In the work of developing extrinsic fabry perot interferometric (EFPI), the key technology of polishing fiber optic endfaces and coating the multilayer of dielectric films on them is raised and resolved to settle the...In the work of developing extrinsic fabry perot interferometric (EFPI), the key technology of polishing fiber optic endfaces and coating the multilayer of dielectric films on them is raised and resolved to settle the disturbance and stability problem of EFPI, which simplifies the sensing system, improves the sensor performance and reduces the cost. In this paper, the relations between the output interferential light intensity and the F P cavity length are calculated based on the theory of mode field coupling. The EFPI fiber optic sensor is adhered to a distributed smart laminate beam to detect vibration frequency and axial strain value, the results coincident with the results tested by PZT.展开更多
AIM: To explore the feasibility of enhancing apoptosis-inducing effects of chemotherapeutic drugs on human gastric cancer cells by stable transfection of extrinsic Smac gene. METHODS: After Smac gene was transferred i...AIM: To explore the feasibility of enhancing apoptosis-inducing effects of chemotherapeutic drugs on human gastric cancer cells by stable transfection of extrinsic Smac gene. METHODS: After Smac gene was transferred into gastric cancer cell line MKN-45, subclone cells were obtained by persistent G_(418) selection. Cellular Smac gene expression was determined by RT-PCR and Western blotting. After treatment with mitomycin (MMC) as an apoptotic inducer, in vitro cell growth activities were investigated by trypan blue-staining method and MTT colorimetry. Cell apoptosis and its rates were determined by electronic microscopy, annexin V-FTTC and propidium iodide staining flow cytometry. Cellular caspase-3 protein expression and its activities were assayed by Western blotting and colorimetry. RESULTS: When compared with MKN-45 cells, the selected subclone cell line MKN-45/Smac had significantly higher Smac mRNA (3.12±0.21 vs 0.82±0.14, t=7.52, P＜0.01) and protein levels (4.02±0.24 vs0.98±0.11, t=8.32, P＜0.01). After treatment with 10 μg/mL MMC for 6-24 h, growth inhibition rate of MKN-45/Smac (15.8±1.2-54.8±2.9%) was significantly higher than that of MKN-45 (5.8±0.4-24.0±1.5%, t=6.42, P＜0.01). Partial MKN-45/Smac cancer cells presented characteristic morphological changes of apoptosis under the electronic microscope with an apoptosis rate of 36.4±2.1%, which was significantly higher than that of MKN-45 (15.2±0.8%, t=9.25, P＜0.01). Compared with MKN-45, caspase-3 expression levels in MKN-45/Smac were improved significantly (3.39±0.42 vs0.96±0.14, t=8.63, P＜0.01), while its activities were 3.25 times as many as those of MKN-45 (0.364±0.010 vs0.112±0.007, t=6.34, P＜0.01). CONCLUSION: Stable transfection of extrinsic Smac gene and its over-expression in gastric cancer cell line can significantly enhance cellular caspase-3 expression and activities, ameliorate apoptosis-inducing effects of mitomycin C on cancer cells, which is a novel strategy to improve chemotherapeutic effects on gastric cancer.展开更多
Objective To assess the spectrum of causes, clinical features, differences between disease phases, and prognosis of extrinsic allergic alveolitis （EAA）. Methods Patients with EAA diagnosed at Peking Union Medical C...Objective To assess the spectrum of causes, clinical features, differences between disease phases, and prognosis of extrinsic allergic alveolitis （EAA）. Methods Patients with EAA diagnosed at Peking Union Medical College Hospital from August 1983 to May 2007 were analyzed retrospectively. Their medical records were examined to gather clinical, laboratorial, radiological, and histopathological data. Patients were divided to three phases （acute, subacute, and chronic） according to clinical presentations. Follow-up data regarding treatment response, subsequent radio- logical and pulmonary function studies, and clinical outcomes were collected. Results A total of 21 cases were enrolled. Among them, 11 were subacute, 10 were chronic. The most common exposure was pet birds （6 cases, 28.6%）. The primary abnormality of pulmonary function was restriction and/or reduction in diffusing capacity （12 cases, 63.2%）. The most common findings on high-resolution computed tomography （HRCT） were ground-glass opacities （13 cases, 68.4%） and centri- lobular nodules （8 cases, 42.1%）. Airway obstruction in pulmonary function test, emphysema, hmg cysts, and fibrosis on HRCT were more frequently seen in chronic than in subacute patients, though the differences were not statistically significant. Bronchoalveolar lavage fluid （BALF） showed lymphocytosis. The total＇cell count and the percentage of neutrophils were significantly higher in subacute than in chronic patients （P〈0.05）. Nonnecrotizing granulomas were seen in 8 （47.1%） cases. Improvement or normalization in symptoms, radiography, and pulmonary function test after treatment were seen in all 18 patients with avail- able follow-up data. Five patients recurred. Conclusions The characteristic abnormalities of pulmonary function, findings on HRCT, and pa- thology are essential for all phases of EAA, and the atypical manifestations such as obstruction and fibrosis can also be present frequently, particularly in chronic cases. Differential cell counts of BALF are related to the phase of the disease. The treatment response and prognosis of EAA are good.展开更多
