目的探讨葡聚糖包裹的超顺磁性Fe_3O_4纳米颗粒(dextran-coated superparamagnetic iron oxides nanoparticles,dextrarr/SPlONP)作为间质注射的MRI造影剂的可行性。方法应用界面共沉淀法,制备dextran/SPIONP,用透射电镜、能谱分析、X...目的探讨葡聚糖包裹的超顺磁性Fe_3O_4纳米颗粒(dextran-coated superparamagnetic iron oxides nanoparticles,dextrarr/SPlONP)作为间质注射的MRI造影剂的可行性。方法应用界面共沉淀法,制备dextran/SPIONP,用透射电镜、能谱分析、X射线衍射、红外光谱测试、热重分析等方法对dextran/SPlONP的大小、磁性能等进行表征,并研究葡聚糖对SPlONP的影响。然后,将dextran/SPIONP稀释成不同剂量,兔舌粘膜下问质注射后的不同时间段,切取前哨淋巴结,行核磁共振波谱分析,确定dextran/SPIONP的最适剂量和最佳检测时间。结果dextran/SPION的平均直径为6～9nm,其表征与经典的共沉淀法制备的颗粒一致,具有超顺磁性,葡聚糖是影响SPIONP饱和磁化强度的主要因素。dextran/SPIONP用于间质注射的最适剂量为含铁量20μmol,最佳检测时间为注射后24h。结论用界面共沉淀法制备的dextran/SPIONP是一种适用于间质注射的MRI造影剂。展开更多
Surface Enhanced Raman Scattering (SERS) of tetrasodium meso-tetrakis (4-sulfonatophenyl) porphine (H2TSPP) and silver tetraphenylporphyrin (Ag(Ⅱ)TSPP)adsorbed spontarleously on uniform Fe3O4 colloids are recorded. T...Surface Enhanced Raman Scattering (SERS) of tetrasodium meso-tetrakis (4-sulfonatophenyl) porphine (H2TSPP) and silver tetraphenylporphyrin (Ag(Ⅱ)TSPP)adsorbed spontarleously on uniform Fe3O4 colloids are recorded. The enhancement of Raman bands is approximately 30. An analysis of the SERS spectrum shows that on the Fe3O4 surface H2TSPP takes its diacid form H42+TSPP.展开更多
文摘目的探讨葡聚糖包裹的超顺磁性Fe_3O_4纳米颗粒(dextran-coated superparamagnetic iron oxides nanoparticles,dextrarr/SPlONP)作为间质注射的MRI造影剂的可行性。方法应用界面共沉淀法,制备dextran/SPIONP,用透射电镜、能谱分析、X射线衍射、红外光谱测试、热重分析等方法对dextran/SPlONP的大小、磁性能等进行表征,并研究葡聚糖对SPlONP的影响。然后,将dextran/SPIONP稀释成不同剂量,兔舌粘膜下问质注射后的不同时间段,切取前哨淋巴结,行核磁共振波谱分析,确定dextran/SPIONP的最适剂量和最佳检测时间。结果dextran/SPION的平均直径为6～9nm,其表征与经典的共沉淀法制备的颗粒一致,具有超顺磁性,葡聚糖是影响SPIONP饱和磁化强度的主要因素。dextran/SPIONP用于间质注射的最适剂量为含铁量20μmol,最佳检测时间为注射后24h。结论用界面共沉淀法制备的dextran/SPIONP是一种适用于间质注射的MRI造影剂。
文摘Surface Enhanced Raman Scattering (SERS) of tetrasodium meso-tetrakis (4-sulfonatophenyl) porphine (H2TSPP) and silver tetraphenylporphyrin (Ag(Ⅱ)TSPP)adsorbed spontarleously on uniform Fe3O4 colloids are recorded. The enhancement of Raman bands is approximately 30. An analysis of the SERS spectrum shows that on the Fe3O4 surface H2TSPP takes its diacid form H42+TSPP.
