The correlation between the expression of COX-2 and p53 protein in basal cell carcinoma (BCC) of eyelid and apoptosis was investigated. Specimens of BCC were collected from 40 cases (aged 28-68 y) at the Department of...The correlation between the expression of COX-2 and p53 protein in basal cell carcinoma (BCC) of eyelid and apoptosis was investigated. Specimens of BCC were collected from 40 cases (aged 28-68 y) at the Department of Pathology, Renmin Hospital of Wuhan University, and Depart-ment of Pathology, Zhongnan Hospital of Wuhan University during from 1999 to 2006. Five specimens of paracancerous tissues served as control group. Immunohistochemical staining was performed to detect the expression of COX-2 and p53 in the tissues. The average absorbance (A) and the average positive area rate of COX-2 and p53 protein were measured by image analysis. The positive area rate of COX-2 and p53 protein was analyzed by linear correlation analysis. It was found that COX-2 and p53 proteins were highly expressed in BCC of eyelid, and weakly expressed in paracancerous tissues. Image analysis revealed that the expression of COX-2 and p53 proteins in BCC of eyelid was significantly higher than that in paracancerous tissues (P<0.01). Spearman rank correlation analysis demonstrated a positive correlation between the expression of COX-2 and p53 (r=0.113, P=0.421). It was concluded that COX-2 can increase the expression of p53 protein, therefore suppressing apoptosis.展开更多
Purpose:Only one previous case of eyelid basal cell carcinoma arising in a facial port wine stain without previous local radiotherapy has been reported.We now report a second case.Methods:A 42-year-old female patient ...Purpose:Only one previous case of eyelid basal cell carcinoma arising in a facial port wine stain without previous local radiotherapy has been reported.We now report a second case.Methods:A 42-year-old female patient with eyelid basal cell carcinoma developing within a facial port wine stain underwent incisional biopsy,surgical excision and repair.Results:The patient had a mass at the inner canthus of the left eye for two years.She had a left facial congenital port wine hemangioma involving the left eyelid,for which no topical treatment had been given.Clinical examination disclosed a 1.5 ×1.2 cm ulcerated skin mass with irregular borders in the medial canthal region involving the medial aspect of both upper and lower left eyelids.Incisional biopsy revealed basal cell carcinoma.She underwent surgical excision by Mohs'.technique and subsequent reconstructive eyelid surgery.The wound healed well postoperatively.At 2 years of follow up the patient showed no recurrence.Conclusion:Patients with congenital facial port wine stain may develop basal cell carcinoma,and should be regularly monitored.展开更多
Background The abundance of closely packed vital structures in the periocular and palpebral regions makes resection and subsequent reconstructive interventions extremely difficult.Methods In this novel article,we desc...Background The abundance of closely packed vital structures in the periocular and palpebral regions makes resection and subsequent reconstructive interventions extremely difficult.Methods In this novel article,we described a method for closing lower eyelid defects after tumor excision using a skin-muscle flap from the upper eyelid along with the use of an adhesive diplene biodegradable membrane.The membrane was used for seamless fixation of the flap and to prevent the development of lower eyelid deformity.Results The case presented herein demonstrated that using diplene adhesive biodegradable membranes has excellent functional and aesthetic results.Conclusion Our findings suggest that an adhesive biodegradable diplene membrane can be used for the reconstruction of the lower eyelid to prevent the occurrence of retraction,for the surgical treatment of ectropion including recurrent cases,and for seamless fixation of flaps to wound surfaces in patients with a tendency to form keloids and hypertrophic scars.展开更多
AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with patholo...AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS: Most eyelid tumors were epidermal in origin(1080, 48.5%), followed by miscellaneous(885, 39.7%) and adnexal tumors(263, 11.8%). Among all the tumors, 292(13.1%) were malignant lesions, 1910(85.7%) benign and 26(1.1%) premalignant lesions. Most malignant tumors originated from epidermal cells(60.0%), followed by adnexal cells(34.6%). The most common malignant tumors were basal cell carcinomas(56.5%) followed by sebaceous carcinoma(34.6%), squamous cell carcinomas(3.8%) and lymphoma/plasmocytoma(1.7%). The benign and premalignant eyelid lesions mostly originated from epidermal cells(46.4%) followed by miscellaneous cell sources(45.2%), including melanocytic nevus(33.8%), seborrheic keratosis(13.7%), squamous cell papilloma(13.0%) and epidermal cysts(11.5%). CONCLUSION: Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.展开更多
