The genetically heterogeneous NIH-HS rat stock has been characterized by its response to anxiety- and fear-inducing situations, thus leading to the conclusion that they are a rather anxious and passive coping type of ...The genetically heterogeneous NIH-HS rat stock has been characterized by its response to anxiety- and fear-inducing situations, thus leading to the conclusion that they are a rather anxious and passive coping type of rats. Taking advantage of these profiles, and knowing that they show very poor performance in the two-way active (shuttle box) escape/avoidance task, we have tested NIH-HS rats (n = 80) in the forced swimming test (FST) as well as we have studied escape response deficits (i.e. response failures) of the same animals in the two-way shuttle box task. They were also tested for anxiety in the elevated zero-maze. The goal of such a study was that of investigating whether there are associations or relationships among helplessness-like or passive coping responses between both models of depression, i.e. the FST and the helplessness-like escape deficits in the shuttle box task. The results for the first time show associations among responses from both depression models and that selecting rats for displaying extreme (active or passive) responses in one of the models predict in a coherent manner (according to the hypothesis) their behaviour in the other model. These findings are discussed in the context of the concurrent validity of both models of depression as well as concerning the possible relevance of NIH-HS rats as a tool for future studies on this field.展开更多
Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reporte...Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reported to have neurological properties,e.g antidepressant and antifatigue.However,its neurological protect in antidepressant-like effect of flavonoids extracted from okra have not yet been demonstrated.The present study was aimed at investigating the antidepressant-like eff ect of the flavonoids extracted from okra fruit(FOF)using the forced swimming test(FST)pattern and preliminary exploration its potential mechanism.We also used the open fi eld test(OFT)to estimate the spontaneous locomotor activity.We found that oral administration(p.o.)of FOF(300 mg/kg)alone signifi cantly reduced the immobility time in the FST without changes in locomotor activity in the OPT.The experimental data indicated the antidepressant-like eff ect of FOF involved in noradrenergic,glutamatergic and dopaminergic systems.展开更多
Objective:Acorus calamus(AC)L.(Araceae)is an annual semi-aquatic and aromatic plant found in Europe,North America and Asia.Its rhizomes are often used by Native Americans,Americans,and Chinese as well as by other cult...Objective:Acorus calamus(AC)L.(Araceae)is an annual semi-aquatic and aromatic plant found in Europe,North America and Asia.Its rhizomes are often used by Native Americans,Americans,and Chinese as well as by other cultures.Ethnobotanical studies and documents have shown their use in various disease treatments,such as insomnia,mental disorders,diabetes mellitus,epilepsy,inflammation,asthma,neuropathic pain,and diarrhea.In this study,the antidepressant activity of methanolic and hydroalcoholic extracts of the AC rhizome part in mice was investigated.Methods:Three doses of methanolic extract of AC rhizome(MEACR)(25,50 and 100 mg/kg b.wt),three doses of hydroalcoholic extract of AC rhizome(HAACR)(100,200 and 400 mg/kg b.wt),and standards(imipramine,15 mg/kg b.wt and fluoxetine,20 mg/kg b.wt)was daily oral administration to the mice for consecutive 14 days.The extract effect on the immobility time was monitored by a tail suspension test(TST)and a forced swimming test(FST).Monoamine oxidase(MAO)levels were also analyzed using standard methods.Results:The optimum antidepressant activity was viewed at 100 mg/kg b.wt of MEACR extract and400 mg/kg b.wt of HAACR extract with 23.82%and 20.59%immobility period reduction,respectively.Besides,the extracts weakened the FST-induced elevation of MAO activity significantly and returned to near-normal levels of neurotransmitters in the brain.100 mg/kg b.wt or above of MEACR extract significantly prevented the MAO-A and MAO-B activities in mice brain at a dose-dependent fashion.But,just 400 mg/kg b.wt of HAACR extract prevented the activity of MAO-A and MAO-B.Fluoxetine and imipramine showed a tendency to prevent the activity of MAO-A and MAO-B.Conclusion:This study suggests that AC rhizome extract mediated antidepressant activity by modulating the central neurochemical and hypothalamic-pituitary-adrenal(HPA)axis in response to FST and TSTinduced stress.Therefore,AC rhizome extract can be used as a valuable plant supplement to treat depressive disorders.展开更多
