BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not scr...BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not screened.Current practice guidelines include male gender as a predisposing factor for BE and EAC.The population-based clinical evidence regarding female gender remains limited.AIM To study comparative trends of gender disparities in patients with BE in the United States.METHODS A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)database.Patients with a primary or secondary diagnosis code of BE were identified.The major outcome of interest was determining the gender disparities in patients with BE.Trend analysis for respective outcomes for females was also reported to ascertain any time-based shifts.RESULTS We identified 1204190 patients with BE for the study period.Among the included patients,717439(59.6%)were men and 486751(40.4%)were women.The mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(H.pylori),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of H.pylori and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among women has steadily increased from 2009 to 2019.The existing knowledge concerning BE development has historically focused on men,but our findings show that the risk in women is not insignificant.展开更多
HFMD can be caused by a variety of enteroviruses,including Coxsackievirus A16 and enterovirus71.There are no effective therapeutic measures to cure HFMD at present.So,this study aimed to analyze the spatial relativity...HFMD can be caused by a variety of enteroviruses,including Coxsackievirus A16 and enterovirus71.There are no effective therapeutic measures to cure HFMD at present.So,this study aimed to analyze the spatial relativity and the local accumulation type based on the theory of spatial analysis and the spatial autocorrelation analysis module of ArcGIS and Geo Da.We found that there was a seasonal trend in HFMD.The lowest incidence appeared in February,and the peak of the reported incidence was occurred during the period from May to June.However,in most cases,another peak appeared from September to November.The trend of incidence was related to age,too.The overall trend of the reported incidence was a U-shape in north-south orientation and exposed an inverted U-shape in east-west.The correlation between the spatial distribution of HFMD was positive.Hunan,Guangxi and Guangdong were the hot areas,while the cold spots were Jilin,Inner Mongolia,Xinjiang,Gansu and Qinghai.展开更多
Objective： To analyze the epidemiological characteristics of sexually transmitted infections （STIs） in Guangzhou from 2000 to 2003, in order to provide scientific evidence for control and prevention efforts. Method...Objective： To analyze the epidemiological characteristics of sexually transmitted infections （STIs） in Guangzhou from 2000 to 2003, in order to provide scientific evidence for control and prevention efforts. Methods： STI reports and demographic data in Guangzhou from 2000 to 2003 were collected and analyzed using the National STD Computer Management Software. Results： The incidence rate of total STIs decreased.The incidence of syphilis, gonorrhea and condyloma acuminata decreased yearly from 41.71/100,000,70.13/100,000 and 83.02/100,000 in 2000 to 32.36/100,000,54.35/100,000 and 67.03/100,000 in 2003, respectively.The incidence of HIV/AIDS increased yearly.Nongonococcal urethritis （cervicitis） was the most prevalent STI. Conclusions： Incidence of STIs in Guangzhou is decreasing overall, but the incidence of HIV/AIDS is increasing and there is a change in the pattern of STI epidemics. Efforts should be made to keep the epidemic under control.展开更多
Coronary artery disease(CAD) occurring in less than 45 years of age is termed as young CAD.Recent studies show a prevalence of 1.2% of CAD cases in this age group.Ethnic wise south Asians especially Indians are more v...Coronary artery disease(CAD) occurring in less than 45 years of age is termed as young CAD.Recent studies show a prevalence of 1.2% of CAD cases in this age group.Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%.Conventional risk factors such as smoking,diabetes,hypertension,obesity and family history seems to be as important as in older CAD subjects.But the prevalence of these risk factors seems to vary in younger subjects.By far the most commonly associated risk factor is smoking in young CAD.Several genes associated with lipoprotein metabolism are now found to be associated with young CAD like cholesterol ester transfer protein(CETP) gene,hepatic lipase gene,lipoprotein lipase gene,apo A1 gene,apo E gene and apo B.Biomarkers such as lipoprotein(a),fibrinogen,D-dimer,serum Wnt,gamma glutamyl transferase,vitamin D2 and osteocalcin are seems to be associated with premature CAD in some newer studies.In general CAD in young has better prognosis than older subjects.In terms of prognosis two risk factors obesity and current smoking are associated with poorer outcomes.Angiographic studies shows predominance of single vessel disease in young CAD patients.Like CAD in older person primary and secondary prevention plays an important role in prevention of new and further coronary events.展开更多