The influence of aging temperature and time on fracture feature of monotonic tensile samples of alumi-num-Iithium alloy 2090+Ce was investigated.The effects and mechanisms of extrinsic strengthening during aging for t...The influence of aging temperature and time on fracture feature of monotonic tensile samples of alumi-num-Iithium alloy 2090+Ce was investigated.The effects and mechanisms of extrinsic strengthening during aging for this alloy with a flat unrecrystallized structure were discussed.The mechanisms were analysed from four aspects.The theory of extrinsic strengthening from the delamination strengthening was presented.The results in this research show that the strength and ductility of aluminum-lithium alloy with a flat unrecrystallized structure are superior to those with recrystallized structure.Several reasons have been advanced for the ductility improvement effect of flat uncrystallized structure,including wedging action between flat grain,action of short-transverse delamination on impeding the growth of main crack,action on the reduction in the detrimental influence of weak grain boundaries and action on impeding the intergranular fracture on main fracture surface.The strengthening effect of flat uncrystallized structure is attributed to the extrinsic strengthening derived from delamination strengthening.From underage to peakage,the fracture mode of this alloy is transgranular fracture plus short-transverse delamination.The tendency of short-transverse delamination in creases with aging,thereby enhancing the delamination strengtheniag effect.Under overaging condition,the fracture mode is predominately intersubgranular,which results in the loss of delamination strengthening.展开更多
Spinal cord injury（SCI）causes disturbances in motor and sensory functions leading to paralysis,the severity of which depends on the spinal level of the injury.Traumatic lesions of spinal cord axon projection tracts ...Spinal cord injury（SCI）causes disturbances in motor and sensory functions leading to paralysis,the severity of which depends on the spinal level of the injury.Traumatic lesions of spinal cord axon projection tracts are untreatable in human patients,although numerous research groupsworldwide are studying putative treatment strategies.展开更多
This paper shows that a substantial amount of dissipationless spin-Hall current contribution may exist in the extrinsic spin-Hall effect,which originates from the spin-orbit coupling induced by the applied external el...This paper shows that a substantial amount of dissipationless spin-Hall current contribution may exist in the extrinsic spin-Hall effect,which originates from the spin-orbit coupling induced by the applied external electric field itself that drives the extrinsic spin-Hall effect in a nonmagnetic semiconductor （or metal）.By assuming that the impurity density is in a moderate range such that the total scattering potential due to all randomly distributed impurities is a smooth function of the space coordinate,it is shown that this dissipationless contribution shall be of the same orders of magnitude as the usual extrinsic contribution from spin-orbit dependent impurity scatterings （or may even be larger than the latter one）.The theoretical results obtained are in good agreement with recent relevant experimental results.展开更多
The influence regular and mechanisms of rare earth element cerium and aged condition on the propertiesand fracture feature of monotonic tension for aluminum-lithium alloy 2090 were researched. The evident plasti-catio...The influence regular and mechanisms of rare earth element cerium and aged condition on the propertiesand fracture feature of monotonic tension for aluminum-lithium alloy 2090 were researched. The evident plasti-cation effect can be achieved by adding cerium into alloy 2090, and the aged condition has a significant influ-ence on this effect. The plastication effect of cerium at peckaging is strongest, and at underaging and overagingis weader. The mechanisms of strengthening and plastication of cerium for aluminum-lithium alloys were dis-cussed in the theory of the extrinac strengthening and the intrinsic toughening. According to the research results about fracture feature, first the theory of extrinsic strengthening was presented, and then the role of ceri-um on aluminum-lithium alloy 2090 was explored from the unite energy, the anti-phase baundary energy andthe electron bonds.展开更多
The limited axonal growth after central nervous system （CNS） injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank...The limited axonal growth after central nervous system （CNS） injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mech- anism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair.展开更多
The various competing contributions to the anomalous Hall effect in spin-polarized two-dimensional electron gases in the presence of both intrinsic, extrinsic and external electric-field induced spin-orbit coupling we...The various competing contributions to the anomalous Hall effect in spin-polarized two-dimensional electron gases in the presence of both intrinsic, extrinsic and external electric-field induced spin-orbit coupling were investigated theoretically. Based on a unified semiclassical theoretical approach, it is shown that the total anomalous Hall conductivity can be expressed as the sum of three distinct contributions in the presence of these competing spin-orbit interactions, namely an intrinsic contribution determined by the Berry curvature in the momentum space, an extrinsic contribution determined by the modified Bloch band group velocity and an extrinsic contribution determined by spin-orbit-dependent impurity scattering. The characteristics of these competing contributions are discussed in detail in the paper.展开更多
AIM: To reveal the cytotoxicity and related mechanisms of gatifloxacin(GFX) to stromal fibroblasts(SFs) in vitro.METHODS: SFs were treated with GFX at different concentrations(0.009375%-0.3%), and their viability was ...AIM: To reveal the cytotoxicity and related mechanisms of gatifloxacin(GFX) to stromal fibroblasts(SFs) in vitro.METHODS: SFs were treated with GFX at different concentrations(0.009375%-0.3%), and their viability was detected by MTT method. The cell morphology was observed using light/transmission electron microscope. The plasma membrane permeability was measured by AO/EB double-staining. Then cell cycle, phosphatidylserine(PS) externalization, and mitochondrial transmembrane potential(MTP) were analyzed by flow cytometry. DNA damage was analyzed by electrophoresis and immunostaining. ELISA was used to evaluate the caspase-3/-8/-9 activation. Finally, Western blotting was applied for detecting the expressions of apoptosis-related proteins.RESULTS: Morphological changes and reduced viability of GFX-treated SFs demonstrated that GFX above 0.009375% had cytotoxicity to SFs with dependence of concentration and time. GFX-treating cells also showed G1 phase arrest, increased membrane permeability, PS externalization and DNA damage, which indicated that GFX induced apoptosis of SFs. Additionally, GFX could activate the caspase-8, caspase-9, and caspase-3, induce MTP disruption, downregulate B-cell leukemia-2(Bcl-2) and B-cell leukemiaXL(Bcl-XL), and upregulate Bcl-2 assaciated X protein(Bax), Bcl-2-associated death promoter(Bad), Bcl-2 interacting domain(Bid) and cytoplasmic cytochrome C in SFs, suggesting that caspase-dependent extrinsic and intrinsic pathways were related to GFX-contributed apoptosis of SFs.CONCLUSION: The cytotoxicity of GFX induces apoptosis of SFs through triggering the caspase-dependent extrinsic and intrinsic pathways.展开更多