AIM:To evaluate the demographic features,location,and histopathologic results in primary eyelid tumors.METHODS:We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated betwee...AIM:To evaluate the demographic features,location,and histopathologic results in primary eyelid tumors.METHODS:We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our service.RESULTS:Nine hundred and eleven lesions from 874 patients were included in this study.Four hundred and fortysix(51.0%)of the patients were females and 428(49.0%)were males.The mean age was 51.0y(range:3 mo-94 y).The lesions were located in the upper eyelid(418 cases,45.9%),lower eyelid(378 cases,41.5%),medial canthus(89 cases,9.8%),and lateral canthus(26 cases,2.8%).Four hundred and seventy(51.6%)lesions were located on the right side and 441(48.4%)on the left.Of the eyelid lesions,666(73.1%)were benign,230(25.2%)malignant,and 15(1.6%)premalignant.When the eyelid tumors were classified according to their tissue or cell of origin,527(57.8%)of the lesions were found to be epidermal,171(18.8%)adnexal,131(14.4%)inflammatory and infectious,and 65(7.1%)stromal.The most common benign lesions were squamous cell papilloma(139 lesions,15.2%),intradermal nevus(97 lesions,10.6%),epidermoid inclusion cysts(78 lesions,8.6%),seborrheic keratosis(60 lesions,6.6%),and inflammatory masses(59 lesions,6.5%).Basal cell carcinoma was the most common malignant tumor(191 lesions,21.0%)followed by squamous cell carcinoma(16 lesions,1.8%),sebaceous carcinoma(14 lesions,1.5%),and malignant melanoma(5 lesions,0.5%).CONCLUSION:In this study,73.1%of eyelid lesions are benign and the remaining 26.9%are premalignant and malignant.Basal cell carcinoma is the most common tumor among all histopathological diagnosis followed by squamous papilloma.展开更多
Introduction:Nevoid basal cell carcinoma syndrome is an autosomal dominant disorder characterized by developmental malformations and carcinogenic activity.Multi-systemic anomalies may occur in this syndrome,such as od...Introduction:Nevoid basal cell carcinoma syndrome is an autosomal dominant disorder characterized by developmental malformations and carcinogenic activity.Multi-systemic anomalies may occur in this syndrome,such as odentogenic keratocysts of the mandible and postnatal tumors,especially multiple basal cell carcinoma.Case presentation:A 60 year old man presented with systemic plaques and nodules for more than 30 years.Cutaneous examination revealed that invasive erythema and black papules scattered on the face,trunk and limbs.He underwent extended surgical excision of lesions at multiple sites.No new lesions were found in the treated areas during a 3-year follow-up.Topical 5-aminolevulinic acid-mediated photodynamic therapy(ALA-PDT)was given as a palliative treatment for ulcerated tumors on the right lower eyelid and bleeding of the right temporal lesion.After application of ALA-PDT,the ulcers almost healed and the recurring hemorrhage ceased.Discussion:The management of multiple tumors in patients with nevoid basal cell carcinoma syndrome is extremely difficult,especially in the face.Surgical excision is the standard method,but the procedure can be applied in limited sites and may result in significant disfigurement and the difficulty of wound recovery.PDT can play a significant role in combination therapy for tumors that are extremely difficult to remove completely by surgical excision.Conclusion:We present a rare case manifested as multiple basal cell carcinoma and palmar pits who treated by surgery combined with topical 5-aminolevulinic acid-mediated photodynamic therapy.The combined therapy plays a complementary role in the treatment of nevoid basal cell carcinoma syndrome.展开更多
文摘The correlation between the expression of COX-2 and p53 protein in basal cell carcinoma (BCC) of eyelid and apoptosis was investigated. Specimens of BCC were collected from 40 cases (aged 28-68 y) at the Department of Pathology, Renmin Hospital of Wuhan University, and Depart-ment of Pathology, Zhongnan Hospital of Wuhan University during from 1999 to 2006. Five specimens of paracancerous tissues served as control group. Immunohistochemical staining was performed to detect the expression of COX-2 and p53 in the tissues. The average absorbance (A) and the average positive area rate of COX-2 and p53 protein were measured by image analysis. The positive area rate of COX-2 and p53 protein was analyzed by linear correlation analysis. It was found that COX-2 and p53 proteins were highly expressed in BCC of eyelid, and weakly expressed in paracancerous tissues. Image analysis revealed that the expression of COX-2 and p53 proteins in BCC of eyelid was significantly higher than that in paracancerous tissues (P<0.01). Spearman rank correlation analysis demonstrated a positive correlation between the expression of COX-2 and p53 (r=0.113, P=0.421). It was concluded that COX-2 can increase the expression of p53 protein, therefore suppressing apoptosis.
文摘Purpose:Only one previous case of eyelid basal cell carcinoma arising in a facial port wine stain without previous local radiotherapy has been reported.We now report a second case.Methods:A 42-year-old female patient with eyelid basal cell carcinoma developing within a facial port wine stain underwent incisional biopsy,surgical excision and repair.Results:The patient had a mass at the inner canthus of the left eye for two years.She had a left facial congenital port wine hemangioma involving the left eyelid,for which no topical treatment had been given.Clinical examination disclosed a 1.5 ×1.2 cm ulcerated skin mass with irregular borders in the medial canthal region involving the medial aspect of both upper and lower left eyelids.Incisional biopsy revealed basal cell carcinoma.She underwent surgical excision by Mohs'.technique and subsequent reconstructive eyelid surgery.The wound healed well postoperatively.At 2 years of follow up the patient showed no recurrence.Conclusion:Patients with congenital facial port wine stain may develop basal cell carcinoma,and should be regularly monitored.