Existing transversely isotropic poroelastodynamics solutions are limited to infinite domains and without experimental validation. Furthermore, there is a lack of analytical simulations for the elastic moduli dispersio...Existing transversely isotropic poroelastodynamics solutions are limited to infinite domains and without experimental validation. Furthermore, there is a lack of analytical simulations for the elastic moduli dispersion of fluid-saturated porous cylinders. To address these three limitations and investigate the mechanisms of moduli dispersion, we present the analytical solutions of the poromechanical responses and the elastic moduli dispersion of a transversely isotropic, fluid-saturated, finite porous cylinder subjected to a forced deformation test. Through an example, we demonstrate the effects of loading frequency, boundary conditions, and material's anisotropy, dimension, and permeability on the responses of pore pressure,force, displacement, and dynamic elastic moduli of the cylinder. The specimen's responses are significantly influenced by the frequency of the applied load, resulting in a drained state at low frequencies and an undrained state at high frequencies. At high frequencies, the sample behaves identically for an open or a closed lateral boundary, and permeability has insignificant effects. The dynamic elastic moduli are mainly controlled by the loading frequency and the ratio of the sample's radius to its height. Lastly,we show excellent matches between the newly derived analytical solution and laboratory measurements on one clay and two shale samples from Mont Terri.展开更多
BACKGROUND:The orbitofrontal cortex(OFC) is a brain region closely associated with emotion. 5-hydroxytryptamine(5-HT) has been shown to be involved in human depression. OBJECTIVE:To investigate OFC actions and mechani...BACKGROUND:The orbitofrontal cortex(OFC) is a brain region closely associated with emotion. 5-hydroxytryptamine(5-HT) has been shown to be involved in human depression. OBJECTIVE:To investigate OFC actions and mechanisms of 5-HT and 5-HT_(1A) receptor(5-HT_(1A)R) in stress-induced depression. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at Laboratory of Neurobiology,College of Life Science,Shaanxi Normal University between May 2006 and March 2008. MATERIALS:5-HT,p-chlorophenylalanine(PCPA,an inhibitor to tryptophan hydroxylase) and spiperone(5-HT_(1A)R antagonist) were provided by Sigma,USA;rabbit anti-rat 5-HT_(1A)R antibody was provided by Tianjin Haoyang Biological Manufacture. METHODS:A total of 40 male Sprague Dawley rats,aged 3 months,were randomly divided into five groups:control,model,5-HT,spiperone+5-HT,and PCPA,with 8 rats in each group.Except for control group,rats in the other four groups were used to establish depression models by forced swimming for 15 minutes.At 30 minutes before forced swimming test,0.5μL of 5-HT(12.5μg/μL), PCPA(20μg/μL),spiperone(1.3μg/μL)+5-HT(12.5μg/μL,10 minutes later),and saline were respectively injected into the OFC of 5-HT,PCPA,spiperone+5-HT,and model groups,respectively. The control group received a saline microinjection into the OFC. MAIN OUTCOME MEASURES:Forced swimming and open field tests were employed to measure animal behaviors,and immunohistochemistry was used to analyze 5-HT_(1A)R expression in the OFC, cingulate cortex,and piriform cortex. RESULTS:(1) Compared with the model group,5-HT microinjection into the OFC prominently reduced immobility time in the forced swimming test and rearing in open field test(P<0.05); locomotion and grooming in open field test were increased,although there was no significance(P>0.05).Furthermore,following PCPA microinjection into the OFC(PCPA+forced swimming stress), immobility time in forced swimming test increased dramatically(P<0.01),locomotion and rearing in open field test declined(P<0.05 and P<0.01,respectively).Compared with the 5-HT group, 5-HT_(1A)R antagonist(spiperone+5-HT+forced swimming stress) increased immobility time in forced swimming test(P<0.01),but decreased locomotion,rearing,and grooming in open field test. (2) Forced swimming stress markedly elevated 5-HT_(1A)R expression in OFC,cingulate cortex,and piriform cortex(P<0.05 or P<0.01). CONCLUSION:5-HT improved stress-induced depression,and 5-HT anti-depression effects are primarily achieved via 5-HT_(1A)R.Stress-induced up regulation of 5-HT_(1A)R expression might be a compensatory mechanism for decreased 5-HT expression.展开更多