This paper addresses the robust visual tracking of multi-feature points for a 3D manipulator with unknown intrinsic and extrinsic parameters of the vision system. This class of control systems are highly nonlinear con...This paper addresses the robust visual tracking of multi-feature points for a 3D manipulator with unknown intrinsic and extrinsic parameters of the vision system. This class of control systems are highly nonlinear control systems characterized as time-varying and strong coupling in states and unknown parameters. It is first pointed out that not only is the Jacobian image matrix nonsingular, but also its minimum singular value has a positive limit. This provides the foundation of kinematics and dynamics control of manipulators with visual feedback. Second, the Euler angle expressed rotation transformation is employed to estimate a subspace of the parameter space of the vision system. Based on the two results above, and arbitrarily chosen parameters in this subspace, the tracking controllers are proposed so that the image errors can be made as small as desired so long as the control gain is allowed to be large. The controller does not use visual velocity to achieve high and robust performance with low sampling rate of the vision system. The obtained results are proved by Lyapunov direct method. Experiments are included to demonstrate the effectiveness of the proposed controller.展开更多
With the widespread utilization of indium-phosphide-based high-electron-mobility transistors(InP HEMTs)in the millimeter-wave(mmW)band,the distributed and high-frequency parasitic coupling behavior of the device is pa...With the widespread utilization of indium-phosphide-based high-electron-mobility transistors(InP HEMTs)in the millimeter-wave(mmW)band,the distributed and high-frequency parasitic coupling behavior of the device is particularly prominent.We present an InP HEMT extrinsic parasitic equivalent circuit,in which the conductance between the device electrodes and a new gate-drain mutual inductance term L_(mgd)are taken into account for the high-frequency magnetic field coupling between device electrodes.Based on the suggested parasitic equivalent circuit,through HFSS and advanced design system(ADS)co-simulation,the equivalent circuit parameters are directly extracted in the multi-step system.The HFSS simulation prediction,measurement data,and modeled frequency response are compared with each other to verify the feasibility of the extraction method and the accuracy of the equivalent circuit.The proposed model demonstrates the distributed and radio-frequency behavior of the device and solves the problem that the equivalent circuit parameters of the conventional InP HEMTs device are limited by the device model and inaccurate at high frequencies when being extracted.展开更多
The extrinsic mechanism for anomalous Hall effect in ferromagnets is extended to include the contributions both from spin-orbit-dependent impurity scattering and from the spin-orbit coupling induced by external electr...The extrinsic mechanism for anomalous Hall effect in ferromagnets is extended to include the contributions both from spin-orbit-dependent impurity scattering and from the spin-orbit coupling induced by external electric fields. The results obtained suggest that, within the framework of the extrinsic mechanisms, the anomalous Hall current in a ferromagnet may also contain a substantial amount of dissipationless contribution independent of impurity scattering. After the contribution from the spin-orbit coupling induced by external electric fields is included, the total anomalous Hall conductivity is about two times larger than that due to soin-orbit dependent impurity scatterings.展开更多
Paraphrase is an expression of a text with alternative words and orders to achieve a better clarity. Paraphrases have been found vital for augmenting training dataset, which aid to enhance performance of machine learn...Paraphrase is an expression of a text with alternative words and orders to achieve a better clarity. Paraphrases have been found vital for augmenting training dataset, which aid to enhance performance of machine learning models that intended for various natural language processing (NLP) tasks. Thus, recently, automatic paraphrase generation has received increasing attention. However, evaluating quality of generated paraphrases is technically challenging. In the literature, the importance of generated paraphrases is tended to be determined by their impact on the performance of other NLP tasks. This kind of evaluation is referred as extrinsic evaluation, which requires high computational resources to train and test the models. So far, very little attention has been paid to the role of intrinsic evaluation in which quality of generated paraphrase is judged against predefined ground truth (reference paraphrases). In fact, it is also very challenging to find ideal and complete reference paraphrases. Therefore, in this study, we propose semantic or meaning oriented automatic evaluation metric that helps to evaluate quality of generated paraphrases against the original text, which is an intrinsic evaluation approach. Further, we evaluate quality of the paraphrases by assessing their impact on other NLP tasks, which is an extrinsic evaluation method. The goal is to explore the relationship between intrinsic and extrinsic evaluation methods. To ensure the effectiveness of proposed evaluation methods, extensive experiments are done on different publicly available datasets. The experimental results demonstrate that our proposed intrinsic and extrinsic evaluation strategies are promising. The results further reveal that there is a significant correlation between intrinsic and extrinsic evaluation approaches.展开更多