Background:Antituberculosis-drug resistance is an important public health issue,and its epidemiological patterns has dramatically changed in recent decades.This study aimed to estimate the trends of multidrug-resistan...Background:Antituberculosis-drug resistance is an important public health issue,and its epidemiological patterns has dramatically changed in recent decades.This study aimed to estimate the trends of multidrug-resistant tuberculosis(MDR-TB),which can be used to inform health strategies.Methods:Data were collected from the Global Burden of Disease study 2017.The estimated annual percentage changes(EAPCs)were calculated to assess the trends of MDR-TB burden at global,regional,and national level from 1990 to 2017 using the linear regression model.展开更多
The suicide rate in Hong Kong has increased significantly over the past four decades.Population subgroups such as the elderly or economically-distressed are reported to be more vulnerable than others to suicidal behav...The suicide rate in Hong Kong has increased significantly over the past four decades.Population subgroups such as the elderly or economically-distressed are reported to be more vulnerable than others to suicidal behaviors,while changing suicide meth-ods(such as charcoal burning which emerged in 1998),has also contributed signifi-cantly to increasing suicide rates.However,the extent of the contribution of different factors to changes in suicide rate remains unclear.This paper reported on a decom-position analysis of the epidemiological profile of suicide in Hong Kong between 1976 and 2015,specifically considering factors underlying the increasing suicide rate over this period.Completed death registry information was available from the Census and Statistics Department of the Hong Kong SAR for this investigation.We compared absolute and relative contributions of gender,age and suicide method to rate changes over time.Changes in suicide rate were generally underpinned by more than one factor.Population aging in a rapidly-aging city contributed significantly to suicide rate increases,whilst jumping from a height had the greatest influence on rate changes throughout the study period.Suicides by male aged 25-34 years and 45-54 years were more likely to be triggered by economic factors,compared with the other gender-age subgroups.The decomposition approach provided a compre-hensive understanding about how socioeconomic factors and suicide methods inter-acted to influence over-time suicide patterns.This research supports development of more focused suicide prevention measures to reduce suicide rate.展开更多
文摘BACKGROUND Barrett's esophagus(BE)is a known premalignant precursor to esophageal adenocarcinoma(EAC).The prevalence rates continue to rise in the United States,but many patients who are at risk of EAC are not screened.Current practice guidelines include male gender as a predisposing factor for BE and EAC.The population-based clinical evidence regarding female gender remains limited.AIM To study comparative trends of gender disparities in patients with BE in the United States.METHODS A nationwide retrospective study was conducted using the 2009-2019 National Inpatient Sample(NIS)database.Patients with a primary or secondary diagnosis code of BE were identified.The major outcome of interest was determining the gender disparities in patients with BE.Trend analysis for respective outcomes for females was also reported to ascertain any time-based shifts.RESULTS We identified 1204190 patients with BE for the study period.Among the included patients,717439(59.6%)were men and 486751(40.4%)were women.The mean age was higher in women than in men(67.1±0.4 vs 66.6±0.3 years,P<0.001).The rate of BE per 100000 total NIS hospitalizations for males increased from 144.6 in 2009 to 213.4 in 2019(P<0.001).The rate for females increased from 96.8 in 2009 to 148.7 in 2019(P<0.001).There was a higher frequency of obesity among women compared to men(17.4%vs 12.6%,P<0.001).Obesity prevalence among females increased from 12.3%in 2009 to 21.9%in 2019(P<0.001).A lower prevalence of smoking was noted in women than in men(20.8%vs 35.7%,P<0.001).However,trend analysis showed an increasing prevalence of smoking among women,from 12.9%in 2009 to 30.7%in 2019(P<0.001).Additionally,there was a lower prevalence of alcohol abuse,Helicobacter pylori(H.pylori),and diabetes mellitus among females than males(P<0.001).Trend analysis showed an increasing prevalence of alcohol use disorder and a decreasing prevalence of H.pylori and diabetes mellitus among women(P<0.001).CONCLUSION The prevalence of BE among women has steadily increased from 2009 to 2019.The existing knowledge concerning BE development has historically focused on men,but our findings show that the risk in women is not insignificant.