Respiratory diseases, especially asthma, are common in children. While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are often unable to pe...Respiratory diseases, especially asthma, are common in children. While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are often unable to perform forced expiratory manoeuvre. The development of novel diagnostic methods which require minimal effort, such as forced oscillation technique(FOT) is, therefore, a welcome and promising addition. FOT involves applying external, small amplitude oscillations to the respiratory system during tidal breathing. Therefore, it requires minimal effort and cooperation. The FOT has the potential to facilitate asthma diagnosis and management in preschool children by faciliting the objective measurement of baseline lung function and airway reactivity in children unable to successfully perform spirometry. Traditionally the use of FOT was limited to specialised centres. However, the availability of commercial equipment resulted in its use both in research and in clinical practice. In this article, we review the available literature on the use of FOT in childhood asthma. The technical aspects of FOT are described followed by a discussion of its practical aspects in the clinical field including the measurement of baseline lung function and associated reference ranges, bronchodilator responsiveness and bronchial hyperresponsiveness. We also highlight the difficulties and limitations that might be encountered and future research directions.展开更多
Previous quasi-static cyclic tests of shear walls,which routinely used an incremental lateral displacement test protocol with a constant axial load,failed to reflect the character of moment-shear force interaction of ...Previous quasi-static cyclic tests of shear walls,which routinely used an incremental lateral displacement test protocol with a constant axial load,failed to reflect the character of moment-shear force interaction of prototype buildings.To study the effect of the moment-shear force interaction on the seismic performance of shear walls,three identical 2-story shear wall specimens with different loading patterns were constructed at 1/2 scale,to represent the lower portion of an 11-story high-rise building,and were tested under reversed cyclic loads.The axial force,shear force and bending moment were simultaneously applied to simulate the effects of gravity loads and earthquake excitations on the prototype.The axial force and bending moment delivered from the upper structure were applied to the top of the specimens by two vertical actuators,and the shear force was applied to the specimens by two horizontal actuators.A mixed force-displacement control test program was adopted to ensure that the bending moment and the lateral shear were increased proportionally.The experimental results show that the moment-shear force interaction had a significant effect on the failure pattern,hysteretic characteristics,ductility and energy dissipation of the specimens.It is recommended that moment-shear force interaction should be considered in the loading condition of RC shear wall substructures cyclic tests.展开更多
The Stinger PDC cutter has high rock-breaking efficiency and excellent impact and wear resistance, which can significantly increase the rate of penetration (ROP) and extend PDC bit life for drilling hard and abrasive ...The Stinger PDC cutter has high rock-breaking efficiency and excellent impact and wear resistance, which can significantly increase the rate of penetration (ROP) and extend PDC bit life for drilling hard and abrasive formation. The knowledge of force response and mechanical specific energy (MSE) for the Stinger PDC cutter is of great importance for improving the cutter's performance and optimizing the hybrid PDC bit design. In this paper, 87 single cutter tests were conducted on the granite. A new method for precisely obtaining the rock broken volume was proposed. The influences of cutting depth, cutting angle, and cutting speed on cutting force and MSE were analyzed. Besides, a phenomenological cutting force model of the Stinger PDC cutter was established by regression of experimental data. Moreover, the surface topography and fracture morphology of the cutting groove and large size cuttings were measured by a 3D profilometer and a scanning electron microscope (SEM). Finally, the rock-breaking mechanism of the Stinger PDC cutter was illustrated. The results indicated that the cutting depth has the greatest influence on the cutting force and MSE, while the cutting speed has no obvious effects, especially at low cutting speeds. As the increase of cutting depth, the cutting force increases linearly, and MSE reduces with a quadratic polynomial relationship. When the cutting angle raises from 10° to 30°, the cutting force increases linearly, and the MSE firstly decreases and then increases. The optimal cutting angle for breaking rock is approximately 20°. The Stinger PDC cutter breaks granite mainly by high concentrated point loading and tensile failure, which can observably improve the rock breaking efficiency. The key findings of this work will help to reveal the rock-breaking mechanisms and optimize the cutter arrangement for the Stinger PDC cutter.展开更多
