Fluoride and nitrate enriched groundwater are potential threats to the safety of the groundwater supply that may cause significant effects on human health and public safety,especially in aggregated population areas an...Fluoride and nitrate enriched groundwater are potential threats to the safety of the groundwater supply that may cause significant effects on human health and public safety,especially in aggregated population areas and economic hubs.This study focuses on the high F^(−)and NO_(3)^(−)concentration groundwater in Tongzhou District,Beijing,North China.A total of 36 groundwater samples were collected to analyze the hydrochemical characteristics,elucidate genetic mechanisms and evaluate the potential human health risks.The results of the analysis indicate:Firstly,most of the groundwater samples are characterized by Mg-HCO_(3) and Na-HCO_(3) with the pH ranging from 7.19 to 8.28 and TDS with a large variation across the range 471-2337 mg/L.The NO_(3)^(−)concentration in 38.89%groundwater samples and the F^(−)concentration in 66.67%groundwater samples exceed the permissible limited value.Secondly,F^(−)in groundwater originates predominantly from water-rock interactions and the fluorite dissolution,which is also regulated by cation exchange,competitive adsorption of HCO_(3)−and an alkaline environment.Thirdly,the effect of sewage disposal and agricultural activities have a significant effect on high NO3-concentration,while the high F^(−)concentration is less influenced by anthropogenic activity.The alkaline environment favors nitrification,thus being conducive to the production of NO_(3)^(−).Finally,the health risk assessment is evaluated for different population groups.The results indicate that high NO_(3)^(−)and F^(−)concentration in groundwater would have the largest threat to children’s health.The findings of this study could contribute to the provision of a scientific basis for groundwater supply policy formulation relating to public health in Tongzhou District.展开更多
The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial produc...The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial production.This paper systematically investigates the ash reduction and desilicification of two typical inferior coal utilizing ammonium fluoride roasting method.Under the optimal conditions,for fat coal and gas coal,the deashing rates are 69.02%and 54.13%,and the desilicification rates are 92.64%and 90.27%,respectively.The molar dosage of ammonium fluoride remains consistent for both coals;however,the gas coal,characterized by a lower ash and silica content(less than half that of the fat coal),achieves optimum deashing effect at a reduced time and temperature.The majority of silicon in coal transforms into gaseous ammonium fluorosilicate,subsequently preparing nanoscale amorphous silica with a purity of 99.90%through ammonia precipitation.Most of the fluorine in deashed coal are assigned in inorganic minerals,suggesting the possibility of further fluorine and ash removal via flotation.This research provides a green and facile route to deash inferior coal and produce nano-scale white carbon black simultaneously.展开更多
BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of...BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the cancer screening group vs follow-up group=1.11;95%CI=0.82-1.49).CONCLUSION CRCs detected during hospital visits for comorbidities were diagnosed earlier,similar to cancer screening.CRC screening should be recommended,particularly for patients without periodical hospital visits for comorbidities.展开更多
As the global temperature continues to increase, the sea level continues to rise at a rapid rate that has never been seen before. This becomes an issue for many facets of life but one of the most impacted is the trans...As the global temperature continues to increase, the sea level continues to rise at a rapid rate that has never been seen before. This becomes an issue for many facets of life but one of the most impacted is the transportation infrastructure. Many people living in low elevation coastal areas can become trapped by flooding with no way in or out. With Delaware being a coastal state, this would affect a large portion of the population and will have detrimental effects over time if nothing is done to combat sea level rise. The issue with sea level rise in transportation is that once the roads become flooded, they become virtually unusable and detour routes would be needed. If all the roads in a coastal area were to be affected by sea level rise, the options for detours would become limited. This article looks at direct solutions to combat sea level rise and indirect solutions that would specifically help transportation infrastructure and evacuation routes in Delaware. There is not one solution that can fix every problem, so many solutions are laid out to see what is applicable to each affected area. Some solutions include defense structures that would be put close to the coast, raising the elevation of vulnerable roads throughout the state and including pumping stations to drain the water on the surface of the road. With an understanding of all these solutions around the world, the ultimate conclusion came in the form of a six-step plan that Delaware should take in order to best design against sea level rise in these coastal areas.展开更多
High-entropy catalysts featuring exceptional properties are,in no doubt,playing an increasingly significant role in aprotic lithium-oxygen batteries.Despite extensive effort devoted to tracing the origin of their unpa...High-entropy catalysts featuring exceptional properties are,in no doubt,playing an increasingly significant role in aprotic lithium-oxygen batteries.Despite extensive effort devoted to tracing the origin of their unparalleled performance,the relationships between multiple active sites and reaction intermediates are still obscure.Here,enlightened by theoretical screening,we tailor a high-entropy perovskite fluoride(KCoMnNiMgZnF_(3)-HEC)with various active sites to overcome the limitations of conventional catalysts in redox process.The entropy effect modulates the d-band center and d orbital occupancy of active centers,which optimizes the d–p hybridization between catalytic sites and key intermediates,enabling a moderate adsorption of LiO_(2)and thus reinforcing the reaction kinetics.As a result,the Li–O2 battery with KCoMnNiMgZnF_(3)-HEC catalyst delivers a minimal discharge/charge polarization and long-term cycle stability,preceding majority of traditional catalysts reported.These encouraging results provide inspiring insights into the electron manipulation and d orbital structure optimization for advanced electrocatalyst.展开更多
Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and t...Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and the route development behavior of airlines is analyzed.Because of rare and often controversial findings in the extant literature regarding relevant influencing variables for attracting airlines at an airport,expert interviews are used as a complement to formulate testable hypotheses in this regard.A fixed effects regression model is used to test the hypotheses with a dataset that covers all seat capacity offered at the 22 largest German commercial airports in the week 46 from 2004 to 2011.It is found that incentives from primary choice,as well as secondary choice airports,have a significant influence on Low Cost Carriers.Furthermore,Low Cost Carriers,in general,do not leave any of both types of airports when the incentives cease.In the case of Network Carriers,no case is found where one joins a primary choice airport and receives an incentive.Insufficient data between Network Carriers and secondary choice airports in the time when incentives have ceased means that no statement can be given.展开更多
