidism,mainly suffered with respiratory tract infection.Diabetic patients accounted for 636(78.33%).In the type2 diabetes patients 376(59.12)suffered with urinary tract infection.192(30.19%)suffered with respiratory system infection,124(19.50%)were accompanied with diabetic foot infection,which had 74(59.67%)patients with HbA1C>9.0%.Statistical comparisons showed that the days of antibiotic use and average length of stay in hospital per capita in patients with HbA1C≥8%were more than ones with HbA1C<8%in those with diabetic infections(P<0.01).The days of antibiotic use per capita in patients with HbA1C>9%were more than ones with HbA1C<7%in those with diabetic foot infections(P<0.01).Conclusion:Endocrine diseases lack rigid and effective long-term control,which may result in the complications involved with urinary tract,respiratory tract and infections in other organs.The time of hospitalization per capita and the duration of antibiotic use rise are longer in diabetic patients with poor blood sugar control and diabetic foot infection.
文摘Practical guide:Glucagon-like peptide-1 and dual glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonists in diabetes mellitus common second-line choice after metformin for treating T2DM.Various considerations can make selecting and switching between different GLP-1 RAs challenging.Our study aims to provide a comprehensive guide for the usage of GLP-1 RAs and dual GIP and GLP-1 RAs for the management of T2DM.
文摘Objective:To investigate the influence of season on live birth and clinical pregnancy rates,as well as assisted reproductive technology(ART)outcomes,in the Hainan region.Methods:Patients were categorized into four groups based on the dates of artificial insemination and transplantation:spring,summer,autumn,or winter.The main outcome measures were clinical pregnancy rates and live birth rates.Secondary outcomes included body mass index(BMI),oocyte number,two pronuclei(2PN)cleavage rate,total gonadotropin(Gn)dosage and days,age,2PN fertilization rate,sperm concentration,sperm PR rate,anti-Müllerian hormone(AMH),and endometrial thickness.Outpatient semen quality indicators included sperm PR rate,total sperm count,sperm concentration,and total sperm motility.Results:This retrospective cohort study analyzed 2,016 artificial insemination cycles and 1,783 ovarian retrieval cycles from January 2017 to October 2022,and assessed the semen quality of 6,651 outpatients from May 2017 to October 2022.In artificial insemination cycles,sperm PR rate and clinical pregnancy rate were highest in winter,with a statistically significant difference between groups(P<0.05).Clinical pregnancy rate was influenced by both age and sperm PR rate(P<0.05).In ovarian retrieval cycles,the winter group had significantly higher clinical pregnancy,2PN fertilization,and 2PN cleavage rates than the other groups.The autumn group had higher live birth rates,though not significantly different.Additionally,winter months showed higher total sperm concentration and total sperm number compared to other seasons.Conclusion:Seasonality affected clinical pregnancy and live birth rates in artificial insemination cycles but not in ovarian retrieval cycles in the Hainan region.These findings suggest that while there is no need to choose a specific season for ovarian retrieval cycles,artificial insemination in winter may be preferable for patients.
文摘The human endocrine system normally functions in abalanced physiological state. Any excess or deficiencywill cause an endocrine imbalance and result in hyper-orhypo-function, requiring readjustment by hormonesuppression or supplementation in order to reestablish anormal physiological balance.
文摘Female reproductive endocrinology plays an important role in obstetrics and gynecology, and is a component part of perinatology, family planning and geriatrics. It is closely linked with the physiological changes, disease conditions and health care in different reproductive stages of a woman’s life. Ovarian function consists of ovulation and hormonal secretion, which acts upon the uterine endometrium and other target organs and feeds back to the hypothalamus-pituitary unit. Thus, it is connected with other endocrine systems, cerebral cortex and the external environment. Whether the ovrian function is normal or not reflects itself clinically in the changes of menstrual cycle and reproductive status and may be evaluated by laboratory assays.
文摘Sargassum species is a group of big marine algae.It can be seen around the world and the coastal people have used it as food for years.The use of Sargassum spp.in medicine is very interesting.In this short article,the authors summarize and discuss on Sargassum spp.and its usefulness in endocrinology.
文摘6.1 Diabetes mellitus 2007165 Evaluation of the first-phase insulin release and insulin sensitivity in patients with newly-diagnosed type 2 diabetes. JIA Weiping(贾伟平), et al. Dept Endocrinol & Metab, 6th People′s Hosp, Shanghai Jiaotong Univ, Shanghai 200233. Chin J Endocrinol Metab 2007;23(2):100-103. Objective To evaluate the first-phase insulin release and insulin sensitivity in patients with newly-diagnosed type 2 diabetes. Methods A total of 332 patients with newly-diagnosed type 2 diabetes were classified into two groups of normal or abnormal islet function according to arginine stimulation test, and their results were evaluated. Results(1)Body weight, body mass index (BMI), waist circumference, hip circumference, femoral circumference, fasting serum true insulin and triglyceride in normal islet function group were significantly higher than those in abnormal group (all P【0.01). (2) After adjusting gender, age, BMI and waist to hip ratio, increment of true insulin (△TI) and insulin resistant index (HOMA-IR) in normal group were significantly higher than those in abnormal group (both P【0.01). (3)The proportion of patients of normal insulin releasing function with insulin resistance, patients of normal insulin releasing function without insulin resistance, patients of impaired insulin releasing function with insulin resistance and patients of impaired insulin releasing function without insulin resistance were 35.11%, 5.02%, 29.78% and 30.09%, respectively. Conclusion The patients with type 2 diabetes could be divided into three categories being simple islet function abnormality, simple insulin resistance and islet function abnormality combined with insulin resistance. Both diagnosis and therapy project should be based on such pathophysiological assessment.
文摘5.1 Diabetes Mellitus2007025 Phenotype-based glomerular gene expression profiling of patients with diabetic nephropathy. CHEN Shan(陈姗),et al, Res Instit Nephrol, Jinling Hosp, Nanjing Univ Sch Med, Nanjing 210002. Chin J Nephrol 2006;22(9):528-533. Objective To get more insight into progression of diabetic nephropathy (DN) and select individual genes associated with the progression of the disease.