A new technique for turbo decoder is proposed by using a local subsidiary maximum likelihood decoding and a probability distributions family for the extrinsic information. The optimal distribution of the extrinsic inf...A new technique for turbo decoder is proposed by using a local subsidiary maximum likelihood decoding and a probability distributions family for the extrinsic information. The optimal distribution of the extrinsic information is dynamically specified for each component decoder.The simulation results show that the iterative decoder with the new technique outperforms that of the decoder with the traditional Gaussian approach for the extrinsic information under the same conditions.展开更多
Spinal cord injury（SCI）is a traumatic event that can lead to permanent motor and sensory deficits.After the initial trauma,axons of surviving neurons rapidly retract.While there may be a small degree of abortive spr...Spinal cord injury（SCI）is a traumatic event that can lead to permanent motor and sensory deficits.After the initial trauma,axons of surviving neurons rapidly retract.While there may be a small degree of abortive sprouting,virtually all attempts at robust regrowth across the lesion site ultimately fail.Thus,neurons below the level of the injury are permanently disconnected from their normal input,resulting in persistent loss of function.展开更多
Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person i...Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person is a hierarchy of five needs： physiological needs, safety needs, social needs, esteem needs, and self-actualization needs Organizations must be able to identify what employees desire to secure optimum performance and to meet the needs of both employees and employers. This research focuses on the generational gap and the significance of intrinsic and extrinsic rewards in the workforce. The purpose and objective of this research are to test the significance of monetary versus non-monetary rewards among the different generations in the organization. A self-designed questionnaire distributed to a multi-generational group of employees of selected organizations was used to collect the analyzed data. Sixty-five （65%） responses were obtained. Secondary data were used to elucidate the needs in this area of study. Because the workforce is predicted to become more diverse in terms of age, organizations will be unlikely to implement one set of rewards for the multiple generations. This is due to the differing expectations and requirements among the generations. However, the results indicate no significant difference in monetary versus non-monetary rewards among the different generations in the workforce.展开更多
What is motivation? What is extrinsic motivation? What are thefactors affecting extrinsic motivation? Does extrinsic motivation haveanything to do with teachers’teaching and students’learning?Motivation is something...What is motivation? What is extrinsic motivation? What are thefactors affecting extrinsic motivation? Does extrinsic motivation haveanything to do with teachers’teaching and students’learning?Motivation is something that can raise one’s strong reason to dothings,or to arouse the desire to learn and the desire to please.It canbe subdivided into intrinsic and extrinsic motivation.Intrinsic motivation,generally speaking,is concerned with biogenic,complex inherited展开更多
As a new type of inorganic ductile semiconductor,silver sulfide(α-Ag_(2)S)has garnered a plethora of interests in recent years due to its promising applications in flexible electronics.However,the lack of detailed de...As a new type of inorganic ductile semiconductor,silver sulfide(α-Ag_(2)S)has garnered a plethora of interests in recent years due to its promising applications in flexible electronics.However,the lack of detailed defect calculations and chemical intuition has largely hindered the optimization of material's performance.In this study,we systematically investigate the defect chemistry of extrinsic doping inα-Ag_(2)S using first-principles calculations.We computationally examine a broad suite of 17 dopants and find that all aliovalent elements have extremely low doping limits(<0.002%)in α-Ag_(2)S,rendering them ineffective in tuning the electron concentrations.In contrast,the isovalent elements Se and Te have relatively high doping limits,being consistent with the experimental observations.While the dopant Se or Te itself does not provide additional electrons,its introduction has a significant impact on the band gap,the band-edge position,and especially the formation energy of Ag interstitials,which effectively improve the electron concentrations by 2–3 orders of magnitudes.The size effects of Se and Te doping are responsible for the more favorable Ag interstitials in Ag_(2)S_(0.875)Se_(0.125) and Ag_(2)S_(0.875)Te_(0.125) with respect to pristine Ag2S.This work serves as a theoretical foundation for the rational design of Ag_(2)S-based functional materials.展开更多
In this paper, we study the blow-up analysis of extrinsic biharmonic maps from a general Riemannian4-manifold into a compact Riemannian manifold. We prove that the energy identity and the no neck property hold with th...In this paper, we study the blow-up analysis of extrinsic biharmonic maps from a general Riemannian4-manifold into a compact Riemannian manifold. We prove that the energy identity and the no neck property hold with the aid of a Pohozaev identity over general Riemannian manifolds.展开更多
文摘In the work of developing extrinsic fabry perot interferometric (EFPI), the key technology of polishing fiber optic endfaces and coating the multilayer of dielectric films on them is raised and resolved to settle the disturbance and stability problem of EFPI, which simplifies the sensing system, improves the sensor performance and reduces the cost. In this paper, the relations between the output interferential light intensity and the F P cavity length are calculated based on the theory of mode field coupling. The EFPI fiber optic sensor is adhered to a distributed smart laminate beam to detect vibration frequency and axial strain value, the results coincident with the results tested by PZT.