文摘Background The abundance of closely packed vital structures in the periocular and palpebral regions makes resection and subsequent reconstructive interventions extremely difficult.Methods In this novel article,we described a method for closing lower eyelid defects after tumor excision using a skin-muscle flap from the upper eyelid along with the use of an adhesive diplene biodegradable membrane.The membrane was used for seamless fixation of the flap and to prevent the development of lower eyelid deformity.Results The case presented herein demonstrated that using diplene adhesive biodegradable membranes has excellent functional and aesthetic results.Conclusion Our findings suggest that an adhesive biodegradable diplene membrane can be used for the reconstruction of the lower eyelid to prevent the occurrence of retraction,for the surgical treatment of ectropion including recurrent cases,and for seamless fixation of flaps to wound surfaces in patients with a tendency to form keloids and hypertrophic scars.
文摘AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS: Most eyelid tumors were epidermal in origin(1080, 48.5%), followed by miscellaneous(885, 39.7%) and adnexal tumors(263, 11.8%). Among all the tumors, 292(13.1%) were malignant lesions, 1910(85.7%) benign and 26(1.1%) premalignant lesions. Most malignant tumors originated from epidermal cells(60.0%), followed by adnexal cells(34.6%). The most common malignant tumors were basal cell carcinomas(56.5%) followed by sebaceous carcinoma(34.6%), squamous cell carcinomas(3.8%) and lymphoma/plasmocytoma(1.7%). The benign and premalignant eyelid lesions mostly originated from epidermal cells(46.4%) followed by miscellaneous cell sources(45.2%), including melanocytic nevus(33.8%), seborrheic keratosis(13.7%), squamous cell papilloma(13.0%) and epidermal cysts(11.5%). CONCLUSION: Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.
文摘AIM:To evaluate the demographic features,location,and histopathologic results in primary eyelid tumors.METHODS:We retrospectively reviewed the records of patients with primary eyelid tumor diagnosed and treated between November 1997 and June 2016 on our service.RESULTS:Nine hundred and eleven lesions from 874 patients were included in this study.Four hundred and fortysix(51.0%)of the patients were females and 428(49.0%)were males.The mean age was 51.0y(range:3 mo-94 y).The lesions were located in the upper eyelid(418 cases,45.9%),lower eyelid(378 cases,41.5%),medial canthus(89 cases,9.8%),and lateral canthus(26 cases,2.8%).Four hundred and seventy(51.6%)lesions were located on the right side and 441(48.4%)on the left.Of the eyelid lesions,666(73.1%)were benign,230(25.2%)malignant,and 15(1.6%)premalignant.When the eyelid tumors were classified according to their tissue or cell of origin,527(57.8%)of the lesions were found to be epidermal,171(18.8%)adnexal,131(14.4%)inflammatory and infectious,and 65(7.1%)stromal.The most common benign lesions were squamous cell papilloma(139 lesions,15.2%),intradermal nevus(97 lesions,10.6%),epidermoid inclusion cysts(78 lesions,8.6%),seborrheic keratosis(60 lesions,6.6%),and inflammatory masses(59 lesions,6.5%).Basal cell carcinoma was the most common malignant tumor(191 lesions,21.0%)followed by squamous cell carcinoma(16 lesions,1.8%),sebaceous carcinoma(14 lesions,1.5%),and malignant melanoma(5 lesions,0.5%).CONCLUSION:In this study,73.1%of eyelid lesions are benign and the remaining 26.9%are premalignant and malignant.Basal cell carcinoma is the most common tumor among all histopathological diagnosis followed by squamous papilloma.
基金This work was supported by the National Natural Science Fund of China(No.81872216)PUMC Postgraduate Education and Teaching Reform Project in 2018(No.10023201801701)。
文摘Introduction:Nevoid basal cell carcinoma syndrome is an autosomal dominant disorder characterized by developmental malformations and carcinogenic activity.Multi-systemic anomalies may occur in this syndrome,such as odentogenic keratocysts of the mandible and postnatal tumors,especially multiple basal cell carcinoma.Case presentation:A 60 year old man presented with systemic plaques and nodules for more than 30 years.Cutaneous examination revealed that invasive erythema and black papules scattered on the face,trunk and limbs.He underwent extended surgical excision of lesions at multiple sites.No new lesions were found in the treated areas during a 3-year follow-up.Topical 5-aminolevulinic acid-mediated photodynamic therapy(ALA-PDT)was given as a palliative treatment for ulcerated tumors on the right lower eyelid and bleeding of the right temporal lesion.After application of ALA-PDT,the ulcers almost healed and the recurring hemorrhage ceased.Discussion:The management of multiple tumors in patients with nevoid basal cell carcinoma syndrome is extremely difficult,especially in the face.Surgical excision is the standard method,but the procedure can be applied in limited sites and may result in significant disfigurement and the difficulty of wound recovery.PDT can play a significant role in combination therapy for tumors that are extremely difficult to remove completely by surgical excision.Conclusion:We present a rare case manifested as multiple basal cell carcinoma and palmar pits who treated by surgery combined with topical 5-aminolevulinic acid-mediated photodynamic therapy.The combined therapy plays a complementary role in the treatment of nevoid basal cell carcinoma syndrome.