基金the National Natural Social Science Found of China(Grant Nos.17AJY008)
文摘HFMD can be caused by a variety of enteroviruses,including Coxsackievirus A16 and enterovirus71.There are no effective therapeutic measures to cure HFMD at present.So,this study aimed to analyze the spatial relativity and the local accumulation type based on the theory of spatial analysis and the spatial autocorrelation analysis module of ArcGIS and Geo Da.We found that there was a seasonal trend in HFMD.The lowest incidence appeared in February,and the peak of the reported incidence was occurred during the period from May to June.However,in most cases,another peak appeared from September to November.The trend of incidence was related to age,too.The overall trend of the reported incidence was a U-shape in north-south orientation and exposed an inverted U-shape in east-west.The correlation between the spatial distribution of HFMD was positive.Hunan,Guangxi and Guangdong were the hot areas,while the cold spots were Jilin,Inner Mongolia,Xinjiang,Gansu and Qinghai.
文摘Objective： To analyze the epidemiological characteristics of sexually transmitted infections （STIs） in Guangzhou from 2000 to 2003, in order to provide scientific evidence for control and prevention efforts. Methods： STI reports and demographic data in Guangzhou from 2000 to 2003 were collected and analyzed using the National STD Computer Management Software. Results： The incidence rate of total STIs decreased.The incidence of syphilis, gonorrhea and condyloma acuminata decreased yearly from 41.71/100,000,70.13/100,000 and 83.02/100,000 in 2000 to 32.36/100,000,54.35/100,000 and 67.03/100,000 in 2003, respectively.The incidence of HIV/AIDS increased yearly.Nongonococcal urethritis （cervicitis） was the most prevalent STI. Conclusions： Incidence of STIs in Guangzhou is decreasing overall, but the incidence of HIV/AIDS is increasing and there is a change in the pattern of STI epidemics. Efforts should be made to keep the epidemic under control.
文摘Coronary artery disease(CAD) occurring in less than 45 years of age is termed as young CAD.Recent studies show a prevalence of 1.2% of CAD cases in this age group.Ethnic wise south Asians especially Indians are more vulnerable to have CAD in young age group with a prevalence of 5% to 10%.Conventional risk factors such as smoking,diabetes,hypertension,obesity and family history seems to be as important as in older CAD subjects.But the prevalence of these risk factors seems to vary in younger subjects.By far the most commonly associated risk factor is smoking in young CAD.Several genes associated with lipoprotein metabolism are now found to be associated with young CAD like cholesterol ester transfer protein(CETP) gene,hepatic lipase gene,lipoprotein lipase gene,apo A1 gene,apo E gene and apo B.Biomarkers such as lipoprotein(a),fibrinogen,D-dimer,serum Wnt,gamma glutamyl transferase,vitamin D2 and osteocalcin are seems to be associated with premature CAD in some newer studies.In general CAD in young has better prognosis than older subjects.In terms of prognosis two risk factors obesity and current smoking are associated with poorer outcomes.Angiographic studies shows predominance of single vessel disease in young CAD patients.Like CAD in older person primary and secondary prevention plays an important role in prevention of new and further coronary events.
文摘Background:Antituberculosis-drug resistance is an important public health issue,and its epidemiological patterns has dramatically changed in recent decades.This study aimed to estimate the trends of multidrug-resistant tuberculosis(MDR-TB),which can be used to inform health strategies.Methods:Data were collected from the Global Burden of Disease study 2017.The estimated annual percentage changes(EAPCs)were calculated to assess the trends of MDR-TB burden at global,regional,and national level from 1990 to 2017 using the linear regression model.
文摘The suicide rate in Hong Kong has increased significantly over the past four decades.Population subgroups such as the elderly or economically-distressed are reported to be more vulnerable than others to suicidal behaviors,while changing suicide meth-ods(such as charcoal burning which emerged in 1998),has also contributed signifi-cantly to increasing suicide rates.However,the extent of the contribution of different factors to changes in suicide rate remains unclear.This paper reported on a decom-position analysis of the epidemiological profile of suicide in Hong Kong between 1976 and 2015,specifically considering factors underlying the increasing suicide rate over this period.Completed death registry information was available from the Census and Statistics Department of the Hong Kong SAR for this investigation.We compared absolute and relative contributions of gender,age and suicide method to rate changes over time.Changes in suicide rate were generally underpinned by more than one factor.Population aging in a rapidly-aging city contributed significantly to suicide rate increases,whilst jumping from a height had the greatest influence on rate changes throughout the study period.Suicides by male aged 25-34 years and 45-54 years were more likely to be triggered by economic factors,compared with the other gender-age subgroups.The decomposition approach provided a compre-hensive understanding about how socioeconomic factors and suicide methods inter-acted to influence over-time suicide patterns.This research supports development of more focused suicide prevention measures to reduce suicide rate.