Physical model test is an effective way to unveil the dynamic response of a slope under seismic condition.The similarity design is the key of physical model test.An isolated similarity design method for shaking table ...Physical model test is an effective way to unveil the dynamic response of a slope under seismic condition.The similarity design is the key of physical model test.An isolated similarity design method for shaking table tests was proposed and verified in this work.In this method,the relevant physical quantities were divided into several subsystems and subcharacteristic equations for each subsystem were then established based on the Buckingham similarity theory.Large-scale shaking table tests on a reinforced slope were adopted herein to illustrate the application of the proposed isolated similarity design method.The similarity system for the studied slope was divided into four parts in the process of similarity design.The geometrical dimension L,densityρand gravity g were selected as fundamental quantities for the similarity design,and four subcharacteristic equations were established for each subsystem.The dynamic responses of the recorded acceleration and axis force show that the seismic waves propagate well in the model slope.The proposed isolated similarity design method solves the conflict between the similarity requirement for all relevant physical quantities and the difficulty of test model fabrication to satisfy all similarity relations.展开更多
基金Supported by grants for the MICINN(SAF2009-10532),“Fundacio La Marato TV3”(ref.092630/31),2009SGR-0051EURATRANS consortium(grant agreement HEALTH-F4-2010-241504)the Welcome Trust(UK).C.M-C is recipient of a FPI(2010,MICINN)PhD fellowship.
文摘The genetically heterogeneous NIH-HS rat stock has been characterized by its response to anxiety- and fear-inducing situations, thus leading to the conclusion that they are a rather anxious and passive coping type of rats. Taking advantage of these profiles, and knowing that they show very poor performance in the two-way active (shuttle box) escape/avoidance task, we have tested NIH-HS rats (n = 80) in the forced swimming test (FST) as well as we have studied escape response deficits (i.e. response failures) of the same animals in the two-way shuttle box task. They were also tested for anxiety in the elevated zero-maze. The goal of such a study was that of investigating whether there are associations or relationships among helplessness-like or passive coping responses between both models of depression, i.e. the FST and the helplessness-like escape deficits in the shuttle box task. The results for the first time show associations among responses from both depression models and that selecting rats for displaying extreme (active or passive) responses in one of the models predict in a coherent manner (according to the hypothesis) their behaviour in the other model. These findings are discussed in the context of the concurrent validity of both models of depression as well as concerning the possible relevance of NIH-HS rats as a tool for future studies on this field.
基金This research was supported by Shenyang Scientific Project(No.F13-287-1-00)Liaoning Province Natural Science Foundation(No.2014020076).
文摘Okra(Abelmoschus esculentus[L.]Moench.)is one of the most frequently used herbals in East or West Africa,and its various biological activities have been widely studied.Flavonoids extracted from many plants are reported to have neurological properties,e.g antidepressant and antifatigue.However,its neurological protect in antidepressant-like effect of flavonoids extracted from okra have not yet been demonstrated.The present study was aimed at investigating the antidepressant-like eff ect of the flavonoids extracted from okra fruit(FOF)using the forced swimming test(FST)pattern and preliminary exploration its potential mechanism.We also used the open fi eld test(OFT)to estimate the spontaneous locomotor activity.We found that oral administration(p.o.)of FOF(300 mg/kg)alone signifi cantly reduced the immobility time in the FST without changes in locomotor activity in the OPT.The experimental data indicated the antidepressant-like eff ect of FOF involved in noradrenergic,glutamatergic and dopaminergic systems.