Organic-dispersible lanthanide fluorides nanocrystals were synthesized at a large scale using colloid-extraction method, in the presence of dialkyl-dithiophosphinic acid (DDPA) as the extraction agent. The products we...Organic-dispersible lanthanide fluorides nanocrystals were synthesized at a large scale using colloid-extraction method, in the presence of dialkyl-dithiophosphinic acid (DDPA) as the extraction agent. The products were characterized by means of X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier transformation infrared (FTIR) spectroscopy. It was found that the synthesized lanthanide fluorides nanoparticles had high purity and crystallinity, and could be well dispersed in organic solvents such as chloroform, toluene etc., which could be closely related to the surface-capping of the nanocrystals by the DDPA molecules. Moreover, the nanocrystals before and after extraction by DDPA showed few differences in the microscopic morphologies. It was implied that DDPA as the extraction agent had good protection to the nanocrystals as well, which could be essential to the commercial application of the titled rare earth nanocrystals as novel multifunctional additives in the fields of lubrication.展开更多
Objective Arsenic(As) and fluoride(F) are two of the most common elements contaminating groundwater resources. A growing number of studies have found that As and F can cause neurotoxicity in infants and children, lead...Objective Arsenic(As) and fluoride(F) are two of the most common elements contaminating groundwater resources. A growing number of studies have found that As and F can cause neurotoxicity in infants and children, leading to cognitive, learning, and memory impairments. However, early biomarkers of learning and memory impairment induced by As and/or F remain unclear. In the present study, the mechanisms by which As and/or F cause learning memory impairment are explored at the multi-omics level(microbiome and metabolome).Methods We stablished an SD rats model exposed to arsenic and/or fluoride from intrauterine to adult period.Results Arsenic and/fluoride exposed groups showed reduced neurobehavioral performance and lesions in the hippocampal CA1 region. 16S rRNA gene sequencing revealed that As and/or F exposure significantly altered the composition and diversity of the gut microbiome, featuring the Lachnospiraceae_NK4A136_group, Ruminococcus_1, Prevotellaceae_NK3B31_group, [Eubacterium]_xylanophilum_group. Metabolome analysis showed that As and/or F-induced learning and memory impairment may be related to tryptophan, lipoic acid, glutamate, gamma-aminobutyric acidergic(GABAergic) synapse, and arachidonic acid(AA) metabolism. The gut microbiota, metabolites, and learning memory indicators were significantly correlated.Conclusion Learning memory impairment triggered by As and/or F exposure may be mediated by different gut microbes and their associated metabolites.展开更多
Here we prepared PEO coatings on Mg alloys in silicate-NaOH-phosphate electrolyte containing different concentrations of NaF addition.The detailed microstructural characterizations combining with potentiodynamic polar...Here we prepared PEO coatings on Mg alloys in silicate-NaOH-phosphate electrolyte containing different concentrations of NaF addition.The detailed microstructural characterizations combining with potentiodynamic polarization and electrochemical impedance spectra(EIS)were employed to investigate the roles of fluoride in the growth and corrosion properties of PEO coating on Mg.The result shows the introduction of NaF led to a fluoride-containing nanolayer(FNL)formed at the Mg/coating interface.The FNL consists of MgO nanoparticles and insoluble MgF_(2)nanoparticles(containing rutile phase and cubic phase).The increase in the NaF concentration of the electrolyte increases the thickness and the MgF_(2)content in the FNL.When anodized in the electrolyte containing 2 g/L NaF,the formed FNL has the highest thickness of 100-200 nm along with the highest value of x of∼0.6 in(MgO)_(1-x)(MgF_(2))x resulted in the highest corrosion performance of PEO coating.In addition,when anodized in the electrolyte containing a low NaF concentration(0.4-0.8 g/L),the formed FNL was thin and discontinuous,which would decrease the pore density and increase the coating's uniformness simultaneously.展开更多
Tourism route planning is widely applied in the smart tourism field.The Pareto-optimal front obtained by the traditional multi-objective evolutionary algorithm exhibits long tails,sharp peaks and disconnected regions ...Tourism route planning is widely applied in the smart tourism field.The Pareto-optimal front obtained by the traditional multi-objective evolutionary algorithm exhibits long tails,sharp peaks and disconnected regions problems,which leads to uneven distribution and weak diversity of optimization solutions of tourism routes.Inspired by these limitations,we propose a multi-objective evolutionary algorithm for tourism route recommendation(MOTRR)with two-stage and Pareto layering based on decomposition.The method decomposes the multiobjective problem into several subproblems,and improves the distribution of solutions through a two-stage method.The crowding degree mechanism between extreme and intermediate populations is used in the two-stage method.The neighborhood is determined according to the weight of the subproblem for crossover mutation.Finally,Pareto layering is used to improve the updating efficiency and population diversity of the solution.The two-stage method is combined with the Pareto layering structure,which not only maintains the distribution and diversity of the algorithm,but also avoids the same solutions.Compared with several classical benchmark algorithms,the experimental results demonstrate competitive advantages on five test functions,hypervolume(HV)and inverted generational distance(IGD)metrics.Using the experimental results of real scenic spot datasets from two famous tourism social networking sites with vast amounts of users and large-scale online comments in Beijing,our proposed algorithm shows better distribution.It proves that the tourism routes recommended by our proposed algorithm have better distribution and diversity,so that the recommended routes can better meet the personalized needs of tourists.展开更多
Wireless Sensor Networks(WSN)have revolutionized the processes involved in industrial communication.However,the most important challenge faced by WSN sensors is the presence of limited energy.Multiple research inves-t...Wireless Sensor Networks(WSN)have revolutionized the processes involved in industrial communication.However,the most important challenge faced by WSN sensors is the presence of limited energy.Multiple research inves-tigations have been conducted so far on how to prolong the energy in WSN.This phenomenon is a result of inability of the network to have battery powered-sensor terminal.Energy-efficient routing on packetflow is a parallel phenomenon to delay nature,whereas the primary energy gets wasted as a result of WSN holes.Energy holes are present in the vicinity of sink and it is an important efficient-routing protocol for WSNs.In order to solve the issues discussed above,an energy-efficient routing protocol is proposed in this study named as Adaptive Route Decision Sink Relocation Protocol using Cluster Head Chain Cycling approach(ARDSR-CHC2H).The proposed method aims at improved communica-tion at sink-inviting routes.At this point,Cluster Head Node(CHN)is selected,since it consumes low energy and permits one node to communicate with others in two groups.The main purpose of the proposed model is to reduce energy con-sumption and define new interchange technology.A comparison of simulation results demonstrates that the proposed algorithm achieved low cluster creation time,better network error and high Packet Delivery Rate with less network failure.展开更多