文摘AIM: To explore the feasibility of enhancing apoptosis-inducing effects of chemotherapeutic drugs on human gastric cancer cells by stable transfection of extrinsic Smac gene. METHODS: After Smac gene was transferred into gastric cancer cell line MKN-45, subclone cells were obtained by persistent G_(418) selection. Cellular Smac gene expression was determined by RT-PCR and Western blotting. After treatment with mitomycin (MMC) as an apoptotic inducer, in vitro cell growth activities were investigated by trypan blue-staining method and MTT colorimetry. Cell apoptosis and its rates were determined by electronic microscopy, annexin V-FTTC and propidium iodide staining flow cytometry. Cellular caspase-3 protein expression and its activities were assayed by Western blotting and colorimetry. RESULTS: When compared with MKN-45 cells, the selected subclone cell line MKN-45/Smac had significantly higher Smac mRNA (3.12±0.21 vs 0.82±0.14, t=7.52, P＜0.01) and protein levels (4.02±0.24 vs0.98±0.11, t=8.32, P＜0.01). After treatment with 10 μg/mL MMC for 6-24 h, growth inhibition rate of MKN-45/Smac (15.8±1.2-54.8±2.9%) was significantly higher than that of MKN-45 (5.8±0.4-24.0±1.5%, t=6.42, P＜0.01). Partial MKN-45/Smac cancer cells presented characteristic morphological changes of apoptosis under the electronic microscope with an apoptosis rate of 36.4±2.1%, which was significantly higher than that of MKN-45 (15.2±0.8%, t=9.25, P＜0.01). Compared with MKN-45, caspase-3 expression levels in MKN-45/Smac were improved significantly (3.39±0.42 vs0.96±0.14, t=8.63, P＜0.01), while its activities were 3.25 times as many as those of MKN-45 (0.364±0.010 vs0.112±0.007, t=6.34, P＜0.01). CONCLUSION: Stable transfection of extrinsic Smac gene and its over-expression in gastric cancer cell line can significantly enhance cellular caspase-3 expression and activities, ameliorate apoptosis-inducing effects of mitomycin C on cancer cells, which is a novel strategy to improve chemotherapeutic effects on gastric cancer.
文摘Objective To assess the spectrum of causes, clinical features, differences between disease phases, and prognosis of extrinsic allergic alveolitis （EAA）. Methods Patients with EAA diagnosed at Peking Union Medical College Hospital from August 1983 to May 2007 were analyzed retrospectively. Their medical records were examined to gather clinical, laboratorial, radiological, and histopathological data. Patients were divided to three phases （acute, subacute, and chronic） according to clinical presentations. Follow-up data regarding treatment response, subsequent radio- logical and pulmonary function studies, and clinical outcomes were collected. Results A total of 21 cases were enrolled. Among them, 11 were subacute, 10 were chronic. The most common exposure was pet birds （6 cases, 28.6%）. The primary abnormality of pulmonary function was restriction and/or reduction in diffusing capacity （12 cases, 63.2%）. The most common findings on high-resolution computed tomography （HRCT） were ground-glass opacities （13 cases, 68.4%） and centri- lobular nodules （8 cases, 42.1%）. Airway obstruction in pulmonary function test, emphysema, hmg cysts, and fibrosis on HRCT were more frequently seen in chronic than in subacute patients, though the differences were not statistically significant. Bronchoalveolar lavage fluid （BALF） showed lymphocytosis. The total＇cell count and the percentage of neutrophils were significantly higher in subacute than in chronic patients （P〈0.05）. Nonnecrotizing granulomas were seen in 8 （47.1%） cases. Improvement or normalization in symptoms, radiography, and pulmonary function test after treatment were seen in all 18 patients with avail- able follow-up data. Five patients recurred. Conclusions The characteristic abnormalities of pulmonary function, findings on HRCT, and pa- thology are essential for all phases of EAA, and the atypical manifestations such as obstruction and fibrosis can also be present frequently, particularly in chronic cases. Differential cell counts of BALF are related to the phase of the disease. The treatment response and prognosis of EAA are good.