文摘Objective:Acorus calamus(AC)L.(Araceae)is an annual semi-aquatic and aromatic plant found in Europe,North America and Asia.Its rhizomes are often used by Native Americans,Americans,and Chinese as well as by other cultures.Ethnobotanical studies and documents have shown their use in various disease treatments,such as insomnia,mental disorders,diabetes mellitus,epilepsy,inflammation,asthma,neuropathic pain,and diarrhea.In this study,the antidepressant activity of methanolic and hydroalcoholic extracts of the AC rhizome part in mice was investigated.Methods:Three doses of methanolic extract of AC rhizome(MEACR)(25,50 and 100 mg/kg b.wt),three doses of hydroalcoholic extract of AC rhizome(HAACR)(100,200 and 400 mg/kg b.wt),and standards(imipramine,15 mg/kg b.wt and fluoxetine,20 mg/kg b.wt)was daily oral administration to the mice for consecutive 14 days.The extract effect on the immobility time was monitored by a tail suspension test(TST)and a forced swimming test(FST).Monoamine oxidase(MAO)levels were also analyzed using standard methods.Results:The optimum antidepressant activity was viewed at 100 mg/kg b.wt of MEACR extract and400 mg/kg b.wt of HAACR extract with 23.82%and 20.59%immobility period reduction,respectively.Besides,the extracts weakened the FST-induced elevation of MAO activity significantly and returned to near-normal levels of neurotransmitters in the brain.100 mg/kg b.wt or above of MEACR extract significantly prevented the MAO-A and MAO-B activities in mice brain at a dose-dependent fashion.But,just 400 mg/kg b.wt of HAACR extract prevented the activity of MAO-A and MAO-B.Fluoxetine and imipramine showed a tendency to prevent the activity of MAO-A and MAO-B.Conclusion:This study suggests that AC rhizome extract mediated antidepressant activity by modulating the central neurochemical and hypothalamic-pituitary-adrenal(HPA)axis in response to FST and TSTinduced stress.Therefore,AC rhizome extract can be used as a valuable plant supplement to treat depressive disorders.
文摘Existing transversely isotropic poroelastodynamics solutions are limited to infinite domains and without experimental validation. Furthermore, there is a lack of analytical simulations for the elastic moduli dispersion of fluid-saturated porous cylinders. To address these three limitations and investigate the mechanisms of moduli dispersion, we present the analytical solutions of the poromechanical responses and the elastic moduli dispersion of a transversely isotropic, fluid-saturated, finite porous cylinder subjected to a forced deformation test. Through an example, we demonstrate the effects of loading frequency, boundary conditions, and material's anisotropy, dimension, and permeability on the responses of pore pressure,force, displacement, and dynamic elastic moduli of the cylinder. The specimen's responses are significantly influenced by the frequency of the applied load, resulting in a drained state at low frequencies and an undrained state at high frequencies. At high frequencies, the sample behaves identically for an open or a closed lateral boundary, and permeability has insignificant effects. The dynamic elastic moduli are mainly controlled by the loading frequency and the ratio of the sample's radius to its height. Lastly,we show excellent matches between the newly derived analytical solution and laboratory measurements on one clay and two shale samples from Mont Terri.