A new one-dimensional(1D) fluoroaluminophosphate chain(C 4 H 15 N 3 )[AlPO 4 F 2 ](denoted AlPO-CJ28) was synthesized in the concentrated fluoride synthetic medium with a gel composition of 1.0Al(OPr i ) 3 :1.0H 3 PO ...A new one-dimensional(1D) fluoroaluminophosphate chain(C 4 H 15 N 3 )[AlPO 4 F 2 ](denoted AlPO-CJ28) was synthesized in the concentrated fluoride synthetic medium with a gel composition of 1.0Al(OPr i ) 3 :1.0H 3 PO 4 : 5.4DETA:1.3HF:2.0H 2 O(DETA=diethylenetriamine). The reagents were mixed directly without introducing addi- tional water solvent. The 1D chain is constructed by alternating AlO 2 F 2 and doubly bridging PO 4 tetrahedra to form the simplest serrate chain. AlPO-CJ28 can be transformed to another 1D aluminophosphate chain AlPO-CSC upon further crystallization at 230 °C.展开更多
First-principles calculation of muons in ionic fluorides has been proposed recently.However,there is a considerable difference between the obtained F-μbond length and the experimental data obtained by muon spin relax...First-principles calculation of muons in ionic fluorides has been proposed recently.However,there is a considerable difference between the obtained F-μbond length and the experimental data obtained by muon spin relaxation(μSR).Considering that the difference may be caused by ignoring the quantum effect of muons,we use two-component density functional theory(TCDFT)to consider the quantized muon and recalculate the bond length and theμSR depolarization spectrum.After testing several muon-electron correlation,we show that TCDFT can give better results than the commonly used“DFT+μ”.展开更多
Recently,Internet of Things(IoT)has been developed into a field of research and it purposes at linking many sensors enabling devices mostly to data collection and track applications.Wireless sensor network(WSN)is a vi...Recently,Internet of Things(IoT)has been developed into a field of research and it purposes at linking many sensors enabling devices mostly to data collection and track applications.Wireless sensor network(WSN)is a vital element of IoT paradigm since its inception and has developed into one of the chosen platforms for deploying many smart city application regions such as disaster management,intelligent transportation,home automation,smart buildings,and other such IoT-based application.The routing approaches were extremely-utilized energy efficient approaches with an initial drive that is,for balancing the energy amongst sensor nodes.The clustering and routing procedures assumed that Non-Polynomial(NP)hard problems but bio-simulated approaches are utilized to a recognized time for resolving such problems.With this motivation,this paper presents a new blockchain with Enhanced Hunger Games Search based Route Planning(BCEHGS-RP)scheme for IoT assisted WSN.The presented BCEHGS-RP model majorly employs BC technology for secure communication in the IoT supportedWSN environment.In addition,an effective multihop route planning approach was designed by the use of EHGS technique.The proposed EHGS technique is derived from the concept of Hill Climbing strategy(HCS)and HGS algorithm.Moreover,a fitness function with two parameters namely residual energy(RE)and intercluster distance to elect optimal routes.The performance validation of the BCEHGS-RP model is experimented with under diverse number of nodes.Extensive experimental outcomes highlighted the better performance of the BCEHGS-RP technique on recent approaches.展开更多
Elucidation of a reaction mechanism is the most critical aspect for designing electrodes for highperformance secondary batteries.Herein,we investigate the sodium insertion/extraction into an iron fluoride hydrate(FeF_...Elucidation of a reaction mechanism is the most critical aspect for designing electrodes for highperformance secondary batteries.Herein,we investigate the sodium insertion/extraction into an iron fluoride hydrate(FeF_(3)·0.5H_(2)O)electrode for sodium-ion batteries(SIBs).The electrode material is prepared by employing an ionic liquid 1-butyl-3-methylimidazolium-tetrafluoroborate,which serves as a reaction medium and precursor for F^(-)ions.The crystal structure of FeF_(3)·0.5H_(2)O is observed as pyrochlore type with large open 3-D tunnels and a unit cell volume of 1129A^(3).The morphology of FeF_(3)·0.5H_(2)O is spherical shape with a mesoporous structure.The microstructure analysis reveals primary particle size of around 10 nm.The FeF_(3)·0.5H_(2)O cathode exhibits stable discharge capacities of 158,210,and 284 mA h g^(-1) in three different potential ranges of 1.5-4.5,1.2-4.5,and 1.0-4.5 V,respectively at 0.05 C rate.The specific capacities remained stable in over 50 cycles in all three potential ranges,while the rate capability was best in the potential range of 1.5-4.5 V.The electrochemical sodium storage mechanism is studied using X-ray absorption spectroscopy,indicating higher conversion at a more discharged state.Ex-situ M?ssbauer spectroscopy strengthens the results for reversible reduction/oxidation of Fe.These results will be favorable to establish high-performance cathode materials with selective voltage window for SIBs.展开更多
The idea of cultural route heritage protection expands the protection theory for world cultural heritage.The Long March route carries the prominent characteristic of cultural route heritage.By actively building the Lo...The idea of cultural route heritage protection expands the protection theory for world cultural heritage.The Long March route carries the prominent characteristic of cultural route heritage.By actively building the Long March National Cultural Park,China has strengthened the overall protection and integrated utilization of the Long March cultural heritage,upgraded the hardware facilities for exhibition,and investigated ways to protect cultural route heritage with Chinese characteristics.During the construction of the Park,it is necessary to draw on the concept and norms of the cultural route heritage protection,optimize the construction approach,and make the construction of the Park more in line with the linear cultural characteristics of Long March heritage.Specifically,it is proposed to improve the Long March cultural route heritage protection system oriented towards“authenticity”protection,to deeply tap and interpret the prominent universal worth of the Long March route,augmenting the international dissemination of the Long March culture in an innovative way,and realizing a more scientific and effective protection and utilization of Long March cultural resources.展开更多
Long-distance migratory birds travel more rapidly in spring than in autumn,as they face temporal breeding constraints.However,several species travel slower in spring owing to environmental influences,such as food avai...Long-distance migratory birds travel more rapidly in spring than in autumn,as they face temporal breeding constraints.However,several species travel slower in spring owing to environmental influences,such as food availability and wind conditions.GPS trackers were attached to 17 Whooper Swans(Cygnus cygnus) inhabiting northeastern Mongolia,to determine their migration routes and stopover sites in spring and autumn.Differences between spring and autumn migrations,migration-influencing parameters,and the effect of spring stopover site temperatures were analyzed.Six swans completed perfect tours between their wintering and breeding sites,and these data were used for analysis.Spring migration lasted 57 days,with 49.2 days spent at 3.7 stopover sites.Autumn migration lasted 21.5 days,with 17.5 days spent at 1.0 stopover sites.Thus,the swans traveled more rapidly in autumn than in spring.Migration distance,number of stopovers,migration speed,and straightness were important migration determinants in both spring and autumn.Migration distance,stopover duration,number of stopovers,daily travel speed,travel duration,and migration speed differed significantly between spring and autumn.During spring migration,the temperature at the current stopover sites and that at the future stopover sites displayed significant variations(t=1585.8,df=631.6,p <0.001).These findings are critical for the conservation and management of Whooper Swans and their key habitats in East Asian regions,and the data are anticipated to make a particularly significant contribution toward developing detailed management plans for the conservation of their key habitats.展开更多