文摘The influence of aging temperature and time on fracture feature of monotonic tensile samples of alumi-num-Iithium alloy 2090+Ce was investigated.The effects and mechanisms of extrinsic strengthening during aging for this alloy with a flat unrecrystallized structure were discussed.The mechanisms were analysed from four aspects.The theory of extrinsic strengthening from the delamination strengthening was presented.The results in this research show that the strength and ductility of aluminum-lithium alloy with a flat unrecrystallized structure are superior to those with recrystallized structure.Several reasons have been advanced for the ductility improvement effect of flat uncrystallized structure,including wedging action between flat grain,action of short-transverse delamination on impeding the growth of main crack,action on the reduction in the detrimental influence of weak grain boundaries and action on impeding the intergranular fracture on main fracture surface.The strengthening effect of flat uncrystallized structure is attributed to the extrinsic strengthening derived from delamination strengthening.From underage to peakage,the fracture mode of this alloy is transgranular fracture plus short-transverse delamination.The tendency of short-transverse delamination in creases with aging,thereby enhancing the delamination strengtheniag effect.Under overaging condition,the fracture mode is predominately intersubgranular,which results in the loss of delamination strengthening.
文摘Spinal cord injury（SCI）causes disturbances in motor and sensory functions leading to paralysis,the severity of which depends on the spinal level of the injury.Traumatic lesions of spinal cord axon projection tracts are untreatable in human patients,although numerous research groupsworldwide are studying putative treatment strategies.
基金Project supported by the National Natural Science Foundation of China (Grant No 10874049)the State Key Program for Basic Research of China (Grant No 2007CB925204)the Natural Science Foundation of Guangdong Province of China (Grant No07005834)
文摘This paper shows that a substantial amount of dissipationless spin-Hall current contribution may exist in the extrinsic spin-Hall effect,which originates from the spin-orbit coupling induced by the applied external electric field itself that drives the extrinsic spin-Hall effect in a nonmagnetic semiconductor （or metal）.By assuming that the impurity density is in a moderate range such that the total scattering potential due to all randomly distributed impurities is a smooth function of the space coordinate,it is shown that this dissipationless contribution shall be of the same orders of magnitude as the usual extrinsic contribution from spin-orbit dependent impurity scatterings （or may even be larger than the latter one）.The theoretical results obtained are in good agreement with recent relevant experimental results.
文摘The influence regular and mechanisms of rare earth element cerium and aged condition on the propertiesand fracture feature of monotonic tension for aluminum-lithium alloy 2090 were researched. The evident plasti-cation effect can be achieved by adding cerium into alloy 2090, and the aged condition has a significant influ-ence on this effect. The plastication effect of cerium at peckaging is strongest, and at underaging and overagingis weader. The mechanisms of strengthening and plastication of cerium for aluminum-lithium alloys were dis-cussed in the theory of the extrinac strengthening and the intrinsic toughening. According to the research results about fracture feature, first the theory of extrinsic strengthening was presented, and then the role of ceri-um on aluminum-lithium alloy 2090 was explored from the unite energy, the anti-phase baundary energy andthe electron bonds.
基金supported by grants from NIH/ NINDS (R01NS054734)the California Institute for Regenerative Medicinethe Craig H. Neilsen Foundation and Wings for Life Spinal Cord Research Foundation
文摘The limited axonal growth after central nervous system （CNS） injury such as spinal cord injury presents a major challenge in promoting repair and recovery. The literature in axonal repair has focused mostly on frank regeneration of injured axons. Here, we argue that sprouting of uninjured axons, an innate repair mech- anism of the CNS, might be more amenable to modulation in order to promote functional repair. Extrinsic inhibitors of axonal growth modulate axon sprouting after injury and may serve as the first group of therapeutic targets to promote functional repair.
基金supported by the National Natural Science Foundation of China (Grant No.10874049)
文摘The various competing contributions to the anomalous Hall effect in spin-polarized two-dimensional electron gases in the presence of both intrinsic, extrinsic and external electric-field induced spin-orbit coupling were investigated theoretically. Based on a unified semiclassical theoretical approach, it is shown that the total anomalous Hall conductivity can be expressed as the sum of three distinct contributions in the presence of these competing spin-orbit interactions, namely an intrinsic contribution determined by the Berry curvature in the momentum space, an extrinsic contribution determined by the modified Bloch band group velocity and an extrinsic contribution determined by spin-orbit-dependent impurity scattering. The characteristics of these competing contributions are discussed in detail in the paper.