基金the Natural Science Foundation of Shaanxi Province,No. 2006C240
文摘BACKGROUND:The orbitofrontal cortex(OFC) is a brain region closely associated with emotion. 5-hydroxytryptamine(5-HT) has been shown to be involved in human depression. OBJECTIVE:To investigate OFC actions and mechanisms of 5-HT and 5-HT_(1A) receptor(5-HT_(1A)R) in stress-induced depression. DESIGN,TIME AND SETTING:A randomized,controlled,animal experiment was performed at Laboratory of Neurobiology,College of Life Science,Shaanxi Normal University between May 2006 and March 2008. MATERIALS:5-HT,p-chlorophenylalanine(PCPA,an inhibitor to tryptophan hydroxylase) and spiperone(5-HT_(1A)R antagonist) were provided by Sigma,USA;rabbit anti-rat 5-HT_(1A)R antibody was provided by Tianjin Haoyang Biological Manufacture. METHODS:A total of 40 male Sprague Dawley rats,aged 3 months,were randomly divided into five groups:control,model,5-HT,spiperone+5-HT,and PCPA,with 8 rats in each group.Except for control group,rats in the other four groups were used to establish depression models by forced swimming for 15 minutes.At 30 minutes before forced swimming test,0.5μL of 5-HT(12.5μg/μL), PCPA(20μg/μL),spiperone(1.3μg/μL)+5-HT(12.5μg/μL,10 minutes later),and saline were respectively injected into the OFC of 5-HT,PCPA,spiperone+5-HT,and model groups,respectively. The control group received a saline microinjection into the OFC. MAIN OUTCOME MEASURES:Forced swimming and open field tests were employed to measure animal behaviors,and immunohistochemistry was used to analyze 5-HT_(1A)R expression in the OFC, cingulate cortex,and piriform cortex. RESULTS:(1) Compared with the model group,5-HT microinjection into the OFC prominently reduced immobility time in the forced swimming test and rearing in open field test(P<0.05); locomotion and grooming in open field test were increased,although there was no significance(P>0.05).Furthermore,following PCPA microinjection into the OFC(PCPA+forced swimming stress), immobility time in forced swimming test increased dramatically(P<0.01),locomotion and rearing in open field test declined(P<0.05 and P<0.01,respectively).Compared with the 5-HT group, 5-HT_(1A)R antagonist(spiperone+5-HT+forced swimming stress) increased immobility time in forced swimming test(P<0.01),but decreased locomotion,rearing,and grooming in open field test. (2) Forced swimming stress markedly elevated 5-HT_(1A)R expression in OFC,cingulate cortex,and piriform cortex(P<0.05 or P<0.01). CONCLUSION:5-HT improved stress-induced depression,and 5-HT anti-depression effects are primarily achieved via 5-HT_(1A)R.Stress-induced up regulation of 5-HT_(1A)R expression might be a compensatory mechanism for decreased 5-HT expression.
文摘Respiratory diseases, especially asthma, are common in children. While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are often unable to perform forced expiratory manoeuvre. The development of novel diagnostic methods which require minimal effort, such as forced oscillation technique(FOT) is, therefore, a welcome and promising addition. FOT involves applying external, small amplitude oscillations to the respiratory system during tidal breathing. Therefore, it requires minimal effort and cooperation. The FOT has the potential to facilitate asthma diagnosis and management in preschool children by faciliting the objective measurement of baseline lung function and airway reactivity in children unable to successfully perform spirometry. Traditionally the use of FOT was limited to specialised centres. However, the availability of commercial equipment resulted in its use both in research and in clinical practice. In this article, we review the available literature on the use of FOT in childhood asthma. The technical aspects of FOT are described followed by a discussion of its practical aspects in the clinical field including the measurement of baseline lung function and associated reference ranges, bronchodilator responsiveness and bronchial hyperresponsiveness. We also highlight the difficulties and limitations that might be encountered and future research directions.