BACKGROUND Incidence of cholangiocarcinoma(CCA)is rising,with overall prognosis remaining very poor.Reasons for the high mortality of CCA include its late presentation in most patients,when curative options are no lon...BACKGROUND Incidence of cholangiocarcinoma(CCA)is rising,with overall prognosis remaining very poor.Reasons for the high mortality of CCA include its late presentation in most patients,when curative options are no longer feasible,and poor response to systemic therapies for advanced disease.Late presentation presents a large barrier to improving outcomes and is often associated with diagnosis via mergency presentation(EP).Earlier diagnoses may be made by Two Week Wait(TWW)referrals through General practitioner(GP).We hypothesise that TWW referrals and EP routes to diagnosis differ across regions in England.AIM To investigate routes to diagnosis of CCA over time,regional variation and influencing factors.METHODS We linked patient records from the National Cancer Registration Dataset to Hospital Episode Statistics,Cancer Waiting Times and Cancer Screening Programme datasets to define routes to diagnosis and certain patient characteristics for patients diagnosed 2006-2017 in England.We used linear probability models to investigate geographic variation by assessing the proportions of patients diagnosed via TWW referral or EP across Cancer Alliances in England,adjusting for potential confounders.Correlation between the proportion of people diagnosed by TWW referral and EP was investigated with Spearman’s correlation coefficient.RESULTS Of 23632 patients diagnosed between 2006-2017 in England,the most common route to diagnosis was EP(49.6%).Non-TWW GP referrals accounted for 20.5%of diagnosis routes,13.8%were diagnosed by TWW referral,and the remainder 16.2%were diagnosed via an‘other’or Unknown route.The proportion diagnosed via a TWW referral doubled between 2006-2017 rising from 9.9%to 19.8%,conversely EP diagnosis route declined,falling from 51.3%to 46.0%.Statistically significant variation in both the TWW referral and EP proportions was found across Cancer Alliances.Age,presence of comorbidity and underlying liver disease were independently associated with both a lower proportion of patients diagnosed via TWW referral,and a higher proportion diagnosed by EP after adjusting for other potential confounders.CONCLUSION There is significant geographic and socio-demographic variation in routes to diagnosis of CCA in England.Knowledge sharing of best practice may improve diagnostic pathways and reduce unwarranted variation.展开更多
Recently,a trust system was introduced to enhance security and cooperation between nodes in wireless sensor networks(WSN).In routing,the trust system includes or avoids nodes related to the estimated trust values in t...Recently,a trust system was introduced to enhance security and cooperation between nodes in wireless sensor networks(WSN).In routing,the trust system includes or avoids nodes related to the estimated trust values in the routing function.This article introduces Enhanced Metaheuristics with Trust Aware Secure Route Selection Protocol(EMTA-SRSP)for WSN.The presented EMTA-SRSP technique majorly involves the optimal selection of routes in WSN.To accomplish this,the EMTA-SRSP technique involves the design of an oppositional Aquila optimization algorithm to choose safe routes for data communication.For the clustering process,the nodes with maximum residual energy will be considered cluster heads(CHs).In addition,the OAOA technique gets executed to choose optimal routes based on objective functions with multiple parameters such as energy,distance,and trust degree.The experimental validation of the EMTA-SRSP technique is tested,and the results exhibited a better performance of the EMTA-SRSP technique over other approaches.展开更多
Vanadium flow batteries(VFBs)are considered ideal for grid-sc ale,long-duration energy storage applications owing to their decoupled output power and storage capacity,high safety,efficiency,and long cycle life.However...Vanadium flow batteries(VFBs)are considered ideal for grid-sc ale,long-duration energy storage applications owing to their decoupled output power and storage capacity,high safety,efficiency,and long cycle life.However,the widespread adoption of VFB s is hindered by the use of expensive Nafion membranes.Herein,we report a soft template-induced method to develop a porous polyvinylidene fluoride(PVDF)membrane for VFB applications.By incorporating water-soluble and flexible polyethylene glycol(PEG 400)as a soft template,we induced the aggregation of hydrophilic sulfonated poly(ether ether ketone),resulting in phase separation from the hydrophobic PVDF polymer during membrane formation.This process led to the creation of a porous PVDF membrane with controllable morphologies determined by the polyethylene glycol content in the cast solution.The optimized porous PVDF membrane enabled a stable VFB performance for 200 cycles at a current density of 80 mA/cm^(2),and the VFB exhibited a Coulombic efficiency of 95.2%and a voltage efficiency of 87.8%.These findings provide valuable insights for the development of highly stable membranes for VFB applications.展开更多
基金supported by the project of China Geological Survey(Grant No.DD20221677-2)the fundamental research funds of Chinese Academy of Geological Sciences Basal Research Fund(Grant No.JKYQN202307).
文摘Fluoride and nitrate enriched groundwater are potential threats to the safety of the groundwater supply that may cause significant effects on human health and public safety,especially in aggregated population areas and economic hubs.This study focuses on the high F^(−)and NO_(3)^(−)concentration groundwater in Tongzhou District,Beijing,North China.A total of 36 groundwater samples were collected to analyze the hydrochemical characteristics,elucidate genetic mechanisms and evaluate the potential human health risks.The results of the analysis indicate:Firstly,most of the groundwater samples are characterized by Mg-HCO_(3) and Na-HCO_(3) with the pH ranging from 7.19 to 8.28 and TDS with a large variation across the range 471-2337 mg/L.The NO_(3)^(−)concentration in 38.89%groundwater samples and the F^(−)concentration in 66.67%groundwater samples exceed the permissible limited value.Secondly,F^(−)in groundwater originates predominantly from water-rock interactions and the fluorite dissolution,which is also regulated by cation exchange,competitive adsorption of HCO_(3)−and an alkaline environment.Thirdly,the effect of sewage disposal and agricultural activities have a significant effect on high NO3-concentration,while the high F^(−)concentration is less influenced by anthropogenic activity.The alkaline environment favors nitrification,thus being conducive to the production of NO_(3)^(−).Finally,the health risk assessment is evaluated for different population groups.The results indicate that high NO_(3)^(−)and F^(−)concentration in groundwater would have the largest threat to children’s health.The findings of this study could contribute to the provision of a scientific basis for groundwater supply policy formulation relating to public health in Tongzhou District.