基金Supported by the National High Technology R&D Program of China(No.2006AA02A132)
文摘AIM: To reveal the cytotoxicity and related mechanisms of gatifloxacin(GFX) to stromal fibroblasts(SFs) in vitro.METHODS: SFs were treated with GFX at different concentrations(0.009375%-0.3%), and their viability was detected by MTT method. The cell morphology was observed using light/transmission electron microscope. The plasma membrane permeability was measured by AO/EB double-staining. Then cell cycle, phosphatidylserine(PS) externalization, and mitochondrial transmembrane potential(MTP) were analyzed by flow cytometry. DNA damage was analyzed by electrophoresis and immunostaining. ELISA was used to evaluate the caspase-3/-8/-9 activation. Finally, Western blotting was applied for detecting the expressions of apoptosis-related proteins.RESULTS: Morphological changes and reduced viability of GFX-treated SFs demonstrated that GFX above 0.009375% had cytotoxicity to SFs with dependence of concentration and time. GFX-treating cells also showed G1 phase arrest, increased membrane permeability, PS externalization and DNA damage, which indicated that GFX induced apoptosis of SFs. Additionally, GFX could activate the caspase-8, caspase-9, and caspase-3, induce MTP disruption, downregulate B-cell leukemia-2(Bcl-2) and B-cell leukemiaXL(Bcl-XL), and upregulate Bcl-2 assaciated X protein(Bax), Bcl-2-associated death promoter(Bad), Bcl-2 interacting domain(Bid) and cytoplasmic cytochrome C in SFs, suggesting that caspase-dependent extrinsic and intrinsic pathways were related to GFX-contributed apoptosis of SFs.CONCLUSION: The cytotoxicity of GFX induces apoptosis of SFs through triggering the caspase-dependent extrinsic and intrinsic pathways.
基金This work was supported by The National Science Foundation(No.60474009),Shu Guang Program(No.05SG48)Scientific Programm ofShanghai Education Committee(No.07zz90).
文摘This paper addresses the robust visual tracking of multi-feature points for a 3D manipulator with unknown intrinsic and extrinsic parameters of the vision system. This class of control systems are highly nonlinear control systems characterized as time-varying and strong coupling in states and unknown parameters. It is first pointed out that not only is the Jacobian image matrix nonsingular, but also its minimum singular value has a positive limit. This provides the foundation of kinematics and dynamics control of manipulators with visual feedback. Second, the Euler angle expressed rotation transformation is employed to estimate a subspace of the parameter space of the vision system. Based on the two results above, and arbitrarily chosen parameters in this subspace, the tracking controllers are proposed so that the image errors can be made as small as desired so long as the control gain is allowed to be large. The controller does not use visual velocity to achieve high and robust performance with low sampling rate of the vision system. The obtained results are proved by Lyapunov direct method. Experiments are included to demonstrate the effectiveness of the proposed controller.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.61434006 and 61704189)the Fund from the Youth Innovation Promotion Association of the Chinese Academy of Sciences。
文摘With the widespread utilization of indium-phosphide-based high-electron-mobility transistors(InP HEMTs)in the millimeter-wave(mmW)band,the distributed and high-frequency parasitic coupling behavior of the device is particularly prominent.We present an InP HEMT extrinsic parasitic equivalent circuit,in which the conductance between the device electrodes and a new gate-drain mutual inductance term L_(mgd)are taken into account for the high-frequency magnetic field coupling between device electrodes.Based on the suggested parasitic equivalent circuit,through HFSS and advanced design system(ADS)co-simulation,the equivalent circuit parameters are directly extracted in the multi-step system.The HFSS simulation prediction,measurement data,and modeled frequency response are compared with each other to verify the feasibility of the extraction method and the accuracy of the equivalent circuit.The proposed model demonstrates the distributed and radio-frequency behavior of the device and solves the problem that the equivalent circuit parameters of the conventional InP HEMTs device are limited by the device model and inaccurate at high frequencies when being extracted.
基金Supported by the National Natural Science Foundation of China under Grant No.10874049the State Key Program for Basic Research of China under Grant No.2007CB925204the Natural Science Foundation of Guangdong Province under Grant No.07005834
文摘The extrinsic mechanism for anomalous Hall effect in ferromagnets is extended to include the contributions both from spin-orbit-dependent impurity scattering and from the spin-orbit coupling induced by external electric fields. The results obtained suggest that, within the framework of the extrinsic mechanisms, the anomalous Hall current in a ferromagnet may also contain a substantial amount of dissipationless contribution independent of impurity scattering. After the contribution from the spin-orbit coupling induced by external electric fields is included, the total anomalous Hall conductivity is about two times larger than that due to soin-orbit dependent impurity scatterings.