基金Scientific Research Fund of Institute of Engineering Mechanics,China Earthquake Administration under Grant No.2019B05the Heilongjiang Provincial Natural Science Foundation of China under Grant No.LH2019E098,the National Natural Science Foundation of China under Grant Nos.51878631 and 51678544the National Key Research and Development Program of China under Grant Nos.2017YFC1500605 and 2018YFC1504602-01。
文摘Previous quasi-static cyclic tests of shear walls,which routinely used an incremental lateral displacement test protocol with a constant axial load,failed to reflect the character of moment-shear force interaction of prototype buildings.To study the effect of the moment-shear force interaction on the seismic performance of shear walls,three identical 2-story shear wall specimens with different loading patterns were constructed at 1/2 scale,to represent the lower portion of an 11-story high-rise building,and were tested under reversed cyclic loads.The axial force,shear force and bending moment were simultaneously applied to simulate the effects of gravity loads and earthquake excitations on the prototype.The axial force and bending moment delivered from the upper structure were applied to the top of the specimens by two vertical actuators,and the shear force was applied to the specimens by two horizontal actuators.A mixed force-displacement control test program was adopted to ensure that the bending moment and the lateral shear were increased proportionally.The experimental results show that the moment-shear force interaction had a significant effect on the failure pattern,hysteretic characteristics,ductility and energy dissipation of the specimens.It is recommended that moment-shear force interaction should be considered in the loading condition of RC shear wall substructures cyclic tests.
基金supported by the Joint Funds of The National Natural Science Foundation of China(Grant No.U19B6003-05)the National Key Research and Development Program of China(No.2019YFA0708302)+2 种基金the National Science Fund for Distinguished Young Scholars(Grant No.51725404)the Beijing Outstanding Young Scientist Program(Grant No.BJJWZYJH01201911414038)the Strategic Cooperation Technology Projects of CNPC and CUPB(Grant No.ZLZX2020-01).
文摘The Stinger PDC cutter has high rock-breaking efficiency and excellent impact and wear resistance, which can significantly increase the rate of penetration (ROP) and extend PDC bit life for drilling hard and abrasive formation. The knowledge of force response and mechanical specific energy (MSE) for the Stinger PDC cutter is of great importance for improving the cutter's performance and optimizing the hybrid PDC bit design. In this paper, 87 single cutter tests were conducted on the granite. A new method for precisely obtaining the rock broken volume was proposed. The influences of cutting depth, cutting angle, and cutting speed on cutting force and MSE were analyzed. Besides, a phenomenological cutting force model of the Stinger PDC cutter was established by regression of experimental data. Moreover, the surface topography and fracture morphology of the cutting groove and large size cuttings were measured by a 3D profilometer and a scanning electron microscope (SEM). Finally, the rock-breaking mechanism of the Stinger PDC cutter was illustrated. The results indicated that the cutting depth has the greatest influence on the cutting force and MSE, while the cutting speed has no obvious effects, especially at low cutting speeds. As the increase of cutting depth, the cutting force increases linearly, and MSE reduces with a quadratic polynomial relationship. When the cutting angle raises from 10° to 30°, the cutting force increases linearly, and the MSE firstly decreases and then increases. The optimal cutting angle for breaking rock is approximately 20°. The Stinger PDC cutter breaks granite mainly by high concentrated point loading and tensile failure, which can observably improve the rock breaking efficiency. The key findings of this work will help to reveal the rock-breaking mechanisms and optimize the cutter arrangement for the Stinger PDC cutter.
基金financially supported by National Natural Science Foundation of China(51708163 and 41907247)Hainan Provincial Natural Science Foundation of China(520MS018)the foundation from the State Key Laboratory of Geohazard Prevention and Geoenvironment Protection(SKLGP2021K008)。
文摘Physical model test is an effective way to unveil the dynamic response of a slope under seismic condition.The similarity design is the key of physical model test.An isolated similarity design method for shaking table tests was proposed and verified in this work.In this method,the relevant physical quantities were divided into several subsystems and subcharacteristic equations for each subsystem were then established based on the Buckingham similarity theory.Large-scale shaking table tests on a reinforced slope were adopted herein to illustrate the application of the proposed isolated similarity design method.The similarity system for the studied slope was divided into four parts in the process of similarity design.The geometrical dimension L,densityρand gravity g were selected as fundamental quantities for the similarity design,and four subcharacteristic equations were established for each subsystem.The dynamic responses of the recorded acceleration and axis force show that the seismic waves propagate well in the model slope.The proposed isolated similarity design method solves the conflict between the similarity requirement for all relevant physical quantities and the difficulty of test model fabrication to satisfy all similarity relations.