文摘The quality upgrading and deashing of inferior coal by chemical method still faces great challenges.The dangers of strong acid,strong alkali,waste water and exhaust gas as well as high cost limit its industrial production.This paper systematically investigates the ash reduction and desilicification of two typical inferior coal utilizing ammonium fluoride roasting method.Under the optimal conditions,for fat coal and gas coal,the deashing rates are 69.02%and 54.13%,and the desilicification rates are 92.64%and 90.27%,respectively.The molar dosage of ammonium fluoride remains consistent for both coals;however,the gas coal,characterized by a lower ash and silica content(less than half that of the fat coal),achieves optimum deashing effect at a reduced time and temperature.The majority of silicon in coal transforms into gaseous ammonium fluorosilicate,subsequently preparing nanoscale amorphous silica with a purity of 99.90%through ammonia precipitation.Most of the fluorine in deashed coal are assigned in inorganic minerals,suggesting the possibility of further fluorine and ash removal via flotation.This research provides a green and facile route to deash inferior coal and produce nano-scale white carbon black simultaneously.
基金the Foundation for Cancer Research supported by Kyoto Preventive Medical Center and the Japan Society for the Promotion of Science(JSPS)Grants-in-Aid KAKENHI,No.JP 22K21080.
文摘BACKGROUND Colorectal cancer(CRC)is a global health concern,with advanced-stage diagnoses contributing to poor prognoses.The efficacy of CRC screening has been well-established;nevertheless,a significant proportion of patients remain unscreened,with>70%of cases diagnosed outside screening.Although identifying specific subgroups for whom CRC screening should be particularly recommended is crucial owing to limited resources,the association between the diagnostic routes and identification of these subgroups has been less appreciated.In the Japanese cancer registry,the diagnostic routes for groups discovered outside of screening are primarily categorized into those with comorbidities found during hospital visits and those with CRC-related symptoms.AIM To clarify the stage at CRC diagnosis based on diagnostic routes.METHODS We conducted a retrospective observational study using a cancer registry of patients with CRC between January 2016 and December 2019 at two hospitals.The diagnostic routes were primarily classified into three groups:Cancer screening,follow-up,and symptomatic.The early-stage was defined as Stages 0 or I.Multivariate and univariate logistic regressions were exploited to determine the odds of early-stage diagnosis in the symptomatic and cancer screening groups,referencing the follow-up group.The adjusted covariates were age,sex,and tumor location.RESULTS Of the 2083 patients,715(34.4%),1064(51.1%),and 304(14.6%)belonged to the follow-up,symptomatic,and cancer screening groups,respectively.Among the 2083 patients,CRCs diagnosed at an early stage were 57.3%(410 of 715),23.9%(254 of 1064),and 59.5%(181 of 304)in the follow-up,symptomatic,and cancer screening groups,respectively.The symptomatic group exhibited a lower likelihood of early-stage diagnosis than the follow-up group[P<0.001,adjusted odds ratio(aOR),0.23;95%confidence interval(95%CI):0.19-0.29].The likelihood of diagnosis at an early stage was similar between the follow-up and cancer screening groups(P=0.493,aOR for early-stage diagnosis in the cancer screening group vs follow-up group=1.11;95%CI=0.82-1.49).CONCLUSION CRCs detected during hospital visits for comorbidities were diagnosed earlier,similar to cancer screening.CRC screening should be recommended,particularly for patients without periodical hospital visits for comorbidities.
文摘As the global temperature continues to increase, the sea level continues to rise at a rapid rate that has never been seen before. This becomes an issue for many facets of life but one of the most impacted is the transportation infrastructure. Many people living in low elevation coastal areas can become trapped by flooding with no way in or out. With Delaware being a coastal state, this would affect a large portion of the population and will have detrimental effects over time if nothing is done to combat sea level rise. The issue with sea level rise in transportation is that once the roads become flooded, they become virtually unusable and detour routes would be needed. If all the roads in a coastal area were to be affected by sea level rise, the options for detours would become limited. This article looks at direct solutions to combat sea level rise and indirect solutions that would specifically help transportation infrastructure and evacuation routes in Delaware. There is not one solution that can fix every problem, so many solutions are laid out to see what is applicable to each affected area. Some solutions include defense structures that would be put close to the coast, raising the elevation of vulnerable roads throughout the state and including pumping stations to drain the water on the surface of the road. With an understanding of all these solutions around the world, the ultimate conclusion came in the form of a six-step plan that Delaware should take in order to best design against sea level rise in these coastal areas.
基金P.G.acknowledges the financial support from the Youth Foundation of Shandong Natural Science Foundation(No.ZR2023OB230)National Natural Science Foundation(No.22309035)Double First-class Discipline Construction Fund Project of Harbin Institute of Technology at Weihai(No.2023SYLHY11).
文摘High-entropy catalysts featuring exceptional properties are,in no doubt,playing an increasingly significant role in aprotic lithium-oxygen batteries.Despite extensive effort devoted to tracing the origin of their unparalleled performance,the relationships between multiple active sites and reaction intermediates are still obscure.Here,enlightened by theoretical screening,we tailor a high-entropy perovskite fluoride(KCoMnNiMgZnF_(3)-HEC)with various active sites to overcome the limitations of conventional catalysts in redox process.The entropy effect modulates the d-band center and d orbital occupancy of active centers,which optimizes the d–p hybridization between catalytic sites and key intermediates,enabling a moderate adsorption of LiO_(2)and thus reinforcing the reaction kinetics.As a result,the Li–O2 battery with KCoMnNiMgZnF_(3)-HEC catalyst delivers a minimal discharge/charge polarization and long-term cycle stability,preceding majority of traditional catalysts reported.These encouraging results provide inspiring insights into the electron manipulation and d orbital structure optimization for advanced electrocatalyst.