文摘Paraphrase is an expression of a text with alternative words and orders to achieve a better clarity. Paraphrases have been found vital for augmenting training dataset, which aid to enhance performance of machine learning models that intended for various natural language processing (NLP) tasks. Thus, recently, automatic paraphrase generation has received increasing attention. However, evaluating quality of generated paraphrases is technically challenging. In the literature, the importance of generated paraphrases is tended to be determined by their impact on the performance of other NLP tasks. This kind of evaluation is referred as extrinsic evaluation, which requires high computational resources to train and test the models. So far, very little attention has been paid to the role of intrinsic evaluation in which quality of generated paraphrase is judged against predefined ground truth (reference paraphrases). In fact, it is also very challenging to find ideal and complete reference paraphrases. Therefore, in this study, we propose semantic or meaning oriented automatic evaluation metric that helps to evaluate quality of generated paraphrases against the original text, which is an intrinsic evaluation approach. Further, we evaluate quality of the paraphrases by assessing their impact on other NLP tasks, which is an extrinsic evaluation method. The goal is to explore the relationship between intrinsic and extrinsic evaluation methods. To ensure the effectiveness of proposed evaluation methods, extensive experiments are done on different publicly available datasets. The experimental results demonstrate that our proposed intrinsic and extrinsic evaluation strategies are promising. The results further reveal that there is a significant correlation between intrinsic and extrinsic evaluation approaches.
基金Supported by the National Aeronautical Foundation of Science and Research of China (No.00F52048)
文摘A new technique for turbo decoder is proposed by using a local subsidiary maximum likelihood decoding and a probability distributions family for the extrinsic information. The optimal distribution of the extrinsic information is dynamically specified for each component decoder.The simulation results show that the iterative decoder with the new technique outperforms that of the decoder with the traditional Gaussian approach for the extrinsic information under the same conditions.
基金funded by NIH R01 NS085426(VJT)the Craig H.Neilsen Foundation(DW)
文摘Spinal cord injury（SCI）is a traumatic event that can lead to permanent motor and sensory deficits.After the initial trauma,axons of surviving neurons rapidly retract.While there may be a small degree of abortive sprouting,virtually all attempts at robust regrowth across the lesion site ultimately fail.Thus,neurons below the level of the injury are permanently disconnected from their normal input,resulting in persistent loss of function.
文摘Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person is a hierarchy of five needs： physiological needs, safety needs, social needs, esteem needs, and self-actualization needs Organizations must be able to identify what employees desire to secure optimum performance and to meet the needs of both employees and employers. This research focuses on the generational gap and the significance of intrinsic and extrinsic rewards in the workforce. The purpose and objective of this research are to test the significance of monetary versus non-monetary rewards among the different generations in the organization. A self-designed questionnaire distributed to a multi-generational group of employees of selected organizations was used to collect the analyzed data. Sixty-five （65%） responses were obtained. Secondary data were used to elucidate the needs in this area of study. Because the workforce is predicted to become more diverse in terms of age, organizations will be unlikely to implement one set of rewards for the multiple generations. This is due to the differing expectations and requirements among the generations. However, the results indicate no significant difference in monetary versus non-monetary rewards among the different generations in the workforce.
文摘What is motivation? What is extrinsic motivation? What are thefactors affecting extrinsic motivation? Does extrinsic motivation haveanything to do with teachers’teaching and students’learning?Motivation is something that can raise one’s strong reason to dothings,or to arouse the desire to learn and the desire to please.It canbe subdivided into intrinsic and extrinsic motivation.Intrinsic motivation,generally speaking,is concerned with biogenic,complex inherited
基金This work was supported by the National Natural Science Foundation of China(No.52372209 and 52232010)the Shanghai Pilot Program for Basic Research-Chinese Academy of Science,Shanghai Branch(JCYJ-SHFY-2022-002)。
文摘As a new type of inorganic ductile semiconductor,silver sulfide(α-Ag_(2)S)has garnered a plethora of interests in recent years due to its promising applications in flexible electronics.However,the lack of detailed defect calculations and chemical intuition has largely hindered the optimization of material's performance.In this study,we systematically investigate the defect chemistry of extrinsic doping inα-Ag_(2)S using first-principles calculations.We computationally examine a broad suite of 17 dopants and find that all aliovalent elements have extremely low doping limits(<0.002%)in α-Ag_(2)S,rendering them ineffective in tuning the electron concentrations.In contrast,the isovalent elements Se and Te have relatively high doping limits,being consistent with the experimental observations.While the dopant Se or Te itself does not provide additional electrons,its introduction has a significant impact on the band gap,the band-edge position,and especially the formation energy of Ag interstitials,which effectively improve the electron concentrations by 2–3 orders of magnitudes.The size effects of Se and Te doping are responsible for the more favorable Ag interstitials in Ag_(2)S_(0.875)Se_(0.125) and Ag_(2)S_(0.875)Te_(0.125) with respect to pristine Ag2S.This work serves as a theoretical foundation for the rational design of Ag_(2)S-based functional materials.
基金supported by Innovation Program of Shanghai Municipal Education Commission(Grant No.2021-01-07-00-02-E00087)National Natural Science Foundation of China(Grant No.12171314)。
文摘In this paper, we study the blow-up analysis of extrinsic biharmonic maps from a general Riemannian4-manifold into a compact Riemannian manifold. We prove that the energy identity and the no neck property hold with the aid of a Pohozaev identity over general Riemannian manifolds.