文摘Given the prominence and magnitude of airport incentive schemes,it is surprising that literature hitherto remains silent as to their effectiveness.In this paper,the relationship between airport incentive schemes and the route development behavior of airlines is analyzed.Because of rare and often controversial findings in the extant literature regarding relevant influencing variables for attracting airlines at an airport,expert interviews are used as a complement to formulate testable hypotheses in this regard.A fixed effects regression model is used to test the hypotheses with a dataset that covers all seat capacity offered at the 22 largest German commercial airports in the week 46 from 2004 to 2011.It is found that incentives from primary choice,as well as secondary choice airports,have a significant influence on Low Cost Carriers.Furthermore,Low Cost Carriers,in general,do not leave any of both types of airports when the incentives cease.In the case of Network Carriers,no case is found where one joins a primary choice airport and receives an incentive.Insufficient data between Network Carriers and secondary choice airports in the time when incentives have ceased means that no statement can be given.
基金Project supported bythe National Natural Science Foundation of China (20401006)Natural Science Foundation of Henan Province (200510475019)
文摘Organic-dispersible lanthanide fluorides nanocrystals were synthesized at a large scale using colloid-extraction method, in the presence of dialkyl-dithiophosphinic acid (DDPA) as the extraction agent. The products were characterized by means of X-ray powder diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier transformation infrared (FTIR) spectroscopy. It was found that the synthesized lanthanide fluorides nanoparticles had high purity and crystallinity, and could be well dispersed in organic solvents such as chloroform, toluene etc., which could be closely related to the surface-capping of the nanocrystals by the DDPA molecules. Moreover, the nanocrystals before and after extraction by DDPA showed few differences in the microscopic morphologies. It was implied that DDPA as the extraction agent had good protection to the nanocrystals as well, which could be essential to the commercial application of the titled rare earth nanocrystals as novel multifunctional additives in the fields of lubrication.
基金supported by National Natural Science Foundation of China [No. 81773405 to Y.Q. and No. 82173644to X.Y.]Shanxi Natural Science Foundation of China [No.202203021211246 and No. 202103021224242]。
文摘Objective Arsenic(As) and fluoride(F) are two of the most common elements contaminating groundwater resources. A growing number of studies have found that As and F can cause neurotoxicity in infants and children, leading to cognitive, learning, and memory impairments. However, early biomarkers of learning and memory impairment induced by As and/or F remain unclear. In the present study, the mechanisms by which As and/or F cause learning memory impairment are explored at the multi-omics level(microbiome and metabolome).Methods We stablished an SD rats model exposed to arsenic and/or fluoride from intrauterine to adult period.Results Arsenic and/fluoride exposed groups showed reduced neurobehavioral performance and lesions in the hippocampal CA1 region. 16S rRNA gene sequencing revealed that As and/or F exposure significantly altered the composition and diversity of the gut microbiome, featuring the Lachnospiraceae_NK4A136_group, Ruminococcus_1, Prevotellaceae_NK3B31_group, [Eubacterium]_xylanophilum_group. Metabolome analysis showed that As and/or F-induced learning and memory impairment may be related to tryptophan, lipoic acid, glutamate, gamma-aminobutyric acidergic(GABAergic) synapse, and arachidonic acid(AA) metabolism. The gut microbiota, metabolites, and learning memory indicators were significantly correlated.Conclusion Learning memory impairment triggered by As and/or F exposure may be mediated by different gut microbes and their associated metabolites.
基金Zhu.L.and Li.H.contributed equally to this work.This work is supported by the National Natural Science Foundation of China(Grant No.51901121)the Natural Science Foundation of Shaanxi Province(Grant No.2021JM-203,2019JQ-433,2020zdzx04-03-02)the Fundamental Research Funds for the Central Universities(Grant No.GK202103022).
文摘Here we prepared PEO coatings on Mg alloys in silicate-NaOH-phosphate electrolyte containing different concentrations of NaF addition.The detailed microstructural characterizations combining with potentiodynamic polarization and electrochemical impedance spectra(EIS)were employed to investigate the roles of fluoride in the growth and corrosion properties of PEO coating on Mg.The result shows the introduction of NaF led to a fluoride-containing nanolayer(FNL)formed at the Mg/coating interface.The FNL consists of MgO nanoparticles and insoluble MgF_(2)nanoparticles(containing rutile phase and cubic phase).The increase in the NaF concentration of the electrolyte increases the thickness and the MgF_(2)content in the FNL.When anodized in the electrolyte containing 2 g/L NaF,the formed FNL has the highest thickness of 100-200 nm along with the highest value of x of∼0.6 in(MgO)_(1-x)(MgF_(2))x resulted in the highest corrosion performance of PEO coating.In addition,when anodized in the electrolyte containing a low NaF concentration(0.4-0.8 g/L),the formed FNL was thin and discontinuous,which would decrease the pore density and increase the coating's uniformness simultaneously.
基金partially supported by the National Natural Science Foundation of China(41930644,61972439)the Collaborative Innovation Project of Anhui Province(GXXT-2022-093)the Key Program in the Youth Elite Support Plan in Universities of Anhui Province(gxyqZD2019010)。
文摘Tourism route planning is widely applied in the smart tourism field.The Pareto-optimal front obtained by the traditional multi-objective evolutionary algorithm exhibits long tails,sharp peaks and disconnected regions problems,which leads to uneven distribution and weak diversity of optimization solutions of tourism routes.Inspired by these limitations,we propose a multi-objective evolutionary algorithm for tourism route recommendation(MOTRR)with two-stage and Pareto layering based on decomposition.The method decomposes the multiobjective problem into several subproblems,and improves the distribution of solutions through a two-stage method.The crowding degree mechanism between extreme and intermediate populations is used in the two-stage method.The neighborhood is determined according to the weight of the subproblem for crossover mutation.Finally,Pareto layering is used to improve the updating efficiency and population diversity of the solution.The two-stage method is combined with the Pareto layering structure,which not only maintains the distribution and diversity of the algorithm,but also avoids the same solutions.Compared with several classical benchmark algorithms,the experimental results demonstrate competitive advantages on five test functions,hypervolume(HV)and inverted generational distance(IGD)metrics.Using the experimental results of real scenic spot datasets from two famous tourism social networking sites with vast amounts of users and large-scale online comments in Beijing,our proposed algorithm shows better distribution.It proves that the tourism routes recommended by our proposed algorithm have better distribution and diversity,so that the recommended routes can better meet the personalized needs of tourists.
文摘Wireless Sensor Networks(WSN)have revolutionized the processes involved in industrial communication.However,the most important challenge faced by WSN sensors is the presence of limited energy.Multiple research inves-tigations have been conducted so far on how to prolong the energy in WSN.This phenomenon is a result of inability of the network to have battery powered-sensor terminal.Energy-efficient routing on packetflow is a parallel phenomenon to delay nature,whereas the primary energy gets wasted as a result of WSN holes.Energy holes are present in the vicinity of sink and it is an important efficient-routing protocol for WSNs.In order to solve the issues discussed above,an energy-efficient routing protocol is proposed in this study named as Adaptive Route Decision Sink Relocation Protocol using Cluster Head Chain Cycling approach(ARDSR-CHC2H).The proposed method aims at improved communica-tion at sink-inviting routes.At this point,Cluster Head Node(CHN)is selected,since it consumes low energy and permits one node to communicate with others in two groups.The main purpose of the proposed model is to reduce energy con-sumption and define new interchange technology.A comparison of simulation results demonstrates that the proposed algorithm achieved low cluster creation time,better network error and high Packet Delivery Rate with less network failure.
基金Supported by the National Natural Science Foundation of China(No.20871051)the Scientific and Technological Plan-ning Project of Jilin Province, China(No.20080504)
文摘A new one-dimensional(1D) fluoroaluminophosphate chain(C 4 H 15 N 3 )[AlPO 4 F 2 ](denoted AlPO-CJ28) was synthesized in the concentrated fluoride synthetic medium with a gel composition of 1.0Al(OPr i ) 3 :1.0H 3 PO 4 : 5.4DETA:1.3HF:2.0H 2 O(DETA=diethylenetriamine). The reagents were mixed directly without introducing addi- tional water solvent. The 1D chain is constructed by alternating AlO 2 F 2 and doubly bridging PO 4 tetrahedra to form the simplest serrate chain. AlPO-CJ28 can be transformed to another 1D aluminophosphate chain AlPO-CSC upon further crystallization at 230 °C.
基金financially supported by the National Natural Science Foundation of China(Grant No.12005221)。
文摘First-principles calculation of muons in ionic fluorides has been proposed recently.However,there is a considerable difference between the obtained F-μbond length and the experimental data obtained by muon spin relaxation(μSR).Considering that the difference may be caused by ignoring the quantum effect of muons,we use two-component density functional theory(TCDFT)to consider the quantized muon and recalculate the bond length and theμSR depolarization spectrum.After testing several muon-electron correlation,we show that TCDFT can give better results than the commonly used“DFT+μ”.
基金Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2022R237)Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.The authors would like to thank the Deanship of Scientific Research at Umm Al-Qura University for supporting this work by Grant Code:(22UQU4310373DSR30).
文摘Recently,Internet of Things(IoT)has been developed into a field of research and it purposes at linking many sensors enabling devices mostly to data collection and track applications.Wireless sensor network(WSN)is a vital element of IoT paradigm since its inception and has developed into one of the chosen platforms for deploying many smart city application regions such as disaster management,intelligent transportation,home automation,smart buildings,and other such IoT-based application.The routing approaches were extremely-utilized energy efficient approaches with an initial drive that is,for balancing the energy amongst sensor nodes.The clustering and routing procedures assumed that Non-Polynomial(NP)hard problems but bio-simulated approaches are utilized to a recognized time for resolving such problems.With this motivation,this paper presents a new blockchain with Enhanced Hunger Games Search based Route Planning(BCEHGS-RP)scheme for IoT assisted WSN.The presented BCEHGS-RP model majorly employs BC technology for secure communication in the IoT supportedWSN environment.In addition,an effective multihop route planning approach was designed by the use of EHGS technique.The proposed EHGS technique is derived from the concept of Hill Climbing strategy(HCS)and HGS algorithm.Moreover,a fitness function with two parameters namely residual energy(RE)and intercluster distance to elect optimal routes.The performance validation of the BCEHGS-RP model is experimented with under diverse number of nodes.Extensive experimental outcomes highlighted the better performance of the BCEHGS-RP technique on recent approaches.
基金supported by the Basic Science Research Program of the National Research Foundation(NRF)of South Koreafunded by the Ministry of Science&ICT and Future Planning(NRF-2020M3H4A3081889)KIST Institutional Program of South Korea(Project Nos.2E31860)。
文摘Elucidation of a reaction mechanism is the most critical aspect for designing electrodes for highperformance secondary batteries.Herein,we investigate the sodium insertion/extraction into an iron fluoride hydrate(FeF_(3)·0.5H_(2)O)electrode for sodium-ion batteries(SIBs).The electrode material is prepared by employing an ionic liquid 1-butyl-3-methylimidazolium-tetrafluoroborate,which serves as a reaction medium and precursor for F^(-)ions.The crystal structure of FeF_(3)·0.5H_(2)O is observed as pyrochlore type with large open 3-D tunnels and a unit cell volume of 1129A^(3).The morphology of FeF_(3)·0.5H_(2)O is spherical shape with a mesoporous structure.The microstructure analysis reveals primary particle size of around 10 nm.The FeF_(3)·0.5H_(2)O cathode exhibits stable discharge capacities of 158,210,and 284 mA h g^(-1) in three different potential ranges of 1.5-4.5,1.2-4.5,and 1.0-4.5 V,respectively at 0.05 C rate.The specific capacities remained stable in over 50 cycles in all three potential ranges,while the rate capability was best in the potential range of 1.5-4.5 V.The electrochemical sodium storage mechanism is studied using X-ray absorption spectroscopy,indicating higher conversion at a more discharged state.Ex-situ M?ssbauer spectroscopy strengthens the results for reversible reduction/oxidation of Fe.These results will be favorable to establish high-performance cathode materials with selective voltage window for SIBs.
基金the National Social Science Fund of the China Western Project,“Research on the Cultural Characteristics of the Display of the Long March History of the Chinese Workers’and Peasants’Red Army”(17XDJ008)The Key Special Project of Sichuan Academy of Social Sciences,“Research on Promoting Cultural Confidence and Self-improvement through the Construction of the National Long March National Cultural Park from the Perspective of World Cultural Heritage”(2022ZX02).
文摘The idea of cultural route heritage protection expands the protection theory for world cultural heritage.The Long March route carries the prominent characteristic of cultural route heritage.By actively building the Long March National Cultural Park,China has strengthened the overall protection and integrated utilization of the Long March cultural heritage,upgraded the hardware facilities for exhibition,and investigated ways to protect cultural route heritage with Chinese characteristics.During the construction of the Park,it is necessary to draw on the concept and norms of the cultural route heritage protection,optimize the construction approach,and make the construction of the Park more in line with the linear cultural characteristics of Long March heritage.Specifically,it is proposed to improve the Long March cultural route heritage protection system oriented towards“authenticity”protection,to deeply tap and interpret the prominent universal worth of the Long March route,augmenting the international dissemination of the Long March culture in an innovative way,and realizing a more scientific and effective protection and utilization of Long March cultural resources.
基金the National Institute of Bio-logical Resources,funded by the Ministry of Environment,Republic of Korea(grant numbers NIBR202216101 and NIBR202223101).
文摘Long-distance migratory birds travel more rapidly in spring than in autumn,as they face temporal breeding constraints.However,several species travel slower in spring owing to environmental influences,such as food availability and wind conditions.GPS trackers were attached to 17 Whooper Swans(Cygnus cygnus) inhabiting northeastern Mongolia,to determine their migration routes and stopover sites in spring and autumn.Differences between spring and autumn migrations,migration-influencing parameters,and the effect of spring stopover site temperatures were analyzed.Six swans completed perfect tours between their wintering and breeding sites,and these data were used for analysis.Spring migration lasted 57 days,with 49.2 days spent at 3.7 stopover sites.Autumn migration lasted 21.5 days,with 17.5 days spent at 1.0 stopover sites.Thus,the swans traveled more rapidly in autumn than in spring.Migration distance,number of stopovers,migration speed,and straightness were important migration determinants in both spring and autumn.Migration distance,stopover duration,number of stopovers,daily travel speed,travel duration,and migration speed differed significantly between spring and autumn.During spring migration,the temperature at the current stopover sites and that at the future stopover sites displayed significant variations(t=1585.8,df=631.6,p <0.001).These findings are critical for the conservation and management of Whooper Swans and their key habitats in East Asian regions,and the data are anticipated to make a particularly significant contribution toward developing detailed management plans for the conservation of their key habitats.
文摘BACKGROUND Incidence of cholangiocarcinoma(CCA)is rising,with overall prognosis remaining very poor.Reasons for the high mortality of CCA include its late presentation in most patients,when curative options are no longer feasible,and poor response to systemic therapies for advanced disease.Late presentation presents a large barrier to improving outcomes and is often associated with diagnosis via mergency presentation(EP).Earlier diagnoses may be made by Two Week Wait(TWW)referrals through General practitioner(GP).We hypothesise that TWW referrals and EP routes to diagnosis differ across regions in England.AIM To investigate routes to diagnosis of CCA over time,regional variation and influencing factors.METHODS We linked patient records from the National Cancer Registration Dataset to Hospital Episode Statistics,Cancer Waiting Times and Cancer Screening Programme datasets to define routes to diagnosis and certain patient characteristics for patients diagnosed 2006-2017 in England.We used linear probability models to investigate geographic variation by assessing the proportions of patients diagnosed via TWW referral or EP across Cancer Alliances in England,adjusting for potential confounders.Correlation between the proportion of people diagnosed by TWW referral and EP was investigated with Spearman’s correlation coefficient.RESULTS Of 23632 patients diagnosed between 2006-2017 in England,the most common route to diagnosis was EP(49.6%).Non-TWW GP referrals accounted for 20.5%of diagnosis routes,13.8%were diagnosed by TWW referral,and the remainder 16.2%were diagnosed via an‘other’or Unknown route.The proportion diagnosed via a TWW referral doubled between 2006-2017 rising from 9.9%to 19.8%,conversely EP diagnosis route declined,falling from 51.3%to 46.0%.Statistically significant variation in both the TWW referral and EP proportions was found across Cancer Alliances.Age,presence of comorbidity and underlying liver disease were independently associated with both a lower proportion of patients diagnosed via TWW referral,and a higher proportion diagnosed by EP after adjusting for other potential confounders.CONCLUSION There is significant geographic and socio-demographic variation in routes to diagnosis of CCA in England.Knowledge sharing of best practice may improve diagnostic pathways and reduce unwarranted variation.
基金This research was supported by the Universiti Sains Malaysia(USM)and the Ministry of Higher Education Malaysia through Fundamental Research GrantScheme(FRGS-Grant No:FRGS/1/2020/TK0/USM/02/1).
文摘Recently,a trust system was introduced to enhance security and cooperation between nodes in wireless sensor networks(WSN).In routing,the trust system includes or avoids nodes related to the estimated trust values in the routing function.This article introduces Enhanced Metaheuristics with Trust Aware Secure Route Selection Protocol(EMTA-SRSP)for WSN.The presented EMTA-SRSP technique majorly involves the optimal selection of routes in WSN.To accomplish this,the EMTA-SRSP technique involves the design of an oppositional Aquila optimization algorithm to choose safe routes for data communication.For the clustering process,the nodes with maximum residual energy will be considered cluster heads(CHs).In addition,the OAOA technique gets executed to choose optimal routes based on objective functions with multiple parameters such as energy,distance,and trust degree.The experimental validation of the EMTA-SRSP technique is tested,and the results exhibited a better performance of the EMTA-SRSP technique over other approaches.
基金financially supported by Open Fund of Material Corrosion and Protection Key Laboratory of Sichuan Province of China(No.2020CL09)Hunan Key Laboratory of Applied Environmental Photocatalysis(No.2214503)。
文摘Vanadium flow batteries(VFBs)are considered ideal for grid-sc ale,long-duration energy storage applications owing to their decoupled output power and storage capacity,high safety,efficiency,and long cycle life.However,the widespread adoption of VFB s is hindered by the use of expensive Nafion membranes.Herein,we report a soft template-induced method to develop a porous polyvinylidene fluoride(PVDF)membrane for VFB applications.By incorporating water-soluble and flexible polyethylene glycol(PEG 400)as a soft template,we induced the aggregation of hydrophilic sulfonated poly(ether ether ketone),resulting in phase separation from the hydrophobic PVDF polymer during membrane formation.This process led to the creation of a porous PVDF membrane with controllable morphologies determined by the polyethylene glycol content in the cast solution.The optimized porous PVDF membrane enabled a stable VFB performance for 200 cycles at a current density of 80 mA/cm^(2),and the VFB exhibited a Coulombic efficiency of 95.2%and a voltage efficiency of 87.8%.These findings provide valuable insights for the development of highly stable membranes for VFB applications.
